Reviewed,
UniProtKB/Swiss-Prot Q13275 (SEM3F_HUMAN)
Last modified
November 25, 2008.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Semaphorin-3F Alternative name(s): Semaphorin IV Short name=Sema IV Sema III/F | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 785 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May play a role in cell motility and cell adhesion. |
| Subcellular location | SecretedBy similarity. |
| Tissue specificity | Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver. |
| Developmental stage | Detected as early as embryonic day 10. |
| Sequence similarities | Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Sema domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Immunoglobulin domain Signal |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | multicellular organismal development Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular space Ref.2 Traceable author statement. Source: ProtInc membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | receptor activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Potential | ||||||||
| Chain | 19 – 785 | 767 | Semaphorin-3F | PRO_0000032320 | |||||||
Regions | |||||||||||
| Domain | 31 – 545 | 515 | Sema | ||||||||
| Domain | 605 – 690 | 86 | Ig-like C2-type | ||||||||
| Compositional bias | 758 – 779 | 22 | Arg/Lys-rich (basic) | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 53 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 126 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 104 ↔ 115 | By similarity | |||||||||
| Disulfide bond | 133 ↔ 142 | By similarity | |||||||||
| Disulfide bond | 300 ↔ 412 | By similarity | |||||||||
| Disulfide bond | 324 ↔ 372 | By similarity | |||||||||
| Disulfide bond | 678 ↔ 746 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 474 | 1 | A → G: dbSNP rs1046955. | VAR_011820 | |||||||
| Natural variant | 503 | 1 | L → M | VAR_008855 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 153 – 183 | 31 | Missing Ref.2 | ||||||||
| Sequence conflict | 270 | 1 | Missing in AAB18276. Ref.2 | ||||||||
| Sequence conflict | 473 | 1 | A → S in AAB18276. Ref.2 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin." Roche J., Boldog F., Robinson M., Robinson L., Varella-Garcia M., Swanton M., Waggoner B., Fishel R., Franklin W., Gemmill R., Drabkin H. Oncogene 12:1289-1297(1996) [PubMed: 8649831] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain. |
| [2] | "Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer." Xiang R.-H., Hensel C.H., Garcia D.K., Carlson H.C., Kok K., Daly M.C., Kerbacher K., van den Berg A., Veldhuis P., Buys C.H.C.M., Naylor S.L. Genomics 32:39-48(1996) [PubMed: 8786119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-503. Tissue: Fetal brain. |
| [3] | "The sequence of H. sapiens cosmid clone LUCA19." Nelson J., Biewald T. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-503. Tissue: Brain. |
| [5] | "Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns." Sekido Y., Bader S., Latif F., Chen J.-Y., Duh F.-M., Wei M.-H., Albanesi J.P., Lee C.-C., Lerman M.I., Minna J.D. Proc. Natl. Acad. Sci. U.S.A. 93:4120-4125(1996) [PubMed: 8633026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 394-436. Tissue: Placenta. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U33920 mRNA. Translation: AAC50568.1. U38276 mRNA. Translation: AAB18276.1. AC000063 Genomic DNA. Translation: AAB46344.1. BC042914 mRNA. Translation: AAH42914.1. U32171 mRNA. Translation: AAB06011.1. U32172 mRNA. Translation: AAB06012.1. | |
| PIR | G02173. |
| RefSeq | NP_004177.3. |
| UniGene | Hs.32981 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q13275. |
Genome annotation databases | |
| Ensembl | ENSG00000001617. Homo sapiens. [Contig view] |
| GeneID | 6405. |
| KEGG | hsa:6405. |
Organism-specific databases | |
| HGNC | HGNC:10728. SEMA3F. |
| MIM | 601124. gene. |
| PharmGKB | PA35650. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q13275. |
| HOVERGEN | Q13275. |
Gene expression databases | |
| ArrayExpress | Q13275. |
| CleanEx | HS_SEMA3F. |
| GermOnline | ENSG00000001617. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003659. Plexin-like. IPR001627. Sema. IPR015943. WD40/YVTN_repeat-like. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit. |
| Pfam | PF00047. ig. 1 hit. PF01403. Sema. 1 hit. [Graphical view] |
| SMART | SM00409. IG. 1 hit. SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view] |
| PROSITE | PS50835. IG_LIKE. 1 hit. PS51004. SEMA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 24886. |
| SOURCE | Search... |
Entry information
| Entry name | SEM3F_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13275 Secondary accession number(s): Q13274 Q6GTR4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


