Q13319 (CD5R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 5 activator 2
Short name=CDK5 activator 2

Alternative name(s):
Cyclin-dependent kinase 5 regulatory subunit 2
p39
p39I

Gene names

Name:	CDK5R2
Synonyms:	NCK5AI

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Activator of CDK5/TPKII.
Subunit structure	Heterodimer of a catalytic subunit and a regulatory subunit.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Ref.4.
Tissue specificity	Brain and neuron specific.
Post-translational modification	Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).
Sequence similarities	Belongs to the cyclin-dependent kinase 5 activator family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	Lipid-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of cyclin-dependent protein kinase activity Traceable author statement. Source: ProtInc
Cellular component	cyclin-dependent protein kinase 5 holoenzyme complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cyclin-dependent protein kinase 5 activator activity Inferred from electronic annotation. Source: InterPro lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Propeptide	2 – ?		Potential		PRO_0000004800
	Chain	? – 367		Cyclin-dependent kinase 5 activator 2		PRO_0000004801
Regions
	Compositional bias	75 – 78	4	Poly-Lys
	Compositional bias	130 – 133	4	Poly-Ala
	Compositional bias	155 – 163	9	Poly-Pro
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Ref.4
Experimental info
	Mutagenesis	2	1	G → A: Absent from the cell periphery. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q13319 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: D8CBB7C8E0AA8200	FASTA	367	38,705
	10 20 30 40 50 60 MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPVGKGGKG ESRLKRPSVL 70 80 90 100 110 120 ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN RENLLRKGRD PPDGGGTAKP 130 140 150 160 170 180 LAVPVPTVPA AAATCEPPSG GSAAAQPPGS GGGKPPPPPP PAPQVAPPVP GGSPRRVIVQ 190 200 210 220 230 240 ASTGELLRCL GDFVCRRCYR LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY 250 260 270 280 290 300 LLCRESLRGD ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL 310 320 330 340 350 360 IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASGGGPPS GGAPAASSAA RDSCAAGTKH WTMNLDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator." Tang D., Yeung J., Lee K.-Y., Matsushita M., Matsui H., Tomizawa K., Hatase O., Wang J.H. J. Biol. Chem. 270:26897-26903(1995) [PubMed: 7592934] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.
[2]	NIEHS SNPs program Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes." Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., Hisanaga S. J. Neurochem. 106:1325-1336(2008) [PubMed: 18507738] [Abstract] Cited for: SUBCELLULAR LOCATION, MYRISTOYLATION, MUTAGENESIS OF GLY-2.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U34051 mRNA. Translation: AAC50278.1. DQ307839 Genomic DNA. Translation: ABB96255.1. AC097468 Genomic DNA. Translation: AAX88916.1.
IPI	IPI00012738.
PIR	I39172.
RefSeq	NP_003927.1. NM_003936.3.
UniGene	Hs.158460.
3D structure databases
ProteinModelPortal	Q13319.
SMR	Q13319. Positions 180-328.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1173509.
STRING	Q13319.
PTM databases
PhosphoSite	Q13319.
Polymorphism databases
DMDM	2498219.
Proteomic databases
PRIDE	Q13319.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302625; ENSP00000304250; ENSG00000171450.
GeneID	8941.
KEGG	hsa:8941.
UCSC	uc002vjf.1. human.
Organism-specific databases
CTD	8941.
GeneCards	GC02P219788.
H-InvDB	HIX0002841.
HGNC	HGNC:1776. CDK5R2.
MIM	603764. gene.
neXtProt	NX_Q13319.
PharmGKB	PA26312.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13854.
HOGENOM	HBG446178.
HOVERGEN	HBG050853.
InParanoid	Q13319.
OMA	EKSLKRH.
PhylomeDB	Q13319.
Enzyme and pathway databases
Pathway_Interaction_DB	lis1pathway. Lissencephaly gene (LIS1) in neuronal migration and development.
Gene expression databases
ArrayExpress	Q13319.
Bgee	Q13319.
CleanEx	HS_CDK5R2.
Genevestigator	Q13319.
GermOnline	ENSG00000171450. Homo sapiens.
Family and domain databases
InterPro	IPR004944. CDK5_activator. IPR013763. Cyclin-like. [Graphical view]
Gene3D	G3DSA:1.10.472.10. Cyclin_related. 1 hit.
PANTHER	PTHR23401. CDK5_activator. 1 hit.
Pfam	PF03261. CDK5_activator. 1 hit. [Graphical view]
PIRSF	PIRSF009324. Cdk5_activator. 1 hit.
SUPFAM	SSF47954. Cyclin_like. 1 hit.
ProtoNet	Search...
Other
NextBio	33626.
PMAP-CutDB	Q13319.
SOURCE	Search...

Entry information

Entry name

CD5R2_HUMAN

Accession

Primary (citable) accession number: Q13319
Secondary accession number(s): Q4ZFW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.