Reviewed, UniProtKB/Swiss-Prot Q13275 (SEM3F_HUMAN)

Names and origin

Protein names

Recommended name:
    Semaphorin-3F
Alternative name(s):
    Semaphorin IV
      Short name=Sema IV
    Sema III/F

Gene names

Name:

SEMA3F

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in cell motility and cell adhesion.
Subcellular location	SecretedBy similarity.
Tissue specificity	Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.
Developmental stage	Detected as early as embryonic day 10.
Sequence similarities	Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Sema domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Ref.2 Traceable author statement. Source: ProtInc membrane Inferred from electronic annotation. Source: InterPro
Molecular function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 785	767	Semaphorin-3F		PRO_0000032320
Regions
	Domain	31 – 545	515	Sema
	Domain	605 – 690	86	Ig-like C2-type
	Compositional bias	758 – 779	22	Arg/Lys-rich (basic)
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	126	1	N-linked (GlcNAc...) Potential
	Disulfide bond	104 ↔ 115		By similarity
	Disulfide bond	133 ↔ 142		By similarity
	Disulfide bond	300 ↔ 412		By similarity
	Disulfide bond	324 ↔ 372		By similarity
	Disulfide bond	678 ↔ 746		By similarity
Natural variations
	Natural variant	474	1	A → G: dbSNP rs1046955.		VAR_011820
	Natural variant	503	1	L → M		VAR_008855
Experimental info
	Sequence conflict	153 – 183	31	Missing Ref.2
	Sequence conflict	270	1	Missing in AAB18276. Ref.2
	Sequence conflict	473	1	A → S in AAB18276. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q13275-1 [UniParc]. Last modified January 1, 1998. Version 2. Checksum: FE3FC796EEC1608E	FASTA	785	88,381
	10 20 30 40 50 60 MLVAGLLLWA SLLTGAWPSF PTQDHLPATP RVRLSFKELK ATGTAHFFNF LLNTTDYRIL 70 80 90 100 110 120 LKDEDHDRMY VGSKDYVLSL DLHDINREPL IIHWAASPQR IEECVLSGKD VNGECGNFVR 130 140 150 160 170 180 LIQPWNRTHL YVCGTGAYNP MCTYVNRGRR AQATPWTQTQ AVRGRGSRAT DGALRPMPTA 190 200 210 220 230 240 PRQDYIFYLE PERLESGKGK CPYDPKLDTA SALINEELYA GVYIDFMGTD AAIFRTLGKQ 250 260 270 280 290 300 TAMRTDQYNS RWLNDPSFIH AELIPDSAER NDDKLYFFFR ERSAEAPQSP AVYARIGRIC 310 320 330 340 350 360 LNDDGGHCCL VNKWSTFLKA RLVCSVPGED GIETHFDELQ DVFVQQTQDV RNPVIYAVFT 370 380 390 400 410 420 SSGSVFRGSA VCVYSMADIR MVFNGPFAHK EGPNYQWMPF SGKMPYPRPG TCPGGTFTPS 430 440 450 460 470 480 MKSTKDYPDE VINFMRSHPL MYQAVYPLQR RPLVVRTGAP YRLTTIAVDQ VDAADGRYEV 490 500 510 520 530 540 LFLGTDRGTV QKVIVLPKDD QELEELMLEE VEVFKDPAPV KTMTISSKRQ QLYVASAVGV 550 560 570 580 590 600 THLSLHRCQA YGAACADCCL ARDPYCAWDG QACSRYTASS KRRSRRQDVR HGNPIRQCRG 610 620 630 640 650 660 FNSNANKNAV ESVQYGVAGS AAFLECQPRS PQATVKWLFQ RDPGDRRREI RAEDRFLRTE 670 680 690 700 710 720 QGLLLRALQL SDRGLYSCTA TENNFKHVVT RVQLHVLGRD AVHAALFPPL SMSAPPPPGA 730 740 750 760 770 780 GPPTPPYQEL AQLLAQPEVG LIHQYCQGYW RHVPPSPREA PGAPRSPEPQ DQKKPRNRRH HPPDT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin." Roche J., Boldog F., Robinson M., Robinson L., Varella-Garcia M., Swanton M., Waggoner B., Fishel R., Franklin W., Gemmill R., Drabkin H. Oncogene 12:1289-1297(1996) [PubMed: 8649831] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer." Xiang R.-H., Hensel C.H., Garcia D.K., Carlson H.C., Kok K., Daly M.C., Kerbacher K., van den Berg A., Veldhuis P., Buys C.H.C.M., Naylor S.L. Genomics 32:39-48(1996) [PubMed: 8786119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-503. Tissue: Fetal brain.
[3]	"The sequence of H. sapiens cosmid clone LUCA19." Nelson J., Biewald T. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-503. Tissue: Brain.
[5]	"Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns." Sekido Y., Bader S., Latif F., Chen J.-Y., Duh F.-M., Wei M.-H., Albanesi J.P., Lee C.-C., Lerman M.I., Minna J.D. Proc. Natl. Acad. Sci. U.S.A. 93:4120-4125(1996) [PubMed: 8633026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 394-436. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U33920 mRNA. Translation: AAC50568.1. U38276 mRNA. Translation: AAB18276.1. AC000063 Genomic DNA. Translation: AAB46344.1. BC042914 mRNA. Translation: AAH42914.1. U32171 mRNA. Translation: AAB06011.1. U32172 mRNA. Translation: AAB06012.1.
PIR	G02173.
RefSeq	NP_004177.3.
UniGene	Hs.32981
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13275.
Genome annotation databases
Ensembl	ENSG00000001617. Homo sapiens. [Contig view]
GeneID	6405.
KEGG	hsa:6405.
Organism-specific databases
HGNC	HGNC:10728. SEMA3F.
MIM	601124. gene.
PharmGKB	PA35650.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q13275.
HOVERGEN	Q13275.
Gene expression databases
ArrayExpress	Q13275.
CleanEx	HS_SEMA3F.
GermOnline	ENSG00000001617. Homo sapiens.
Family and domain databases
InterPro	IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003659. Plexin-like. IPR001627. Sema. IPR015943. WD40/YVTN_repeat-like. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00047. ig. 1 hit. PF01403. Sema. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	24886.
SOURCE	Search...

Entry information

Entry name

SEM3F_HUMAN

Accession

Primary (citable) accession number: Q13275
Secondary accession number(s): Q13274 , Q13372, Q15704, Q6GTR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 25, 2008
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)