Q13304 (GPR17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uracil nucleotide/cysteinyl leukotriene receptor
Short name=UDP/CysLT receptor

Alternative name(s):
G-protein coupled receptor 17
P2Y-like receptor
R12

Gene names

Name:

GPR17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. Ref.6
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. Ref.6
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro chemokine receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13304-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13304-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Uracil nucleotide/cysteinyl leukotriene receptor		PRO_0000069536
Regions
	Topological domain	1 – 64	64	Extracellular Potential
	Transmembrane	65 – 85	21	Helical; Name=1; Potential
	Topological domain	86 – 92	7	Cytoplasmic Potential
	Transmembrane	93 – 113	21	Helical; Name=2; Potential
	Topological domain	114 – 133	20	Extracellular Potential
	Transmembrane	134 – 154	21	Helical; Name=3; Potential
	Topological domain	155 – 175	21	Cytoplasmic Potential
	Transmembrane	176 – 196	21	Helical; Name=4; Potential
	Topological domain	197 – 223	27	Extracellular Potential
	Transmembrane	224 – 244	21	Helical; Name=5; Potential
	Topological domain	245 – 260	16	Cytoplasmic Potential
	Transmembrane	261 – 281	21	Helical; Name=6; Potential
	Topological domain	282 – 308	27	Extracellular Potential
	Transmembrane	309 – 329	21	Helical; Name=7; Potential
	Topological domain	330 – 367	38	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	204	1	N-linked (GlcNAc...) Potential
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Disulfide bond	132 ↔ 209		By similarity
Natural variations
	Alternative sequence	1 – 28	28	Missing in isoform 2.		VSP_001987
Experimental info
	Sequence conflict	83	1	L → F in AAH31653. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: 132FBE97BE83C60C	FASTA	367	40,989
	10 20 30 40 50 60 MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM 70 80 90 100 110 120 LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH LAVADLSCVL VLPTRLVYHF 130 140 150 160 170 180 SGNHWPFGEI ACRLTGFLFY LNMYASIYFL TCISADRFLA IVHPVKSLKL RRPLYAHLAC 190 200 210 220 230 240 AFLWVVVAVA MAPLLVSPQT VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY 250 260 270 280 290 300 LLIIRSLRQG LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ 310 320 330 340 350 360 RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP SFEGKTNESS LSAKSEL
	Isoform 2 [UniParc]. Checksum: BD2AEDB2FEBF15E1	FASTA	339	37,827
	10 20 30 40 50 60 MNGLEVAPPG LITNFSLATA EQCGQETPLE NMLFASFYLL DFILALVGNT LALWLFIRDH 70 80 90 100 110 120 KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG EIACRLTGFL FYLNMYASIY 130 140 150 160 170 180 FLTCISADRF LAIVHPVKSL KLRRPLYAHL ACAFLWVVVA VAMAPLLVSP QTVQTNHTVV 190 200 210 220 230 240 CLQLYREKAS HHALVSLAVA FTFPFITTVT CYLLIIRSLR QGLRVEKRLK TKAVRMIAIV 250 260 270 280 290 300 LAIFLVCFVP YHVNRSVYVL HYRSHGASCA TQRILALANR ITSCLTSLNG ALDPIMYFFV 310 320 330 AEKFRHALCN LLCGKRLKGP PPSFEGKTNE SSLSAKSEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New members of the chemokine receptor gene family." Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B., Godiska R., Gray P.W. J. Leukoc. Biol. 59:18-23(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[2]	"A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21." Blaesius R.H., Weber R.G., Lichter P., Ogilvie A. J. Neurochem. 70:1357-1365(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Hippocampus.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[6]	"The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor." Ciana P., Fumagalli M., Trincavelli M.L., Verderio C., Rosa P., Lecca D., Ferrario S., Parravicini C., Capra V., Gelosa P., Guerrini U., Belcredito S., Cimino M., Sironi L., Tremoli E., Rovati G.E., Martini C., Abbracchio M.P. EMBO J. 25:4615-4627(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33447 Genomic DNA. Translation: AAB16746.1. Y12546 mRNA. Translation: CAA73144.1. Z94154 mRNA. Translation: CAB08107.1. Z94155 mRNA. Translation: CAB08108.1. AK292725 mRNA. Translation: BAF85414.1. AK313949 mRNA. Translation: BAG36667.1. CH471103 Genomic DNA. Translation: EAW95337.1. BC031653 mRNA. Translation: AAH31653.1. BC039595 mRNA. No translation available.
IPI	IPI00012717. IPI00218454.
RefSeq	NP_001154887.1. NM_001161415.1. NP_001154888.1. NM_001161416.1. NP_001154889.1. NM_001161417.1. NP_005282.1. NM_005291.2.
UniGene	Hs.46453. Hs.736277.
3D structure databases
ProteinModelPortal	Q13304.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000272644.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q13304.
Polymorphism databases
DMDM	21264435.
Proteomic databases
PaxDb	Q13304.
PRIDE	Q13304.
Protocols and materials databases
DNASU	2840.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272644; ENSP00000272644; ENSG00000144230. ENST00000393018; ENSP00000376741; ENSG00000144230. ENST00000544369; ENSP00000442982; ENSG00000144230.
GeneID	2840.
KEGG	hsa:2840.
UCSC	uc002tpc.3. human.
Organism-specific databases
CTD	2840.
GeneCards	GC02P128403.
HGNC	HGNC:4471. GPR17.
HPA	HPA029766.
MIM	603071. gene.
neXtProt	NX_Q13304.
PharmGKB	PA28859.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149667.
HOGENOM	HOG000236328.
HOVERGEN	HBG102010.
InParanoid	Q13304.
KO	K08404.
OMA	FSGNHWP.
OrthoDB	EOG44BB2S.
PhylomeDB	Q13304.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q13304.
Bgee	Q13304.
CleanEx	HS_GPR17.
Genevestigator	Q13304.
GermOnline	ENSG00000144230. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002286. P2_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q13304.
ChEMBL	CHEMBL1075162.
GenomeRNAi	2840.
NextBio	11201.
SOURCE	Search...

Entry information

Entry name

GPR17_HUMAN

Accession

Primary (citable) accession number: Q13304
Secondary accession number(s): A8K9L0 , B2R9X0, Q8N5S7, Q9UDZ6, Q9UE21

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 27, 2002
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.