Q13275 (SEM3F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Semaphorin-3F

Alternative name(s):
Sema III/F
Semaphorin IV
Short name=Sema IV

Gene names

Name:

SEMA3F

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in cell motility and cell adhesion.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.
Developmental stage	Detected as early as embryonic day 10.
Sequence similarities	Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Sema domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from direct assay PubMed 15814794. Source: MGI negative regulation of axon extension involved in axon guidance Inferred from electronic annotation. Source: Compara neural crest cell migration Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Traceable author statement Ref.2. Source: ProtInc membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	chemorepellent activity Inferred from direct assay PubMed 15814794. Source: MGI receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 785	767	Semaphorin-3F		PRO_0000032320
Regions
	Domain	31 – 545	515	Sema
	Domain	605 – 690	86	Ig-like C2-type
	Compositional bias	758 – 779	22	Arg/Lys-rich (basic)
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	126	1	N-linked (GlcNAc...) Potential
	Disulfide bond	104 ↔ 115		By similarity
	Disulfide bond	133 ↔ 142		By similarity
	Disulfide bond	300 ↔ 412		By similarity
	Disulfide bond	324 ↔ 372		By similarity
	Disulfide bond	548 ↔ 566		By similarity
	Disulfide bond	678 ↔ 746		By similarity
Natural variations
	Natural variant	474	1	A → G. Corresponds to variant rs1046955 [ dbSNP | Ensembl ].		VAR_011820
	Natural variant	503	1	L → M. Ref.2 Ref.4 Corresponds to variant rs1046956 [ dbSNP | Ensembl ].		VAR_008855
Experimental info
	Sequence conflict	153 – 183	31	Missing Ref.2
	Sequence conflict	270	1	Missing in AAB18276. Ref.2
	Sequence conflict	473	1	A → S in AAB18276. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q13275 [UniParc]. Last modified January 1, 1998. Version 2. Checksum: FE3FC796EEC1608E	FASTA	785	88,381
	10 20 30 40 50 60 MLVAGLLLWA SLLTGAWPSF PTQDHLPATP RVRLSFKELK ATGTAHFFNF LLNTTDYRIL 70 80 90 100 110 120 LKDEDHDRMY VGSKDYVLSL DLHDINREPL IIHWAASPQR IEECVLSGKD VNGECGNFVR 130 140 150 160 170 180 LIQPWNRTHL YVCGTGAYNP MCTYVNRGRR AQATPWTQTQ AVRGRGSRAT DGALRPMPTA 190 200 210 220 230 240 PRQDYIFYLE PERLESGKGK CPYDPKLDTA SALINEELYA GVYIDFMGTD AAIFRTLGKQ 250 260 270 280 290 300 TAMRTDQYNS RWLNDPSFIH AELIPDSAER NDDKLYFFFR ERSAEAPQSP AVYARIGRIC 310 320 330 340 350 360 LNDDGGHCCL VNKWSTFLKA RLVCSVPGED GIETHFDELQ DVFVQQTQDV RNPVIYAVFT 370 380 390 400 410 420 SSGSVFRGSA VCVYSMADIR MVFNGPFAHK EGPNYQWMPF SGKMPYPRPG TCPGGTFTPS 430 440 450 460 470 480 MKSTKDYPDE VINFMRSHPL MYQAVYPLQR RPLVVRTGAP YRLTTIAVDQ VDAADGRYEV 490 500 510 520 530 540 LFLGTDRGTV QKVIVLPKDD QELEELMLEE VEVFKDPAPV KTMTISSKRQ QLYVASAVGV 550 560 570 580 590 600 THLSLHRCQA YGAACADCCL ARDPYCAWDG QACSRYTASS KRRSRRQDVR HGNPIRQCRG 610 620 630 640 650 660 FNSNANKNAV ESVQYGVAGS AAFLECQPRS PQATVKWLFQ RDPGDRRREI RAEDRFLRTE 670 680 690 700 710 720 QGLLLRALQL SDRGLYSCTA TENNFKHVVT RVQLHVLGRD AVHAALFPPL SMSAPPPPGA 730 740 750 760 770 780 GPPTPPYQEL AQLLAQPEVG LIHQYCQGYW RHVPPSPREA PGAPRSPEPQ DQKKPRNRRH HPPDT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin." Roche J., Boldog F., Robinson M., Robinson L., Varella-Garcia M., Swanton M., Waggoner B., Fishel R., Franklin W., Gemmill R., Drabkin H. Oncogene 12:1289-1297(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer." Xiang R.-H., Hensel C.H., Garcia D.K., Carlson H.C., Kok K., Daly M.C., Kerbacher K., van den Berg A., Veldhuis P., Buys C.H.C.M., Naylor S.L. Genomics 32:39-48(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-503. Tissue: Fetal brain.
[3]	"The sequence of H. sapiens cosmid clone LUCA19." Nelson J., Biewald T. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-503. Tissue: Brain.
[5]	"Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns." Sekido Y., Bader S., Latif F., Chen J.-Y., Duh F.-M., Wei M.-H., Albanesi J.P., Lee C.-C., Lerman M.I., Minna J.D. Proc. Natl. Acad. Sci. U.S.A. 93:4120-4125(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 394-436. Tissue: Placenta.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33920 mRNA. Translation: AAC50568.1. U38276 mRNA. Translation: AAB18276.1. AC000063 Genomic DNA. Translation: AAB46344.1. BC042914 mRNA. Translation: AAH42914.1. U32171 mRNA. Translation: AAB06011.1. U32172 mRNA. Translation: AAB06012.1.
IPI	IPI00298003.
PIR	G02173.
RefSeq	NP_004177.3. NM_004186.3.
UniGene	Hs.32981.
3D structure databases
ProteinModelPortal	Q13275.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13275. 2 interactions.
MINT	MINT-1392156.
STRING	9606.ENSP00000002829.
PTM databases
PhosphoSite	Q13275.
Polymorphism databases
DMDM	8134696.
Proteomic databases
PaxDb	Q13275.
PRIDE	Q13275.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000002829; ENSP00000002829; ENSG00000001617.
GeneID	6405.
KEGG	hsa:6405.
UCSC	uc003cyj.3. human.
Organism-specific databases
CTD	6405.
GeneCards	GC03P050167.
H-InvDB	HIX0204323.
HGNC	HGNC:10728. SEMA3F.
HPA	HPA035008.
MIM	601124. gene.
neXtProt	NX_Q13275.
PharmGKB	PA35650.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320723.
HOGENOM	HOG000039964.
HOVERGEN	HBG055071.
InParanoid	Q13275.
KO	K06840.
OMA	AYNPMCT.
PhylomeDB	Q13275.
Gene expression databases
ArrayExpress	Q13275.
Bgee	Q13275.
CleanEx	HS_SEMA3F.
Genevestigator	Q13275.
GermOnline	ENSG00000001617. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits. 2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR027231. Semaphorin. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
PANTHER	PTHR11036. PTHR11036. 1 hit.
Pfam	PF01403. Sema. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit. SSF101912. Sema. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6405.
NextBio	24886.
SOURCE	Search...

Entry information

Entry name

SEM3F_HUMAN

Accession

Primary (citable) accession number: Q13275
Secondary accession number(s): Q13274 , Q13372, Q15704, Q6GTR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.