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Q13258

- PD2R_HUMAN

UniProt

Q13258 - PD2R_HUMAN

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Protein
Prostaglandin D2 receptor
Gene
PTGDR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.

GO - Molecular functioni

  1. prostaglandin D receptor activity Source: InterPro
  2. prostaglandin J receptor activity Source: Ensembl
  3. protein binding Source: BHF-UCL

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. adenosine metabolic process Source: Ensembl
  3. cellular response to prostaglandin D stimulus Source: Ensembl
  4. inflammatory response Source: Ensembl
  5. male sex determination Source: Ensembl
  6. sleep Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:PTGDR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:9591. PTGDR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Extracellular Reviewed prediction
Add
BLAST
Transmembranei22 – 4221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini43 – 5917Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini81 – 10727Extracellular Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini129 – 15022Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei151 – 17121Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini172 – 19524Extracellular Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini217 – 26246Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei263 – 28321Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini284 – 31027Extracellular Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini332 – 35928Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi607277. phenotype.
PharmGKBiPA285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Prostaglandin D2 receptor
PRO_0000070047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi105 ↔ 183 By similarity
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13258.
PRIDEiQ13258.

Expressioni

Tissue specificityi

Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.2 Publications

Gene expression databases

ArrayExpressiQ13258.
BgeeiQ13258.
CleanExiHS_PTGDR.
GenevestigatoriQ13258.

Interactioni

Protein-protein interaction databases

BioGridi111701. 2 interactions.
STRINGi9606.ENSP00000303424.

Structurei

3D structure databases

ProteinModelPortaliQ13258.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248831.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ13258.
KOiK04332.
OMAiAYYGAFK.
OrthoDBiEOG72VH6G.
PhylomeDBiQ13258.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13258-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS    50
RRPLRPLPSV FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL 100
DNSLCQAFAF FMSFFGLSST LQLLAMALEC WLSLGHPFFY RRHITLRLGA 150
LVAPVVSAFS LAFCALPFMG FGKFVQYCPG TWCFIQMVHE EGSLSVLGYS 200
VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT RDCAEPRADG 250
REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS 300
EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS 350
NSTNMESSL 359
Length:359
Mass (Da):40,271
Last modified:November 1, 1997 - v2
Checksum:i098F89F08D0BE12A
GO
Isoform 2 (identifier: Q13258-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-296: YRAYYGAFKDVKEK → AFVPGVPAKTPGSR
     297-359: Missing.

Note: No experimental confirmation available. Derived from EST data.

Show »
Length:296
Mass (Da):32,354
Checksum:i08BEEFB74CD0FBF0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → C.1 Publication
Corresponds to variant rs41311442 [ dbSNP | Ensembl ].
VAR_033482
Natural varianti198 – 1981G → E.1 Publication
Corresponds to variant rs41312444 [ dbSNP | Ensembl ].
VAR_054975
Natural varianti301 – 3011E → A.1 Publication
Corresponds to variant rs41312504 [ dbSNP | Ensembl ].
VAR_033483
Natural varianti332 – 3321R → Q.1 Publication
Corresponds to variant rs41312506 [ dbSNP | Ensembl ].
VAR_054976

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei283 – 29614YRAYY…DVKEK → AFVPGVPAKTPGSR in isoform 2.
VSP_055141Add
BLAST
Alternative sequencei297 – 35963Missing in isoform 2.
VSP_055142Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31098 Genomic DNA. Translation: AAC50176.1.
U31099 mRNA. Translation: AAC50177.1.
U31332 Genomic DNA. Translation: AAC50178.1.
EF577397 mRNA. Translation: ABQ52417.1.
DQ418808 Genomic DNA. Translation: ABD72608.1.
AL365475 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65657.1.
BC040968 mRNA. Translation: AAH40968.1.
CCDSiCCDS9707.1. [Q13258-1]
PIRiI39153.
RefSeqiNP_000944.1. NM_000953.2.
NP_001268398.1. NM_001281469.1.
XP_005267948.1. XM_005267891.1.
UniGeneiHs.306831.

Genome annotation databases

EnsembliENST00000306051; ENSP00000303424; ENSG00000168229.
ENST00000553372; ENSP00000452408; ENSG00000168229.
GeneIDi5729.
KEGGihsa:5729.
UCSCiuc001wzq.3. human. [Q13258-1]

Polymorphism databases

DMDMi2495009.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31098 Genomic DNA. Translation: AAC50176.1 .
U31099 mRNA. Translation: AAC50177.1 .
U31332 Genomic DNA. Translation: AAC50178.1 .
EF577397 mRNA. Translation: ABQ52417.1 .
DQ418808 Genomic DNA. Translation: ABD72608.1 .
AL365475 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65657.1 .
BC040968 mRNA. Translation: AAH40968.1 .
CCDSi CCDS9707.1. [Q13258-1 ]
PIRi I39153.
RefSeqi NP_000944.1. NM_000953.2.
NP_001268398.1. NM_001281469.1.
XP_005267948.1. XM_005267891.1.
UniGenei Hs.306831.

3D structure databases

ProteinModelPortali Q13258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111701. 2 interactions.
STRINGi 9606.ENSP00000303424.

Chemistry

BindingDBi Q13258.
ChEMBLi CHEMBL4427.
DrugBanki DB00716. Nedocromil.
GuidetoPHARMACOLOGYi 338.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 2495009.

Proteomic databases

PaxDbi Q13258.
PRIDEi Q13258.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306051 ; ENSP00000303424 ; ENSG00000168229 .
ENST00000553372 ; ENSP00000452408 ; ENSG00000168229 .
GeneIDi 5729.
KEGGi hsa:5729.
UCSCi uc001wzq.3. human. [Q13258-1 ]

Organism-specific databases

CTDi 5729.
GeneCardsi GC14P052734.
HGNCi HGNC:9591. PTGDR.
MIMi 604687. gene.
607277. phenotype.
neXtProti NX_Q13258.
PharmGKBi PA285.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248831.
HOGENOMi HOG000115475.
HOVERGENi HBG003074.
InParanoidi Q13258.
KOi K04332.
OMAi AYYGAFK.
OrthoDBi EOG72VH6G.
PhylomeDBi Q13258.
TreeFami TF324982.

Enzyme and pathway databases

Reactomei REACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Prostaglandin_D2_receptor.
GenomeRNAii 5729.
NextBioi 22286.
PROi Q13258.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13258.
Bgeei Q13258.
CleanExi HS_PTGDR.
Genevestigatori Q13258.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human prostanoid DP receptor."
    Boie Y., Sawyer N., Slipetz D.M., Metters K.M., Abramovitz M.
    J. Biol. Chem. 270:18910-18916(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. Martin A.L., Kaighin V.A., Aronstam R.S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  3. SeattleSNPs variation discovery resource
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-7; GLU-198; ALA-301 AND GLN-332.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
    Town M.H., Casals-Stenzel J., Schillinger E.
    Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand."
    Sharif N.A., Williams G.W., Davis T.L.
    Br. J. Pharmacol. 131:1025-1038(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Role of prostanoid DP receptor variants in susceptibility to asthma."
    Oguma T., Palmer L.J., Birben E., Sonna L.A., Asano K., Lilly C.M.
    N. Engl. J. Med. 351:1752-1763(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASRT1.

Entry informationi

Entry nameiPD2R_HUMAN
AccessioniPrimary (citable) accession number: Q13258
Secondary accession number(s): G3V5L3
, Q13250, Q13251, Q1ZZ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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