Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bcl-2-interacting killer

Gene

BIK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.1 Publication

GO - Biological processi

  • apoptotic mitochondrial changes Source: Ensembl
  • apoptotic process Source: UniProtKB
  • male gonad development Source: GO_Central
  • positive regulation of protein homooligomerization Source: BHF-UCL
  • positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
  • spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100290-MONOMER.
SIGNORiQ13323.

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-interacting killer
Alternative name(s):
Apoptosis inducer NBK
BIP1
BP4
Gene namesi
Name:BIK
Synonyms:NBK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1051. BIK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi153 – 154GG → FF: Inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication2

Organism-specific databases

DisGeNETi638.
OpenTargetsiENSG00000100290.
PharmGKBiPA25354.

Polymorphism and mutation databases

BioMutaiBIK.
DMDMi2493284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431001 – 160Bcl-2-interacting killerAdd BLAST160

Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei153 – 154Cleavage; by RHBDL4/RHBDD1Curated2

Proteomic databases

PaxDbiQ13323.
PeptideAtlasiQ13323.
PRIDEiQ13323.

PTM databases

iPTMnetiQ13323.
PhosphoSitePlusiQ13323.

Expressioni

Gene expression databases

BgeeiENSG00000100290.
CleanExiHS_BIK.
ExpressionAtlasiQ13323. baseline and differential.
GenevisibleiQ13323. HS.

Organism-specific databases

HPAiHPA051360.

Interactioni

Subunit structurei

Interacts with RHBDL4/RHBDD1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2P104155EBI-700794,EBI-77694
BCL2A1Q165485EBI-700794,EBI-1003550
BCL2L1Q078179EBI-700794,EBI-78035
BCL2L1Q07817-13EBI-700794,EBI-287195
BCL2L2Q9284315EBI-700794,EBI-707714
FATE1Q969F06EBI-700794,EBI-743099

Protein-protein interaction databases

BioGridi107107. 13 interactors.
DIPiDIP-928N.
IntActiQ13323. 15 interactors.
MINTiMINT-1457938.
STRINGi9606.ENSP00000216115.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPEmodel-@1-160[»]
ProteinModelPortaliQ13323.
SMRiQ13323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 158Leucine-zipperSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi57 – 71BH3Add BLAST15

Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JHX0. Eukaryota.
ENOG41116I0. LUCA.
GeneTreeiENSGT00530000064453.
HOGENOMiHOG000095229.
HOVERGENiHBG001515.
InParanoidiQ13323.
KOiK18452.
OMAiDPMEDFD.
OrthoDBiEOG091G0VGV.
PhylomeDBiQ13323.
TreeFamiTF338339.

Family and domain databases

InterProiIPR024579. Bcl2-int_killer.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15018. PTHR15018. 1 hit.
PfamiPF12201. bcl-2I13. 1 hit.
[Graphical view]
ProDomiPD032623. PD032623. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC
60 70 80 90 100
MEGSDALALR LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI
110 120 130 140 150
RDVLRSFMDG FTTLKENIMR FWRSPNPGSW VSCEQVLLAL LLLLALLLPL
160
LSGGLHLLLK
Length:160
Mass (Da):18,016
Last modified:November 1, 1997 - v2
Checksum:i89034F4443F5A136
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02917919E → K.1 PublicationCorresponds to variant rs4988415dbSNPEnsembl.1
Natural variantiVAR_04842026T → I.Corresponds to variant rs11090143dbSNPEnsembl.1
Natural variantiVAR_029180148L → P.Corresponds to variant rs11574527dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34584 mRNA. Translation: AAC50413.1.
U49730 mRNA. Translation: AAC79124.1.
X89986 mRNA. Translation: CAA62013.1.
AF174424
, AF174421, AF174422, AF174423 Genomic DNA. Translation: AAF01156.1.
CR456390 mRNA. Translation: CAG30276.1.
BT006728 mRNA. Translation: AAP35374.1.
AY245248 Genomic DNA. Translation: AAO61089.1.
CR541863 mRNA. Translation: CAG46661.1.
CR541883 mRNA. Translation: CAG46681.1.
AL022237 Genomic DNA. Translation: CAA18260.2.
CH471138 Genomic DNA. Translation: EAW73282.1.
BC001599 mRNA. Translation: AAH01599.1.
CCDSiCCDS14044.1.
PIRiS58214.
RefSeqiNP_001188.1. NM_001197.4.
UniGeneiHs.475055.

Genome annotation databases

EnsembliENST00000216115; ENSP00000216115; ENSG00000100290.
GeneIDi638.
KEGGihsa:638.
UCSCiuc003bdk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34584 mRNA. Translation: AAC50413.1.
U49730 mRNA. Translation: AAC79124.1.
X89986 mRNA. Translation: CAA62013.1.
AF174424
, AF174421, AF174422, AF174423 Genomic DNA. Translation: AAF01156.1.
CR456390 mRNA. Translation: CAG30276.1.
BT006728 mRNA. Translation: AAP35374.1.
AY245248 Genomic DNA. Translation: AAO61089.1.
CR541863 mRNA. Translation: CAG46661.1.
CR541883 mRNA. Translation: CAG46681.1.
AL022237 Genomic DNA. Translation: CAA18260.2.
CH471138 Genomic DNA. Translation: EAW73282.1.
BC001599 mRNA. Translation: AAH01599.1.
CCDSiCCDS14044.1.
PIRiS58214.
RefSeqiNP_001188.1. NM_001197.4.
UniGeneiHs.475055.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPEmodel-@1-160[»]
ProteinModelPortaliQ13323.
SMRiQ13323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107107. 13 interactors.
DIPiDIP-928N.
IntActiQ13323. 15 interactors.
MINTiMINT-1457938.
STRINGi9606.ENSP00000216115.

PTM databases

iPTMnetiQ13323.
PhosphoSitePlusiQ13323.

Polymorphism and mutation databases

BioMutaiBIK.
DMDMi2493284.

Proteomic databases

PaxDbiQ13323.
PeptideAtlasiQ13323.
PRIDEiQ13323.

Protocols and materials databases

DNASUi638.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216115; ENSP00000216115; ENSG00000100290.
GeneIDi638.
KEGGihsa:638.
UCSCiuc003bdk.3. human.

Organism-specific databases

CTDi638.
DisGeNETi638.
GeneCardsiBIK.
HGNCiHGNC:1051. BIK.
HPAiHPA051360.
MIMi603392. gene.
neXtProtiNX_Q13323.
OpenTargetsiENSG00000100290.
PharmGKBiPA25354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JHX0. Eukaryota.
ENOG41116I0. LUCA.
GeneTreeiENSGT00530000064453.
HOGENOMiHOG000095229.
HOVERGENiHBG001515.
InParanoidiQ13323.
KOiK18452.
OMAiDPMEDFD.
OrthoDBiEOG091G0VGV.
PhylomeDBiQ13323.
TreeFamiTF338339.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100290-MONOMER.
SIGNORiQ13323.

Miscellaneous databases

GeneWikiiBcl-2-interacting_killer.
GenomeRNAii638.
PROiQ13323.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100290.
CleanExiHS_BIK.
ExpressionAtlasiQ13323. baseline and differential.
GenevisibleiQ13323. HS.

Family and domain databases

InterProiIPR024579. Bcl2-int_killer.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]
PANTHERiPTHR15018. PTHR15018. 1 hit.
PfamiPF12201. bcl-2I13. 1 hit.
[Graphical view]
ProDomiPD032623. PD032623. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01259. BH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIK_HUMAN
AccessioniPrimary (citable) accession number: Q13323
Secondary accession number(s): Q16582, Q6FH93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.