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Protein

Cyclin-dependent kinase 5 activator 2

Gene

CDK5R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activator of CDK5/TPKII.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 activator 2
Short name:
CDK5 activator 2
Alternative name(s):
Cyclin-dependent kinase 5 regulatory subunit 2
p39
p39I
Gene namesi
Name:CDK5R2
Synonyms:NCK5AI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:1776. CDK5R2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Absent from the cell periphery. 1 Publication

Organism-specific databases

PharmGKBiPA26312.

Polymorphism and mutation databases

BioMutaiCDK5R2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 367Cyclin-dependent kinase 5 activator 2PRO_0000004801
Initiator methionineiRemoved
Propeptidei2 – ?Sequence analysisPRO_0000004800

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei84 – 841PhosphothreonineBy similarity

Post-translational modificationi

Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ13319.
PRIDEiQ13319.

PTM databases

iPTMnetiQ13319.
PhosphoSiteiQ13319.

Miscellaneous databases

PMAP-CutDBQ13319.

Expressioni

Tissue specificityi

Brain and neuron specific.

Gene expression databases

BgeeiQ13319.
CleanExiHS_CDK5R2.
GenevisibleiQ13319. HS.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit and a regulatory subunit.

Protein-protein interaction databases

BioGridi114453. 1 interaction.
MINTiMINT-1173509.
STRINGi9606.ENSP00000304250.

Structurei

3D structure databases

ProteinModelPortaliQ13319.
SMRiQ13319. Positions 180-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 784Poly-Lys
Compositional biasi130 – 1334Poly-Ala
Compositional biasi155 – 1639Poly-Pro

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3932. Eukaryota.
ENOG410YFUI. LUCA.
GeneTreeiENSGT00390000008812.
HOGENOMiHOG000063677.
HOVERGENiHBG050853.
InParanoidiQ13319.
KOiK19929.
OMAiGTKHWTM.
OrthoDBiEOG7GTT4Q.
PhylomeDBiQ13319.
TreeFamiTF101036.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR004944. CDK5_activator.
IPR013763. Cyclin-like.
[Graphical view]
PANTHERiPTHR23401. PTHR23401. 1 hit.
PfamiPF03261. CDK5_activator. 1 hit.
[Graphical view]
PIRSFiPIRSF009324. Cdk5_activator. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPVGKGGKG
60 70 80 90 100
ESRLKRPSVL ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN
110 120 130 140 150
RENLLRKGRD PPDGGGTAKP LAVPVPTVPA AAATCEPPSG GSAAAQPPGS
160 170 180 190 200
GGGKPPPPPP PAPQVAPPVP GGSPRRVIVQ ASTGELLRCL GDFVCRRCYR
210 220 230 240 250
LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY LLCRESLRGD
260 270 280 290 300
ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL
310 320 330 340 350
IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASGGGPPS GGAPAASSAA
360
RDSCAAGTKH WTMNLDR
Length:367
Mass (Da):38,705
Last modified:November 1, 1997 - v1
Checksum:iD8CBB7C8E0AA8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34051 mRNA. Translation: AAC50278.1.
DQ307839 Genomic DNA. Translation: ABB96255.1.
AC097468 Genomic DNA. Translation: AAX88916.1.
CCDSiCCDS2427.1.
PIRiI39172.
RefSeqiNP_003927.1. NM_003936.4.
UniGeneiHs.158460.

Genome annotation databases

EnsembliENST00000302625; ENSP00000304250; ENSG00000171450.
GeneIDi8941.
KEGGihsa:8941.
UCSCiuc002vjf.5. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34051 mRNA. Translation: AAC50278.1.
DQ307839 Genomic DNA. Translation: ABB96255.1.
AC097468 Genomic DNA. Translation: AAX88916.1.
CCDSiCCDS2427.1.
PIRiI39172.
RefSeqiNP_003927.1. NM_003936.4.
UniGeneiHs.158460.

3D structure databases

ProteinModelPortaliQ13319.
SMRiQ13319. Positions 180-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114453. 1 interaction.
MINTiMINT-1173509.
STRINGi9606.ENSP00000304250.

PTM databases

iPTMnetiQ13319.
PhosphoSiteiQ13319.

Polymorphism and mutation databases

BioMutaiCDK5R2.

Proteomic databases

PaxDbiQ13319.
PRIDEiQ13319.

Protocols and materials databases

DNASUi8941.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302625; ENSP00000304250; ENSG00000171450.
GeneIDi8941.
KEGGihsa:8941.
UCSCiuc002vjf.5. human.

Organism-specific databases

CTDi8941.
GeneCardsiCDK5R2.
H-InvDBHIX0161641.
HGNCiHGNC:1776. CDK5R2.
MIMi603764. gene.
neXtProtiNX_Q13319.
PharmGKBiPA26312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3932. Eukaryota.
ENOG410YFUI. LUCA.
GeneTreeiENSGT00390000008812.
HOGENOMiHOG000063677.
HOVERGENiHBG050853.
InParanoidiQ13319.
KOiK19929.
OMAiGTKHWTM.
OrthoDBiEOG7GTT4Q.
PhylomeDBiQ13319.
TreeFamiTF101036.

Miscellaneous databases

ChiTaRSiCDK5R2. human.
GeneWikiiCDK5R2.
GenomeRNAii8941.
NextBioi33626.
PMAP-CutDBQ13319.
PROiQ13319.
SOURCEiSearch...

Gene expression databases

BgeeiQ13319.
CleanExiHS_CDK5R2.
GenevisibleiQ13319. HS.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR004944. CDK5_activator.
IPR013763. Cyclin-like.
[Graphical view]
PANTHERiPTHR23401. PTHR23401. 1 hit.
PfamiPF03261. CDK5_activator. 1 hit.
[Graphical view]
PIRSFiPIRSF009324. Cdk5_activator. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator."
    Tang D., Yeung J., Lee K.-Y., Matsushita M., Matsui H., Tomizawa K., Hatase O., Wang J.H.
    J. Biol. Chem. 270:26897-26903(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. NIEHS SNPs program
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes."
    Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., Hisanaga S.
    J. Neurochem. 106:1325-1336(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MYRISTOYLATION, MUTAGENESIS OF GLY-2.

Entry informationi

Entry nameiCD5R2_HUMAN
AccessioniPrimary (citable) accession number: Q13319
Secondary accession number(s): Q4ZFW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.