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Q13258 (PD2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin D2 receptor

Short name=PGD receptor
Short name=PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene names
Name:PTGDR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. Ref.7 Ref.8

Involvement in disease

Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.9

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Prostaglandin D2 receptor
PRO_0000070047

Regions

Topological domain1 – 2121Extracellular Potential
Transmembrane22 – 4221Helical; Name=1; Potential
Topological domain43 – 5917Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 10727Extracellular Potential
Transmembrane108 – 12821Helical; Name=3; Potential
Topological domain129 – 15022Cytoplasmic Potential
Transmembrane151 – 17121Helical; Name=4; Potential
Topological domain172 – 19524Extracellular Potential
Transmembrane196 – 21621Helical; Name=5; Potential
Topological domain217 – 26246Cytoplasmic Potential
Transmembrane263 – 28321Helical; Name=6; Potential
Topological domain284 – 31027Extracellular Potential
Transmembrane311 – 33121Helical; Name=7; Potential
Topological domain332 – 35928Cytoplasmic Potential

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential
Disulfide bond105 ↔ 183 By similarity

Natural variations

Natural variant71R → C. Ref.3
Corresponds to variant rs41311442 [ dbSNP | Ensembl ].
VAR_033482
Natural variant1981G → E. Ref.3
Corresponds to variant rs41312444 [ dbSNP | Ensembl ].
VAR_054975
Natural variant3011E → A. Ref.3
Corresponds to variant rs41312504 [ dbSNP | Ensembl ].
VAR_033483
Natural variant3321R → Q. Ref.3
Corresponds to variant rs41312506 [ dbSNP | Ensembl ].
VAR_054976

Sequences

Sequence LengthMass (Da)Tools
Q13258 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 098F89F08D0BE12A

FASTA35940,271
        10         20         30         40         50         60 
MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS RRPLRPLPSV 

        70         80         90        100        110        120 
FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL DNSLCQAFAF FMSFFGLSST 

       130        140        150        160        170        180 
LQLLAMALEC WLSLGHPFFY RRHITLRLGA LVAPVVSAFS LAFCALPFMG FGKFVQYCPG 

       190        200        210        220        230        240 
TWCFIQMVHE EGSLSVLGYS VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT 

       250        260        270        280        290        300 
RDCAEPRADG REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS 

       310        320        330        340        350 
EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS NSTNMESSL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the human prostanoid DP receptor."
Boie Y., Sawyer N., Slipetz D.M., Metters K.M., Abramovitz M.
J. Biol. Chem. 270:18910-18916(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]Martin A.L., Kaighin V.A., Aronstam R.S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Small intestine.
[3]SeattleSNPs variation discovery resource
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-7; GLU-198; ALA-301 AND GLN-332.
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
Town M.H., Casals-Stenzel J., Schillinger E.
Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand."
Sharif N.A., Williams G.W., Davis T.L.
Br. J. Pharmacol. 131:1025-1038(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Role of prostanoid DP receptor variants in susceptibility to asthma."
Oguma T., Palmer L.J., Birben E., Sonna L.A., Asano K., Lilly C.M.
N. Engl. J. Med. 351:1752-1763(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASRT1.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31098 Genomic DNA. Translation: AAC50176.1.
U31099 mRNA. Translation: AAC50177.1.
U31332 Genomic DNA. Translation: AAC50178.1.
EF577397 mRNA. Translation: ABQ52417.1.
DQ418808 Genomic DNA. Translation: ABD72608.1.
AL365475 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65657.1.
BC040968 mRNA. Translation: AAH40968.1.
PIRI39153.
RefSeqNP_000944.1. NM_000953.2.
XP_005267948.1. XM_005267891.1.
UniGeneHs.306831.

3D structure databases

ProteinModelPortalQ13258.
SMRQ13258. Positions 117-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111701. 2 interactions.
STRING9606.ENSP00000303424.

Chemistry

BindingDBQ13258.
ChEMBLCHEMBL4427.
DrugBankDB00716. Nedocromil.
GuidetoPHARMACOLOGY338.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM2495009.

Proteomic databases

PaxDbQ13258.
PRIDEQ13258.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306051; ENSP00000303424; ENSG00000168229.
GeneID5729.
KEGGhsa:5729.
UCSCuc001wzq.3. human.

Organism-specific databases

CTD5729.
GeneCardsGC14P052734.
HGNCHGNC:9591. PTGDR.
MIM604687. gene.
607277. phenotype.
neXtProtNX_Q13258.
PharmGKBPA285.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG248831.
HOGENOMHOG000115475.
HOVERGENHBG003074.
InParanoidQ13258.
KOK04332.
OMAAYYGAFK.
OrthoDBEOG72VH6G.
PhylomeDBQ13258.
TreeFamTF324982.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ13258.
BgeeQ13258.
CleanExHS_PTGDR.
GenevestigatorQ13258.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF9. PTHR11866:SF9. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiProstaglandin_D2_receptor.
GenomeRNAi5729.
NextBio22286.
PROQ13258.
SOURCESearch...

Entry information

Entry namePD2R_HUMAN
AccessionPrimary (citable) accession number: Q13258
Secondary accession number(s): Q13250, Q13251, Q1ZZ52
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries