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Protein

Uracil nucleotide/cysteinyl leukotriene receptor

Gene

GPR17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.1 Publication

GO - Molecular functioni

  • chemokine receptor activity Source: ProtInc

GO - Biological processi

  • chemokine-mediated signaling pathway Source: GOC
  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391906. Leukotriene receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil nucleotide/cysteinyl leukotriene receptor
Short name:
UDP/CysLT receptor
Alternative name(s):
G-protein coupled receptor 17
P2Y-like receptor
R12
Gene namesi
Name:GPR17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4471. GPR17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464ExtracellularSequence analysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini86 – 927CytoplasmicSequence analysis
Transmembranei93 – 11321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini114 – 13320ExtracellularSequence analysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini155 – 17521CytoplasmicSequence analysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini197 – 22327ExtracellularSequence analysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini245 – 26016CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini282 – 30827ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 32921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini330 – 36738CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28859.

Chemistry

ChEMBLiCHEMBL1075162.
GuidetoPHARMACOLOGYi88.

Polymorphism and mutation databases

BioMutaiGPR17.
DMDMi21264435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Uracil nucleotide/cysteinyl leukotriene receptorPRO_0000069536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi132 ↔ 209PROSITE-ProRule annotation
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence analysis
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13304.
PRIDEiQ13304.

PTM databases

PhosphoSiteiQ13304.

Expressioni

Tissue specificityi

Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.1 Publication

Gene expression databases

BgeeiQ13304.
CleanExiHS_GPR17.
ExpressionAtlasiQ13304. baseline and differential.
GenevisibleiQ13304. HS.

Organism-specific databases

HPAiHPA029766.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000272644.

Chemistry

BindingDBiQ13304.

Structurei

3D structure databases

ProteinModelPortaliQ13304.
SMRiQ13304. Positions 60-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZC. Eukaryota.
ENOG41110RZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG102010.
InParanoidiQ13304.
KOiK08404.
OMAiFSGNHWP.
OrthoDBiEOG7F5121.
PhylomeDBiQ13304.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13304-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ
60 70 80 90 100
CGQETPLENM LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH
110 120 130 140 150
LAVADLSCVL VLPTRLVYHF SGNHWPFGEI ACRLTGFLFY LNMYASIYFL
160 170 180 190 200
TCISADRFLA IVHPVKSLKL RRPLYAHLAC AFLWVVVAVA MAPLLVSPQT
210 220 230 240 250
VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY LLIIRSLRQG
260 270 280 290 300
LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ
310 320 330 340 350
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP
360
SFEGKTNESS LSAKSEL
Length:367
Mass (Da):40,989
Last modified:May 27, 2002 - v2
Checksum:i132FBE97BE83C60C
GO
Isoform 2 (identifier: Q13304-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:339
Mass (Da):37,827
Checksum:iBD2AEDB2FEBF15E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831L → F in AAH31653 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828Missing in isoform 2. 3 PublicationsVSP_001987Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33447 Genomic DNA. Translation: AAB16746.1.
Y12546 mRNA. Translation: CAA73144.1.
Z94154 mRNA. Translation: CAB08107.1.
Z94155 mRNA. Translation: CAB08108.1.
AK292725 mRNA. Translation: BAF85414.1.
AK313949 mRNA. Translation: BAG36667.1.
CH471103 Genomic DNA. Translation: EAW95337.1.
BC031653 mRNA. Translation: AAH31653.1.
BC039595 mRNA. No translation available.
CCDSiCCDS2148.1. [Q13304-1]
RefSeqiNP_001154887.1. NM_001161415.1. [Q13304-1]
NP_001154888.1. NM_001161416.1. [Q13304-2]
NP_001154889.1. NM_001161417.1. [Q13304-2]
NP_005282.1. NM_005291.2. [Q13304-1]
UniGeneiHs.46453.
Hs.736277.

Genome annotation databases

EnsembliENST00000272644; ENSP00000272644; ENSG00000144230. [Q13304-1]
ENST00000393018; ENSP00000376741; ENSG00000144230. [Q13304-1]
ENST00000544369; ENSP00000442982; ENSG00000144230. [Q13304-1]
GeneIDi2840.
KEGGihsa:2840.
UCSCiuc002tpc.4. human. [Q13304-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33447 Genomic DNA. Translation: AAB16746.1.
Y12546 mRNA. Translation: CAA73144.1.
Z94154 mRNA. Translation: CAB08107.1.
Z94155 mRNA. Translation: CAB08108.1.
AK292725 mRNA. Translation: BAF85414.1.
AK313949 mRNA. Translation: BAG36667.1.
CH471103 Genomic DNA. Translation: EAW95337.1.
BC031653 mRNA. Translation: AAH31653.1.
BC039595 mRNA. No translation available.
CCDSiCCDS2148.1. [Q13304-1]
RefSeqiNP_001154887.1. NM_001161415.1. [Q13304-1]
NP_001154888.1. NM_001161416.1. [Q13304-2]
NP_001154889.1. NM_001161417.1. [Q13304-2]
NP_005282.1. NM_005291.2. [Q13304-1]
UniGeneiHs.46453.
Hs.736277.

3D structure databases

ProteinModelPortaliQ13304.
SMRiQ13304. Positions 60-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000272644.

Chemistry

BindingDBiQ13304.
ChEMBLiCHEMBL1075162.
GuidetoPHARMACOLOGYi88.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ13304.

Polymorphism and mutation databases

BioMutaiGPR17.
DMDMi21264435.

Proteomic databases

PaxDbiQ13304.
PRIDEiQ13304.

Protocols and materials databases

DNASUi2840.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272644; ENSP00000272644; ENSG00000144230. [Q13304-1]
ENST00000393018; ENSP00000376741; ENSG00000144230. [Q13304-1]
ENST00000544369; ENSP00000442982; ENSG00000144230. [Q13304-1]
GeneIDi2840.
KEGGihsa:2840.
UCSCiuc002tpc.4. human. [Q13304-1]

Organism-specific databases

CTDi2840.
GeneCardsiGPR17.
HGNCiHGNC:4471. GPR17.
HPAiHPA029766.
MIMi603071. gene.
neXtProtiNX_Q13304.
PharmGKBiPA28859.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGZC. Eukaryota.
ENOG41110RZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG102010.
InParanoidiQ13304.
KOiK08404.
OMAiFSGNHWP.
OrthoDBiEOG7F5121.
PhylomeDBiQ13304.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiR-HSA-391906. Leukotriene receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiGPR17.
GenomeRNAii2840.
NextBioi11201.
PROiQ13304.
SOURCEiSearch...

Gene expression databases

BgeeiQ13304.
CleanExiHS_GPR17.
ExpressionAtlasiQ13304. baseline and differential.
GenevisibleiQ13304. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New members of the chemokine receptor gene family."
    Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B., Godiska R., Gray P.W.
    J. Leukoc. Biol. 59:18-23(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
  2. "A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21."
    Blaesius R.H., Weber R.G., Lichter P., Ogilvie A.
    J. Neurochem. 70:1357-1365(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Hippocampus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  6. Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR17_HUMAN
AccessioniPrimary (citable) accession number: Q13304
Secondary accession number(s): A8K9L0
, B2R9X0, Q8N5S7, Q9UDZ6, Q9UE21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: March 16, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.