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Protein

Syntaxin-3

Gene

STX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • long-term synaptic potentiation Source: Ensembl
  • neuron projection development Source: HGNC
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of chemotaxis Source: UniProtKB
  • positive regulation of protein localization to cell surface Source: UniProtKB
  • positive regulation of protein localization to plasma membrane Source: UniProtKB
  • synaptic vesicle docking Source: InterPro
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • vesicle docking Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166900-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:STX3
Synonyms:STX3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11438. STX3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263CytoplasmicSequence analysisAdd BLAST263
Transmembranei264 – 284Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini285 – 289ExtracellularSequence analysis5

GO - Cellular componenti

  • apical plasma membrane Source: HGNC
  • azurophil granule Source: UniProtKB
  • cell-cell junction Source: UniProtKB
  • dendrite Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • growth cone Source: HGNC
  • integral component of membrane Source: GO_Central
  • lamellipodium Source: UniProtKB
  • melanosome Source: Ensembl
  • neuron projection Source: HGNC
  • photoreceptor cell terminal bouton Source: Ensembl
  • plasma membrane Source: UniProtKB
  • presynaptic membrane Source: Ensembl
  • ribbon synapse Source: Ensembl
  • SNARE complex Source: HGNC
  • specific granule Source: UniProtKB
  • synaptic vesicle Source: GO_Central
  • vacuole Source: HGNC
  • zymogen granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6809.
MalaCardsiSTX3.
OpenTargetsiENSG00000166900.
Orphaneti2290. Microvillus inclusion disease.
PharmGKBiPA36235.

Polymorphism and mutation databases

BioMutaiSTX3.
DMDMi116242806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101991 – 289Syntaxin-3Add BLAST289

Proteomic databases

EPDiQ13277.
PaxDbiQ13277.
PeptideAtlasiQ13277.
PRIDEiQ13277.

PTM databases

iPTMnetiQ13277.
PhosphoSitePlusiQ13277.

Expressioni

Gene expression databases

BgeeiENSG00000166900.
CleanExiHS_STX3.
ExpressionAtlasiQ13277. baseline and differential.
GenevisibleiQ13277. HS.

Organism-specific databases

HPAiHPA002191.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAPBQ9H1157EBI-1394295,EBI-3921185
STX4Q128465EBI-1394295,EBI-744942
ZFYVE9O954053EBI-1394295,EBI-296817

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112678. 75 interactors.
IntActiQ13277. 44 interactors.
MINTiMINT-3027462.
STRINGi9606.ENSP00000338562.

Structurei

3D structure databases

ProteinModelPortaliQ13277.
SMRiQ13277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 111Sequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ13277.
KOiK08486.
OMAiNMERHIE.
OrthoDBiEOG091G0EUK.
PhylomeDBiQ13277.
TreeFamiTF313763.

Family and domain databases

InterProiIPR031186. Stx3.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF34. PTHR19957:SF34. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q13277-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN
Length:289
Mass (Da):33,155
Last modified:October 17, 2006 - v3
Checksum:i0E12EBC7CBEDB81E
GO
Isoform B (identifier: Q13277-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-262: Missing.

Show »
Length:252
Mass (Da):28,860
Checksum:i3851D8EB8A25D529
GO
Isoform 3 (identifier: Q13277-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-289: IIIVLVVVLLGILALIIGLSVGLN → SLQTGVATLVFR

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):32,018
Checksum:i1881B458BF96C46C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 11Missing (PubMed:9378770).Curated10
Sequence conflicti81T → S in CAA62209 (PubMed:9378770).Curated1
Sequence conflicti152 – 153QL → HV in AAA75303 (Ref. 1) Curated2
Sequence conflicti250T → S (Ref. 1) Curated1
Sequence conflicti250T → S (PubMed:9378770).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02818983E → D.Corresponds to variant rs12282741dbSNPEnsembl.1
Natural variantiVAR_052246276G → S.Corresponds to variant rs34563654dbSNPEnsembl.1
Natural variantiVAR_052247285S → P.Corresponds to variant rs34753750dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006340226 – 262Missing in isoform B. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_043187266 – 289IIIVL…SVGLN → SLQTGVATLVFR in isoform 3. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32315 mRNA. Translation: AAA75303.1.
X90581 mRNA. Translation: CAA62209.1.
AJ002076 mRNA. Translation: CAA05175.1.
AJ002077 mRNA. Translation: CAA05176.1.
AK297419 mRNA. Translation: BAG59852.1.
AP000640 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73854.1.
BC007405 mRNA. Translation: AAH07405.1.
BC007429 mRNA. Translation: AAH07429.1.
CCDSiCCDS53637.1. [Q13277-3]
CCDS7975.1. [Q13277-1]
PIRiG01969.
RefSeqiNP_001171511.1. NM_001178040.1. [Q13277-3]
NP_004168.1. NM_004177.4. [Q13277-1]
XP_005274252.1. XM_005274195.3. [Q13277-1]
XP_005274257.1. XM_005274200.3. [Q13277-2]
UniGeneiHs.180711.

Genome annotation databases

EnsembliENST00000337979; ENSP00000338562; ENSG00000166900. [Q13277-1]
ENST00000529177; ENSP00000433248; ENSG00000166900. [Q13277-3]
GeneIDi6809.
KEGGihsa:6809.
UCSCiuc010rkx.3. human. [Q13277-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32315 mRNA. Translation: AAA75303.1.
X90581 mRNA. Translation: CAA62209.1.
AJ002076 mRNA. Translation: CAA05175.1.
AJ002077 mRNA. Translation: CAA05176.1.
AK297419 mRNA. Translation: BAG59852.1.
AP000640 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73854.1.
BC007405 mRNA. Translation: AAH07405.1.
BC007429 mRNA. Translation: AAH07429.1.
CCDSiCCDS53637.1. [Q13277-3]
CCDS7975.1. [Q13277-1]
PIRiG01969.
RefSeqiNP_001171511.1. NM_001178040.1. [Q13277-3]
NP_004168.1. NM_004177.4. [Q13277-1]
XP_005274252.1. XM_005274195.3. [Q13277-1]
XP_005274257.1. XM_005274200.3. [Q13277-2]
UniGeneiHs.180711.

3D structure databases

ProteinModelPortaliQ13277.
SMRiQ13277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112678. 75 interactors.
IntActiQ13277. 44 interactors.
MINTiMINT-3027462.
STRINGi9606.ENSP00000338562.

PTM databases

iPTMnetiQ13277.
PhosphoSitePlusiQ13277.

Polymorphism and mutation databases

BioMutaiSTX3.
DMDMi116242806.

Proteomic databases

EPDiQ13277.
PaxDbiQ13277.
PeptideAtlasiQ13277.
PRIDEiQ13277.

Protocols and materials databases

DNASUi6809.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337979; ENSP00000338562; ENSG00000166900. [Q13277-1]
ENST00000529177; ENSP00000433248; ENSG00000166900. [Q13277-3]
GeneIDi6809.
KEGGihsa:6809.
UCSCiuc010rkx.3. human. [Q13277-1]

Organism-specific databases

CTDi6809.
DisGeNETi6809.
GeneCardsiSTX3.
HGNCiHGNC:11438. STX3.
HPAiHPA002191.
MalaCardsiSTX3.
MIMi600876. gene.
neXtProtiNX_Q13277.
OpenTargetsiENSG00000166900.
Orphaneti2290. Microvillus inclusion disease.
PharmGKBiPA36235.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ13277.
KOiK08486.
OMAiNMERHIE.
OrthoDBiEOG091G0EUK.
PhylomeDBiQ13277.
TreeFamiTF313763.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166900-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Miscellaneous databases

ChiTaRSiSTX3. human.
GeneWikiiSyntaxin_3.
GenomeRNAii6809.
PROiQ13277.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166900.
CleanExiHS_STX3.
ExpressionAtlasiQ13277. baseline and differential.
GenevisibleiQ13277. HS.

Family and domain databases

InterProiIPR031186. Stx3.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF34. PTHR19957:SF34. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX3_HUMAN
AccessioniPrimary (citable) accession number: Q13277
Secondary accession number(s): B4DME0
, O43750, O43751, Q15360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.