Q13296 (SG2A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mammaglobin-A

Alternative name(s):
Mammaglobin-1
Secretoglobin family 2A member 2

Gene names

Name:	SCGB2A2
Synonyms:	MGB1, UGB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	93 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Mammary gland specific. Over-expressed in breast cancer.
Sequence similarities	Belongs to the secretoglobin family. Lipophilin subfamily.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	steroid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13296-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13296-2)

The sequence of this isoform differs from the canonical sequence as follows:
     79-81: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 93	75	Mammaglobin-A		PRO_0000036372
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	79 – 81	3	Missing in isoform 2.		VSP_009122

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2896E8C43BF053E2	FASTA	93	10,499
	10 20 30 40 50 60 MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID 70 80 90 ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF
	Isoform 2 [UniParc]. Checksum: D166F3FC34FE990D	FASTA	90	10,122
	10 20 30 40 50 60 MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID 70 80 90 ELKECFLNQT DETLSNVEQL IYDSSLCDLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer." Watson M.A., Fleming T.P. Cancer Res. 56:860-865(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Mammary gland.
[2]	"Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13." Watson M.A., Darrow C., Zimonjic D.B., Popescu N.C., Fleming T. Oncogene 16:817-824(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]	"An alternative splicing isoform of mammaglobin." Zhao L., Nan K. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33147 mRNA. Translation: AAC50375.1. AF015224 Genomic DNA. Translation: AAC39608.1. AY217100 mRNA. Translation: AAO60111.1. BC128252 mRNA. Translation: AAI28253.1. BC128402 mRNA. Translation: AAI28403.1.
IPI	IPI00012476. IPI00398870.
RefSeq	NP_002402.1. NM_002411.2.
UniGene	Hs.46452.
3D structure databases
ProteinModelPortal	Q13296.
SMR	Q13296. Positions 22-90.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000227918.
Polymorphism databases
DMDM	2833243.
Proteomic databases
PaxDb	Q13296.
PRIDE	Q13296.
Protocols and materials databases
DNASU	4250.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000227918; ENSP00000227918; ENSG00000110484.
GeneID	4250.
KEGG	hsa:4250.
UCSC	uc001ntc.3. human. uc009ynx.3. human.
Organism-specific databases
CTD	4250.
GeneCards	GC11P062038.
HGNC	HGNC:7050. SCGB2A2.
HPA	CAB026270.
MIM	605562. gene.
neXtProt	NX_Q13296.
PharmGKB	PA34993.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG257325.
HOGENOM	HOG000294150.
HOVERGEN	HBG005021.
InParanoid	Q13296.
OMA	QLIYDSS.
OrthoDB	EOG4BRWNH.
PhylomeDB	Q13296.
Gene expression databases
ArrayExpress	Q13296.
Bgee	Q13296.
CleanEx	HS_SCGB2A2.
Genevestigator	Q13296.
GermOnline	ENSG00000110484. Homo sapiens.
Family and domain databases
InterPro	IPR003627. Mamgb/prostatn. IPR016126. Secretoglobin. IPR006039. Uteroglobin-like_fam. IPR006038. Uteroglobin-like_superfam. [Graphical view]
PANTHER	PTHR14037. PTHR14037. 1 hit.
Pfam	PF01099. Uteroglobin. 1 hit. [Graphical view]
SMART	SM00096. UTG. 1 hit. [Graphical view]
SUPFAM	SSF48201. Secretoglobin. 1 hit.
PROSITE	PS51311. SCGB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4250.
NextBio	16755.
SOURCE	Search...

Entry information

Entry name

SG2A2_HUMAN

Accession

Primary (citable) accession number: Q13296
Secondary accession number(s): A1A522, Q86WH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.