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Protein

Prostaglandin D2 receptor

Gene

PTGDR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

  • prostaglandin D receptor activity Source: UniProtKB
  • prostaglandin J receptor activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:PTGDR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9591. PTGDR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini43 – 5917CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 15022CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 19524ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 26246CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini284 – 31027ExtracellularSequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 35928CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma-related traits 1 (ASRT1)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionAsthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

See also OMIM:607277

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi607277. phenotype.
PharmGKBiPA285.

Chemistry

DrugBankiDB00716. Nedocromil.

Polymorphism and mutation databases

BioMutaiPTGDR.
DMDMi2495009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Prostaglandin D2 receptorPRO_0000070047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 183PROSITE-ProRule annotation
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13258.
PRIDEiQ13258.

Expressioni

Tissue specificityi

Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.2 Publications

Gene expression databases

BgeeiQ13258.
CleanExiHS_PTGDR.
GenevestigatoriQ13258.

Interactioni

Protein-protein interaction databases

BioGridi111701. 6 interactions.
STRINGi9606.ENSP00000303424.

Structurei

3D structure databases

ProteinModelPortaliQ13258.
SMRiQ13258. Positions 117-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248831.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ13258.
KOiK04332.
OMAiAYYGAFK.
OrthoDBiEOG72VH6G.
PhylomeDBiQ13258.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS
60 70 80 90 100
RRPLRPLPSV FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL
110 120 130 140 150
DNSLCQAFAF FMSFFGLSST LQLLAMALEC WLSLGHPFFY RRHITLRLGA
160 170 180 190 200
LVAPVVSAFS LAFCALPFMG FGKFVQYCPG TWCFIQMVHE EGSLSVLGYS
210 220 230 240 250
VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT RDCAEPRADG
260 270 280 290 300
REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS
310 320 330 340 350
EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS

NSTNMESSL
Length:359
Mass (Da):40,271
Last modified:November 1, 1997 - v2
Checksum:i098F89F08D0BE12A
GO
Isoform 2 (identifier: Q13258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-296: YRAYYGAFKDVKEK → AFVPGVPAKTPGSR
     297-359: Missing.

Note: No experimental confirmation available. Derived from EST data.

Show »
Length:296
Mass (Da):32,354
Checksum:i08BEEFB74CD0FBF0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → C.1 Publication
Corresponds to variant rs41311442 [ dbSNP | Ensembl ].
VAR_033482
Natural varianti198 – 1981G → E.1 Publication
Corresponds to variant rs41312444 [ dbSNP | Ensembl ].
VAR_054975
Natural varianti301 – 3011E → A.1 Publication
Corresponds to variant rs41312504 [ dbSNP | Ensembl ].
VAR_033483
Natural varianti332 – 3321R → Q.1 Publication
Corresponds to variant rs41312506 [ dbSNP | Ensembl ].
VAR_054976

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei283 – 29614YRAYY…DVKEK → AFVPGVPAKTPGSR in isoform 2. CuratedVSP_055141Add
BLAST
Alternative sequencei297 – 35963Missing in isoform 2. CuratedVSP_055142Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31098 Genomic DNA. Translation: AAC50176.1.
U31099 mRNA. Translation: AAC50177.1.
U31332 Genomic DNA. Translation: AAC50178.1.
EF577397 mRNA. Translation: ABQ52417.1.
DQ418808 Genomic DNA. Translation: ABD72608.1.
AL365475 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65657.1.
BC040968 mRNA. Translation: AAH40968.1.
CCDSiCCDS61454.1. [Q13258-2]
CCDS9707.1. [Q13258-1]
PIRiI39153.
RefSeqiNP_000944.1. NM_000953.2. [Q13258-1]
NP_001268398.1. NM_001281469.1. [Q13258-2]
XP_005267948.1. XM_005267891.2. [Q13258-1]
UniGeneiHs.306831.

Genome annotation databases

EnsembliENST00000306051; ENSP00000303424; ENSG00000168229. [Q13258-1]
ENST00000553372; ENSP00000452408; ENSG00000168229. [Q13258-2]
GeneIDi5729.
KEGGihsa:5729.
UCSCiuc001wzq.3. human. [Q13258-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31098 Genomic DNA. Translation: AAC50176.1.
U31099 mRNA. Translation: AAC50177.1.
U31332 Genomic DNA. Translation: AAC50178.1.
EF577397 mRNA. Translation: ABQ52417.1.
DQ418808 Genomic DNA. Translation: ABD72608.1.
AL365475 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65657.1.
BC040968 mRNA. Translation: AAH40968.1.
CCDSiCCDS61454.1. [Q13258-2]
CCDS9707.1. [Q13258-1]
PIRiI39153.
RefSeqiNP_000944.1. NM_000953.2. [Q13258-1]
NP_001268398.1. NM_001281469.1. [Q13258-2]
XP_005267948.1. XM_005267891.2. [Q13258-1]
UniGeneiHs.306831.

3D structure databases

ProteinModelPortaliQ13258.
SMRiQ13258. Positions 117-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111701. 6 interactions.
STRINGi9606.ENSP00000303424.

Chemistry

BindingDBiQ13258.
ChEMBLiCHEMBL4427.
DrugBankiDB00716. Nedocromil.
GuidetoPHARMACOLOGYi338.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiPTGDR.
DMDMi2495009.

Proteomic databases

PaxDbiQ13258.
PRIDEiQ13258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306051; ENSP00000303424; ENSG00000168229. [Q13258-1]
ENST00000553372; ENSP00000452408; ENSG00000168229. [Q13258-2]
GeneIDi5729.
KEGGihsa:5729.
UCSCiuc001wzq.3. human. [Q13258-1]

Organism-specific databases

CTDi5729.
GeneCardsiGC14P052734.
HGNCiHGNC:9591. PTGDR.
MIMi604687. gene.
607277. phenotype.
neXtProtiNX_Q13258.
PharmGKBiPA285.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG248831.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ13258.
KOiK04332.
OMAiAYYGAFK.
OrthoDBiEOG72VH6G.
PhylomeDBiQ13258.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiREACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiProstaglandin_D2_receptor.
GenomeRNAii5729.
NextBioi22286.
PROiQ13258.
SOURCEiSearch...

Gene expression databases

BgeeiQ13258.
CleanExiHS_PTGDR.
GenevestigatoriQ13258.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human prostanoid DP receptor."
    Boie Y., Sawyer N., Slipetz D.M., Metters K.M., Abramovitz M.
    J. Biol. Chem. 270:18910-18916(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. Martin A.L., Kaighin V.A., Aronstam R.S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  3. SeattleSNPs variation discovery resource
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-7; GLU-198; ALA-301 AND GLN-332.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
    Town M.H., Casals-Stenzel J., Schillinger E.
    Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand."
    Sharif N.A., Williams G.W., Davis T.L.
    Br. J. Pharmacol. 131:1025-1038(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Role of prostanoid DP receptor variants in susceptibility to asthma."
    Oguma T., Palmer L.J., Birben E., Sonna L.A., Asano K., Lilly C.M.
    N. Engl. J. Med. 351:1752-1763(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASRT1.

Entry informationi

Entry nameiPD2R_HUMAN
AccessioniPrimary (citable) accession number: Q13258
Secondary accession number(s): G3V5L3
, Q13250, Q13251, Q1ZZ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.