Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prostaglandin D2 receptor

Gene

PTGDR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168229-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-418555. G alpha (s) signalling events.

Chemistry databases

SwissLipidsiSLP:000001561.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:PTGDR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9591. PTGDR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 59CytoplasmicSequence analysisAdd BLAST17
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 107ExtracellularSequence analysisAdd BLAST27
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 150CytoplasmicSequence analysisAdd BLAST22
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 195ExtracellularSequence analysisAdd BLAST24
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 262CytoplasmicSequence analysisAdd BLAST46
Transmembranei263 – 283Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini284 – 310ExtracellularSequence analysisAdd BLAST27
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 359CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma-related traits 1 (ASRT1)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAsthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
See also OMIM:607277

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNETi5729.
MalaCardsiPTGDR.
MIMi607277. phenotype.
OpenTargetsiENSG00000168229.
PharmGKBiPA285.

Chemistry databases

ChEMBLiCHEMBL4427.
DrugBankiDB00716. Nedocromil.
GuidetoPHARMACOLOGYi338.

Polymorphism and mutation databases

BioMutaiPTGDR.
DMDMi2495009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700471 – 359Prostaglandin D2 receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 183PROSITE-ProRule annotation
Glycosylationi297N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13258.
PaxDbiQ13258.
PRIDEiQ13258.

PTM databases

iPTMnetiQ13258.
PhosphoSitePlusiQ13258.

Expressioni

Tissue specificityi

Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.2 Publications

Gene expression databases

BgeeiENSG00000168229.
CleanExiHS_PTGDR.
GenevisibleiQ13258. HS.

Interactioni

Protein-protein interaction databases

BioGridi111701. 6 interactors.
STRINGi9606.ENSP00000303424.

Chemistry databases

BindingDBiQ13258.

Structurei

3D structure databases

ProteinModelPortaliQ13258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ13258.
KOiK04332.
OMAiSLCQAFA.
OrthoDBiEOG091G0F07.
PhylomeDBiQ13258.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS
60 70 80 90 100
RRPLRPLPSV FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL
110 120 130 140 150
DNSLCQAFAF FMSFFGLSST LQLLAMALEC WLSLGHPFFY RRHITLRLGA
160 170 180 190 200
LVAPVVSAFS LAFCALPFMG FGKFVQYCPG TWCFIQMVHE EGSLSVLGYS
210 220 230 240 250
VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT RDCAEPRADG
260 270 280 290 300
REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS
310 320 330 340 350
EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS

NSTNMESSL
Length:359
Mass (Da):40,271
Last modified:November 1, 1997 - v2
Checksum:i098F89F08D0BE12A
GO
Isoform 2 (identifier: Q13258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-296: YRAYYGAFKDVKEK → AFVPGVPAKTPGSR
     297-359: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:296
Mass (Da):32,354
Checksum:i08BEEFB74CD0FBF0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0334827R → C.1 PublicationCorresponds to variant rs41311442dbSNPEnsembl.1
Natural variantiVAR_054975198G → E.1 PublicationCorresponds to variant rs41312444dbSNPEnsembl.1
Natural variantiVAR_033483301E → A.1 PublicationCorresponds to variant rs41312504dbSNPEnsembl.1
Natural variantiVAR_054976332R → Q.1 PublicationCorresponds to variant rs41312506dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055141283 – 296YRAYY…DVKEK → AFVPGVPAKTPGSR in isoform 2. CuratedAdd BLAST14
Alternative sequenceiVSP_055142297 – 359Missing in isoform 2. CuratedAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31098 Genomic DNA. Translation: AAC50176.1.
U31099 mRNA. Translation: AAC50177.1.
U31332 Genomic DNA. Translation: AAC50178.1.
EF577397 mRNA. Translation: ABQ52417.1.
DQ418808 Genomic DNA. Translation: ABD72608.1.
AL365475 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65657.1.
BC040968 mRNA. Translation: AAH40968.1.
CCDSiCCDS61454.1. [Q13258-2]
CCDS9707.1. [Q13258-1]
PIRiI39153.
RefSeqiNP_000944.1. NM_000953.2. [Q13258-1]
NP_001268398.1. NM_001281469.1. [Q13258-2]
XP_005267948.1. XM_005267891.3. [Q13258-1]
UniGeneiHs.306831.

Genome annotation databases

EnsembliENST00000306051; ENSP00000303424; ENSG00000168229. [Q13258-1]
ENST00000553372; ENSP00000452408; ENSG00000168229. [Q13258-2]
GeneIDi5729.
KEGGihsa:5729.
UCSCiuc001wzq.3. human. [Q13258-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31098 Genomic DNA. Translation: AAC50176.1.
U31099 mRNA. Translation: AAC50177.1.
U31332 Genomic DNA. Translation: AAC50178.1.
EF577397 mRNA. Translation: ABQ52417.1.
DQ418808 Genomic DNA. Translation: ABD72608.1.
AL365475 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65657.1.
BC040968 mRNA. Translation: AAH40968.1.
CCDSiCCDS61454.1. [Q13258-2]
CCDS9707.1. [Q13258-1]
PIRiI39153.
RefSeqiNP_000944.1. NM_000953.2. [Q13258-1]
NP_001268398.1. NM_001281469.1. [Q13258-2]
XP_005267948.1. XM_005267891.3. [Q13258-1]
UniGeneiHs.306831.

3D structure databases

ProteinModelPortaliQ13258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111701. 6 interactors.
STRINGi9606.ENSP00000303424.

Chemistry databases

BindingDBiQ13258.
ChEMBLiCHEMBL4427.
DrugBankiDB00716. Nedocromil.
GuidetoPHARMACOLOGYi338.
SwissLipidsiSLP:000001561.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ13258.
PhosphoSitePlusiQ13258.

Polymorphism and mutation databases

BioMutaiPTGDR.
DMDMi2495009.

Proteomic databases

EPDiQ13258.
PaxDbiQ13258.
PRIDEiQ13258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306051; ENSP00000303424; ENSG00000168229. [Q13258-1]
ENST00000553372; ENSP00000452408; ENSG00000168229. [Q13258-2]
GeneIDi5729.
KEGGihsa:5729.
UCSCiuc001wzq.3. human. [Q13258-1]

Organism-specific databases

CTDi5729.
DisGeNETi5729.
GeneCardsiPTGDR.
HGNCiHGNC:9591. PTGDR.
MalaCardsiPTGDR.
MIMi604687. gene.
607277. phenotype.
neXtProtiNX_Q13258.
OpenTargetsiENSG00000168229.
PharmGKBiPA285.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ13258.
KOiK04332.
OMAiSLCQAFA.
OrthoDBiEOG091G0F07.
PhylomeDBiQ13258.
TreeFamiTF324982.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168229-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiProstaglandin_D2_receptor.
GenomeRNAii5729.
PROiQ13258.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168229.
CleanExiHS_PTGDR.
GenevisibleiQ13258. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPD2R_HUMAN
AccessioniPrimary (citable) accession number: Q13258
Secondary accession number(s): G3V5L3
, Q13250, Q13251, Q1ZZ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.