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Q13277 (STX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-3
Gene names
Name:STX3
Synonyms:STX3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
   Biological processNeurotransmitter transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processexocytosis

Inferred from electronic annotation. Source: Ensembl

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

membrane fusion

Inferred from electronic annotation. Source: Ensembl

neuron projection development

Inferred from sequence or structural similarity. Source: HGNC

neurotransmitter transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentSNARE complex

Inferred from sequence or structural similarity. Source: HGNC

apical plasma membrane

Inferred from direct assay PubMed 16339081. Source: HGNC

azurophil granule

Inferred from direct assay PubMed 18588921. Source: UniProtKB

cell-cell junction

Inferred from direct assay PubMed 15576373. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 11487543PubMed 19056867PubMed 23376485. Source: UniProt

growth cone

Inferred from sequence or structural similarity. Source: HGNC

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection

Inferred from sequence or structural similarity. Source: HGNC

specific granule

Inferred from direct assay PubMed 18588921. Source: UniProtKB

vacuole

Traceable author statement PubMed 16339081. Source: HGNC

   Molecular_functionarachidonic acid binding

Inferred from sequence or structural similarity. Source: HGNC

protein binding

Inferred from physical interaction PubMed 18588921. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ZFYVE9O954053EBI-1394295,EBI-296817

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q13277-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q13277-2)

The sequence of this isoform differs from the canonical sequence as follows:
     226-262: Missing.
Isoform 3 (identifier: Q13277-3)

The sequence of this isoform differs from the canonical sequence as follows:
     266-289: IIIVLVVVLLGILALIIGLSVGLN → SLQTGVATLVFR
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Syntaxin-3
PRO_0000210199

Regions

Topological domain1 – 263263Cytoplasmic Potential
Transmembrane264 – 28421Helical; Anchor for type IV membrane protein; Potential
Topological domain285 – 2895Extracellular Potential
Domain191 – 25363t-SNARE coiled-coil homology
Coiled coil32 – 11180 Potential

Natural variations

Alternative sequence226 – 26237Missing in isoform B.
VSP_006340
Alternative sequence266 – 28924IIIVL…SVGLN → SLQTGVATLVFR in isoform 3.
VSP_043187
Natural variant831E → D.
Corresponds to variant rs12282741 [ dbSNP | Ensembl ].
VAR_028189
Natural variant2761G → S.
Corresponds to variant rs34563654 [ dbSNP | Ensembl ].
VAR_052246
Natural variant2851S → P.
Corresponds to variant rs34753750 [ dbSNP | Ensembl ].
VAR_052247

Experimental info

Sequence conflict2 – 1110Missing Ref.2
Sequence conflict811T → S in CAA62209. Ref.2
Sequence conflict152 – 1532QL → HV in AAA75303. Ref.1
Sequence conflict2501T → S Ref.1
Sequence conflict2501T → S Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 0E12EBC7CBEDB81E

FASTA28933,155
        10         20         30         40         50         60 
MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY 

        70         80         90        100        110        120 
SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH 

       130        140        150        160        170        180 
SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG 

       190        200        210        220        230        240 
IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV 

       250        260        270        280 
DHVEKARDET KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN 

« Hide

Isoform B [UniParc].

Checksum: 3851D8EB8A25D529
Show »

FASTA25228,860
Isoform 3 [UniParc].

Checksum: 1881B458BF96C46C
Show »

FASTA27732,018

References

« Hide 'large scale' references
[1]"Syntaxin and n-Sec1 isoforms in colonic epithelial cells: association of syntaxins 1A and 3 with apical endocytic pathway."
Naren A.P., Bradbury N.A., Bennett M.K., Kirk K.L.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
Tissue: Colon.
[2]"Human syntaxin 3 is localized apically in human intestinal cells."
Delgrossi M.H., Breuza L., Mirre C., Chavrier P., le Bivic A.
J. Cell Sci. 110:2207-2214(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
Tissue: Duodenum.
[3]"Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1."
Martin-Martin B., Nabokina S.M., Lazo P.A., Mollinedo F.
J. Leukoc. Biol. 65:397-406(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Muscle.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32315 mRNA. Translation: AAA75303.1.
X90581 mRNA. Translation: CAA62209.1.
AJ002076 mRNA. Translation: CAA05175.1.
AJ002077 mRNA. Translation: CAA05176.1.
AK297419 mRNA. Translation: BAG59852.1.
AP000640 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73854.1.
BC007405 mRNA. Translation: AAH07405.1.
BC007429 mRNA. Translation: AAH07429.1.
CCDSCCDS53637.1. [Q13277-3]
CCDS7975.1. [Q13277-1]
PIRG01969.
RefSeqNP_001171511.1. NM_001178040.1. [Q13277-3]
NP_004168.1. NM_004177.4. [Q13277-1]
XP_005274252.1. XM_005274195.1. [Q13277-1]
XP_005274253.1. XM_005274196.2. [Q13277-1]
XP_005274257.1. XM_005274200.1. [Q13277-2]
UniGeneHs.180711.

3D structure databases

ProteinModelPortalQ13277.
SMRQ13277. Positions 31-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112678. 13 interactions.
IntActQ13277. 3 interactions.
MINTMINT-3027462.
STRING9606.ENSP00000338562.

PTM databases

PhosphoSiteQ13277.

Polymorphism databases

DMDM116242806.

Proteomic databases

MaxQBQ13277.
PaxDbQ13277.
PRIDEQ13277.

Protocols and materials databases

DNASU6809.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000337979; ENSP00000338562; ENSG00000166900. [Q13277-1]
ENST00000528805; ENSP00000431386; ENSG00000166900.
ENST00000529177; ENSP00000433248; ENSG00000166900. [Q13277-3]
ENST00000535361; ENSP00000441649; ENSG00000166900. [Q13277-2]
GeneID6809.
KEGGhsa:6809.
UCSCuc001nog.3. human. [Q13277-1]
uc009ymt.1. human. [Q13277-2]
uc010rkx.2. human. [Q13277-3]

Organism-specific databases

CTD6809.
GeneCardsGC11P059480.
HGNCHGNC:11438. STX3.
HPAHPA002191.
MIM600876. gene.
neXtProtNX_Q13277.
PharmGKBPA36235.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5074.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidQ13277.
KOK08486.
OMATSGIMDS.
OrthoDBEOG7X9G7R.
PhylomeDBQ13277.
TreeFamTF313763.

Gene expression databases

ArrayExpressQ13277.
BgeeQ13277.
CleanExHS_STX3.
GenevestigatorQ13277.

Family and domain databases

InterProIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTX3. human.
GeneWikiSyntaxin_3.
GenomeRNAi6809.
NextBio26569.
PROQ13277.
SOURCESearch...

Entry information

Entry nameSTX3_HUMAN
AccessionPrimary (citable) accession number: Q13277
Secondary accession number(s): B4DME0 expand/collapse secondary AC list , O43750, O43751, Q15360
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM