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Q13277

- STX3_HUMAN

UniProt

Q13277 - STX3_HUMAN

Protein

Syntaxin-3

Gene

STX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Potentially involved in docking of synaptic vesicles at presynaptic active zones.

    GO - Molecular functioni

    1. arachidonic acid binding Source: HGNC
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. exocytosis Source: Ensembl
    2. intracellular protein transport Source: InterPro
    3. membrane fusion Source: Ensembl
    4. neuron projection development Source: HGNC
    5. neurotransmitter transport Source: UniProtKB-KW

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-3
    Gene namesi
    Name:STX3
    Synonyms:STX3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11438. STX3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: HGNC
    2. azurophil granule Source: UniProtKB
    3. cell-cell junction Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. growth cone Source: HGNC
    6. integral component of membrane Source: UniProtKB-KW
    7. neuron projection Source: HGNC
    8. SNARE complex Source: HGNC
    9. specific granule Source: UniProtKB
    10. vacuole Source: HGNC

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36235.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Syntaxin-3PRO_0000210199Add
    BLAST

    Proteomic databases

    MaxQBiQ13277.
    PaxDbiQ13277.
    PRIDEiQ13277.

    PTM databases

    PhosphoSiteiQ13277.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13277.
    BgeeiQ13277.
    CleanExiHS_STX3.
    GenevestigatoriQ13277.

    Organism-specific databases

    HPAiHPA002191.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ZFYVE9O954053EBI-1394295,EBI-296817

    Protein-protein interaction databases

    BioGridi112678. 13 interactions.
    IntActiQ13277. 3 interactions.
    MINTiMINT-3027462.
    STRINGi9606.ENSP00000338562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13277.
    SMRiQ13277. Positions 31-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2895ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28421Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili32 – 11180Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiQ13277.
    KOiK08486.
    OMAiTSGIMDS.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiQ13277.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q13277-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS    50
    EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK 100
    HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ 150
    RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD 200
    IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET 250
    KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN 289
    Length:289
    Mass (Da):33,155
    Last modified:October 17, 2006 - v3
    Checksum:i0E12EBC7CBEDB81E
    GO
    Isoform B (identifier: Q13277-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         226-262: Missing.

    Show »
    Length:252
    Mass (Da):28,860
    Checksum:i3851D8EB8A25D529
    GO
    Isoform 3 (identifier: Q13277-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         266-289: IIIVLVVVLLGILALIIGLSVGLN → SLQTGVATLVFR

    Note: No experimental confirmation available.

    Show »
    Length:277
    Mass (Da):32,018
    Checksum:i1881B458BF96C46C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 1110Missing(PubMed:9378770)Curated
    Sequence conflicti81 – 811T → S in CAA62209. (PubMed:9378770)Curated
    Sequence conflicti152 – 1532QL → HV in AAA75303. 1 PublicationCurated
    Sequence conflicti250 – 2501T → S1 PublicationCurated
    Sequence conflicti250 – 2501T → S(PubMed:9378770)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831E → D.
    Corresponds to variant rs12282741 [ dbSNP | Ensembl ].
    VAR_028189
    Natural varianti276 – 2761G → S.
    Corresponds to variant rs34563654 [ dbSNP | Ensembl ].
    VAR_052246
    Natural varianti285 – 2851S → P.
    Corresponds to variant rs34753750 [ dbSNP | Ensembl ].
    VAR_052247

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei226 – 26237Missing in isoform B. 1 PublicationVSP_006340Add
    BLAST
    Alternative sequencei266 – 28924IIIVL…SVGLN → SLQTGVATLVFR in isoform 3. 1 PublicationVSP_043187Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32315 mRNA. Translation: AAA75303.1.
    X90581 mRNA. Translation: CAA62209.1.
    AJ002076 mRNA. Translation: CAA05175.1.
    AJ002077 mRNA. Translation: CAA05176.1.
    AK297419 mRNA. Translation: BAG59852.1.
    AP000640 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73854.1.
    BC007405 mRNA. Translation: AAH07405.1.
    BC007429 mRNA. Translation: AAH07429.1.
    CCDSiCCDS53637.1. [Q13277-3]
    CCDS7975.1. [Q13277-1]
    PIRiG01969.
    RefSeqiNP_001171511.1. NM_001178040.1. [Q13277-3]
    NP_004168.1. NM_004177.4. [Q13277-1]
    XP_005274252.1. XM_005274195.1. [Q13277-1]
    XP_005274253.1. XM_005274196.2. [Q13277-1]
    XP_005274257.1. XM_005274200.1. [Q13277-2]
    UniGeneiHs.180711.

    Genome annotation databases

    EnsembliENST00000337979; ENSP00000338562; ENSG00000166900. [Q13277-1]
    ENST00000528805; ENSP00000431386; ENSG00000166900.
    ENST00000529177; ENSP00000433248; ENSG00000166900. [Q13277-3]
    GeneIDi6809.
    KEGGihsa:6809.
    UCSCiuc001nog.3. human. [Q13277-1]
    uc009ymt.1. human. [Q13277-2]
    uc010rkx.2. human. [Q13277-3]

    Polymorphism databases

    DMDMi116242806.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32315 mRNA. Translation: AAA75303.1 .
    X90581 mRNA. Translation: CAA62209.1 .
    AJ002076 mRNA. Translation: CAA05175.1 .
    AJ002077 mRNA. Translation: CAA05176.1 .
    AK297419 mRNA. Translation: BAG59852.1 .
    AP000640 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73854.1 .
    BC007405 mRNA. Translation: AAH07405.1 .
    BC007429 mRNA. Translation: AAH07429.1 .
    CCDSi CCDS53637.1. [Q13277-3 ]
    CCDS7975.1. [Q13277-1 ]
    PIRi G01969.
    RefSeqi NP_001171511.1. NM_001178040.1. [Q13277-3 ]
    NP_004168.1. NM_004177.4. [Q13277-1 ]
    XP_005274252.1. XM_005274195.1. [Q13277-1 ]
    XP_005274253.1. XM_005274196.2. [Q13277-1 ]
    XP_005274257.1. XM_005274200.1. [Q13277-2 ]
    UniGenei Hs.180711.

    3D structure databases

    ProteinModelPortali Q13277.
    SMRi Q13277. Positions 31-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112678. 13 interactions.
    IntActi Q13277. 3 interactions.
    MINTi MINT-3027462.
    STRINGi 9606.ENSP00000338562.

    PTM databases

    PhosphoSitei Q13277.

    Polymorphism databases

    DMDMi 116242806.

    Proteomic databases

    MaxQBi Q13277.
    PaxDbi Q13277.
    PRIDEi Q13277.

    Protocols and materials databases

    DNASUi 6809.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337979 ; ENSP00000338562 ; ENSG00000166900 . [Q13277-1 ]
    ENST00000528805 ; ENSP00000431386 ; ENSG00000166900 .
    ENST00000529177 ; ENSP00000433248 ; ENSG00000166900 . [Q13277-3 ]
    GeneIDi 6809.
    KEGGi hsa:6809.
    UCSCi uc001nog.3. human. [Q13277-1 ]
    uc009ymt.1. human. [Q13277-2 ]
    uc010rkx.2. human. [Q13277-3 ]

    Organism-specific databases

    CTDi 6809.
    GeneCardsi GC11P059480.
    HGNCi HGNC:11438. STX3.
    HPAi HPA002191.
    MIMi 600876. gene.
    neXtProti NX_Q13277.
    PharmGKBi PA36235.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5074.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi Q13277.
    KOi K08486.
    OMAi TSGIMDS.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi Q13277.
    TreeFami TF313763.

    Miscellaneous databases

    ChiTaRSi STX3. human.
    GeneWikii Syntaxin_3.
    GenomeRNAii 6809.
    NextBioi 26569.
    PROi Q13277.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13277.
    Bgeei Q13277.
    CleanExi HS_STX3.
    Genevestigatori Q13277.

    Family and domain databases

    InterProi IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Syntaxin and n-Sec1 isoforms in colonic epithelial cells: association of syntaxins 1A and 3 with apical endocytic pathway."
      Naren A.P., Bradbury N.A., Bennett M.K., Kirk K.L.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Tissue: Colon.
    2. "Human syntaxin 3 is localized apically in human intestinal cells."
      Delgrossi M.H., Breuza L., Mirre C., Chavrier P., le Bivic A.
      J. Cell Sci. 110:2207-2214(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Tissue: Duodenum.
    3. "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1."
      Martin-Martin B., Nabokina S.M., Lazo P.A., Mollinedo F.
      J. Leukoc. Biol. 65:397-406(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Muscle.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX3_HUMAN
    AccessioniPrimary (citable) accession number: Q13277
    Secondary accession number(s): B4DME0
    , O43750, O43751, Q15360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3