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Q13296 (SG2A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mammaglobin-A
Alternative name(s):
Mammaglobin-1
Secretoglobin family 2A member 2
Gene names
Name:SCGB2A2
Synonyms:MGB1, UGB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length93 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Mammary gland specific. Over-expressed in breast cancer.

Sequence similarities

Belongs to the secretoglobin family. Lipophilin subfamily.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13296-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13296-2)

The sequence of this isoform differs from the canonical sequence as follows:
     79-81: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 9375Mammaglobin-A
PRO_0000036372

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence79 – 813Missing in isoform 2.
VSP_009122

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2896E8C43BF053E2

FASTA9310,499
        10         20         30         40         50         60 
MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID 

        70         80         90 
ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF 

« Hide

Isoform 2 [UniParc].

Checksum: D166F3FC34FE990D
Show »

FASTA9010,122

References

« Hide 'large scale' references
[1]"Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer."
Watson M.A., Fleming T.P.
Cancer Res. 56:860-865(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Mammary gland.
[2]"Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13."
Watson M.A., Darrow C., Zimonjic D.B., Popescu N.C., Fleming T.
Oncogene 16:817-824(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]"An alternative splicing isoform of mammaglobin."
Zhao L., Nan K.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33147 mRNA. Translation: AAC50375.1.
AF015224 Genomic DNA. Translation: AAC39608.1.
AY217100 mRNA. Translation: AAO60111.1.
BC128252 mRNA. Translation: AAI28253.1.
BC128402 mRNA. Translation: AAI28403.1.
CCDSCCDS8018.1. [Q13296-1]
RefSeqNP_002402.1. NM_002411.3. [Q13296-1]
UniGeneHs.46452.

3D structure databases

ProteinModelPortalQ13296.
SMRQ13296. Positions 22-90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000227918.

Polymorphism databases

DMDM2833243.

Proteomic databases

PaxDbQ13296.
PRIDEQ13296.

Protocols and materials databases

DNASU4250.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000227918; ENSP00000227918; ENSG00000110484. [Q13296-1]
GeneID4250.
KEGGhsa:4250.
UCSCuc001ntc.3. human. [Q13296-1]

Organism-specific databases

CTD4250.
GeneCardsGC11P062038.
HGNCHGNC:7050. SCGB2A2.
HPACAB026270.
HPA036184.
MIM605562. gene.
neXtProtNX_Q13296.
PharmGKBPA34993.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG257325.
HOGENOMHOG000294150.
HOVERGENHBG005021.
InParanoidQ13296.
OMAAMERDEI.
OrthoDBEOG79W97Q.
PhylomeDBQ13296.
TreeFamTF338521.

Gene expression databases

ArrayExpressQ13296.
BgeeQ13296.
CleanExHS_SCGB2A2.
GenevestigatorQ13296.

Family and domain databases

InterProIPR016126. Secretoglobin.
[Graphical view]
PfamPF01099. Uteroglobin. 1 hit.
[Graphical view]
SMARTSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMSSF48201. SSF48201. 1 hit.
PROSITEPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMammaglobin-A.
GenomeRNAi4250.
NextBio16755.
PROQ13296.
SOURCESearch...

Entry information

Entry nameSG2A2_HUMAN
AccessionPrimary (citable) accession number: Q13296
Secondary accession number(s): A1A522, Q86WH8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM