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Q13296

- SG2A2_HUMAN

UniProt

Q13296 - SG2A2_HUMAN

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Protein
Mammaglobin-A
Gene
SCGB2A2, MGB1, UGB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mammaglobin-A
Alternative name(s):
Mammaglobin-1
Secretoglobin family 2A member 2
Gene namesi
Name:SCGB2A2
Synonyms:MGB1, UGB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7050. SCGB2A2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 9375Mammaglobin-A
PRO_0000036372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ13296.
PRIDEiQ13296.

Expressioni

Tissue specificityi

Mammary gland specific. Over-expressed in breast cancer.

Gene expression databases

ArrayExpressiQ13296.
BgeeiQ13296.
CleanExiHS_SCGB2A2.
GenevestigatoriQ13296.

Organism-specific databases

HPAiCAB026270.
HPA036184.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000227918.

Structurei

3D structure databases

ProteinModelPortaliQ13296.
SMRiQ13296. Positions 22-90.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG257325.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiQ13296.
OMAiAMERDEI.
OrthoDBiEOG79W97Q.
PhylomeDBiQ13296.
TreeFamiTF338521.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13296-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI   50
DDNATTNAID ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF 93
Length:93
Mass (Da):10,499
Last modified:November 1, 1996 - v1
Checksum:i2896E8C43BF053E2
GO
Isoform 2 (identifier: Q13296-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-81: Missing.

Show »
Length:90
Mass (Da):10,122
Checksum:iD166F3FC34FE990D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 813Missing in isoform 2.
VSP_009122

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33147 mRNA. Translation: AAC50375.1.
AF015224 Genomic DNA. Translation: AAC39608.1.
AY217100 mRNA. Translation: AAO60111.1.
BC128252 mRNA. Translation: AAI28253.1.
BC128402 mRNA. Translation: AAI28403.1.
CCDSiCCDS8018.1. [Q13296-1]
RefSeqiNP_002402.1. NM_002411.3. [Q13296-1]
UniGeneiHs.46452.

Genome annotation databases

EnsembliENST00000227918; ENSP00000227918; ENSG00000110484. [Q13296-1]
GeneIDi4250.
KEGGihsa:4250.
UCSCiuc001ntc.3. human. [Q13296-1]

Polymorphism databases

DMDMi2833243.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33147 mRNA. Translation: AAC50375.1 .
AF015224 Genomic DNA. Translation: AAC39608.1 .
AY217100 mRNA. Translation: AAO60111.1 .
BC128252 mRNA. Translation: AAI28253.1 .
BC128402 mRNA. Translation: AAI28403.1 .
CCDSi CCDS8018.1. [Q13296-1 ]
RefSeqi NP_002402.1. NM_002411.3. [Q13296-1 ]
UniGenei Hs.46452.

3D structure databases

ProteinModelPortali Q13296.
SMRi Q13296. Positions 22-90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000227918.

Polymorphism databases

DMDMi 2833243.

Proteomic databases

PaxDbi Q13296.
PRIDEi Q13296.

Protocols and materials databases

DNASUi 4250.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227918 ; ENSP00000227918 ; ENSG00000110484 . [Q13296-1 ]
GeneIDi 4250.
KEGGi hsa:4250.
UCSCi uc001ntc.3. human. [Q13296-1 ]

Organism-specific databases

CTDi 4250.
GeneCardsi GC11P062038.
HGNCi HGNC:7050. SCGB2A2.
HPAi CAB026270.
HPA036184.
MIMi 605562. gene.
neXtProti NX_Q13296.
PharmGKBi PA34993.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257325.
HOGENOMi HOG000294150.
HOVERGENi HBG005021.
InParanoidi Q13296.
OMAi AMERDEI.
OrthoDBi EOG79W97Q.
PhylomeDBi Q13296.
TreeFami TF338521.

Miscellaneous databases

GeneWikii Mammaglobin-A.
GenomeRNAii 4250.
NextBioi 16755.
PROi Q13296.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13296.
Bgeei Q13296.
CleanExi HS_SCGB2A2.
Genevestigatori Q13296.

Family and domain databases

InterProi IPR016126. Secretoglobin.
[Graphical view ]
Pfami PF01099. Uteroglobin. 1 hit.
[Graphical view ]
SMARTi SM00096. UTG. 1 hit.
[Graphical view ]
SUPFAMi SSF48201. SSF48201. 1 hit.
PROSITEi PS51311. SCGB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer."
    Watson M.A., Fleming T.P.
    Cancer Res. 56:860-865(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  2. "Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13."
    Watson M.A., Darrow C., Zimonjic D.B., Popescu N.C., Fleming T.
    Oncogene 16:817-824(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "An alternative splicing isoform of mammaglobin."
    Zhao L., Nan K.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiSG2A2_HUMAN
AccessioniPrimary (citable) accession number: Q13296
Secondary accession number(s): A1A522, Q86WH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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