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Protein

Dentin matrix acidic phosphoprotein 1

Gene

DMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • extracellular matrix binding Source: Ensembl
  • integrin binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processBiomineralization

Enzyme and pathway databases

ReactomeiR-HSA-3000178. ECM proteoglycans.
R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-HSA-8957275. Post-translational protein phosphorylation.
SignaLinkiQ13316.

Names & Taxonomyi

Protein namesi
Recommended name:
Dentin matrix acidic phosphoprotein 1
Short name:
DMP-1
Short name:
Dentin matrix protein 1
Gene namesi
Name:DMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000152592.13.
HGNCiHGNC:2932. DMP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities.
See also OMIM:241520

Organism-specific databases

DisGeNETi1758.
MalaCardsiDMP1.
MIMi241520. phenotype.
OpenTargetsiENSG00000152592.
Orphaneti289176. Autosomal recessive hypophosphatemic rickets.
PharmGKBiPA27379.

Polymorphism and mutation databases

BioMutaiDMP1.
DMDMi7673998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002111017 – 513Dentin matrix acidic phosphoprotein 1Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ13316.
PeptideAtlasiQ13316.
PRIDEiQ13316.

PTM databases

iPTMnetiQ13316.
PhosphoSitePlusiQ13316.

Expressioni

Tissue specificityi

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.

Gene expression databases

BgeeiENSG00000152592.
CleanExiHS_DMP1.
GenevisibleiQ13316. HS.

Organism-specific databases

HPAiHPA037465.

Interactioni

Subunit structurei

Interacts with importin alpha.1 Publication

GO - Molecular functioni

  • integrin binding Source: ProtInc

Protein-protein interaction databases

IntActiQ13316. 1 interactor.
STRINGi9606.ENSP00000340935.

Structurei

3D structure databases

ProteinModelPortaliQ13316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi364 – 366Cell attachment siteSequence analysis3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1181. Eukaryota.
ENOG4111M3T. LUCA.
GeneTreeiENSGT00730000111375.
HOGENOMiHOG000220909.
HOVERGENiHBG073257.
InParanoidiQ13316.
OMAiPIGDQDD.
OrthoDBiEOG091G0U5E.
PhylomeDBiQ13316.
TreeFamiTF337029.

Family and domain databases

InterProiView protein in InterPro
IPR009889. DMP1.
PANTHERiPTHR23400. PTHR23400. 1 hit.
PfamiView protein in Pfam
PF07263. DMP1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13316-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKISILLMFL WGLSCALPVT RYQNNESEDS EEWKGHLAQA PTPPLESSES
60 70 80 90 100
SEGSKVSSEE QANEDPSDST QSEEGLGSDD HQYIYRLAGG FSRSTGKGGD
110 120 130 140 150
DKDDDEDDSG DDTFGDDDSG PGPKDRQEGG NSRLGSDEDS DDTIQASEES
160 170 180 190 200
APQGQDSAQD TTSESRELDN EDRVDSKPEG GDSTQESESE EHWVGGGSDG
210 220 230 240 250
ESSHGDGSEL DDEGMQSDDP ESIRSERGNS RMNSAGMKSK ESGENSEQAN
260 270 280 290 300
TQDSGGSQLL EHPSRKIFRK SRISEEDDRS ELDDNNTMEE VKSDSTENSN
310 320 330 340 350
SRDTGLSQPR RDSKGDSQED SKENLSQEES QNVDGPSSES SQEANLSSQE
360 370 380 390 400
NSSESQEEVV SESRGDNPDP TTSYVEDQED SDSSEEDSSH TLSHSKSESR
410 420 430 440 450
EEQADSESSE SLNFSEESPE SPEDENSSSQ EGLQSHSSSA ESQSEESHSE
460 470 480 490 500
EDDSDSQDSS RSKEDSNSTE SKSSSEEDGQ LKNIEIESRK LTVDAYHNKP
510
IGDQDDNDCQ DGY
Length:513
Mass (Da):55,782
Last modified:January 1, 1998 - v2
Checksum:i2C1FDE319A5D106F
GO
Isoform 2 (identifier: Q13316-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-61: Missing.

Show »
Length:497
Mass (Da):54,115
Checksum:i6E146232B6365507
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03075069S → C2 PublicationsCorresponds to variant dbSNP:rs10019009Ensembl.1
Natural variantiVAR_030751117D → N in one individual with tumoral calcinosis. 1 PublicationCorresponds to variant dbSNP:rs140719182Ensembl.1
Natural variantiVAR_030752272R → H1 PublicationCorresponds to variant dbSNP:rs145237146Ensembl.1
Natural variantiVAR_033848463K → R. Corresponds to variant dbSNP:rs34661425Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00419146 – 61Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89012 mRNA. Translation: AAC51332.1.
U34037 Genomic DNA. Translation: AAA97602.1.
CH471057 Genomic DNA. Translation: EAX05996.1.
BC130581 mRNA. Translation: AAI30582.1.
BC132865 mRNA. Translation: AAI32866.1.
U65378 mRNA. Translation: AAB87728.1.
CCDSiCCDS3623.1. [Q13316-1]
CCDS43249.1. [Q13316-2]
RefSeqiNP_001073380.1. NM_001079911.2. [Q13316-2]
NP_004398.1. NM_004407.3. [Q13316-1]
UniGeneiHs.652366.

Genome annotation databases

EnsembliENST00000282479; ENSP00000282479; ENSG00000152592. [Q13316-2]
ENST00000339673; ENSP00000340935; ENSG00000152592. [Q13316-1]
GeneIDi1758.
KEGGihsa:1758.
UCSCiuc003hqv.4. human. [Q13316-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDMP1_HUMAN
AccessioniPrimary (citable) accession number: Q13316
Secondary accession number(s): A1L4L3, O43265
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 27, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot