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Q13303

- KCAB2_HUMAN

UniProt

Q13303 - KCAB2_HUMAN

Protein

Voltage-gated potassium channel subunit beta-2

Gene

KCNAB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.4.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631NADP1 Publication
    Binding sitei85 – 851NADP1 Publication
    Binding sitei90 – 901NADP1 Publication
    Binding sitei214 – 2141NADP1 Publication
    Binding sitei254 – 2541NADP1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 572NADP1 Publication
    Nucleotide bindingi188 – 1892NADP1 Publication
    Nucleotide bindingi243 – 2486NADP1 Publication
    Nucleotide bindingi323 – 3297NADP1 Publication

    GO - Molecular functioni

    1. potassium channel regulator activity Source: ProtInc
    2. voltage-gated potassium channel activity Source: InterPro

    GO - Biological processi

    1. protein heterooligomerization Source: Ensembl
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    NADP, Potassium

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-2009-MONOMER.
    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-gated potassium channel subunit beta-2
    Alternative name(s):
    K(+) channel subunit beta-2
    Kv-beta-2
    Short name:
    hKvbeta2
    Gene namesi
    Name:KCNAB2
    Synonyms:KCNA2B, KCNK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6229. KCNAB2.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro
    3. juxtaparanode region of axon Source: BHF-UCL
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti1606. 1p36 deletion syndrome.
    PharmGKBiPA373.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Voltage-gated potassium channel subunit beta-2PRO_0000148746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine1 Publication
    Modified residuei124 – 1241N6-acetyllysine1 Publication

    Post-translational modificationi

    Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13303.
    PaxDbiQ13303.
    PRIDEiQ13303.

    PTM databases

    PhosphoSiteiQ13303.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13303.
    BgeeiQ13303.
    CleanExiHS_KCNAB2.
    HS_KCNK2.
    GenevestigatoriQ13303.

    Organism-specific databases

    HPAiCAB001975.
    HPA030185.

    Interactioni

    Subunit structurei

    Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114086. 10 interactions.
    IntActiQ13303. 1 interaction.
    MINTiMINT-2865320.
    STRINGi9606.ENSP00000164247.

    Structurei

    Secondary structure

    1
    367
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 424
    Beta strandi48 – 558
    Helixi59 – 635
    Helixi66 – 7813
    Beta strandi83 – 853
    Helixi90 – 934
    Helixi94 – 10613
    Helixi110 – 1123
    Beta strandi114 – 1218
    Helixi126 – 1283
    Beta strandi129 – 1313
    Helixi133 – 14715
    Beta strandi152 – 1598
    Helixi166 – 17813
    Beta strandi181 – 1899
    Helixi192 – 20514
    Beta strandi212 – 2165
    Helixi223 – 2264
    Helixi228 – 2369
    Beta strandi239 – 2435
    Helixi247 – 2526
    Turni253 – 2575
    Helixi264 – 2663
    Helixi271 – 2777
    Helixi280 – 29920
    Helixi303 – 31311
    Beta strandi317 – 3226
    Helixi327 – 3348
    Helixi336 – 3394
    Helixi340 – 3423
    Helixi345 – 35511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZSXX-ray1.90A39-360[»]
    ProteinModelPortaliQ13303.
    SMRiQ13303. Positions 37-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13303.

    Family & Domainsi

    Domaini

    Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0667.
    HOVERGENiHBG052216.
    KOiK04883.
    OMAiAIGFIEV.
    PhylomeDBiQ13303.
    TreeFamiTF324563.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PRINTSiPR01579. KCNAB2CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13303-1) [UniParc]FASTAAdd to Basket

    Also known as: KvB2.1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS    50
    CLGLGTWVTF GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG 100
    NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE 150
    YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS 200
    VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI 250
    VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 300
    CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE 350
    IDSILGNKPY SKKDYRS 367
    Length:367
    Mass (Da):41,000
    Last modified:January 1, 1998 - v2
    Checksum:i91A673F8992140DA
    GO
    Isoform 2 (identifier: Q13303-2) [UniParc]FASTAAdd to Basket

    Also known as: KvB2.2

    The sequence of this isoform differs from the canonical sequence as follows:
         26-39: Missing.

    Show »
    Length:353
    Mass (Da):39,287
    Checksum:i7D59C8203AC5606F
    GO
    Isoform 3 (identifier: Q13303-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-38: MYPESTTGSP...YGSPKRQLQF → MLSMTYSESL...GCTAQRTGMK
         167-167: E → EGDPFSSSKSRTFIIE

    Show »
    Length:415
    Mass (Da):46,527
    Checksum:i3AD46E32E4B200AF
    GO
    Isoform 4 (identifier: Q13303-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: Missing.

    Show »
    Length:300
    Mass (Da):33,657
    Checksum:i3ADDAAE15216B737
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti88 – 881E → K.
    Corresponds to variant rs2229003 [ dbSNP | Ensembl ].
    VAR_048747

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6767Missing in isoform 4. 1 PublicationVSP_044311Add
    BLAST
    Alternative sequencei1 – 3838MYPES…RQLQF → MLSMTYSESLRSVSSRCHSE WALHPVRQTDTLELQRLREV RAAAQARNMESFLRMHGLSL DGCTAQRTGMK in isoform 3. 1 PublicationVSP_041189Add
    BLAST
    Alternative sequencei26 – 3914Missing in isoform 2. 1 PublicationVSP_001054Add
    BLAST
    Alternative sequencei167 – 1671E → EGDPFSSSKSRTFIIE in isoform 3. 1 PublicationVSP_041190

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33429 mRNA. Translation: AAC50955.1.
    AF029749 mRNA. Translation: AAB84170.1.
    AF044253 mRNA. Translation: AAB99859.1.
    AK124696 mRNA. Translation: BAG54071.1.
    AK131252 mRNA. Translation: BAD18431.1.
    AK289819 mRNA. Translation: BAF82508.1.
    AK315858 mRNA. Translation: BAF98749.1.
    AL035406 Genomic DNA. Translation: CAC08512.1.
    AL035406 Genomic DNA. Translation: CAI19885.1.
    BC126424 mRNA. Translation: AAI26425.1.
    BC130413 mRNA. Translation: AAI30414.1.
    CCDSiCCDS55.1. [Q13303-1]
    CCDS55570.1. [Q13303-3]
    CCDS55571.1. [Q13303-4]
    CCDS56.1. [Q13303-2]
    PIRiS66502.
    RefSeqiNP_001186789.1. NM_001199860.1. [Q13303-1]
    NP_001186790.1. NM_001199861.1. [Q13303-1]
    NP_001186791.1. NM_001199862.1. [Q13303-3]
    NP_001186792.1. NM_001199863.1. [Q13303-4]
    NP_003627.1. NM_003636.3. [Q13303-1]
    NP_742128.1. NM_172130.2. [Q13303-2]
    XP_005263571.1. XM_005263514.1. [Q13303-2]
    UniGeneiHs.440497.
    Hs.735032.

    Genome annotation databases

    EnsembliENST00000164247; ENSP00000164247; ENSG00000069424. [Q13303-1]
    ENST00000341524; ENSP00000340824; ENSG00000069424. [Q13303-1]
    ENST00000352527; ENSP00000318772; ENSG00000069424. [Q13303-2]
    ENST00000378083; ENSP00000367323; ENSG00000069424. [Q13303-3]
    ENST00000378092; ENSP00000367332; ENSG00000069424. [Q13303-2]
    ENST00000378097; ENSP00000367337; ENSG00000069424. [Q13303-1]
    ENST00000458166; ENSP00000396167; ENSG00000069424. [Q13303-4]
    GeneIDi8514.
    KEGGihsa:8514.
    UCSCiuc001alv.2. human. [Q13303-1]
    uc001alw.2. human. [Q13303-2]
    uc001aly.2. human. [Q13303-3]

    Polymorphism databases

    DMDMi18202496.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33429 mRNA. Translation: AAC50955.1 .
    AF029749 mRNA. Translation: AAB84170.1 .
    AF044253 mRNA. Translation: AAB99859.1 .
    AK124696 mRNA. Translation: BAG54071.1 .
    AK131252 mRNA. Translation: BAD18431.1 .
    AK289819 mRNA. Translation: BAF82508.1 .
    AK315858 mRNA. Translation: BAF98749.1 .
    AL035406 Genomic DNA. Translation: CAC08512.1 .
    AL035406 Genomic DNA. Translation: CAI19885.1 .
    BC126424 mRNA. Translation: AAI26425.1 .
    BC130413 mRNA. Translation: AAI30414.1 .
    CCDSi CCDS55.1. [Q13303-1 ]
    CCDS55570.1. [Q13303-3 ]
    CCDS55571.1. [Q13303-4 ]
    CCDS56.1. [Q13303-2 ]
    PIRi S66502.
    RefSeqi NP_001186789.1. NM_001199860.1. [Q13303-1 ]
    NP_001186790.1. NM_001199861.1. [Q13303-1 ]
    NP_001186791.1. NM_001199862.1. [Q13303-3 ]
    NP_001186792.1. NM_001199863.1. [Q13303-4 ]
    NP_003627.1. NM_003636.3. [Q13303-1 ]
    NP_742128.1. NM_172130.2. [Q13303-2 ]
    XP_005263571.1. XM_005263514.1. [Q13303-2 ]
    UniGenei Hs.440497.
    Hs.735032.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZSX X-ray 1.90 A 39-360 [» ]
    ProteinModelPortali Q13303.
    SMRi Q13303. Positions 37-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114086. 10 interactions.
    IntActi Q13303. 1 interaction.
    MINTi MINT-2865320.
    STRINGi 9606.ENSP00000164247.

    PTM databases

    PhosphoSitei Q13303.

    Polymorphism databases

    DMDMi 18202496.

    Proteomic databases

    MaxQBi Q13303.
    PaxDbi Q13303.
    PRIDEi Q13303.

    Protocols and materials databases

    DNASUi 8514.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000164247 ; ENSP00000164247 ; ENSG00000069424 . [Q13303-1 ]
    ENST00000341524 ; ENSP00000340824 ; ENSG00000069424 . [Q13303-1 ]
    ENST00000352527 ; ENSP00000318772 ; ENSG00000069424 . [Q13303-2 ]
    ENST00000378083 ; ENSP00000367323 ; ENSG00000069424 . [Q13303-3 ]
    ENST00000378092 ; ENSP00000367332 ; ENSG00000069424 . [Q13303-2 ]
    ENST00000378097 ; ENSP00000367337 ; ENSG00000069424 . [Q13303-1 ]
    ENST00000458166 ; ENSP00000396167 ; ENSG00000069424 . [Q13303-4 ]
    GeneIDi 8514.
    KEGGi hsa:8514.
    UCSCi uc001alv.2. human. [Q13303-1 ]
    uc001alw.2. human. [Q13303-2 ]
    uc001aly.2. human. [Q13303-3 ]

    Organism-specific databases

    CTDi 8514.
    GeneCardsi GC01P006020.
    HGNCi HGNC:6229. KCNAB2.
    HPAi CAB001975.
    HPA030185.
    MIMi 601142. gene.
    neXtProti NX_Q13303.
    Orphaneti 1606. 1p36 deletion syndrome.
    PharmGKBi PA373.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0667.
    HOVERGENi HBG052216.
    KOi K04883.
    OMAi AIGFIEV.
    PhylomeDBi Q13303.
    TreeFami TF324563.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-2009-MONOMER.
    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    ChiTaRSi KCNAB2. human.
    EvolutionaryTracei Q13303.
    GeneWikii KCNAB2.
    GenomeRNAii 8514.
    NextBioi 31868.
    PROi Q13303.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13303.
    Bgeei Q13303.
    CleanExi HS_KCNAB2.
    HS_KCNK2.
    Genevestigatori Q13303.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PRINTSi PR01579. KCNAB2CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product."
      Mccormack K., McCormack T., Tanouye M.A., Rudy B., Stuehmer W.
      FEBS Lett. 370:32-36(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
      Tissue: Hippocampus.
    2. McCormack K.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Rae J.L., Shepard A.R.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lens epithelium.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Amygdala, Brain and Hippocampus.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Crystal structure of human potassium channel Kv beta-subunit (KCNAB2)."
      Structural genomics consortium (SGC)
      Submitted (JUN-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 36-360 IN COMPLEX WITH NADP.

    Entry informationi

    Entry nameiKCAB2_HUMAN
    AccessioniPrimary (citable) accession number: Q13303
    Secondary accession number(s): A0AVM9
    , A8K1A4, B0AZR7, O43659, Q5TG82, Q5TG83, Q6ZNE4, Q99411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3