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Protein

N-myc-interactor

Gene

NMI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transcription cofactor activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ13287.

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc-interactor
Short name:
Nmi
Alternative name(s):
N-myc and STAT interactor
Gene namesi
Name:NMI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7854. NMI.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9111.
OpenTargetsiENSG00000123609.
PharmGKBiPA31659.

Polymorphism and mutation databases

BioMutaiNMI.
DMDMi116242679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597021 – 307N-myc-interactorAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13287.
MaxQBiQ13287.
PaxDbiQ13287.
PeptideAtlasiQ13287.
PRIDEiQ13287.

PTM databases

iPTMnetiQ13287.
PhosphoSitePlusiQ13287.

Expressioni

Tissue specificityi

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Inductioni

By IL2/interleukin-2 and IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000123609.
CleanExiHS_NMI.
ExpressionAtlasiQ13287. baseline and differential.
GenevisibleiQ13287. HS.

Organism-specific databases

HPAiHPA008588.

Interactioni

Subunit structurei

Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi114561. 67 interactors.
IntActiQ13287. 63 interactors.
STRINGi9606.ENSP00000243346.

Structurei

3D structure databases

ProteinModelPortaliQ13287.
SMRiQ13287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiENOG410IFIM. Eukaryota.
ENOG4111N1Z. LUCA.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000072676.
HOVERGENiHBG019086.
InParanoidiQ13287.
OMAiEDQMRDK.
OrthoDBiEOG090A08G9.
PhylomeDBiQ13287.
TreeFamiTF332752.

Family and domain databases

InterProiView protein in InterPro
IPR033527. NMI.
IPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
PANTHERiPTHR15225:SF11. PTHR15225:SF11. 1 hit.
PfamiView protein in Pfam
PF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.

Sequencei

Sequence statusi: Complete.

Q13287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQL KKEIQKLETE
60 70 80 90 100
LQEATKEFQI KEDIPETKMK FLSVETPEND SQLSNISCSF QVSSKVPYEI
110 120 130 140 150
QKGQALITFE KEEVAQNVVS MSKHHVQIKD VNLEVTAKPV PLNSGVRFQV
160 170 180 190 200
YVEVSKMKIN VTEIPDTLRE DQMRDKLELS FSKSRNGGGE VDRVDYDRQS
210 220 230 240 250
GSAVITFVEI GVADKILKKK EYPLYINQTC HRVTVSPYTE IHLKKYQIFS
260 270 280 290 300
GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP

HIAYFEE
Length:307
Mass (Da):35,057
Last modified:October 17, 2006 - v2
Checksum:iEC228BD0C9E643F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184S → F in AAC12949 (PubMed:8668343).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02819016S → L. Corresponds to variant dbSNP:rs1048135Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32849 mRNA. Translation: AAC12949.1.
AB451305 mRNA. Translation: BAG70119.1.
AB451436 mRNA. Translation: BAG70250.1.
AC009311 Genomic DNA. Translation: AAY15066.1.
CH471058 Genomic DNA. Translation: EAX11513.1.
BC001268 mRNA. Translation: AAH01268.1.
CCDSiCCDS2192.1.
RefSeqiNP_004679.2. NM_004688.2.
XP_005246998.1. XM_005246941.2.
XP_016860736.1. XM_017005247.1.
UniGeneiHs.54483.

Genome annotation databases

EnsembliENST00000243346; ENSP00000243346; ENSG00000123609.
GeneIDi9111.
KEGGihsa:9111.
UCSCiuc002txi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32849 mRNA. Translation: AAC12949.1.
AB451305 mRNA. Translation: BAG70119.1.
AB451436 mRNA. Translation: BAG70250.1.
AC009311 Genomic DNA. Translation: AAY15066.1.
CH471058 Genomic DNA. Translation: EAX11513.1.
BC001268 mRNA. Translation: AAH01268.1.
CCDSiCCDS2192.1.
RefSeqiNP_004679.2. NM_004688.2.
XP_005246998.1. XM_005246941.2.
XP_016860736.1. XM_017005247.1.
UniGeneiHs.54483.

3D structure databases

ProteinModelPortaliQ13287.
SMRiQ13287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114561. 67 interactors.
IntActiQ13287. 63 interactors.
STRINGi9606.ENSP00000243346.

PTM databases

iPTMnetiQ13287.
PhosphoSitePlusiQ13287.

Polymorphism and mutation databases

BioMutaiNMI.
DMDMi116242679.

Proteomic databases

EPDiQ13287.
MaxQBiQ13287.
PaxDbiQ13287.
PeptideAtlasiQ13287.
PRIDEiQ13287.

Protocols and materials databases

DNASUi9111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243346; ENSP00000243346; ENSG00000123609.
GeneIDi9111.
KEGGihsa:9111.
UCSCiuc002txi.3. human.

Organism-specific databases

CTDi9111.
DisGeNETi9111.
GeneCardsiNMI.
H-InvDBHIX0002501.
HGNCiHGNC:7854. NMI.
HPAiHPA008588.
MIMi603525. gene.
neXtProtiNX_Q13287.
OpenTargetsiENSG00000123609.
PharmGKBiPA31659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFIM. Eukaryota.
ENOG4111N1Z. LUCA.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000072676.
HOVERGENiHBG019086.
InParanoidiQ13287.
OMAiEDQMRDK.
OrthoDBiEOG090A08G9.
PhylomeDBiQ13287.
TreeFamiTF332752.

Enzyme and pathway databases

SIGNORiQ13287.

Miscellaneous databases

ChiTaRSiNMI. human.
GeneWikiiN-myc-interactor.
GenomeRNAii9111.
PROiQ13287.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123609.
CleanExiHS_NMI.
ExpressionAtlasiQ13287. baseline and differential.
GenevisibleiQ13287. HS.

Family and domain databases

InterProiView protein in InterPro
IPR033527. NMI.
IPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
PANTHERiPTHR15225:SF11. PTHR15225:SF11. 1 hit.
PfamiView protein in Pfam
PF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNMI_HUMAN
AccessioniPrimary (citable) accession number: Q13287
Secondary accession number(s): B5BU69, Q53TI8, Q9BVE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 17, 2006
Last modified: February 15, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.