ID SG2A2_HUMAN Reviewed; 93 AA. AC Q13296; A1A522; Q86WH8; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 27-MAR-2024, entry version 163. DE RecName: Full=Mammaglobin-A; DE AltName: Full=Mammaglobin-1; DE AltName: Full=Secretoglobin family 2A member 2; DE Flags: Precursor; GN Name=SCGB2A2; Synonyms=MGB1, UGB2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Mammary gland; RX PubMed=8631025; RA Watson M.A., Fleming T.P.; RT "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is RT overexpressed in human breast cancer."; RL Cancer Res. 56:860-865(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). RX PubMed=9488047; DOI=10.1038/sj.onc.1201597; RA Watson M.A., Darrow C., Zimonjic D.B., Popescu N.C., Fleming T.; RT "Structure and transcriptional regulation of the human mammaglobin gene, a RT breast cancer associated member of the uteroglobin gene family localized to RT chromosome 11q13."; RL Oncogene 16:817-824(1998). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RA Zhao L., Nan K.; RT "An alternative splicing isoform of mammaglobin."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q13296; P50552: VASP; NbExp=3; IntAct=EBI-9058786, EBI-748201; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q13296-1; Sequence=Displayed; CC Name=2; CC IsoId=Q13296-2; Sequence=VSP_009122; CC -!- TISSUE SPECIFICITY: Mammary gland specific. Over-expressed in breast CC cancer. CC -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U33147; AAC50375.1; -; mRNA. DR EMBL; AF015224; AAC39608.1; -; Genomic_DNA. DR EMBL; AY217100; AAO60111.1; -; mRNA. DR EMBL; BC128252; AAI28253.1; -; mRNA. DR EMBL; BC128402; AAI28403.1; -; mRNA. DR CCDS; CCDS8018.1; -. [Q13296-1] DR RefSeq; NP_002402.1; NM_002411.3. [Q13296-1] DR AlphaFoldDB; Q13296; -. DR SMR; Q13296; -. DR BioGRID; 110406; 268. DR IntAct; Q13296; 78. DR MINT; Q13296; -. DR STRING; 9606.ENSP00000227918; -. DR GlyConnect; 1486; 26 N-Linked glycans (1 site). DR GlyCosmos; Q13296; 2 sites, 25 glycans. DR GlyGen; Q13296; 2 sites, 25 N-linked glycans (1 site). DR iPTMnet; Q13296; -. DR PhosphoSitePlus; Q13296; -. DR BioMuta; SCGB2A2; -. DR DMDM; 2833243; -. DR jPOST; Q13296; -. DR MassIVE; Q13296; -. DR PaxDb; 9606-ENSP00000227918; -. DR PeptideAtlas; Q13296; -. DR ProteomicsDB; 59286; -. [Q13296-1] DR ProteomicsDB; 59287; -. [Q13296-2] DR Antibodypedia; 28425; 532 antibodies from 40 providers. DR DNASU; 4250; -. DR Ensembl; ENST00000227918.3; ENSP00000227918.2; ENSG00000110484.7. [Q13296-1] DR GeneID; 4250; -. DR KEGG; hsa:4250; -. DR MANE-Select; ENST00000227918.3; ENSP00000227918.2; NM_002411.4; NP_002402.1. DR UCSC; uc001ntc.5; human. [Q13296-1] DR AGR; HGNC:7050; -. DR CTD; 4250; -. DR DisGeNET; 4250; -. DR GeneCards; SCGB2A2; -. DR HGNC; HGNC:7050; SCGB2A2. DR HPA; ENSG00000110484; Group enriched (breast, skin). DR MIM; 605562; gene. DR neXtProt; NX_Q13296; -. DR OpenTargets; ENSG00000110484; -. DR PharmGKB; PA34993; -. DR VEuPathDB; HostDB:ENSG00000110484; -. DR eggNOG; ENOG502TE5J; Eukaryota. DR GeneTree; ENSGT00390000013802; -. DR HOGENOM; CLU_161063_0_0_1; -. DR InParanoid; Q13296; -. DR OMA; ALMNTIY; -. DR OrthoDB; 5266337at2759; -. DR PhylomeDB; Q13296; -. DR TreeFam; TF338521; -. DR PathwayCommons; Q13296; -. DR SignaLink; Q13296; -. DR BioGRID-ORCS; 4250; 15 hits in 1142 CRISPR screens. DR ChiTaRS; SCGB2A2; human. DR GeneWiki; Mammaglobin-A; -. DR GenomeRNAi; 4250; -. DR Pharos; Q13296; Tbio. DR PRO; PR:Q13296; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q13296; Protein. DR Bgee; ENSG00000110484; Expressed in upper leg skin and 97 other cell types or tissues. DR ExpressionAtlas; Q13296; baseline and differential. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030521; P:androgen receptor signaling pathway; IBA:GO_Central. DR CDD; cd00633; Secretoglobin; 1. DR InterPro; IPR016126; Secretoglobin. DR InterPro; IPR035960; Secretoglobin_sf. DR PANTHER; PTHR14037:SF7; MAMMAGLOBIN-A; 1. DR PANTHER; PTHR14037; MAMMAGLOBIN-RELATED; 1. DR Pfam; PF01099; Uteroglobin; 1. DR SUPFAM; SSF48201; Uteroglobin-like; 1. DR PROSITE; PS51311; SCGB; 1. DR Genevisible; Q13296; HS. PE 1: Evidence at protein level; KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal. FT SIGNAL 1..18 FT /evidence="ECO:0000255" FT CHAIN 19..93 FT /note="Mammaglobin-A" FT /id="PRO_0000036372" FT CARBOHYD 53 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 68 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 79..81 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|Ref.3" FT /id="VSP_009122" SQ SEQUENCE 93 AA; 10499 MW; 2896E8C43BF053E2 CRC64; MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF //