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Protein

Growth factor receptor-bound protein 10

Gene

GRB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.4 Publications

Enzyme regulationi

Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.1 Publication

GO - Molecular functioni

  • insulin receptor binding Source: BHF-UCL
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106070-MONOMER.
ReactomeiR-HSA-1433557. Signaling by SCF-KIT.
R-HSA-74713. IRS activation.
R-HSA-74749. Signal attenuation.
R-HSA-74751. Insulin receptor signalling cascade.
R-HSA-8853659. RET signaling.
SignaLinkiQ13322.
SIGNORiQ13322.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth factor receptor-bound protein 10
Alternative name(s):
GRB10 adapter protein
Insulin receptor-binding protein Grb-IR
Gene namesi
Name:GRB10
Synonyms:GRBIR, KIAA0207
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4564. GRB10.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104S → G: No effect on phosphorylation. 1 Publication1
Mutagenesisi134S → A: No effect on YWHAE-binding. 1 Publication1
Mutagenesisi136P → A: No effect on NEDD4-binding; when associated with A-139 and A-141. 1 Publication1
Mutagenesisi139P → A: No effect on NEDD4-binding; when associated with A-136 and A-141. 1 Publication1
Mutagenesisi141P → S: No effect on NEDD4-binding; when associated with A-136 and A-139. 1 Publication1
Mutagenesisi150S → I: Loss of phosphorylation. 1 Publication1
Mutagenesisi300K → A: 2-fold loss of inositide-binding. 1 Publication1
Mutagenesisi305K → A: 5-fold loss of inositide-binding. 1 Publication1
Mutagenesisi308K → A: 5-fold loss of inositide-binding. 1 Publication1
Mutagenesisi355N → G: 5-fold loss of inositide-binding. 1 Publication1
Mutagenesisi418S → A: No net loss of phosphorylation, this may be due to a compensatory phosphorylation of T-422 in vitro. 1 Publication1
Mutagenesisi428S → A: Impairs YWHAE-binding. 1 Publication1
Mutagenesisi476S → A: Loss of phosphorylation. 1 Publication1
Mutagenesisi520R → K: No effect on NEDD4-binding. No effect on the disruption of the interaction between INSR and IRS1 and IRS2. 2 Publications1

Organism-specific databases

DisGeNETi2887.
OpenTargetsiENSG00000106070.
PharmGKBiPA28960.

Chemistry databases

ChEMBLiCHEMBL3621028.

Polymorphism and mutation databases

BioMutaiGRB10.
DMDMi6166186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001503461 – 594Growth factor receptor-bound protein 10Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Phosphotyrosine; by TEC1 Publication1
Modified residuei104PhosphoserineCombined sources1
Modified residuei150Phosphoserine; by MTOR, MAPK1 and MAPK32 Publications1
Modified residuei418Phosphoserine; by MAPK1 and MAPK3; in vitroCombined sources1 Publication1
Modified residuei428Phosphoserine; by MTOR and PKB/AKT12 Publications1
Modified residuei431PhosphoserineBy similarity1
Modified residuei476Phosphoserine; by MTOR, MAPK1 and MAPK32 Publications1

Post-translational modificationi

Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by TEC.By similarity4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13322.
MaxQBiQ13322.
PaxDbiQ13322.
PeptideAtlasiQ13322.
PRIDEiQ13322.

PTM databases

iPTMnetiQ13322.
PhosphoSitePlusiQ13322.

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.1 Publication

Gene expression databases

BgeeiENSG00000106070.
CleanExiHS_GRB10.
ExpressionAtlasiQ13322. baseline and differential.
GenevisibleiQ13322. HS.

Organism-specific databases

HPAiCAB019423.
HPA027502.
HPA031818.

Interactioni

Subunit structurei

Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain (By similarity). Poorly binds to the EGFR (By similarity). Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15 (By similarity). When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6 (By similarity). Binds to activated NRAS.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EPHB1P547622EBI-80275,EBI-80252
INSRP062133EBI-80275,EBI-475899
RCAN3Q9UKA83EBI-80275,EBI-9091952

GO - Molecular functioni

  • insulin receptor binding Source: BHF-UCL
  • SH3/SH2 adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi109144. 37 interactors.
DIPiDIP-31657N.
IntActiQ13322. 15 interactors.
MINTiMINT-1534184.
STRINGi9606.ENSP00000381793.

Structurei

Secondary structure

1594
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi168 – 174Combined sources7
Beta strandi179 – 184Combined sources6
Helixi190 – 198Combined sources9
Beta strandi209 – 215Combined sources7
Turni216 – 219Combined sources4
Beta strandi220 – 223Combined sources4
Helixi230 – 235Combined sources6
Beta strandi242 – 247Combined sources6
Turni249 – 252Combined sources4
Helixi253 – 256Combined sources4
Helixi258 – 260Combined sources3
Beta strandi266 – 269Combined sources4
Helixi281 – 285Combined sources5
Beta strandi291 – 300Combined sources10
Beta strandi307 – 315Combined sources9
Beta strandi318 – 324Combined sources7
Helixi330 – 332Combined sources3
Beta strandi333 – 337Combined sources5
Beta strandi342 – 349Combined sources8
Helixi351 – 354Combined sources4
Beta strandi357 – 366Combined sources10
Beta strandi377 – 383Combined sources7
Helixi384 – 399Combined sources16
Helixi401 – 407Combined sources7
Helixi500 – 509Combined sources10
Beta strandi516 – 521Combined sources6
Beta strandi529 – 535Combined sources7
Beta strandi538 – 546Combined sources9
Beta strandi555 – 558Combined sources4
Beta strandi564 – 566Combined sources3
Helixi567 – 574Combined sources8
Beta strandi581 – 583Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRVX-ray1.65A/B487-591[»]
3HK0X-ray2.60A/B164-415[»]
ProteinModelPortaliQ13322.
SMRiQ13322.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13322.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 250Ras-associatingPROSITE-ProRule annotationAdd BLAST85
Domaini290 – 399PHPROSITE-ProRule annotationAdd BLAST110
Domaini493 – 574SH2PROSITE-ProRule annotationAdd BLAST82

Domaini

The PH domain binds relatively non-specifically to several phosphoinositides, including PI5P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities.

Sequence similaritiesi

Belongs to the GRB7/10/14 family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3751. Eukaryota.
ENOG410XXC8. LUCA.
GeneTreeiENSGT00550000074537.
HOVERGENiHBG000468.
InParanoidiQ13322.
KOiK20064.
OMAiCEDDGQI.
OrthoDBiEOG091G135G.
PhylomeDBiQ13322.
TreeFamiTF317511.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR015042. BPS-dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR000980. SH2.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08947. BPS. 1 hit.
PF00169. PH. 1 hit.
PF00788. RA. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist, many of which involve splicing of 5' non-coding exons.
Isoform 3 (identifier: Q13322-1) [UniParc]FASTAAdd to basket
Also known as: Zeta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV
60 70 80 90 100
DLEALVNDMN ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ
110 120 130 140 150
PQVSPRQRVQ RSQPVHILAV RRLQEEDQQF RTSSLPAIPN PFPELCGPGS
160 170 180 190 200
PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK VVEILADMTA RDLCQLLVYK
210 220 230 240 250
SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE SKFLFRKNYA
260 270 280 290 300
KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK
310 320 330 340 350
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG
360 370 380 390 400
RKQYNAPTDH GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG
410 420 430 440 450
MLLYQNYRIP QQRKALLSPF STPVRSVSEN SLVAMDFSGQ TGRVIENPAE
460 470 480 490 500
AQSAALEEGH AWRKRSTRMN ILGSQSPLHP STLSTVIHRT QHWFHGRISR
510 520 530 540 550
EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK NFQILPCEDD
560 570 580 590
GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL
Length:594
Mass (Da):67,231
Last modified:July 15, 1999 - v2
Checksum:i53A5F885E17C6C6B
GO
Isoform 1 (identifier: Q13322-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     283-328: Missing.

Show »
Length:548
Mass (Da):62,026
Checksum:iFCAA0792DBEB8AC3
GO
Isoform 2 (identifier: Q13322-3) [UniParc]FASTAAdd to basket
Also known as: Gamma, Beta, SV-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:536
Mass (Da):60,848
Checksum:i626377A169AE6530
GO
Isoform 4 (identifier: Q13322-4) [UniParc]FASTAAdd to basket
Also known as: Epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MALAGCPDSFLHHPYYQ → MQAAGPLFRSK

Note: No experimental confirmation available.
Show »
Length:588
Mass (Da):66,487
Checksum:iB5EE8FA86A240D21
GO

Sequence cautioni

The sequence BAA13198 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152P → A in BAA13198 (PubMed:9039502).Curated1
Sequence conflicti400G → E in AAB08431 (PubMed:9006901).Curated1
Sequence conflicti428S → F in BAF82200 (PubMed:14702039).Curated1
Sequence conflicti498I → F in AAB08431 (PubMed:9006901).Curated1
Sequence conflicti541N → I in AAC50671 (PubMed:8798417).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05311236P → L.Corresponds to variant rs35647889dbSNPEnsembl.1
Natural variantiVAR_06286495P → S.1 PublicationCorresponds to variant rs80244589dbSNPEnsembl.1
Natural variantiVAR_053113558D → H.Corresponds to variant rs11768472dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018421 – 58Missing in isoform 2. 4 PublicationsAdd BLAST58
Alternative sequenceiVSP_0387841 – 17MALAG…HPYYQ → MQAAGPLFRSK in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_001843283 – 328Missing in isoform 1. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34355 mRNA. Translation: AAA88819.1.
U66065 mRNA. Translation: AAC50671.1.
U69276 mRNA. Translation: AAB08431.1.
AF001534 mRNA. Translation: AAB81134.1.
AF000017 mRNA. Translation: AAC19748.1.
AB000731 mRNA. Translation: BAF76353.1.
AJ271366 mRNA. Translation: CAB96542.1.
D86962 mRNA. Translation: BAA13198.2. Different initiation.
AK289511 mRNA. Translation: BAF82200.1.
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073370, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA. Translation: AAC83655.1.
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA. Translation: AAC83654.1.
AC005153 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23897.1.
CH471128 Genomic DNA. Translation: EAW60964.1.
CH471128 Genomic DNA. Translation: EAW60965.1.
CH471128 Genomic DNA. Translation: EAW60967.1.
BC024285 mRNA. Translation: AAH24285.1.
CCDSiCCDS43582.1. [Q13322-1]
CCDS43583.1. [Q13322-3]
CCDS47586.1. [Q13322-2]
PIRiI39175.
RefSeqiNP_001001549.1. NM_001001549.2. [Q13322-2]
NP_001001550.1. NM_001001550.2. [Q13322-3]
NP_001001555.1. NM_001001555.2. [Q13322-3]
NP_005302.3. NM_005311.4. [Q13322-1]
XP_011513606.1. XM_011515304.1. [Q13322-1]
XP_011513614.1. XM_011515312.2. [Q13322-4]
XP_011513618.1. XM_011515316.1. [Q13322-3]
XP_016867534.1. XM_017012045.1. [Q13322-3]
XP_016867535.1. XM_017012046.1. [Q13322-1]
XP_016867552.1. XM_017012063.1. [Q13322-3]
XP_016867553.1. XM_017012064.1. [Q13322-3]
XP_016867554.1. XM_017012065.1. [Q13322-3]
XP_016867555.1. XM_017012066.1. [Q13322-3]
XP_016867556.1. XM_017012067.1. [Q13322-3]
XP_016867557.1. XM_017012068.1. [Q13322-3]
UniGeneiHs.164060.

Genome annotation databases

EnsembliENST00000335866; ENSP00000338543; ENSG00000106070. [Q13322-3]
ENST00000357271; ENSP00000349818; ENSG00000106070. [Q13322-2]
ENST00000398810; ENSP00000381790; ENSG00000106070. [Q13322-3]
ENST00000398812; ENSP00000381793; ENSG00000106070. [Q13322-1]
ENST00000401949; ENSP00000385770; ENSG00000106070. [Q13322-1]
ENST00000402497; ENSP00000385748; ENSG00000106070. [Q13322-3]
ENST00000402578; ENSP00000385189; ENSG00000106070. [Q13322-3]
ENST00000403097; ENSP00000385544; ENSG00000106070. [Q13322-4]
ENST00000406641; ENSP00000385366; ENSG00000106070. [Q13322-3]
ENST00000407526; ENSP00000385046; ENSG00000106070. [Q13322-3]
GeneIDi2887.
KEGGihsa:2887.
UCSCiuc003tph.4. human. [Q13322-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34355 mRNA. Translation: AAA88819.1.
U66065 mRNA. Translation: AAC50671.1.
U69276 mRNA. Translation: AAB08431.1.
AF001534 mRNA. Translation: AAB81134.1.
AF000017 mRNA. Translation: AAC19748.1.
AB000731 mRNA. Translation: BAF76353.1.
AJ271366 mRNA. Translation: CAB96542.1.
D86962 mRNA. Translation: BAA13198.2. Different initiation.
AK289511 mRNA. Translation: BAF82200.1.
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073370, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA. Translation: AAC83655.1.
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA. Translation: AAC83654.1.
AC005153 Genomic DNA. No translation available.
CH236955 Genomic DNA. Translation: EAL23897.1.
CH471128 Genomic DNA. Translation: EAW60964.1.
CH471128 Genomic DNA. Translation: EAW60965.1.
CH471128 Genomic DNA. Translation: EAW60967.1.
BC024285 mRNA. Translation: AAH24285.1.
CCDSiCCDS43582.1. [Q13322-1]
CCDS43583.1. [Q13322-3]
CCDS47586.1. [Q13322-2]
PIRiI39175.
RefSeqiNP_001001549.1. NM_001001549.2. [Q13322-2]
NP_001001550.1. NM_001001550.2. [Q13322-3]
NP_001001555.1. NM_001001555.2. [Q13322-3]
NP_005302.3. NM_005311.4. [Q13322-1]
XP_011513606.1. XM_011515304.1. [Q13322-1]
XP_011513614.1. XM_011515312.2. [Q13322-4]
XP_011513618.1. XM_011515316.1. [Q13322-3]
XP_016867534.1. XM_017012045.1. [Q13322-3]
XP_016867535.1. XM_017012046.1. [Q13322-1]
XP_016867552.1. XM_017012063.1. [Q13322-3]
XP_016867553.1. XM_017012064.1. [Q13322-3]
XP_016867554.1. XM_017012065.1. [Q13322-3]
XP_016867555.1. XM_017012066.1. [Q13322-3]
XP_016867556.1. XM_017012067.1. [Q13322-3]
XP_016867557.1. XM_017012068.1. [Q13322-3]
UniGeneiHs.164060.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRVX-ray1.65A/B487-591[»]
3HK0X-ray2.60A/B164-415[»]
ProteinModelPortaliQ13322.
SMRiQ13322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109144. 37 interactors.
DIPiDIP-31657N.
IntActiQ13322. 15 interactors.
MINTiMINT-1534184.
STRINGi9606.ENSP00000381793.

Chemistry databases

ChEMBLiCHEMBL3621028.

PTM databases

iPTMnetiQ13322.
PhosphoSitePlusiQ13322.

Polymorphism and mutation databases

BioMutaiGRB10.
DMDMi6166186.

Proteomic databases

EPDiQ13322.
MaxQBiQ13322.
PaxDbiQ13322.
PeptideAtlasiQ13322.
PRIDEiQ13322.

Protocols and materials databases

DNASUi2887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335866; ENSP00000338543; ENSG00000106070. [Q13322-3]
ENST00000357271; ENSP00000349818; ENSG00000106070. [Q13322-2]
ENST00000398810; ENSP00000381790; ENSG00000106070. [Q13322-3]
ENST00000398812; ENSP00000381793; ENSG00000106070. [Q13322-1]
ENST00000401949; ENSP00000385770; ENSG00000106070. [Q13322-1]
ENST00000402497; ENSP00000385748; ENSG00000106070. [Q13322-3]
ENST00000402578; ENSP00000385189; ENSG00000106070. [Q13322-3]
ENST00000403097; ENSP00000385544; ENSG00000106070. [Q13322-4]
ENST00000406641; ENSP00000385366; ENSG00000106070. [Q13322-3]
ENST00000407526; ENSP00000385046; ENSG00000106070. [Q13322-3]
GeneIDi2887.
KEGGihsa:2887.
UCSCiuc003tph.4. human. [Q13322-1]

Organism-specific databases

CTDi2887.
DisGeNETi2887.
GeneCardsiGRB10.
HGNCiHGNC:4564. GRB10.
HPAiCAB019423.
HPA027502.
HPA031818.
MIMi601523. gene.
neXtProtiNX_Q13322.
OpenTargetsiENSG00000106070.
PharmGKBiPA28960.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3751. Eukaryota.
ENOG410XXC8. LUCA.
GeneTreeiENSGT00550000074537.
HOVERGENiHBG000468.
InParanoidiQ13322.
KOiK20064.
OMAiCEDDGQI.
OrthoDBiEOG091G135G.
PhylomeDBiQ13322.
TreeFamiTF317511.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106070-MONOMER.
ReactomeiR-HSA-1433557. Signaling by SCF-KIT.
R-HSA-74713. IRS activation.
R-HSA-74749. Signal attenuation.
R-HSA-74751. Insulin receptor signalling cascade.
R-HSA-8853659. RET signaling.
SignaLinkiQ13322.
SIGNORiQ13322.

Miscellaneous databases

ChiTaRSiGRB10. human.
EvolutionaryTraceiQ13322.
GeneWikiiGRB10.
GenomeRNAii2887.
PROiQ13322.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106070.
CleanExiHS_GRB10.
ExpressionAtlasiQ13322. baseline and differential.
GenevisibleiQ13322. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR015042. BPS-dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR000980. SH2.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08947. BPS. 1 hit.
PF00169. PH. 1 hit.
PF00788. RA. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRB10_HUMAN
AccessioniPrimary (citable) accession number: Q13322
Secondary accession number(s): A4D258
, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q92606, Q92907, Q92948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The GRB10 locus is imprinted. During embryonic development, the expression in the brain and spinal cord is from the paternal allele, while in placental villous trophoblasts and skeletal muscle, it is from the maternal one. Expression is biallelic in most other tissues. Paternal expression in the brain is maintained throughout adulthood. Imprinting often is isoform-specific.
GRB10 is unlikely to be responsible for Silver-Russell syndrome (SRS).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.