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Q13258

- PD2R_HUMAN

UniProt

Q13258 - PD2R_HUMAN

Protein

Prostaglandin D2 receptor

Gene

PTGDR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.By similarity

    GO - Molecular functioni

    1. prostaglandin D receptor activity Source: UniProtKB
    2. prostaglandin J receptor activity Source: Ensembl
    3. protein binding Source: BHF-UCL

    GO - Biological processi

    1. adenosine metabolic process Source: Ensembl
    2. cellular response to prostaglandin D stimulus Source: Ensembl
    3. G-protein coupled receptor signaling pathway Source: UniProtKB
    4. inflammatory response Source: Ensembl
    5. male sex determination Source: Ensembl
    6. sleep Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18425. Prostanoid ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin D2 receptor
    Short name:
    PGD receptor
    Short name:
    PGD2 receptor
    Alternative name(s):
    Prostanoid DP receptor
    Gene namesi
    Name:PTGDR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:9591. PTGDR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Asthma

    Organism-specific databases

    MIMi607277. phenotype.
    PharmGKBiPA285.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Prostaglandin D2 receptorPRO_0000070047Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 183PROSITE-ProRule annotation
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ13258.
    PRIDEiQ13258.

    Expressioni

    Tissue specificityi

    Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.2 Publications

    Gene expression databases

    ArrayExpressiQ13258.
    BgeeiQ13258.
    CleanExiHS_PTGDR.
    GenevestigatoriQ13258.

    Interactioni

    Protein-protein interaction databases

    BioGridi111701. 2 interactions.
    STRINGi9606.ENSP00000303424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13258.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 5917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 10727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 15022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 19524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 26246CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 31027ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 35928CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG248831.
    HOGENOMiHOG000115475.
    HOVERGENiHBG003074.
    InParanoidiQ13258.
    KOiK04332.
    OMAiAYYGAFK.
    OrthoDBiEOG72VH6G.
    PhylomeDBiQ13258.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000376. Pglndn_D_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01788. PROSTANOIDR.
    PR00854. PRSTNOIDDPR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13258-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS    50
    RRPLRPLPSV FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL 100
    DNSLCQAFAF FMSFFGLSST LQLLAMALEC WLSLGHPFFY RRHITLRLGA 150
    LVAPVVSAFS LAFCALPFMG FGKFVQYCPG TWCFIQMVHE EGSLSVLGYS 200
    VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT RDCAEPRADG 250
    REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS 300
    EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS 350
    NSTNMESSL 359
    Length:359
    Mass (Da):40,271
    Last modified:November 1, 1997 - v2
    Checksum:i098F89F08D0BE12A
    GO
    Isoform 2 (identifier: Q13258-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         283-296: YRAYYGAFKDVKEK → AFVPGVPAKTPGSR
         297-359: Missing.

    Note: No experimental confirmation available. Derived from EST data.

    Show »
    Length:296
    Mass (Da):32,354
    Checksum:i08BEEFB74CD0FBF0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71R → C.1 Publication
    Corresponds to variant rs41311442 [ dbSNP | Ensembl ].
    VAR_033482
    Natural varianti198 – 1981G → E.1 Publication
    Corresponds to variant rs41312444 [ dbSNP | Ensembl ].
    VAR_054975
    Natural varianti301 – 3011E → A.1 Publication
    Corresponds to variant rs41312504 [ dbSNP | Ensembl ].
    VAR_033483
    Natural varianti332 – 3321R → Q.1 Publication
    Corresponds to variant rs41312506 [ dbSNP | Ensembl ].
    VAR_054976

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei283 – 29614YRAYY…DVKEK → AFVPGVPAKTPGSR in isoform 2. CuratedVSP_055141Add
    BLAST
    Alternative sequencei297 – 35963Missing in isoform 2. CuratedVSP_055142Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31098 Genomic DNA. Translation: AAC50176.1.
    U31099 mRNA. Translation: AAC50177.1.
    U31332 Genomic DNA. Translation: AAC50178.1.
    EF577397 mRNA. Translation: ABQ52417.1.
    DQ418808 Genomic DNA. Translation: ABD72608.1.
    AL365475 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65657.1.
    BC040968 mRNA. Translation: AAH40968.1.
    CCDSiCCDS61454.1. [Q13258-2]
    CCDS9707.1. [Q13258-1]
    PIRiI39153.
    RefSeqiNP_000944.1. NM_000953.2.
    NP_001268398.1. NM_001281469.1.
    XP_005267948.1. XM_005267891.1.
    UniGeneiHs.306831.

    Genome annotation databases

    EnsembliENST00000306051; ENSP00000303424; ENSG00000168229. [Q13258-1]
    ENST00000553372; ENSP00000452408; ENSG00000168229. [Q13258-2]
    GeneIDi5729.
    KEGGihsa:5729.
    UCSCiuc001wzq.3. human. [Q13258-1]

    Polymorphism databases

    DMDMi2495009.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31098 Genomic DNA. Translation: AAC50176.1 .
    U31099 mRNA. Translation: AAC50177.1 .
    U31332 Genomic DNA. Translation: AAC50178.1 .
    EF577397 mRNA. Translation: ABQ52417.1 .
    DQ418808 Genomic DNA. Translation: ABD72608.1 .
    AL365475 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65657.1 .
    BC040968 mRNA. Translation: AAH40968.1 .
    CCDSi CCDS61454.1. [Q13258-2 ]
    CCDS9707.1. [Q13258-1 ]
    PIRi I39153.
    RefSeqi NP_000944.1. NM_000953.2.
    NP_001268398.1. NM_001281469.1.
    XP_005267948.1. XM_005267891.1.
    UniGenei Hs.306831.

    3D structure databases

    ProteinModelPortali Q13258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111701. 2 interactions.
    STRINGi 9606.ENSP00000303424.

    Chemistry

    BindingDBi Q13258.
    ChEMBLi CHEMBL4427.
    DrugBanki DB00716. Nedocromil.
    GuidetoPHARMACOLOGYi 338.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 2495009.

    Proteomic databases

    PaxDbi Q13258.
    PRIDEi Q13258.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306051 ; ENSP00000303424 ; ENSG00000168229 . [Q13258-1 ]
    ENST00000553372 ; ENSP00000452408 ; ENSG00000168229 . [Q13258-2 ]
    GeneIDi 5729.
    KEGGi hsa:5729.
    UCSCi uc001wzq.3. human. [Q13258-1 ]

    Organism-specific databases

    CTDi 5729.
    GeneCardsi GC14P052734.
    HGNCi HGNC:9591. PTGDR.
    MIMi 604687. gene.
    607277. phenotype.
    neXtProti NX_Q13258.
    PharmGKBi PA285.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248831.
    HOGENOMi HOG000115475.
    HOVERGENi HBG003074.
    InParanoidi Q13258.
    KOi K04332.
    OMAi AYYGAFK.
    OrthoDBi EOG72VH6G.
    PhylomeDBi Q13258.
    TreeFami TF324982.

    Enzyme and pathway databases

    Reactomei REACT_18425. Prostanoid ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Prostaglandin_D2_receptor.
    GenomeRNAii 5729.
    NextBioi 22286.
    PROi Q13258.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13258.
    Bgeei Q13258.
    CleanExi HS_PTGDR.
    Genevestigatori Q13258.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000376. Pglndn_D_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01788. PROSTANOIDR.
    PR00854. PRSTNOIDDPR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the human prostanoid DP receptor."
      Boie Y., Sawyer N., Slipetz D.M., Metters K.M., Abramovitz M.
      J. Biol. Chem. 270:18910-18916(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. Martin A.L., Kaighin V.A., Aronstam R.S.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Small intestine.
    3. SeattleSNPs variation discovery resource
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-7; GLU-198; ALA-301 AND GLN-332.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
      Town M.H., Casals-Stenzel J., Schillinger E.
      Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand."
      Sharif N.A., Williams G.W., Davis T.L.
      Br. J. Pharmacol. 131:1025-1038(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Role of prostanoid DP receptor variants in susceptibility to asthma."
      Oguma T., Palmer L.J., Birben E., Sonna L.A., Asano K., Lilly C.M.
      N. Engl. J. Med. 351:1752-1763(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASRT1.

    Entry informationi

    Entry nameiPD2R_HUMAN
    AccessioniPrimary (citable) accession number: Q13258
    Secondary accession number(s): G3V5L3
    , Q13250, Q13251, Q1ZZ52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3