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Protein

N-myc-interactor

Gene

NMI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

GO - Molecular functioni

  • transcription cofactor activity Source: ProtInc

GO - Biological processi

  • inflammatory response Source: ProtInc
  • JAK-STAT cascade Source: UniProtKB
  • regulation of nucleic acid-templated transcription Source: GOC
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc-interactor
Short name:
Nmi
Alternative name(s):
N-myc and STAT interactor
Gene namesi
Name:NMI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7854. NMI.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31659.

Polymorphism and mutation databases

BioMutaiNMI.
DMDMi116242679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307N-myc-interactorPRO_0000159702Add
BLAST

Proteomic databases

MaxQBiQ13287.
PaxDbiQ13287.
PeptideAtlasiQ13287.
PRIDEiQ13287.

PTM databases

PhosphoSiteiQ13287.

Expressioni

Tissue specificityi

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Inductioni

By IL2/interleukin-2 and IFNG/IFN-gamma.

Gene expression databases

BgeeiQ13287.
CleanExiHS_NMI.
ExpressionAtlasiQ13287. baseline and differential.
GenevisibleiQ13287. HS.

Organism-specific databases

HPAiHPA008588.

Interactioni

Subunit structurei

Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K2R33EBI-372942,EBI-9977437
BRMS1Q9HCU92EBI-372942,EBI-714781
C1orf216Q8TAB53EBI-372942,EBI-747505
C9orf72Q96LT73EBI-372942,EBI-2961725
CNKSR3Q6P9H43EBI-372942,EBI-10253274
COPS7BQ9H9Q23EBI-372942,EBI-2510162
DKFZp451B226Q5HYH73EBI-372942,EBI-10173842
GCSHQ53XL73EBI-372942,EBI-10242961
GOLGA8DPQ0D2H93EBI-372942,EBI-10181276
HDDC3Q8N4P34EBI-372942,EBI-750003
HHLA3Q9XRX55EBI-372942,EBI-750554
HSPA8Q96IS63EBI-372942,EBI-10289199
LCA5LO954473EBI-372942,EBI-8473670
MAD2L1BPQ150133EBI-372942,EBI-712181
MTMR6Q9Y2173EBI-372942,EBI-766064
MTMR9Q96QG73EBI-372942,EBI-744593
MYCNP041983EBI-372942,EBI-878369
SCELO951714EBI-372942,EBI-7543896
SFR1Q86XK33EBI-372942,EBI-1104535
SNAPC5O759715EBI-372942,EBI-749483
SOX10P566932EBI-372942,EBI-1167533
Sox10O551704EBI-372942,EBI-1185693From a different organism.
STAT5BP516927EBI-372942,EBI-1186119
TRAF5O004634EBI-372942,EBI-523498
TUBA3DQ137482EBI-372942,EBI-355068
TUBA3EQ6PEY23EBI-372942,EBI-2551023
TXLNAP402223EBI-372942,EBI-359793

Protein-protein interaction databases

BioGridi114561. 66 interactions.
IntActiQ13287. 52 interactions.
STRINGi9606.ENSP00000243346.

Structurei

3D structure databases

ProteinModelPortaliQ13287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiNOG39231.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000072676.
HOVERGENiHBG019086.
InParanoidiQ13287.
OMAiEDQMRDK.
OrthoDBiEOG7SR4N0.
PhylomeDBiQ13287.
TreeFamiTF332752.

Family and domain databases

InterProiIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQL KKEIQKLETE
60 70 80 90 100
LQEATKEFQI KEDIPETKMK FLSVETPEND SQLSNISCSF QVSSKVPYEI
110 120 130 140 150
QKGQALITFE KEEVAQNVVS MSKHHVQIKD VNLEVTAKPV PLNSGVRFQV
160 170 180 190 200
YVEVSKMKIN VTEIPDTLRE DQMRDKLELS FSKSRNGGGE VDRVDYDRQS
210 220 230 240 250
GSAVITFVEI GVADKILKKK EYPLYINQTC HRVTVSPYTE IHLKKYQIFS
260 270 280 290 300
GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP

HIAYFEE
Length:307
Mass (Da):35,057
Last modified:October 17, 2006 - v2
Checksum:iEC228BD0C9E643F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841S → F in AAC12949 (PubMed:8668343).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161S → L.
Corresponds to variant rs1048135 [ dbSNP | Ensembl ].
VAR_028190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32849 mRNA. Translation: AAC12949.1.
AB451305 mRNA. Translation: BAG70119.1.
AB451436 mRNA. Translation: BAG70250.1.
AC009311 Genomic DNA. Translation: AAY15066.1.
CH471058 Genomic DNA. Translation: EAX11513.1.
BC001268 mRNA. Translation: AAH01268.1.
CCDSiCCDS2192.1.
RefSeqiNP_004679.2. NM_004688.2.
XP_005246998.1. XM_005246941.2.
UniGeneiHs.54483.

Genome annotation databases

EnsembliENST00000243346; ENSP00000243346; ENSG00000123609.
GeneIDi9111.
KEGGihsa:9111.
UCSCiuc002txi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32849 mRNA. Translation: AAC12949.1.
AB451305 mRNA. Translation: BAG70119.1.
AB451436 mRNA. Translation: BAG70250.1.
AC009311 Genomic DNA. Translation: AAY15066.1.
CH471058 Genomic DNA. Translation: EAX11513.1.
BC001268 mRNA. Translation: AAH01268.1.
CCDSiCCDS2192.1.
RefSeqiNP_004679.2. NM_004688.2.
XP_005246998.1. XM_005246941.2.
UniGeneiHs.54483.

3D structure databases

ProteinModelPortaliQ13287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114561. 66 interactions.
IntActiQ13287. 52 interactions.
STRINGi9606.ENSP00000243346.

PTM databases

PhosphoSiteiQ13287.

Polymorphism and mutation databases

BioMutaiNMI.
DMDMi116242679.

Proteomic databases

MaxQBiQ13287.
PaxDbiQ13287.
PeptideAtlasiQ13287.
PRIDEiQ13287.

Protocols and materials databases

DNASUi9111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243346; ENSP00000243346; ENSG00000123609.
GeneIDi9111.
KEGGihsa:9111.
UCSCiuc002txi.2. human.

Organism-specific databases

CTDi9111.
GeneCardsiGC02M152126.
H-InvDBHIX0002501.
HGNCiHGNC:7854. NMI.
HPAiHPA008588.
MIMi603525. gene.
neXtProtiNX_Q13287.
PharmGKBiPA31659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39231.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000072676.
HOVERGENiHBG019086.
InParanoidiQ13287.
OMAiEDQMRDK.
OrthoDBiEOG7SR4N0.
PhylomeDBiQ13287.
TreeFamiTF332752.

Miscellaneous databases

ChiTaRSiNMI. human.
GeneWikiiN-myc-interactor.
GenomeRNAii9111.
NextBioi34149.
PROiQ13287.
SOURCEiSearch...

Gene expression databases

BgeeiQ13287.
CleanExiHS_NMI.
ExpressionAtlasiQ13287. baseline and differential.
GenevisibleiQ13287. HS.

Family and domain databases

InterProiIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of Nmi, a novel partner of Myc proteins."
    Bao J., Zervos A.S.
    Oncogene 12:2171-2176(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cervix carcinoma.
  2. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling."
    Zhu M.-H., John S., Berg M., Leonard W.J.
    Cell 96:121-130(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STATS.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNMI_HUMAN
AccessioniPrimary (citable) accession number: Q13287
Secondary accession number(s): B5BU69, Q53TI8, Q9BVE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.