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Protein

Metabotropic glutamate receptor 1

Gene

GRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.2 Publications

Enzyme regulationi

Signaling is inhibited by the antagonist LY341495. The LY341495 binding site partially overlaps with the glutamate binding site. Signaling is also inhibited by synthetic allosteric regulators, such as FITM (4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide) that bind in a pocket between the transmembrane helices.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74GlutamateCurated1
Binding sitei165GlutamateCurated1
Binding sitei236GlutamateBy similarity1
Binding sitei318GlutamateBy similarity1
Binding sitei409GlutamateBy similarity1

GO - Molecular functioni

  • glutamate receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152822-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
SignaLinkiQ13255.
SIGNORiQ13255.

Protein family/group databases

TCDBi9.A.14.7.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 1
Short name:
mGluR1
Gene namesi
Name:GRM1
Synonyms:GPRC1A, MGLUR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4593. GRM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 592Extracellular1 PublicationAdd BLAST574
Transmembranei593 – 615Helical; Name=1Add BLAST23
Topological domaini616 – 629Cytoplasmic1 PublicationAdd BLAST14
Transmembranei630 – 650Helical; Name=2Add BLAST21
Topological domaini651 – 658Extracellular1 Publication8
Transmembranei659 – 680Helical; Name=3Add BLAST22
Topological domaini681 – 703Cytoplasmic1 PublicationAdd BLAST23
Transmembranei704 – 727Helical; Name=4Add BLAST24
Topological domaini728 – 750Extracellular1 PublicationAdd BLAST23
Transmembranei751 – 772Helical; Name=5Add BLAST22
Topological domaini773 – 785Cytoplasmic1 PublicationAdd BLAST13
Transmembranei786 – 807Helical; Name=6Add BLAST22
Topological domaini808 – 815Extracellular1 Publication8
Transmembranei816 – 840Helical; Name=7Add BLAST25
Topological domaini841 – 1194Cytoplasmic1 PublicationAdd BLAST354

GO - Cellular componenti

  • dendrite Source: Ensembl
  • G-protein coupled receptor dimeric complex Source: UniProtKB
  • G-protein coupled receptor homodimeric complex Source: FlyBase
  • integral component of plasma membrane Source: UniProtKB
  • nucleus Source: Ensembl
  • plasma membrane Source: Reactome
  • postsynaptic density Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.
See also OMIM:614831

Keywords - Diseasei

Neurodegeneration

Organism-specific databases

DisGeNETi2911.
MalaCardsiGRM1.
MIMi614831. phenotype.
OpenTargetsiENSG00000152822.
Orphaneti324262. Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency.
404507. Chondromyxoid fibroma.
PharmGKBiPA28990.

Chemistry databases

ChEMBLiCHEMBL3772.
GuidetoPHARMACOLOGYi289.

Polymorphism and mutation databases

DMDMi311033443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001292219 – 1194Metabotropic glutamate receptor 1Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi67 ↔ 109
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi140Interchain
Glycosylationi223N-linked (GlcNAc...)1 Publication1
Disulfide bondi289 ↔ 291By similarity
Disulfide bondi378 ↔ 394
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi432 ↔ 439
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi657 ↔ 746
Modified residuei853PhosphoserineBy similarity1
Modified residuei871PhosphothreonineBy similarity1
Modified residuei894PhosphoserineBy similarity1
Modified residuei969PhosphoserineBy similarity1
Modified residuei1091PhosphoserineBy similarity1
Modified residuei1142PhosphoserineBy similarity1
Modified residuei1146PhosphothreonineBy similarity1
Modified residuei1149PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ13255.
PaxDbiQ13255.
PeptideAtlasiQ13255.
PRIDEiQ13255.

PTM databases

iPTMnetiQ13255.
PhosphoSitePlusiQ13255.

Expressioni

Tissue specificityi

Detected in brain.

Gene expression databases

BgeeiENSG00000152822.
GenevisibleiQ13255. HS.

Organism-specific databases

HPAiHPA015701.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KPNA1P522942EBI-8527352,EBI-358383

Protein-protein interaction databases

BioGridi109168. 7 interactors.
DIPiDIP-57522N.
IntActiQ13255. 2 interactors.
MINTiMINT-2806316.
STRINGi9606.ENSP00000282753.

Chemistry databases

BindingDBiQ13255.

Structurei

Secondary structure

11194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 41Combined sources3
Beta strandi44 – 51Combined sources8
Helixi59 – 61Combined sources3
Turni62 – 65Combined sources4
Turni72 – 75Combined sources4
Helixi76 – 90Combined sources15
Beta strandi93 – 96Combined sources4
Beta strandi101 – 107Combined sources7
Helixi112 – 123Combined sources12
Beta strandi156 – 160Combined sources5
Helixi165 – 175Combined sources11
Helixi176 – 178Combined sources3
Beta strandi182 – 186Combined sources5
Helixi190 – 193Combined sources4
Turni195 – 197Combined sources3
Beta strandi201 – 205Combined sources5
Helixi209 – 221Combined sources13
Beta strandi226 – 234Combined sources9
Helixi235 – 250Combined sources16
Beta strandi254 – 261Combined sources8
Helixi267 – 278Combined sources12
Turni279 – 284Combined sources6
Beta strandi286 – 290Combined sources5
Helixi293 – 306Combined sources14
Beta strandi313 – 316Combined sources4
Turni318 – 322Combined sources5
Helixi324 – 327Combined sources4
Helixi331 – 334Combined sources4
Beta strandi338 – 342Combined sources5
Helixi348 – 354Combined sources7
Turni359 – 361Combined sources3
Helixi368 – 375Combined sources8
Beta strandi391 – 393Combined sources3
Turni400 – 403Combined sources4
Helixi410 – 431Combined sources22
Helixi440 – 442Combined sources3
Helixi447 – 455Combined sources9
Beta strandi458 – 460Combined sources3
Beta strandi466 – 468Combined sources3
Beta strandi478 – 486Combined sources9
Beta strandi492 – 501Combined sources10
Beta strandi504 – 507Combined sources4
Turni509 – 511Combined sources3
Helixi591 – 616Combined sources26
Beta strandi618 – 620Combined sources3
Helixi621 – 624Combined sources4
Helixi628 – 649Combined sources22
Helixi654 – 685Combined sources32
Helixi703 – 727Combined sources25
Beta strandi732 – 735Combined sources4
Beta strandi738 – 740Combined sources3
Beta strandi742 – 746Combined sources5
Helixi750 – 773Combined sources24
Turni774 – 776Combined sources3
Helixi779 – 807Combined sources29
Helixi811 – 839Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KS9X-ray1.90A/B28-518[»]
4OR2X-ray2.80A/B581-860[»]
ProteinModelPortaliQ13255.
SMRiQ13255.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13255.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 188Glutamate bindingCurated3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1014 – 1035Gln/Pro-richAdd BLAST22
Compositional biasi1067 – 1081Gln/Pro-richAdd BLAST15
Compositional biasi1095 – 1130Asp/Glu-rich (acidic)Add BLAST36
Compositional biasi1142 – 1194Ser-richAdd BLAST53

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOVERGENiHBG107965.
InParanoidiQ13255.
KOiK04603.
OMAiKTNETAC.
OrthoDBiEOG091G177R.
PhylomeDBiQ13255.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SMARTiSM01229. GluR_Homer-bdg. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q13255-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL
60 70 80 90 100
FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT
110 120 130 140 150
LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGINRC LPDGQSLPPG
160 170 180 190 200
RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY
210 220 230 240 250
FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ
260 270 280 290 300
EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL
310 320 330 340 350
SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF
360 370 380 390 400
DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL
410 420 430 440 450
EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL
460 470 480 490 500
LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW
510 520 530 540 550
HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC
560 570 580 590 600
KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS
610 620 630 640 650
CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA
660 670 680 690 700
KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF
710 720 730 740 750
MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN
760 770 780 790 800
LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA
810 820 830 840 850
FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF
860 870 880 890 900
TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNANSNG KSVSWSEPGG
910 920 930 940 950
GQVPKGQHMW HRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDTS
960 970 980 990 1000
TKTLYNVEEE EDAQPIRFSP PGSPSMVVHR RVPSAATTPP LPSHLTAEET
1010 1020 1030 1040 1050
PLFLAEPALP KGLPPPLQQQ QQPPPQQKSL MDQLQGVVSN FSTAIPDFHA
1060 1070 1080 1090 1100
VLAGPGGPGN GLRSLYPPPP PPQHLQMLPL QLSTFGEELV SPPADDDDDS
1110 1120 1130 1140 1150
ERFKLLQEYV YEHEREGNTE EDELEEEEED LQAASKLTPD DSPALTPPSP
1160 1170 1180 1190
FRDSVASGSS VPSSPVSESV LCTPPNVSYA SVILRDYKQS SSTL
Length:1,194
Mass (Da):132,357
Last modified:November 2, 2010 - v3
Checksum:i0A633505F6D51909
GO
Isoform Beta (identifier: Q13255-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGGQVPKG → KKRQPEFSPTSQCPSAHVQL
     907-1194: Missing.

Show »
Length:906
Mass (Da):101,323
Checksum:iD63470CF9A15361E
GO
Isoform 3 (identifier: Q13255-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-908: NSNGKSVSWSEPGGGQVPKGQH → KWRTGAQGTAYVAPPLCAREDQ
     909-1194: Missing.

Note: No experimental confirmation available.
Show »
Length:908
Mass (Da):101,473
Checksum:i214EC733A9D585B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform Beta (identifier: Q13255-2)
Sequence conflicti896T → S in AAA87844 (PubMed:7476890).Curated1
Sequence conflicti904V → A in AAA87844 (PubMed:7476890).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02818434S → Y.Corresponds to variant rs12190109dbSNPEnsembl.1
Natural variantiVAR_028185285R → K.Corresponds to variant rs7760248dbSNPEnsembl.1
Natural variantiVAR_055875593S → P.1 PublicationCorresponds to variant rs1047005dbSNPEnsembl.1
Natural variantiVAR_036194696R → W in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_028186741E → D.Corresponds to variant rs3025919dbSNPEnsembl.1
Natural variantiVAR_028187884G → E.Corresponds to variant rs362936dbSNPEnsembl.1
Natural variantiVAR_024482929V → I.Corresponds to variant rs2941dbSNPEnsembl.1
Natural variantiVAR_028188993S → P.2 PublicationsCorresponds to variant rs6923492dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055127887 – 908NSNGK…PKGQH → KWRTGAQGTAYVAPPLCARE DQ in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_002024887 – 906NSNGK…QVPKG → KKRQPEFSPTSQCPSAHVQL in isoform Beta. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_002025907 – 1194Missing in isoform Beta. 2 PublicationsAdd BLAST288
Alternative sequenceiVSP_055128909 – 1194Missing in isoform 3. 1 PublicationAdd BLAST286

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31215 mRNA. Translation: AAA87843.1.
U31216 mRNA. Translation: AAA87844.1.
L76627 mRNA. Translation: AAB05337.1.
L76631 mRNA. Translation: AAB05338.1.
AL031769 Genomic DNA. No translation available.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71181.1.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71182.1.
AL096867, AL592423, AL035698 Genomic DNA. Translation: CAI20335.1.
AL096867, AL035698, AL592423 Genomic DNA. Translation: CAI20336.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22468.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22469.1.
BC136280 mRNA. Translation: AAI36281.1.
BC143779 mRNA. No translation available.
CCDSiCCDS47497.1. [Q13255-2]
CCDS5209.1. [Q13255-1]
CCDS64548.1. [Q13255-3]
RefSeqiNP_001264993.1. NM_001278064.1. [Q13255-1]
NP_001264994.1. NM_001278065.1. [Q13255-2]
NP_001264995.1. NM_001278066.1. [Q13255-2]
NP_001264996.1. NM_001278067.1. [Q13255-3]
XP_011534084.1. XM_011535782.1. [Q13255-1]
XP_016866272.1. XM_017010783.1. [Q13255-1]
XP_016866273.1. XM_017010784.1. [Q13255-1]
XP_016866274.1. XM_017010785.1. [Q13255-2]
XP_016866275.1. XM_017010786.1. [Q13255-2]
XP_016866276.1. XM_017010787.1. [Q13255-2]
UniGeneiHs.32945.

Genome annotation databases

EnsembliENST00000282753; ENSP00000282753; ENSG00000152822. [Q13255-1]
ENST00000355289; ENSP00000347437; ENSG00000152822. [Q13255-3]
ENST00000361719; ENSP00000354896; ENSG00000152822. [Q13255-1]
ENST00000492807; ENSP00000424095; ENSG00000152822. [Q13255-2]
ENST00000507907; ENSP00000425599; ENSG00000152822. [Q13255-2]
GeneIDi2911.
KEGGihsa:2911.
UCSCiuc003qll.4. human. [Q13255-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31215 mRNA. Translation: AAA87843.1.
U31216 mRNA. Translation: AAA87844.1.
L76627 mRNA. Translation: AAB05337.1.
L76631 mRNA. Translation: AAB05338.1.
AL031769 Genomic DNA. No translation available.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71181.1.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71182.1.
AL096867, AL592423, AL035698 Genomic DNA. Translation: CAI20335.1.
AL096867, AL035698, AL592423 Genomic DNA. Translation: CAI20336.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22468.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22469.1.
BC136280 mRNA. Translation: AAI36281.1.
BC143779 mRNA. No translation available.
CCDSiCCDS47497.1. [Q13255-2]
CCDS5209.1. [Q13255-1]
CCDS64548.1. [Q13255-3]
RefSeqiNP_001264993.1. NM_001278064.1. [Q13255-1]
NP_001264994.1. NM_001278065.1. [Q13255-2]
NP_001264995.1. NM_001278066.1. [Q13255-2]
NP_001264996.1. NM_001278067.1. [Q13255-3]
XP_011534084.1. XM_011535782.1. [Q13255-1]
XP_016866272.1. XM_017010783.1. [Q13255-1]
XP_016866273.1. XM_017010784.1. [Q13255-1]
XP_016866274.1. XM_017010785.1. [Q13255-2]
XP_016866275.1. XM_017010786.1. [Q13255-2]
XP_016866276.1. XM_017010787.1. [Q13255-2]
UniGeneiHs.32945.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KS9X-ray1.90A/B28-518[»]
4OR2X-ray2.80A/B581-860[»]
ProteinModelPortaliQ13255.
SMRiQ13255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109168. 7 interactors.
DIPiDIP-57522N.
IntActiQ13255. 2 interactors.
MINTiMINT-2806316.
STRINGi9606.ENSP00000282753.

Chemistry databases

BindingDBiQ13255.
ChEMBLiCHEMBL3772.
GuidetoPHARMACOLOGYi289.

Protein family/group databases

TCDBi9.A.14.7.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ13255.
PhosphoSitePlusiQ13255.

Polymorphism and mutation databases

DMDMi311033443.

Proteomic databases

MaxQBiQ13255.
PaxDbiQ13255.
PeptideAtlasiQ13255.
PRIDEiQ13255.

Protocols and materials databases

DNASUi2911.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282753; ENSP00000282753; ENSG00000152822. [Q13255-1]
ENST00000355289; ENSP00000347437; ENSG00000152822. [Q13255-3]
ENST00000361719; ENSP00000354896; ENSG00000152822. [Q13255-1]
ENST00000492807; ENSP00000424095; ENSG00000152822. [Q13255-2]
ENST00000507907; ENSP00000425599; ENSG00000152822. [Q13255-2]
GeneIDi2911.
KEGGihsa:2911.
UCSCiuc003qll.4. human. [Q13255-1]

Organism-specific databases

CTDi2911.
DisGeNETi2911.
GeneCardsiGRM1.
HGNCiHGNC:4593. GRM1.
HPAiHPA015701.
MalaCardsiGRM1.
MIMi604473. gene.
614831. phenotype.
neXtProtiNX_Q13255.
OpenTargetsiENSG00000152822.
Orphaneti324262. Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency.
404507. Chondromyxoid fibroma.
PharmGKBiPA28990.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOVERGENiHBG107965.
InParanoidiQ13255.
KOiK04603.
OMAiKTNETAC.
OrthoDBiEOG091G177R.
PhylomeDBiQ13255.
TreeFamiTF313240.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152822-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
SignaLinkiQ13255.
SIGNORiQ13255.

Miscellaneous databases

EvolutionaryTraceiQ13255.
GeneWikiiMetabotropic_glutamate_receptor_1.
GenomeRNAii2911.
PROiQ13255.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152822.
GenevisibleiQ13255. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SMARTiSM01229. GluR_Homer-bdg. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRM1_HUMAN
AccessioniPrimary (citable) accession number: Q13255
Secondary accession number(s): B9EG79
, F8W805, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.