Q13258 (PD2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prostaglandin D2 receptor
Short name=PGD receptor
Short name=PGD2 receptor

Alternative name(s):
Prostanoid DP receptor

Gene names

Name:

PTGDR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. Ref.7 Ref.8
Involvement in disease	Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.9
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Disease	Asthma
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenosine metabolic process Inferred from electronic annotation. Source: Compara cellular response to prostaglandin D stimulus Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara male sex determination Inferred from electronic annotation. Source: Compara sleep Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Inferred from direct assay PubMed 20959461. Source: BHF-UCL
Molecular_function	prostaglandin D receptor activity Non-traceable author statement Ref.1. Source: UniProtKB prostaglandin J receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Prostaglandin D2 receptor		PRO_0000070047
Regions
	Topological domain	1 – 21	21	Extracellular Potential
	Transmembrane	22 – 42	21	Helical; Name=1; Potential
	Topological domain	43 – 59	17	Cytoplasmic Potential
	Transmembrane	60 – 80	21	Helical; Name=2; Potential
	Topological domain	81 – 107	27	Extracellular Potential
	Transmembrane	108 – 128	21	Helical; Name=3; Potential
	Topological domain	129 – 150	22	Cytoplasmic Potential
	Transmembrane	151 – 171	21	Helical; Name=4; Potential
	Topological domain	172 – 195	24	Extracellular Potential
	Transmembrane	196 – 216	21	Helical; Name=5; Potential
	Topological domain	217 – 262	46	Cytoplasmic Potential
	Transmembrane	263 – 283	21	Helical; Name=6; Potential
	Topological domain	284 – 310	27	Extracellular Potential
	Transmembrane	311 – 331	21	Helical; Name=7; Potential
	Topological domain	332 – 359	28	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	297	1	N-linked (GlcNAc...) Potential
	Disulfide bond	105 ↔ 183		By similarity
Natural variations
	Natural variant	7	1	R → C. Ref.3 Corresponds to variant rs41311442 [ dbSNP | Ensembl ].		VAR_033482
	Natural variant	198	1	G → E. Ref.3 Corresponds to variant rs41312444 [ dbSNP | Ensembl ].		VAR_054975
	Natural variant	301	1	E → A. Ref.3 Corresponds to variant rs41312504 [ dbSNP | Ensembl ].		VAR_033483
	Natural variant	332	1	R → Q. Ref.3 Corresponds to variant rs41312506 [ dbSNP | Ensembl ].		VAR_054976

Sequences

	Sequence		Length	Mass (Da)
	Q13258 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 098F89F08D0BE12A	FASTA	359	40,271
	10 20 30 40 50 60 MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS RRPLRPLPSV 70 80 90 100 110 120 FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL DNSLCQAFAF FMSFFGLSST 130 140 150 160 170 180 LQLLAMALEC WLSLGHPFFY RRHITLRLGA LVAPVVSAFS LAFCALPFMG FGKFVQYCPG 190 200 210 220 230 240 TWCFIQMVHE EGSLSVLGYS VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT 250 260 270 280 290 300 RDCAEPRADG REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS 310 320 330 340 350 EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS NSTNMESSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of the human prostanoid DP receptor." Boie Y., Sawyer N., Slipetz D.M., Metters K.M., Abramovitz M. J. Biol. Chem. 270:18910-18916(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	Martin A.L., Kaighin V.A., Aronstam R.S. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Small intestine.
[3]	SeattleSNPs variation discovery resource Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-7; GLU-198; ALA-301 AND GLN-332.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors." Town M.H., Casals-Stenzel J., Schillinger E. Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand." Sharif N.A., Williams G.W., Davis T.L. Br. J. Pharmacol. 131:1025-1038(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Role of prostanoid DP receptor variants in susceptibility to asthma." Oguma T., Palmer L.J., Birben E., Sonna L.A., Asano K., Lilly C.M. N. Engl. J. Med. 351:1752-1763(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASRT1.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31098 Genomic DNA. Translation: AAC50176.1. U31099 mRNA. Translation: AAC50177.1. U31332 Genomic DNA. Translation: AAC50178.1. EF577397 mRNA. Translation: ABQ52417.1. DQ418808 Genomic DNA. Translation: ABD72608.1. AL365475 Genomic DNA. No translation available. CH471078 Genomic DNA. Translation: EAW65657.1. BC040968 mRNA. Translation: AAH40968.1.
IPI	IPI00012371.
PIR	I39153.
RefSeq	NP_000944.1. NM_000953.2.
UniGene	Hs.306831.
3D structure databases
ProteinModelPortal	Q13258.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303424.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	2495009.
Proteomic databases
PaxDb	Q13258.
PRIDE	Q13258.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306051; ENSP00000303424; ENSG00000168229.
GeneID	5729.
KEGG	hsa:5729.
UCSC	uc001wzq.3. human.
Organism-specific databases
CTD	5729.
GeneCards	GC14P052734.
HGNC	HGNC:9591. PTGDR.
MIM	604687. gene. 607277. phenotype.
neXtProt	NX_Q13258.
PharmGKB	PA285.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG248831.
HOGENOM	HOG000115475.
HOVERGEN	HBG003074.
InParanoid	Q13258.
KO	K04332.
OMA	AYYGAFK.
OrthoDB	EOG41JZCX.
PhylomeDB	Q13258.
Enzyme and pathway databases
Pathway_Interaction_DB	txa2pathway. Thromboxane A2 receptor signaling.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q13258.
Bgee	Q13258.
CleanEx	HS_PTGDR.
Genevestigator	Q13258.
GermOnline	ENSG00000168229. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000376. Pglndn_D_rcpt. IPR008365. Prostanoid_rcpt. [Graphical view]
PANTHER	PTHR11866. PTHR11866. 1 hit. PTHR11866:SF9. PTHR11866:SF9. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01788. PROSTANOIDR. PR00854. PRSTNOIDDPR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q13258.
ChEMBL	CHEMBL4427.
DrugBank	DB00716. Nedocromil.
GenomeRNAi	5729.
NextBio	22286.
SOURCE	Search...

Entry information

Entry name

PD2R_HUMAN

Accession

Primary (citable) accession number: Q13258
Secondary accession number(s): Q13250, Q13251, Q1ZZ52

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.