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Protein

Mammaglobin-A

Gene

SCGB2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mammaglobin-A
Alternative name(s):
Mammaglobin-1
Secretoglobin family 2A member 2
Gene namesi
Name:SCGB2A2
Synonyms:MGB1, UGB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7050. SCGB2A2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 9375Mammaglobin-APRO_0000036372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ13296.
PRIDEiQ13296.

Expressioni

Tissue specificityi

Mammary gland specific. Over-expressed in breast cancer.

Gene expression databases

BgeeiQ13296.
CleanExiHS_SCGB2A2.
ExpressionAtlasiQ13296. baseline and differential.
GenevestigatoriQ13296.

Organism-specific databases

HPAiCAB026270.
HPA036184.

Interactioni

Protein-protein interaction databases

BioGridi110406. 1 interaction.
STRINGi9606.ENSP00000227918.

Structurei

3D structure databases

ProteinModelPortaliQ13296.
SMRiQ13296. Positions 22-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG257325.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiQ13296.
OMAiQLIYDSS.
OrthoDBiEOG79W97Q.
PhylomeDBiQ13296.
TreeFamiTF338521.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13296-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI
60 70 80 90
DDNATTNAID ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF
Length:93
Mass (Da):10,499
Last modified:November 1, 1996 - v1
Checksum:i2896E8C43BF053E2
GO
Isoform 2 (identifier: Q13296-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-81: Missing.

Show »
Length:90
Mass (Da):10,122
Checksum:iD166F3FC34FE990D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 813Missing in isoform 2. 1 PublicationVSP_009122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33147 mRNA. Translation: AAC50375.1.
AF015224 Genomic DNA. Translation: AAC39608.1.
AY217100 mRNA. Translation: AAO60111.1.
BC128252 mRNA. Translation: AAI28253.1.
BC128402 mRNA. Translation: AAI28403.1.
CCDSiCCDS8018.1. [Q13296-1]
RefSeqiNP_002402.1. NM_002411.3. [Q13296-1]
UniGeneiHs.46452.

Genome annotation databases

EnsembliENST00000227918; ENSP00000227918; ENSG00000110484. [Q13296-1]
GeneIDi4250.
KEGGihsa:4250.
UCSCiuc001ntc.3. human. [Q13296-1]

Polymorphism databases

DMDMi2833243.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33147 mRNA. Translation: AAC50375.1.
AF015224 Genomic DNA. Translation: AAC39608.1.
AY217100 mRNA. Translation: AAO60111.1.
BC128252 mRNA. Translation: AAI28253.1.
BC128402 mRNA. Translation: AAI28403.1.
CCDSiCCDS8018.1. [Q13296-1]
RefSeqiNP_002402.1. NM_002411.3. [Q13296-1]
UniGeneiHs.46452.

3D structure databases

ProteinModelPortaliQ13296.
SMRiQ13296. Positions 22-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110406. 1 interaction.
STRINGi9606.ENSP00000227918.

Polymorphism databases

DMDMi2833243.

Proteomic databases

PaxDbiQ13296.
PRIDEiQ13296.

Protocols and materials databases

DNASUi4250.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227918; ENSP00000227918; ENSG00000110484. [Q13296-1]
GeneIDi4250.
KEGGihsa:4250.
UCSCiuc001ntc.3. human. [Q13296-1]

Organism-specific databases

CTDi4250.
GeneCardsiGC11P062038.
HGNCiHGNC:7050. SCGB2A2.
HPAiCAB026270.
HPA036184.
MIMi605562. gene.
neXtProtiNX_Q13296.
PharmGKBiPA34993.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG257325.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiQ13296.
OMAiQLIYDSS.
OrthoDBiEOG79W97Q.
PhylomeDBiQ13296.
TreeFamiTF338521.

Miscellaneous databases

GeneWikiiMammaglobin-A.
GenomeRNAii4250.
NextBioi16755.
PROiQ13296.
SOURCEiSearch...

Gene expression databases

BgeeiQ13296.
CleanExiHS_SCGB2A2.
ExpressionAtlasiQ13296. baseline and differential.
GenevestigatoriQ13296.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer."
    Watson M.A., Fleming T.P.
    Cancer Res. 56:860-865(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  2. "Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13."
    Watson M.A., Darrow C., Zimonjic D.B., Popescu N.C., Fleming T.
    Oncogene 16:817-824(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "An alternative splicing isoform of mammaglobin."
    Zhao L., Nan K.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiSG2A2_HUMAN
AccessioniPrimary (citable) accession number: Q13296
Secondary accession number(s): A1A522, Q86WH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.