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Protein

Semaphorin-3F

Gene

SEMA3F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cell motility and cell adhesion.

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • neuropilin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ13275.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3F
Alternative name(s):
Sema III/F
Semaphorin IV
Short name:
Sema IV
Gene namesi
Name:SEMA3F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000001617.11.
HGNCiHGNC:10728. SEMA3F.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6405.
OpenTargetsiENSG00000001617.
PharmGKBiPA35650.

Polymorphism and mutation databases

BioMutaiSEMA3F.
DMDMi8134696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003232019 – 785Semaphorin-3FAdd BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 115By similarity
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 142By similarity
Disulfide bondi300 ↔ 412By similarity
Disulfide bondi324 ↔ 372By similarity
Disulfide bondi548 ↔ 566By similarity
Disulfide bondi678 ↔ 746By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13275.
MaxQBiQ13275.
PaxDbiQ13275.
PeptideAtlasiQ13275.
PRIDEiQ13275.

PTM databases

iPTMnetiQ13275.
PhosphoSitePlusiQ13275.

Expressioni

Tissue specificityi

Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.

Developmental stagei

Detected as early as embryonic day 10.

Gene expression databases

BgeeiENSG00000001617.
CleanExiHS_SEMA3F.
ExpressionAtlasiQ13275. baseline and differential.
GenevisibleiQ13275. HS.

Organism-specific databases

HPAiHPA035008.

Interactioni

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • neuropilin binding Source: GO_Central

Protein-protein interaction databases

BioGridi112305. 6 interactors.
IntActiQ13275. 2 interactors.
MINTiMINT-1392156.
STRINGi9606.ENSP00000002829.

Structurei

3D structure databases

ProteinModelPortaliQ13275.
SMRiQ13275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 545SemaPROSITE-ProRule annotationAdd BLAST515
Domaini605 – 690Ig-like C2-typeAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi758 – 779Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ13275.
KOiK06840.
OMAiHGNPIRQ.
OrthoDBiEOG091G01W0.
PhylomeDBiQ13275.
TreeFamiTF352628.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR036352. Semap_dom_sf.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiView protein in Pfam
PF01403. Sema. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SUPFAMiSSF101912. SSF101912. 2 hits.
SSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13275-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVAGLLLWA SLLTGAWPSF PTQDHLPATP RVRLSFKELK ATGTAHFFNF
60 70 80 90 100
LLNTTDYRIL LKDEDHDRMY VGSKDYVLSL DLHDINREPL IIHWAASPQR
110 120 130 140 150
IEECVLSGKD VNGECGNFVR LIQPWNRTHL YVCGTGAYNP MCTYVNRGRR
160 170 180 190 200
AQATPWTQTQ AVRGRGSRAT DGALRPMPTA PRQDYIFYLE PERLESGKGK
210 220 230 240 250
CPYDPKLDTA SALINEELYA GVYIDFMGTD AAIFRTLGKQ TAMRTDQYNS
260 270 280 290 300
RWLNDPSFIH AELIPDSAER NDDKLYFFFR ERSAEAPQSP AVYARIGRIC
310 320 330 340 350
LNDDGGHCCL VNKWSTFLKA RLVCSVPGED GIETHFDELQ DVFVQQTQDV
360 370 380 390 400
RNPVIYAVFT SSGSVFRGSA VCVYSMADIR MVFNGPFAHK EGPNYQWMPF
410 420 430 440 450
SGKMPYPRPG TCPGGTFTPS MKSTKDYPDE VINFMRSHPL MYQAVYPLQR
460 470 480 490 500
RPLVVRTGAP YRLTTIAVDQ VDAADGRYEV LFLGTDRGTV QKVIVLPKDD
510 520 530 540 550
QELEELMLEE VEVFKDPAPV KTMTISSKRQ QLYVASAVGV THLSLHRCQA
560 570 580 590 600
YGAACADCCL ARDPYCAWDG QACSRYTASS KRRSRRQDVR HGNPIRQCRG
610 620 630 640 650
FNSNANKNAV ESVQYGVAGS AAFLECQPRS PQATVKWLFQ RDPGDRRREI
660 670 680 690 700
RAEDRFLRTE QGLLLRALQL SDRGLYSCTA TENNFKHVVT RVQLHVLGRD
710 720 730 740 750
AVHAALFPPL SMSAPPPPGA GPPTPPYQEL AQLLAQPEVG LIHQYCQGYW
760 770 780
RHVPPSPREA PGAPRSPEPQ DQKKPRNRRH HPPDT
Length:785
Mass (Da):88,381
Last modified:January 1, 1998 - v2
Checksum:iFE3FC796EEC1608E
GO
Isoform 2 (identifier: Q13275-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-183: Missing.

Show »
Length:754
Mass (Da):85,064
Checksum:iAF4203BD1D2F2665
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270Missing in AAB18276 (PubMed:8786119).Curated1
Sequence conflicti473A → S in AAB18276 (PubMed:8786119).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011820474A → G. Corresponds to variant dbSNP:rs1046955Ensembl.1
Natural variantiVAR_008855503L → M2 PublicationsCorresponds to variant dbSNP:rs1046956Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053417153 – 183Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33920 mRNA. Translation: AAC50568.1.
U38276 mRNA. Translation: AAB18276.1.
AC000063 Genomic DNA. Translation: AAB46344.1.
AC104450 Genomic DNA. No translation available.
BC042914 mRNA. Translation: AAH42914.1.
U32171 mRNA. Translation: AAB06011.1.
U32172 mRNA. Translation: AAB06012.1.
CCDSiCCDS2811.1. [Q13275-1]
CCDS82779.1. [Q13275-2]
PIRiG02173.
RefSeqiNP_001305729.1. NM_001318800.1. [Q13275-2]
NP_004177.3. NM_004186.4. [Q13275-1]
XP_005265438.1. XM_005265381.4. [Q13275-1]
XP_005265439.1. XM_005265382.4. [Q13275-2]
XP_011532300.1. XM_011533998.2. [Q13275-1]
UniGeneiHs.32981.

Genome annotation databases

EnsembliENST00000002829; ENSP00000002829; ENSG00000001617. [Q13275-1]
ENST00000434342; ENSP00000409859; ENSG00000001617. [Q13275-2]
GeneIDi6405.
KEGGihsa:6405.
UCSCiuc003cyj.4. human. [Q13275-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSEM3F_HUMAN
AccessioniPrimary (citable) accession number: Q13275
Secondary accession number(s): C9JQ85
, Q13274, Q13372, Q15704, Q6GTR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families