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Q13255

- GRM1_HUMAN

UniProt

Q13255 - GRM1_HUMAN

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Protein
Metabotropic glutamate receptor 1
Gene
GRM1, GPRC1A, MGLUR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741Glutamate By similarity
Binding sitei165 – 1651Glutamate By similarity
Binding sitei236 – 2361Glutamate By similarity
Binding sitei318 – 3181Glutamate By similarity
Binding sitei409 – 4091Glutamate By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. glutamate receptor activity Source: UniProtKB
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled glutamate receptor signaling pathway Source: RefGenome
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. activation of MAPK activity Source: Ensembl
  4. activation of MAPKK activity Source: Ensembl
  5. cell death Source: UniProtKB-KW
  6. cellular response to electrical stimulus Source: Ensembl
  7. locomotory behavior Source: Ensembl
  8. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RefGenome
  9. regulation of sensory perception of pain Source: Ensembl
  10. regulation of synaptic transmission, glutamatergic Source: RefGenome
  11. sensory perception of pain Source: Ensembl
  12. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
SignaLinkiQ13255.

Protein family/group databases

TCDBi9.A.14.7.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 1
Short name:
mGluR1
Gene namesi
Name:GRM1
Synonyms:GPRC1A, MGLUR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4593. GRM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 592574Extracellular Reviewed prediction
Add
BLAST
Transmembranei593 – 61523Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini616 – 62914Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei630 – 65021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini651 – 66111Extracellular Reviewed prediction
Add
BLAST
Transmembranei662 – 68019Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini681 – 70626Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei707 – 72721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini728 – 75023Extracellular Reviewed prediction
Add
BLAST
Transmembranei751 – 77222Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini773 – 78513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei786 – 80823Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini809 – 8146Extracellular Reviewed prediction
Transmembranei815 – 84026Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini841 – 1194354Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. G-protein coupled receptor homodimeric complex Source: FlyBase
  2. dendrite Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. integral component of plasma membrane Source: RefGenome
  5. nucleus Source: Ensembl
  6. plasma membrane Source: UniProtKB-KW
  7. postsynaptic density Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13) [MIM:614831]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Neurodegeneration

Organism-specific databases

MIMi614831. phenotype.
Orphaneti324262. Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency.
PharmGKBiPA28990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 11941176Metabotropic glutamate receptor 1
PRO_0000012922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 1092 Publications
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 – 140Interchain2 Publications
Glycosylationi223 – 2231N-linked (GlcNAc...)1 Publication
Disulfide bondi289 ↔ 291 By similarity
Disulfide bondi378 ↔ 3942 Publications
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi432 ↔ 4392 Publications
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13255.
PRIDEiQ13255.

PTM databases

PhosphoSiteiQ13255.

Expressioni

Tissue specificityi

Detected in brain.

Gene expression databases

ArrayExpressiQ13255.
BgeeiQ13255.
GenevestigatoriQ13255.

Organism-specific databases

HPAiHPA015701.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP By similarity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KPNA1P522942EBI-8527352,EBI-358383

Protein-protein interaction databases

BioGridi109168. 6 interactions.
IntActiQ13255. 2 interactions.
MINTiMINT-2806316.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 413
Beta strandi44 – 518
Helixi59 – 613
Turni62 – 654
Turni72 – 754
Helixi76 – 9015
Beta strandi93 – 964
Beta strandi101 – 1077
Helixi112 – 12312
Beta strandi156 – 1605
Helixi165 – 17511
Helixi176 – 1783
Beta strandi182 – 1865
Helixi190 – 1934
Turni195 – 1973
Beta strandi201 – 2055
Helixi209 – 22113
Beta strandi226 – 2349
Helixi235 – 25016
Beta strandi254 – 2618
Helixi267 – 27812
Turni279 – 2846
Beta strandi286 – 2905
Helixi293 – 30614
Beta strandi313 – 3164
Turni318 – 3225
Helixi324 – 3274
Helixi331 – 3344
Beta strandi338 – 3425
Helixi348 – 3547
Turni359 – 3613
Helixi368 – 3758
Beta strandi391 – 3933
Turni400 – 4034
Helixi410 – 43122
Helixi440 – 4423
Helixi447 – 4559
Beta strandi458 – 4603
Beta strandi466 – 4683
Beta strandi478 – 4869
Beta strandi492 – 50110
Beta strandi504 – 5074
Turni509 – 5113
Helixi591 – 61626
Beta strandi618 – 6203
Helixi621 – 6244
Helixi628 – 64922
Helixi654 – 68532
Helixi703 – 72725
Beta strandi732 – 7354
Beta strandi738 – 7403
Beta strandi742 – 7465
Helixi750 – 77324
Turni774 – 7763
Helixi779 – 80729
Helixi811 – 83929

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KS9X-ray1.90A/B28-518[»]
4OR2X-ray2.80A/B581-860[»]
ProteinModelPortaliQ13255.
SMRiQ13255. Positions 35-846.

Miscellaneous databases

EvolutionaryTraceiQ13255.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni186 – 1883Glutamate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1014 – 103522Gln/Pro-rich
Add
BLAST
Compositional biasi1067 – 108115Gln/Pro-rich
Add
BLAST
Compositional biasi1095 – 113036Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi1142 – 119453Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
HOVERGENiHBG107965.
InParanoidiQ13255.
KOiK04603.
OMAiKTNETAC.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ13255.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q13255-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL     50
FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT 100
LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGINRC LPDGQSLPPG 150
RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY 200
FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ 250
EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 300
SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF 350
DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL 400
EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL 450
LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW 500
HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC 550
KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS 600
CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA 650
KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF 700
MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN 750
LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA 800
FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF 850
TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNANSNG KSVSWSEPGG 900
GQVPKGQHMW HRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDTS 950
TKTLYNVEEE EDAQPIRFSP PGSPSMVVHR RVPSAATTPP LPSHLTAEET 1000
PLFLAEPALP KGLPPPLQQQ QQPPPQQKSL MDQLQGVVSN FSTAIPDFHA 1050
VLAGPGGPGN GLRSLYPPPP PPQHLQMLPL QLSTFGEELV SPPADDDDDS 1100
ERFKLLQEYV YEHEREGNTE EDELEEEEED LQAASKLTPD DSPALTPPSP 1150
FRDSVASGSS VPSSPVSESV LCTPPNVSYA SVILRDYKQS SSTL 1194
Length:1,194
Mass (Da):132,357
Last modified:November 2, 2010 - v3
Checksum:i0A633505F6D51909
GO
Isoform Beta (identifier: Q13255-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGGQVPKG → KKRQPEFSPTSQCPSAHVQL
     907-1194: Missing.

Note: Ref.1 (AAA87844) sequence is in conflict in positions: 896:T->S and 904:V->A.

Show »
Length:906
Mass (Da):101,323
Checksum:iD63470CF9A15361E
GO
Isoform 3 (identifier: Q13255-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-908: NSNGKSVSWSEPGGGQVPKGQH → KWRTGAQGTAYVAPPLCAREDQ
     909-1194: Missing.

Note: No experimental confirmation available.

Show »
Length:908
Mass (Da):101,473
Checksum:i214EC733A9D585B1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341S → Y.
Corresponds to variant rs12190109 [ dbSNP | Ensembl ].
VAR_028184
Natural varianti285 – 2851R → K.
Corresponds to variant rs7760248 [ dbSNP | Ensembl ].
VAR_028185
Natural varianti593 – 5931S → P.1 Publication
Corresponds to variant rs1047005 [ dbSNP | Ensembl ].
VAR_055875
Natural varianti696 – 6961R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036194
Natural varianti741 – 7411E → D.
Corresponds to variant rs3025919 [ dbSNP | Ensembl ].
VAR_028186
Natural varianti884 – 8841G → E.
Corresponds to variant rs362936 [ dbSNP | Ensembl ].
VAR_028187
Natural varianti929 – 9291V → I.
Corresponds to variant rs2941 [ dbSNP | Ensembl ].
VAR_024482
Natural varianti993 – 9931S → P.2 Publications
Corresponds to variant rs6923492 [ dbSNP | Ensembl ].
VAR_028188

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei887 – 90822NSNGK…PKGQH → KWRTGAQGTAYVAPPLCARE DQ in isoform 3.
VSP_055127Add
BLAST
Alternative sequencei887 – 90620NSNGK…QVPKG → KKRQPEFSPTSQCPSAHVQL in isoform Beta.
VSP_002024Add
BLAST
Alternative sequencei907 – 1194288Missing in isoform Beta.
VSP_002025Add
BLAST
Alternative sequencei909 – 1194286Missing in isoform 3.
VSP_055128Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31215 mRNA. Translation: AAA87843.1.
U31216 mRNA. Translation: AAA87844.1.
L76627 mRNA. Translation: AAB05337.1.
L76631 mRNA. Translation: AAB05338.1.
AL031769 Genomic DNA. No translation available.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71181.1.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71182.1.
AL096867, AL592423, AL035698 Genomic DNA. Translation: CAI20335.1.
AL096867, AL035698, AL592423 Genomic DNA. Translation: CAI20336.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22468.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22469.1.
BC136280 mRNA. Translation: AAI36281.1.
BC143779 mRNA. No translation available.
CCDSiCCDS47497.1. [Q13255-2]
CCDS5209.1. [Q13255-1]
RefSeqiNP_001264993.1. NM_001278064.1. [Q13255-1]
NP_001264994.1. NM_001278065.1. [Q13255-2]
NP_001264995.1. NM_001278066.1. [Q13255-2]
NP_001264996.1. NM_001278067.1.
XP_006715530.1. XM_006715467.1. [Q13255-2]
UniGeneiHs.32945.

Genome annotation databases

EnsembliENST00000282753; ENSP00000282753; ENSG00000152822. [Q13255-1]
ENST00000355289; ENSP00000347437; ENSG00000152822.
ENST00000361719; ENSP00000354896; ENSG00000152822. [Q13255-1]
ENST00000392299; ENSP00000376119; ENSG00000152822. [Q13255-2]
ENST00000492807; ENSP00000424095; ENSG00000152822. [Q13255-2]
ENST00000507907; ENSP00000425599; ENSG00000152822. [Q13255-2]
GeneIDi2911.
KEGGihsa:2911.
UCSCiuc003qll.3. human. [Q13255-2]
uc010khw.2. human. [Q13255-1]

Polymorphism databases

DMDMi311033443.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31215 mRNA. Translation: AAA87843.1 .
U31216 mRNA. Translation: AAA87844.1 .
L76627 mRNA. Translation: AAB05337.1 .
L76631 mRNA. Translation: AAB05338.1 .
AL031769 Genomic DNA. No translation available.
AL592423 , AL035698 , AL096867 Genomic DNA. Translation: CAH71181.1 .
AL592423 , AL035698 , AL096867 Genomic DNA. Translation: CAH71182.1 .
AL096867 , AL592423 , AL035698 Genomic DNA. Translation: CAI20335.1 .
AL096867 , AL035698 , AL592423 Genomic DNA. Translation: CAI20336.1 .
AL035698 , AL096867 , AL592423 Genomic DNA. Translation: CAI22468.1 .
AL035698 , AL096867 , AL592423 Genomic DNA. Translation: CAI22469.1 .
BC136280 mRNA. Translation: AAI36281.1 .
BC143779 mRNA. No translation available.
CCDSi CCDS47497.1. [Q13255-2 ]
CCDS5209.1. [Q13255-1 ]
RefSeqi NP_001264993.1. NM_001278064.1. [Q13255-1 ]
NP_001264994.1. NM_001278065.1. [Q13255-2 ]
NP_001264995.1. NM_001278066.1. [Q13255-2 ]
NP_001264996.1. NM_001278067.1.
XP_006715530.1. XM_006715467.1. [Q13255-2 ]
UniGenei Hs.32945.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KS9 X-ray 1.90 A/B 28-518 [» ]
4OR2 X-ray 2.80 A/B 581-860 [» ]
ProteinModelPortali Q13255.
SMRi Q13255. Positions 35-846.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109168. 6 interactions.
IntActi Q13255. 2 interactions.
MINTi MINT-2806316.

Chemistry

BindingDBi Q13255.
ChEMBLi CHEMBL3772.
DrugBanki DB00659. Acamprosate.
DB00142. L-Glutamic Acid.
GuidetoPHARMACOLOGYi 289.

Protein family/group databases

TCDBi 9.A.14.7.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q13255.

Polymorphism databases

DMDMi 311033443.

Proteomic databases

PaxDbi Q13255.
PRIDEi Q13255.

Protocols and materials databases

DNASUi 2911.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282753 ; ENSP00000282753 ; ENSG00000152822 . [Q13255-1 ]
ENST00000355289 ; ENSP00000347437 ; ENSG00000152822 .
ENST00000361719 ; ENSP00000354896 ; ENSG00000152822 . [Q13255-1 ]
ENST00000392299 ; ENSP00000376119 ; ENSG00000152822 . [Q13255-2 ]
ENST00000492807 ; ENSP00000424095 ; ENSG00000152822 . [Q13255-2 ]
ENST00000507907 ; ENSP00000425599 ; ENSG00000152822 . [Q13255-2 ]
GeneIDi 2911.
KEGGi hsa:2911.
UCSCi uc003qll.3. human. [Q13255-2 ]
uc010khw.2. human. [Q13255-1 ]

Organism-specific databases

CTDi 2911.
GeneCardsi GC06P146390.
HGNCi HGNC:4593. GRM1.
HPAi HPA015701.
MIMi 604473. gene.
614831. phenotype.
neXtProti NX_Q13255.
Orphaneti 324262. Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency.
PharmGKBi PA28990.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295200.
HOVERGENi HBG107965.
InParanoidi Q13255.
KOi K04603.
OMAi KTNETAC.
OrthoDBi EOG7Z0JXG.
PhylomeDBi Q13255.
TreeFami TF313240.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
SignaLinki Q13255.

Miscellaneous databases

EvolutionaryTracei Q13255.
GeneWikii Metabotropic_glutamate_receptor_1.
GenomeRNAii 2911.
NextBioi 11539.
PROi Q13255.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13255.
Bgeei Q13255.
Genevestigatori Q13255.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter."
    Desai M.A., Burnett J.P., Mayne N.G., Schoepp D.D.
    Mol. Pharmacol. 48:648-657(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), FUNCTION, VARIANTS PRO-593 AND PRO-993.
  2. "Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants."
    Stephan D., Bon C., Holzwarth J.A., Galvan M., Pruss R.M.
    Neuropharmacology 35:1649-1660(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANT PRO-993.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 3).
    Tissue: Testis.
  5. "Cys-140 is critical for metabotropic glutamate receptor-1 dimerization."
    Ray K., Hauschild B.C.
    J. Biol. Chem. 275:34245-34251(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERCHAIN DISULFIDE BOND.
  6. Cited for: INVOLVEMENT IN SCAR13.
  7. "Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist."
    Structural genomics consortium (SGC)
    Submitted (JUL-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 28-518 IN COMPLEX WITH ANTAGONIST LY341495, GLYCOSYLATION AT ASN-223, DISULFIDE BONDS.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-696.

Entry informationi

Entry nameiGRM1_HUMAN
AccessioniPrimary (citable) accession number: Q13255
Secondary accession number(s): B9EG79
, F8W805, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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