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Q13310

- PABP4_HUMAN

UniProt

Q13310 - PABP4_HUMAN

Protein

Polyadenylate-binding protein 4

Gene

PABPC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) binding Source: MGI
    3. poly(A) RNA binding Source: UniProtKB
    4. poly(U) RNA binding Source: MGI
    5. protein binding Source: IntAct

    GO - Biological processi

    1. blood coagulation Source: ProtInc
    2. RNA catabolic process Source: ProtInc
    3. RNA processing Source: ProtInc
    4. translation Source: ProtInc

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyadenylate-binding protein 4
    Short name:
    PABP-4
    Short name:
    Poly(A)-binding protein 4
    Alternative name(s):
    Activated-platelet protein 1
    Short name:
    APP-1
    Inducible poly(A)-binding protein
    Short name:
    iPABP
    Gene namesi
    Name:PABPC4
    Synonyms:APP1, PABP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8557. PABPC4.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytoplasmic stress granule Source: MGI
    3. nucleus Source: MGI
    4. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32883.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 644644Polyadenylate-binding protein 4PRO_0000081703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei140 – 1401Phosphotyrosine1 Publication
    Modified residuei315 – 3151Phosphoserine1 Publication
    Modified residuei361 – 3611N6,N6-dimethyllysine1 Publication
    Modified residuei518 – 5181Dimethylated arginine; alternate1 Publication
    Modified residuei518 – 5181Omega-N-methylated arginine; alternate1 Publication
    Modified residuei531 – 5311Phosphoserine1 Publication

    Post-translational modificationi

    Arg-518 is dimethylated, probably to asymmetric dimethylarginine.

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13310.
    PaxDbiQ13310.
    PRIDEiQ13310.

    PTM databases

    PhosphoSiteiQ13310.

    Expressioni

    Tissue specificityi

    Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

    Gene expression databases

    BgeeiQ13310.
    CleanExiHS_PABPC4.
    GenevestigatoriQ13310.

    Organism-specific databases

    HPAiHPA027301.
    HPA056496.

    Interactioni

    Subunit structurei

    Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PHLDA1Q8WV242EBI-372844,EBI-738731

    Protein-protein interaction databases

    BioGridi114296. 60 interactions.
    IntActiQ13310. 30 interactions.
    MINTiMINT-1189867.
    STRINGi9606.ENSP00000361949.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13310.
    SMRiQ13310. Positions 10-376, 510-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 8979RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini99 – 17577RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 26878RRM 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 37077RRM 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini551 – 62878PABCPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi510 – 5167Poly-Ala

    Sequence similaritiesi

    Contains 1 PABC domain.PROSITE-ProRule annotation
    Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOGENOMiHOG000217922.
    HOVERGENiHBG002295.
    KOiK13126.
    OMAiNHESAEA.
    PhylomeDBiQ13310.
    TreeFamiTF300458.

    Family and domain databases

    Gene3Di1.10.1900.10. 1 hit.
    3.30.70.330. 4 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR006515. PABP_1234.
    IPR002004. PABP_HYD.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00658. PABP. 1 hit.
    PF00076. RRM_1. 4 hits.
    [Graphical view]
    SMARTiSM00517. PolyA. 1 hit.
    SM00360. RRM. 4 hits.
    [Graphical view]
    SUPFAMiSSF63570. SSF63570. 1 hit.
    TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
    PROSITEiPS51309. PABC. 1 hit.
    PS50102. RRM. 4 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13310-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR    50
    SLGYAYVNFQ QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN 100
    VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA 150
    ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE 200
    EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK HEDANKAVEE 250
    MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN 300
    LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV 350
    TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ 400
    FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP 450
    SAIRQSGPRP TLRHLAPTGS ECPDRLAMDF GGAGAAQQGL TDSCQSGGVP 500
    TAVQNLAPRA AVAAAAPRAV APYKYASSVR SPHPAIQPLQ APQPAVHVQG 550
    QEPLTASMLA AAPPQEQKQM LGERLFPLIQ TMHSNLAGKI TGMLLEIDNS 600
    ELLHMLESPE SLRSKVDEAV AVLQAHHAKK EAAQKVGAVA AATS 644
    Length:644
    Mass (Da):70,783
    Last modified:November 1, 1996 - v1
    Checksum:iA761488F0B10DF5A
    GO
    Isoform 2 (identifier: Q13310-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         470-497: SECPDRLAMDFGGAGAAQQGLTDSCQSG → NAPASRGLPTTTQRV

    Note: No experimental confirmation available.

    Show »
    Length:631
    Mass (Da):69,579
    Checksum:i1891E205916695F6
    GO
    Isoform 3 (identifier: Q13310-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         468-468: T → TGNAPASRGLPTTTQRV

    Note: No experimental confirmation available.

    Show »
    Length:660
    Mass (Da):72,391
    Checksum:iBC4FB29689689633
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141A → V in AAH65540. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti382 – 3821Y → F.
    Corresponds to variant rs9820 [ dbSNP | Ensembl ].
    VAR_054048

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei468 – 4681T → TGNAPASRGLPTTTQRV in isoform 3. 1 PublicationVSP_043357
    Alternative sequencei470 – 49728SECPD…SCQSG → NAPASRGLPTTTQRV in isoform 2. 1 PublicationVSP_013335Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33818 mRNA. Translation: AAC50350.1.
    U75686 mRNA. Translation: AAB97309.1.
    AL365277, AL845289 Genomic DNA. Translation: CAI16412.1.
    AL365277, AL845289 Genomic DNA. Translation: CAI16414.1.
    AL845289, AL365277 Genomic DNA. Translation: CAI12298.1.
    AL845289, AL365277 Genomic DNA. Translation: CAI12300.1.
    CH471059 Genomic DNA. Translation: EAX07263.1.
    CH471059 Genomic DNA. Translation: EAX07264.1.
    BC065540 mRNA. Translation: AAH65540.1.
    BC094755 mRNA. Translation: AAH94755.1.
    CCDSiCCDS438.1. [Q13310-1]
    CCDS44114.1. [Q13310-2]
    CCDS44115.1. [Q13310-3]
    RefSeqiNP_001129125.1. NM_001135653.1. [Q13310-3]
    NP_001129126.1. NM_001135654.1. [Q13310-2]
    NP_003810.1. NM_003819.3. [Q13310-1]
    UniGeneiHs.169900.

    Genome annotation databases

    EnsembliENST00000372856; ENSP00000361947; ENSG00000090621. [Q13310-2]
    ENST00000372857; ENSP00000361948; ENSG00000090621. [Q13310-1]
    ENST00000372858; ENSP00000361949; ENSG00000090621. [Q13310-3]
    GeneIDi8761.
    KEGGihsa:8761.
    UCSCiuc001cdl.2. human. [Q13310-3]
    uc001cdm.2. human. [Q13310-2]
    uc010oiv.1. human. [Q13310-1]

    Polymorphism databases

    DMDMi12229875.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33818 mRNA. Translation: AAC50350.1 .
    U75686 mRNA. Translation: AAB97309.1 .
    AL365277 , AL845289 Genomic DNA. Translation: CAI16412.1 .
    AL365277 , AL845289 Genomic DNA. Translation: CAI16414.1 .
    AL845289 , AL365277 Genomic DNA. Translation: CAI12298.1 .
    AL845289 , AL365277 Genomic DNA. Translation: CAI12300.1 .
    CH471059 Genomic DNA. Translation: EAX07263.1 .
    CH471059 Genomic DNA. Translation: EAX07264.1 .
    BC065540 mRNA. Translation: AAH65540.1 .
    BC094755 mRNA. Translation: AAH94755.1 .
    CCDSi CCDS438.1. [Q13310-1 ]
    CCDS44114.1. [Q13310-2 ]
    CCDS44115.1. [Q13310-3 ]
    RefSeqi NP_001129125.1. NM_001135653.1. [Q13310-3 ]
    NP_001129126.1. NM_001135654.1. [Q13310-2 ]
    NP_003810.1. NM_003819.3. [Q13310-1 ]
    UniGenei Hs.169900.

    3D structure databases

    ProteinModelPortali Q13310.
    SMRi Q13310. Positions 10-376, 510-643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114296. 60 interactions.
    IntActi Q13310. 30 interactions.
    MINTi MINT-1189867.
    STRINGi 9606.ENSP00000361949.

    Chemistry

    ChEMBLi CHEMBL5333.

    PTM databases

    PhosphoSitei Q13310.

    Polymorphism databases

    DMDMi 12229875.

    Proteomic databases

    MaxQBi Q13310.
    PaxDbi Q13310.
    PRIDEi Q13310.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372856 ; ENSP00000361947 ; ENSG00000090621 . [Q13310-2 ]
    ENST00000372857 ; ENSP00000361948 ; ENSG00000090621 . [Q13310-1 ]
    ENST00000372858 ; ENSP00000361949 ; ENSG00000090621 . [Q13310-3 ]
    GeneIDi 8761.
    KEGGi hsa:8761.
    UCSCi uc001cdl.2. human. [Q13310-3 ]
    uc001cdm.2. human. [Q13310-2 ]
    uc010oiv.1. human. [Q13310-1 ]

    Organism-specific databases

    CTDi 8761.
    GeneCardsi GC01M040026.
    HGNCi HGNC:8557. PABPC4.
    HPAi HPA027301.
    HPA056496.
    MIMi 603407. gene.
    neXtProti NX_Q13310.
    PharmGKBi PA32883.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0724.
    HOGENOMi HOG000217922.
    HOVERGENi HBG002295.
    KOi K13126.
    OMAi NHESAEA.
    PhylomeDBi Q13310.
    TreeFami TF300458.

    Miscellaneous databases

    ChiTaRSi PABPC4. human.
    GeneWikii PABPC4.
    GenomeRNAii 8761.
    NextBioi 32864.
    PROi Q13310.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13310.
    CleanExi HS_PABPC4.
    Genevestigatori Q13310.

    Family and domain databases

    Gene3Di 1.10.1900.10. 1 hit.
    3.30.70.330. 4 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR006515. PABP_1234.
    IPR002004. PABP_HYD.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00658. PABP. 1 hit.
    PF00076. RRM_1. 4 hits.
    [Graphical view ]
    SMARTi SM00517. PolyA. 1 hit.
    SM00360. RRM. 4 hits.
    [Graphical view ]
    SUPFAMi SSF63570. SSF63570. 1 hit.
    TIGRFAMsi TIGR01628. PABP-1234. 1 hit.
    PROSITEi PS51309. PABC. 1 hit.
    PS50102. RRM. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "iPABP, an inducible poly(A)-binding protein detected in activated human T cells."
      Yang H., Duckett C.S., Lindsten T.
      Mol. Cell. Biol. 15:6770-6776(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets."
      Houng A.K., Maggini L., Clement C.Y., Reed G.L.
      Eur. J. Biochem. 243:209-218(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Placenta and Skin.
    6. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 31-41; 51-78; 84-89; 96-104; 114-129; 139-153; 158-166; 187-216; 232-240; 291-311; 313-324; 334-348; 357-370; 376-385; 510-524 AND 575-629, METHYLATION AT LYS-361 AND ARG-518, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells."
      Katzenellenbogen R.A., Egelkrout E.M., Vliet-Gregg P., Gewin L.C., Gafken P.R., Galloway D.A.
      J. Virol. 81:3786-3796(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NFX1.
    9. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-531, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPABP4_HUMAN
    AccessioniPrimary (citable) accession number: Q13310
    Secondary accession number(s): B1ANQ8, Q4VC03, Q6P0N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3