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Q13277

- STX3_HUMAN

UniProt

Q13277 - STX3_HUMAN

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Protein

Syntaxin-3

Gene

STX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

  1. arachidonic acid binding Source: HGNC

GO - Biological processi

  1. exocytosis Source: Ensembl
  2. intracellular protein transport Source: InterPro
  3. long-term synaptic potentiation Source: Ensembl
  4. membrane fusion Source: Ensembl
  5. neuron projection development Source: HGNC
  6. neurotransmitter transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:STX3
Synonyms:STX3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11438. STX3.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: HGNC
  2. azurophil granule Source: UniProtKB
  3. cell-cell junction Source: UniProtKB
  4. dendrite Source: Ensembl
  5. extracellular vesicular exosome Source: UniProt
  6. growth cone Source: HGNC
  7. integral component of membrane Source: UniProtKB-KW
  8. neuron projection Source: HGNC
  9. SNARE complex Source: HGNC
  10. specific granule Source: UniProtKB
  11. vacuole Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2290. Microvillus inclusion disease.
PharmGKBiPA36235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Syntaxin-3PRO_0000210199Add
BLAST

Proteomic databases

MaxQBiQ13277.
PaxDbiQ13277.
PRIDEiQ13277.

PTM databases

PhosphoSiteiQ13277.

Expressioni

Gene expression databases

BgeeiQ13277.
CleanExiHS_STX3.
ExpressionAtlasiQ13277. baseline and differential.
GenevestigatoriQ13277.

Organism-specific databases

HPAiHPA002191.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZFYVE9O954053EBI-1394295,EBI-296817

Protein-protein interaction databases

BioGridi112678. 30 interactions.
IntActiQ13277. 3 interactions.
MINTiMINT-3027462.
STRINGi9606.ENSP00000338562.

Structurei

3D structure databases

ProteinModelPortaliQ13277.
SMRiQ13277. Positions 31-283.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini285 – 2895ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei264 – 28421Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 11180Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ13277.
KOiK08486.
OMAiTSGIMDS.
OrthoDBiEOG7X9G7R.
PhylomeDBiQ13277.
TreeFamiTF313763.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q13277-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN
Length:289
Mass (Da):33,155
Last modified:October 17, 2006 - v3
Checksum:i0E12EBC7CBEDB81E
GO
Isoform B (identifier: Q13277-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-262: Missing.

Show »
Length:252
Mass (Da):28,860
Checksum:i3851D8EB8A25D529
GO
Isoform 3 (identifier: Q13277-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-289: IIIVLVVVLLGILALIIGLSVGLN → SLQTGVATLVFR

Note: No experimental confirmation available.

Show »
Length:277
Mass (Da):32,018
Checksum:i1881B458BF96C46C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 1110Missing(PubMed:9378770)Curated
Sequence conflicti81 – 811T → S in CAA62209. (PubMed:9378770)Curated
Sequence conflicti152 – 1532QL → HV in AAA75303. 1 PublicationCurated
Sequence conflicti250 – 2501T → S1 PublicationCurated
Sequence conflicti250 – 2501T → S(PubMed:9378770)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831E → D.
Corresponds to variant rs12282741 [ dbSNP | Ensembl ].
VAR_028189
Natural varianti276 – 2761G → S.
Corresponds to variant rs34563654 [ dbSNP | Ensembl ].
VAR_052246
Natural varianti285 – 2851S → P.
Corresponds to variant rs34753750 [ dbSNP | Ensembl ].
VAR_052247

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei226 – 26237Missing in isoform B. 1 PublicationVSP_006340Add
BLAST
Alternative sequencei266 – 28924IIIVL…SVGLN → SLQTGVATLVFR in isoform 3. 1 PublicationVSP_043187Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32315 mRNA. Translation: AAA75303.1.
X90581 mRNA. Translation: CAA62209.1.
AJ002076 mRNA. Translation: CAA05175.1.
AJ002077 mRNA. Translation: CAA05176.1.
AK297419 mRNA. Translation: BAG59852.1.
AP000640 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73854.1.
BC007405 mRNA. Translation: AAH07405.1.
BC007429 mRNA. Translation: AAH07429.1.
CCDSiCCDS53637.1. [Q13277-3]
CCDS7975.1. [Q13277-1]
PIRiG01969.
RefSeqiNP_001171511.1. NM_001178040.1. [Q13277-3]
NP_004168.1. NM_004177.4. [Q13277-1]
XP_005274252.1. XM_005274195.1. [Q13277-1]
XP_005274253.1. XM_005274196.2. [Q13277-1]
XP_005274257.1. XM_005274200.1. [Q13277-2]
UniGeneiHs.180711.

Genome annotation databases

EnsembliENST00000337979; ENSP00000338562; ENSG00000166900. [Q13277-1]
ENST00000528805; ENSP00000431386; ENSG00000166900.
ENST00000529177; ENSP00000433248; ENSG00000166900. [Q13277-3]
GeneIDi6809.
KEGGihsa:6809.
UCSCiuc001nog.3. human. [Q13277-1]
uc009ymt.1. human. [Q13277-2]
uc010rkx.2. human. [Q13277-3]

Polymorphism databases

DMDMi116242806.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32315 mRNA. Translation: AAA75303.1 .
X90581 mRNA. Translation: CAA62209.1 .
AJ002076 mRNA. Translation: CAA05175.1 .
AJ002077 mRNA. Translation: CAA05176.1 .
AK297419 mRNA. Translation: BAG59852.1 .
AP000640 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73854.1 .
BC007405 mRNA. Translation: AAH07405.1 .
BC007429 mRNA. Translation: AAH07429.1 .
CCDSi CCDS53637.1. [Q13277-3 ]
CCDS7975.1. [Q13277-1 ]
PIRi G01969.
RefSeqi NP_001171511.1. NM_001178040.1. [Q13277-3 ]
NP_004168.1. NM_004177.4. [Q13277-1 ]
XP_005274252.1. XM_005274195.1. [Q13277-1 ]
XP_005274253.1. XM_005274196.2. [Q13277-1 ]
XP_005274257.1. XM_005274200.1. [Q13277-2 ]
UniGenei Hs.180711.

3D structure databases

ProteinModelPortali Q13277.
SMRi Q13277. Positions 31-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112678. 30 interactions.
IntActi Q13277. 3 interactions.
MINTi MINT-3027462.
STRINGi 9606.ENSP00000338562.

PTM databases

PhosphoSitei Q13277.

Polymorphism databases

DMDMi 116242806.

Proteomic databases

MaxQBi Q13277.
PaxDbi Q13277.
PRIDEi Q13277.

Protocols and materials databases

DNASUi 6809.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337979 ; ENSP00000338562 ; ENSG00000166900 . [Q13277-1 ]
ENST00000528805 ; ENSP00000431386 ; ENSG00000166900 .
ENST00000529177 ; ENSP00000433248 ; ENSG00000166900 . [Q13277-3 ]
GeneIDi 6809.
KEGGi hsa:6809.
UCSCi uc001nog.3. human. [Q13277-1 ]
uc009ymt.1. human. [Q13277-2 ]
uc010rkx.2. human. [Q13277-3 ]

Organism-specific databases

CTDi 6809.
GeneCardsi GC11P059480.
HGNCi HGNC:11438. STX3.
HPAi HPA002191.
MIMi 600876. gene.
neXtProti NX_Q13277.
Orphaneti 2290. Microvillus inclusion disease.
PharmGKBi PA36235.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5074.
GeneTreei ENSGT00760000119200.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi Q13277.
KOi K08486.
OMAi TSGIMDS.
OrthoDBi EOG7X9G7R.
PhylomeDBi Q13277.
TreeFami TF313763.

Miscellaneous databases

ChiTaRSi STX3. human.
GeneWikii Syntaxin_3.
GenomeRNAii 6809.
NextBioi 26569.
PROi Q13277.
SOURCEi Search...

Gene expression databases

Bgeei Q13277.
CleanExi HS_STX3.
ExpressionAtlasi Q13277. baseline and differential.
Genevestigatori Q13277.

Family and domain databases

InterProi IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Syntaxin and n-Sec1 isoforms in colonic epithelial cells: association of syntaxins 1A and 3 with apical endocytic pathway."
    Naren A.P., Bradbury N.A., Bennett M.K., Kirk K.L.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Tissue: Colon.
  2. "Human syntaxin 3 is localized apically in human intestinal cells."
    Delgrossi M.H., Breuza L., Mirre C., Chavrier P., le Bivic A.
    J. Cell Sci. 110:2207-2214(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Tissue: Duodenum.
  3. "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1."
    Martin-Martin B., Nabokina S.M., Lazo P.A., Mollinedo F.
    J. Leukoc. Biol. 65:397-406(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Muscle.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTX3_HUMAN
AccessioniPrimary (citable) accession number: Q13277
Secondary accession number(s): B4DME0
, O43750, O43751, Q15360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3