Q13308 (PTK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inactive tyrosine-protein kinase 7

Alternative name(s):
Colon carcinoma kinase 4
Short name=CCK-4
Protein-tyrosine kinase 7
Pseudo tyrosine kinase receptor 7
Tyrosine-protein kinase-like 7

Gene names

Name:	PTK7
Synonyms:	CCK4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1070 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Ref.10 Ref.12 Ref.13 Ref.14 Ref.16
Subunit structure	Interacts with CTNNB1. Ref.16
Subcellular location	Membrane; Single-pass type I membrane protein. Cell junction. Note: Co-localizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. Ref.13
Tissue specificity	Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Induction	Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines established from highly metastatic invasive carcinomas (at protein level). Ref.13
Domain	The protein kinase domain is predicted to be catalytically inactive.
Post-translational modification	MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell adhesion Wnt signaling pathway
Cellular component	Cell junction Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton reorganization Inferred from mutant phenotype Ref.13. Source: UniProtKB axis elongation Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from mutant phenotype Ref.16. Source: UniProtKB cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell migration Inferred from mutant phenotype Ref.13. Source: UniProtKB cellular response to retinoic acid Inferred from mutant phenotype PubMed 17910947. Source: BHF-UCL cochlea morphogenesis Inferred from electronic annotation. Source: Compara convergent extension Inferred from electronic annotation. Source: Compara establishment of epithelial cell apical/basal polarity Inferred from electronic annotation. Source: Compara establishment of planar polarity Inferred from electronic annotation. Source: Compara lung-associated mesenchyme development Inferred from electronic annotation. Source: Compara neural tube closure Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in neural tube closure Inferred from electronic annotation. Source: Compara positive regulation of neuron projection development Inferred from mutant phenotype PubMed 17910947. Source: BHF-UCL wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	cell-cell junction Inferred from direct assay Ref.13. Source: UniProtKB integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13308-1)

Also known as: PTK7-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13308-2)

Also known as: PTK7-2;

The sequence of this isoform differs from the canonical sequence as follows:
     500-539: Missing.

Isoform 3 (identifier: Q13308-3)

Also known as: PTK7-3;

The sequence of this isoform differs from the canonical sequence as follows:
     410-540: TVPSWLKKPQ...KPTIKWERAD → N

Isoform 4 (identifier: Q13308-4)

Also known as: PTK7-4;

The sequence of this isoform differs from the canonical sequence as follows:
     627-682: Missing.

Isoform 5 (identifier: Q13308-5)

Also known as: PTK7-5;

The sequence of this isoform differs from the canonical sequence as follows:
     804-816: KSEFGEVFLAKAQ → RPQAVPEDFQEQG
     817-1070: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 6 (identifier: Q13308-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MGAARGSPARPRRLPLLSVLLLPLLG → MGSFLSGEKRPSAPTVGSAMEKKEFPTPPGRVGP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 1070	1040	Inactive tyrosine-protein kinase 7		PRO_0000016748
Regions
	Topological domain	31 – 704	674	Extracellular Potential
	Transmembrane	705 – 725	21	Helical; Potential
	Topological domain	726 – 1070	345	Cytoplasmic Potential
	Domain	31 – 120	90	Ig-like C2-type 1
	Domain	128 – 218	91	Ig-like C2-type 2
	Domain	225 – 317	93	Ig-like C2-type 3
	Domain	309 – 407	99	Ig-like C2-type 4
	Domain	412 – 497	86	Ig-like C2-type 5
	Domain	503 – 586	84	Ig-like C2-type 6
	Domain	578 – 680	103	Ig-like C2-type 7
	Domain	796 – 1066	271	Protein kinase; inactive
	Region	794 – 1070	277	Interaction with CTNNB1
Sites
	Site	621 – 622	2	Cleavage; by MMP14
Amino acid modifications
	Glycosylation	116	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	175	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Glycosylation	214	1	N-linked (GlcNAc...) Potential
	Glycosylation	268	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	283	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	405	1	N-linked (GlcNAc...) Potential
	Glycosylation	463	1	N-linked (GlcNAc...) Potential
	Glycosylation	567	1	N-linked (GlcNAc...) Potential
	Glycosylation	646	1	N-linked (GlcNAc...) Ref.8 Ref.9
	Disulfide bond	53 ↔ 101		By similarity
	Disulfide bond	150 ↔ 200		By similarity
	Disulfide bond	246 ↔ 301		By similarity
	Disulfide bond	343 ↔ 391		By similarity
	Disulfide bond	433 ↔ 481		By similarity
	Disulfide bond	524 ↔ 570		By similarity
	Disulfide bond	613 ↔ 664		By similarity
Natural variations
	Alternative sequence	1 – 26	26	MGAAR…LPLLG → MGSFLSGEKRPSAPTVGSAM EKKEFPTPPGRVGP in isoform 6.		VSP_044775
	Alternative sequence	410 – 540	131	TVPSW…WERAD → N in isoform 3.		VSP_037181
	Alternative sequence	500 – 539	40	Missing in isoform 2.		VSP_037182
	Alternative sequence	627 – 682	56	Missing in isoform 4.		VSP_037183
	Alternative sequence	804 – 816	13	KSEFG…LAKAQ → RPQAVPEDFQEQG in isoform 5.		VSP_037184
	Alternative sequence	817 – 1070	254	Missing in isoform 5.		VSP_037185
	Natural variant	276	1	R → H. Ref.17 Corresponds to variant rs56188167 [ dbSNP | Ensembl ].		VAR_041502
	Natural variant	410	1	T → S. Ref.17 Corresponds to variant rs34021075 [ dbSNP | Ensembl ].		VAR_041503
	Natural variant	745	1	E → D. Ref.17 Corresponds to variant rs9472017 [ dbSNP | Ensembl ].		VAR_041504
	Natural variant	766	1	E → Q. Ref.17 Corresponds to variant rs56216742 [ dbSNP | Ensembl ].		VAR_041505
	Natural variant	777	1	A → V. Ref.17 Corresponds to variant rs34764696 [ dbSNP | Ensembl ].		VAR_041506
	Natural variant	783	1	H → R. Ref.17 Corresponds to variant rs55820547 [ dbSNP | Ensembl ].		VAR_041507
	Natural variant	933	1	A → V in a colorectal adenocarcinoma sample; somatic mutation. Ref.17		VAR_041508
	Natural variant	1029	1	P → T. Ref.17 Corresponds to variant rs55755163 [ dbSNP | Ensembl ].		VAR_041509
	Natural variant	1038	1	R → Q. Ref.17 Corresponds to variant rs34865794 [ dbSNP | Ensembl ].		VAR_041510
Experimental info
	Mutagenesis	622	1	L → D: Prevents proteolysis by MMP14. Ref.13
	Mutagenesis	641	1	M → R: No impact on proteolysis by MMP14. Ref.13
	Mutagenesis	701	1	M → D: No impact on proteolysis by MMP14. Ref.13
	Sequence conflict	87	1	F → L in BAF85278. Ref.4
	Sequence conflict	92	1	R → P in AAA87565. Ref.1
	Sequence conflict	93	1	L → P in AAH71557. Ref.7
	Sequence conflict	147	1	T → K in AAA87565. Ref.1
	Sequence conflict	207	1	G → S in AAA87565. Ref.1
	Sequence conflict	495 – 496	2	RV → VL in AAA87565. Ref.1
	Sequence conflict	515	1	E → G in AAA87565. Ref.1
	Sequence conflict	755	1	Q → R in BAH12463. Ref.4
	Sequence conflict	799	1	I → F in BAF85278. Ref.4
	Sequence conflict	881	1	G → E in AAA87565. Ref.1
	Sequence conflict	969	1	P → A in AAA87565. Ref.1
	Sequence conflict	992	1	F → S in AAA87565. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PTK7-1) [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 304926A1774EB5F4	FASTA	1,070	118,392
	10 20 30 40 50 60 MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 70 80 90 100 110 120 VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 130 140 150 160 170 180 IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 190 200 210 220 230 240 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 250 260 270 280 290 300 EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 310 320 330 340 350 360 CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 370 380 390 400 410 420 VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 430 440 450 460 470 480 SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 490 500 510 520 530 540 CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 550 560 570 580 590 600 GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 610 620 630 640 650 660 TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG 670 680 690 700 710 720 RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL 730 740 750 760 770 780 GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN 790 800 810 820 830 840 KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ 850 860 870 880 890 900 LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ 910 920 930 940 950 960 PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY 970 980 990 1000 1010 1020 YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ 1030 1040 1050 1060 1070 AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSTVDSKP
	Isoform 2 (PTK7-2) [UniParc]. Checksum: 34501D254ED02C49	FASTA	1,030	113,805
	10 20 30 40 50 60 MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 70 80 90 100 110 120 VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 130 140 150 160 170 180 IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 190 200 210 220 230 240 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 250 260 270 280 290 300 EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 310 320 330 340 350 360 CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 370 380 390 400 410 420 VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 430 440 450 460 470 480 SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 490 500 510 520 530 540 CMSSTPAGSI EAQARVQVLD GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI 550 560 570 580 590 600 RAHVQLTVAV FITFKVEPER TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR 610 620 630 640 650 660 MHIFQNGSLV IHDVAPEDSG RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK 670 680 690 700 710 720 MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS 730 740 750 760 770 780 AEIQEEVALT SLGSGPAATN KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE 790 800 810 820 830 840 GVAETLVLVK SLQSKDEQQQ LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL 850 860 870 880 890 900 GDLKQFLRIS KSKDEKLKSQ PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA 910 920 930 940 950 960 QRQVKVSALG LSKDVYNSEY YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF 970 980 990 1000 1010 1020 THGEMPHGGQ ADDEVLADLQ AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA 1030 LGDSTVDSKP
	Isoform 3 (PTK7-3) [UniParc]. Checksum: 33FEE51123972DA8	FASTA	940	103,581
	10 20 30 40 50 60 MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 70 80 90 100 110 120 VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 130 140 150 160 170 180 IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 190 200 210 220 230 240 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 250 260 270 280 290 300 EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 310 320 330 340 350 360 CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 370 380 390 400 410 420 VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAN GSSLPEWVTD 430 440 450 460 470 480 NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER TTVYQGHTAL 490 500 510 520 530 540 LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG RYTCIAGNSC 550 560 570 580 590 600 NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC 610 620 630 640 650 660 KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN KRHSTSDKMH 670 680 690 700 710 720 FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ LDFRRELEMF 730 740 750 760 770 780 GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ PLSTKQKVAL 790 800 810 820 830 840 CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY YHFRQAWVPL 850 860 870 880 890 900 RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ AGKARLPQPE 910 920 930 940 GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSTVDSKP
	Isoform 4 (PTK7-4) [UniParc]. Checksum: BCAA8FEBBF9909B8	FASTA	1,014	112,261
	10 20 30 40 50 60 MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 70 80 90 100 110 120 VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 130 140 150 160 170 180 IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 190 200 210 220 230 240 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 250 260 270 280 290 300 EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 310 320 330 340 350 360 CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 370 380 390 400 410 420 VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 430 440 450 460 470 480 SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 490 500 510 520 530 540 CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 550 560 570 580 590 600 GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 610 620 630 640 650 660 TTVYQGHTAL LQCEAQGDPK PLIQWKDKPV PEESEGPGSP PPYKMIQTIG LSVGAAVAYI 670 680 690 700 710 720 IAVLGLMFYC KKRCKAKRLQ KQPEGEEPEM ECLNGGPLQN GQPSAEIQEE VALTSLGSGP 730 740 750 760 770 780 AATNKRHSTS DKMHFPRSSL QPITTLGKSE FGEVFLAKAQ GLEEGVAETL VLVKSLQSKD 790 800 810 820 830 840 EQQQLDFRRE LEMFGKLNHA NVVRLLGLCR EAEPHYMVLE YVDLGDLKQF LRISKSKDEK 850 860 870 880 890 900 LKSQPLSTKQ KVALCTQVAL GMEHLSNNRF VHKDLAARNC LVSAQRQVKV SALGLSKDVY 910 920 930 940 950 960 NSEYYHFRQA WVPLRWMSPE AILEGDFSTK SDVWAFGVLM WEVFTHGEMP HGGQADDEVL 970 980 990 1000 1010 ADLQAGKARL PQPEGCPSKL YRLMQRCWAL SPKDRPSFSE IASALGDSTV DSKP
	Isoform 5 (PTK7-5) [UniParc]. Checksum: 20405B0B94CA99EB	FASTA	816	89,764
	10 20 30 40 50 60 MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 70 80 90 100 110 120 VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 130 140 150 160 170 180 IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 190 200 210 220 230 240 KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 250 260 270 280 290 300 EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 310 320 330 340 350 360 CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 370 380 390 400 410 420 VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 430 440 450 460 470 480 SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 490 500 510 520 530 540 CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 550 560 570 580 590 600 GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 610 620 630 640 650 660 TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG 670 680 690 700 710 720 RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL 730 740 750 760 770 780 GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN 790 800 810 KRHSTSDKMH FPRSSLQPIT TLGRPQAVPE DFQEQG
	Isoform 6 [UniParc]. Checksum: E5F3E9970734EAF8	FASTA	1,078	119,197
	10 20 30 40 50 60 MGSFLSGEKR PSAPTVGSAM EKKEFPTPPG RVGPGTQTAI VFIKQPSSQD ALQGRRALLR 70 80 90 100 110 120 CEVEAPGPVH VYWLLDGAPV QDTERRFAQG SSLSFAAVDR LQDSGTFQCV ARDDVTGEEA 130 140 150 160 170 180 RSANASFNIK WIEAGPVVLK HPASEAEIQP QTQVTLRCHI DGHPRPTYQW FRDGTPLSDG 190 200 210 220 230 240 QSNHTVSSKE RNLTLRPAGP EHSGLYSCCA HSAFGQACSS QNFTLSIADE SFARVVLAPQ 250 260 270 280 290 300 DVVVARYEEA MFHCQFSAQP PPSLQWLFED ETPITNRSRP PHLRRATVFA NGSLLLTQVR 310 320 330 340 350 360 PRNAGIYRCI GQGQRGPPII LEATLHLAEI EDMPLFEPRV FTAGSEERVT CLPPKGLPEP 370 380 390 400 410 420 SVWWEHAGVR LPTHGRVYQK GHELVLANIA ESDAGVYTCH AANLAGQRRQ DVNITVATVP 430 440 450 460 470 480 SWLKKPQDSQ LEEGKPGYLD CLTQATPKPT VVWYRNQMLI SEDSRFEVFK NGTLRINSVE 490 500 510 520 530 540 VYDGTWYRCM SSTPAGSIEA QARVQVLEKL KFTPPPQPQQ CMEFDKEATV PCSATGREKP 550 560 570 580 590 600 TIKWERADGS SLPEWVTDNA GTLHFARVTR DDAGNYTCIA SNGPQGQIRA HVQLTVAVFI 610 620 630 640 650 660 TFKVEPERTT VYQGHTALLQ CEAQGDPKPL IQWKGKDRIL DPTKLGPRMH IFQNGSLVIH 670 680 690 700 710 720 DVAPEDSGRY TCIAGNSCNI KHTEAPLYVV DKPVPEESEG PGSPPPYKMI QTIGLSVGAA 730 740 750 760 770 780 VAYIIAVLGL MFYCKKRCKA KRLQKQPEGE EPEMECLNGG PLQNGQPSAE IQEEVALTSL 790 800 810 820 830 840 GSGPAATNKR HSTSDKMHFP RSSLQPITTL GKSEFGEVFL AKAQGLEEGV AETLVLVKSL 850 860 870 880 890 900 QSKDEQQQLD FRRELEMFGK LNHANVVRLL GLCREAEPHY MVLEYVDLGD LKQFLRISKS 910 920 930 940 950 960 KDEKLKSQPL STKQKVALCT QVALGMEHLS NNRFVHKDLA ARNCLVSAQR QVKVSALGLS 970 980 990 1000 1010 1020 KDVYNSEYYH FRQAWVPLRW MSPEAILEGD FSTKSDVWAF GVLMWEVFTH GEMPHGGQAD 1030 1040 1050 1060 1070 DEVLADLQAG KARLPQPEGC PSKLYRLMQR CWALSPKDRP SFSEIASALG DSTVDSKP

References

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[1]	"Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family." Mossie K., Jallal B., Alves F., Sures I., Plowman G.D., Ullrich A. Oncogene 11:2179-2184(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Colon carcinoma and Placenta.
[2]	"Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG." Park S.-K., Lee H.-S., Lee S.-T. J. Biochem. 119:235-239(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fibroblast.
[3]	"Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA." Jung J.-W., Ji A.-R., Lee J., Kim U.-J., Lee S.-T. Biochim. Biophys. Acta 1579:153-163(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5). Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6). Tissue: Testis and Tongue.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[8]	"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-646.
[9]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-646, MASS SPECTROMETRY. Tissue: Liver.
[10]	"Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis." Shin W.-S., Maeng Y.-S., Jung J.-W., Min J.-K., Kwon Y.-G., Lee S.-T. Biochem. Biophys. Res. Commun. 371:793-798(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-116; ASN-175; ASN-268 AND ASN-283, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome." Prebet T., Lhoumeau A.-C., Arnoulet C., Aulas A., Marchetto S., Audebert S., Puppo F., Chabannon C., Sainty D., Santoni M.-J., Sebbagh M., Summerour V., Huon Y., Shin W.-S., Lee S.-T., Esterni B., Vey N., Borg J.-P. Blood 116:2315-2323(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[13]	"The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis." Golubkov V.S., Chekanov A.V., Cieplak P., Aleshin A.E., Chernov A.V., Zhu W., Radichev I.A., Zhang D., Dong P.D., Strongin A.Y. J. Biol. Chem. 285:35740-35749(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, CLEAVAGE, MUTAGENESIS OF LEU-622; MET-641 AND MET-701.
[14]	"Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway." Meng L., Sefah K., O'Donoghue M.B., Zhu G., Shangguan D., Noorali A., Chen Y., Zhou L., Tan W. PLoS ONE 5:E14018-E14018(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling." Puppo F., Thome V., Lhoumeau A.-C., Cibois M., Gangar A., Lembo F., Belotti E., Marchetto S., Lecine P., Prebet T., Sebbagh M., Shin W.-S., Lee S.-T., Kodjabachian L., Borg J.-P. EMBO Rep. 12:43-49(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CTNNB1, REGION.
[17]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-276; SER-410; ASP-745; GLN-766; VAL-777; ARG-783; VAL-933; THR-1029 AND GLN-1038.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33635 mRNA. Translation: AAA87565.1. U40271 mRNA. Translation: AAC50484.2. AF447176 , AF447157, AF447158, AF447162, AF447164, AF447167, AF447170, AF447171, AF447173, AF447174, AF447175 Genomic DNA. Translation: AAL39062.1. AF531868 mRNA. Translation: AAN04862.1. AF531869 mRNA. Translation: AAN04863.1. AF531870 mRNA. Translation: AAN04864.1. AF531871 mRNA. Translation: AAN04865.1. AF531872 mRNA. Translation: AAN04866.1. AK291016 mRNA. Translation: BAF83705.1. AK292589 mRNA. Translation: BAF85278.1. AK296953 mRNA. Translation: BAH12463.1. AL355385 Genomic DNA. Translation: CAI13783.1. CH471081 Genomic DNA. Translation: EAX04154.1. CH471081 Genomic DNA. Translation: EAX04155.1. CH471081 Genomic DNA. Translation: EAX04156.1. CH471081 Genomic DNA. Translation: EAX04158.1. CH471081 Genomic DNA. Translation: EAX04160.1. BC071557 mRNA. Translation: AAH71557.1.
IPI	IPI00168813. IPI00170814. IPI00174794. IPI00298292. IPI00478565. IPI00946792.
PIR	JC4593.
RefSeq	NP_001257327.1. NM_001270398.1. NP_002812.2. NM_002821.4. NP_690619.1. NM_152880.3. NP_690620.1. NM_152881.3. NP_690621.1. NM_152882.3.
UniGene	Hs.90572.
3D structure databases
ProteinModelPortal	Q13308.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13308. 1 interaction.
PTM databases
PhosphoSite	Q13308.
Polymorphism databases
DMDM	116242736.
Proteomic databases
PaxDb	Q13308.
PRIDE	Q13308.
Protocols and materials databases
DNASU	5754.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000230418; ENSP00000230418; ENSG00000112655. ENST00000230419; ENSP00000230419; ENSG00000112655. ENST00000345201; ENSP00000325992; ENSG00000112655. ENST00000349241; ENSP00000325462; ENSG00000112655. ENST00000352931; ENSP00000326029; ENSG00000112655. ENST00000481273; ENSP00000418754; ENSG00000112655.
GeneID	5754.
KEGG	hsa:5754.
UCSC	uc003oub.1. human. uc003ouc.1. human. uc003oud.1. human. uc003oue.1. human.
Organism-specific databases
CTD	5754.
GeneCards	GC06P043044.
HGNC	HGNC:9618. PTK7.
HPA	HPA003222.
MIM	601890. gene.
neXtProt	NX_Q13308.
PharmGKB	PA33961.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG008320.
InParanoid	Q13308.
KO	K05127.
OrthoDB	EOG4DBTCZ.
PhylomeDB	Q13308.
Gene expression databases
ArrayExpress	Q13308.
Bgee	Q13308.
CleanEx	HS_PTK7.
Genevestigator	Q13308.
GermOnline	ENSG00000112655. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 7 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07679. I-set. 6 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00409. IG. 2 hits. SM00408. IGc2. 5 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50835. IG_LIKE. 7 hits. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PTK7. human.
GenomeRNAi	5754.
NextBio	22390.
SOURCE	Search...

Entry information

Entry name

PTK7_HUMAN

Accession

Primary (citable) accession number: Q13308
Secondary accession number(s): A8K974 , B7Z477, E9PFZ5, Q13417, Q5T650, Q6IQ54, Q8NFA5, Q8NFA6, Q8NFA7, Q8NFA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.