Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q13287 (NMI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-myc-interactor

Short name=Nmi
Alternative name(s):
N-myc and STAT interactor
Gene names
Name:NMI
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

Subunit structure

Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2. Ref.6

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Induction

By IL2/interleukin-2 and IFNG/IFN-gamma.

Sequence similarities

Belongs to the NMI family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307N-myc-interactor
PRO_0000159702

Natural variations

Natural variant161S → L.
Corresponds to variant rs1048135 [ dbSNP | Ensembl ].
VAR_028190

Experimental info

Sequence conflict1841S → F in AAC12949. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q13287 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: EC228BD0C9E643F1

FASTA30735,057
        10         20         30         40         50         60 
MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQL KKEIQKLETE LQEATKEFQI 

        70         80         90        100        110        120 
KEDIPETKMK FLSVETPEND SQLSNISCSF QVSSKVPYEI QKGQALITFE KEEVAQNVVS 

       130        140        150        160        170        180 
MSKHHVQIKD VNLEVTAKPV PLNSGVRFQV YVEVSKMKIN VTEIPDTLRE DQMRDKLELS 

       190        200        210        220        230        240 
FSKSRNGGGE VDRVDYDRQS GSAVITFVEI GVADKILKKK EYPLYINQTC HRVTVSPYTE 

       250        260        270        280        290        300 
IHLKKYQIFS GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP 


HIAYFEE 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of Nmi, a novel partner of Myc proteins."
Bao J., Zervos A.S.
Oncogene 12:2171-2176(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cervix carcinoma.
[2]"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. expand/collapse author list , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling."
Zhu M.-H., John S., Berg M., Leonard W.J.
Cell 96:121-130(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH STATS.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32849 mRNA. Translation: AAC12949.1.
AB451305 mRNA. Translation: BAG70119.1.
AB451436 mRNA. Translation: BAG70250.1.
AC009311 Genomic DNA. Translation: AAY15066.1.
CH471058 Genomic DNA. Translation: EAX11513.1.
BC001268 mRNA. Translation: AAH01268.1.
RefSeqNP_004679.2. NM_004688.2.
XP_005246998.1. XM_005246941.1.
UniGeneHs.54483.

3D structure databases

ProteinModelPortalQ13287.
SMRQ13287. Positions 157-235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114561. 44 interactions.
IntActQ13287. 35 interactions.
STRING9606.ENSP00000243346.

PTM databases

PhosphoSiteQ13287.

Polymorphism databases

DMDM116242679.

Proteomic databases

PaxDbQ13287.
PeptideAtlasQ13287.
PRIDEQ13287.

Protocols and materials databases

DNASU9111.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243346; ENSP00000243346; ENSG00000123609.
GeneID9111.
KEGGhsa:9111.
UCSCuc002txi.2. human.

Organism-specific databases

CTD9111.
GeneCardsGC02M152126.
H-InvDBHIX0002501.
HGNCHGNC:7854. NMI.
HPAHPA008588.
MIM603525. gene.
neXtProtNX_Q13287.
PharmGKBPA31659.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39231.
HOGENOMHOG000072676.
HOVERGENHBG019086.
InParanoidQ13287.
OMAEDQMRDK.
OrthoDBEOG7SR4N0.
PhylomeDBQ13287.
TreeFamTF332752.

Gene expression databases

ArrayExpressQ13287.
BgeeQ13287.
CleanExHS_NMI.
GenevestigatorQ13287.

Family and domain databases

InterProIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNMI. human.
GeneWikiN-myc-interactor.
GenomeRNAi9111.
NextBio34149.
PROQ13287.
SOURCESearch...

Entry information

Entry nameNMI_HUMAN
AccessionPrimary (citable) accession number: Q13287
Secondary accession number(s): B5BU69, Q53TI8, Q9BVE5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM