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Protein

Polyadenylate-binding protein 4

Gene

PABPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).By similarity

GO - Molecular functioni

  • mRNA binding Source: Ensembl
  • poly(A) binding Source: MGI
  • poly(U) RNA binding Source: MGI
  • RNA binding Source: UniProtKB

GO - Biological processi

  • blood coagulation Source: ProtInc
  • myeloid cell development Source: Ensembl
  • regulation of mRNA stability Source: Ensembl
  • RNA catabolic process Source: ProtInc
  • RNA processing Source: ProtInc
  • translation Source: ProtInc

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 4
Short name:
PABP-4
Short name:
Poly(A)-binding protein 4
Alternative name(s):
Activated-platelet protein 1
Short name:
APP-1
Inducible poly(A)-binding protein
Short name:
iPABP
Gene namesi
Name:PABPC4
Synonyms:APP1, PABP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000090621.13
HGNCiHGNC:8557 PABPC4
MIMi603407 gene
neXtProtiNX_Q13310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8761
OpenTargetsiENSG00000090621
PharmGKBiPA32883

Chemistry databases

ChEMBLiCHEMBL5333

Polymorphism and mutation databases

BioMutaiPABPC4
DMDMi12229875

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817031 – 644Polyadenylate-binding protein 4Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140PhosphotyrosineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei304PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei361N6,N6-dimethyllysine; alternate1 Publication1
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei364PhosphotyrosineCombined sources1
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei419Omega-N-methylarginineCombined sources1
Modified residuei432Omega-N-methylarginineCombined sources1
Modified residuei436Omega-N-methylarginineCombined sources1
Modified residuei454Omega-N-methylarginineCombined sources1
Modified residuei518Dimethylated arginine1 Publication1
Modified residuei530Omega-N-methylarginineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei584PhosphoserineCombined sources1
Isoform 2 (identifier: Q13310-2)
Modified residuei496Omega-N-methylarginineCombined sources1

Post-translational modificationi

Arg-518 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13310
MaxQBiQ13310
PaxDbiQ13310
PeptideAtlasiQ13310
PRIDEiQ13310

PTM databases

iPTMnetiQ13310
PhosphoSitePlusiQ13310
SwissPalmiQ13310

Expressioni

Tissue specificityi

Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

Gene expression databases

BgeeiENSG00000090621
CleanExiHS_PABPC4
ExpressionAtlasiQ13310 baseline and differential
GenevisibleiQ13310 HS

Organism-specific databases

HPAiHPA027301
HPA056496

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1. Interacts with ZFC3H1 in a RNase-sensitive manner (PubMed:27871484).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PHLDA1Q8WV242EBI-372844,EBI-738731

Protein-protein interaction databases

BioGridi114296, 148 interactors
ELMiQ13310
IntActiQ13310, 46 interactors
MINTiQ13310
STRINGi9606.ENSP00000361949

Structurei

3D structure databases

ProteinModelPortaliQ13310
SMRiQ13310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini551 – 628PABCPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi510 – 516Poly-Ala7

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ13310
KOiK13126
OMAiKKVYVGH
OrthoDBiEOG091G03ZE
PhylomeDBiQ13310
TreeFamiTF300458

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13310-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR
60 70 80 90 100
SLGYAYVNFQ QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN
110 120 130 140 150
VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA
160 170 180 190 200
ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE
210 220 230 240 250
EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK HEDANKAVEE
260 270 280 290 300
MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN
310 320 330 340 350
LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ
410 420 430 440 450
FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP
460 470 480 490 500
SAIRQSGPRP TLRHLAPTGS ECPDRLAMDF GGAGAAQQGL TDSCQSGGVP
510 520 530 540 550
TAVQNLAPRA AVAAAAPRAV APYKYASSVR SPHPAIQPLQ APQPAVHVQG
560 570 580 590 600
QEPLTASMLA AAPPQEQKQM LGERLFPLIQ TMHSNLAGKI TGMLLEIDNS
610 620 630 640
ELLHMLESPE SLRSKVDEAV AVLQAHHAKK EAAQKVGAVA AATS
Length:644
Mass (Da):70,783
Last modified:November 1, 1996 - v1
Checksum:iA761488F0B10DF5A
GO
Isoform 2 (identifier: Q13310-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-497: SECPDRLAMDFGGAGAAQQGLTDSCQSG → NAPASRGLPTTTQRV

Note: No experimental confirmation available.Combined sources
Show »
Length:631
Mass (Da):69,579
Checksum:i1891E205916695F6
GO
Isoform 3 (identifier: Q13310-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-468: T → TGNAPASRGLPTTTQRV

Note: No experimental confirmation available.
Show »
Length:660
Mass (Da):72,391
Checksum:iBC4FB29689689633
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → V in AAH65540 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054048382Y → F. Corresponds to variant dbSNP:rs9820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043357468T → TGNAPASRGLPTTTQRV in isoform 3. 1 Publication1
Alternative sequenceiVSP_013335470 – 497SECPD…SCQSG → NAPASRGLPTTTQRV in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33818 mRNA Translation: AAC50350.1
U75686 mRNA Translation: AAB97309.1
AL365277 Genomic DNA No translation available.
AL845289 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07263.1
CH471059 Genomic DNA Translation: EAX07264.1
BC065540 mRNA Translation: AAH65540.1
BC094755 mRNA Translation: AAH94755.1
CCDSiCCDS438.1 [Q13310-1]
CCDS44114.1 [Q13310-2]
CCDS44115.1 [Q13310-3]
RefSeqiNP_001129125.1, NM_001135653.1 [Q13310-3]
NP_001129126.1, NM_001135654.1 [Q13310-2]
NP_003810.1, NM_003819.3 [Q13310-1]
UniGeneiHs.169900

Genome annotation databases

EnsembliENST00000372856; ENSP00000361947; ENSG00000090621 [Q13310-2]
ENST00000372857; ENSP00000361948; ENSG00000090621 [Q13310-1]
ENST00000372858; ENSP00000361949; ENSG00000090621 [Q13310-3]
GeneIDi8761
KEGGihsa:8761
UCSCiuc001cdl.3 human [Q13310-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPABP4_HUMAN
AccessioniPrimary (citable) accession number: Q13310
Secondary accession number(s): B1ANQ8, Q4VC03, Q6P0N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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