Q13255 (GRM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metabotropic glutamate receptor 1
Short name=mGluR1

Gene names

Name:	GRM1
Synonyms:	GPRC1A, MGLUR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Subunit structure	Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP By similarity. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein.
Involvement in disease	Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13) [MIM:614831]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Neurodegeneration
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from electronic annotation. Source: Compara activation of MAPKK activity Inferred from electronic annotation. Source: Compara cell death Inferred from electronic annotation. Source: UniProtKB-KW cellular response to electrical stimulus Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara regulation of sensory perception of pain Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement Ref.2. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc nucleus Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: UniProtKB glutamate receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: Q13255-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q13255-2)

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGGQVPKG → KKRQPEFSPTSQCPSAHVQL
     907-1194: Missing.

Note: Ref.1 (AAA87844) sequence is in conflict in positions: 896:T->S and 904:V->A.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

18

Potential

Chain

19 – 1194

1176

Metabotropic glutamate receptor 1

PRO_0000012922

Regions

Topological domain

19 – 592

574

Extracellular Potential

Transmembrane

593 – 615

23

Helical; Name=1; Potential

Topological domain

616 – 629

14

Cytoplasmic Potential

Transmembrane

630 – 650

21

Helical; Name=2; Potential

Topological domain

651 – 661

11

Extracellular Potential

Transmembrane

662 – 680

19

Helical; Name=3; Potential

Topological domain

681 – 706

26

Cytoplasmic Potential

Transmembrane

707 – 727

21

Helical; Name=4; Potential

Topological domain

728 – 750

23

Extracellular Potential

Transmembrane

751 – 772

22

Helical; Name=5; Potential

Topological domain

773 – 785

13

Cytoplasmic Potential

Transmembrane

786 – 808

23

Helical; Name=6; Potential

Topological domain

809 – 814

6

Extracellular Potential

Transmembrane

815 – 840

26

Helical; Name=7; Potential

Topological domain

841 – 1194

354

Cytoplasmic Potential

Compositional bias

1014 – 1035

22

Gln/Pro-rich

Compositional bias

1067 – 1081

15

Gln/Pro-rich

Compositional bias

1095 – 1130

36

Asp/Glu-rich (acidic)

Compositional bias

1142 – 1194

53

Ser-rich

Sites

Binding site

74

1

Glutamate By similarity

Binding site

164

1

Glutamate By similarity

Binding site

188

1

Glutamate By similarity

Binding site

318

1

Glutamate By similarity

Binding site

409

1

Glutamate By similarity

Amino acid modifications

Glycosylation

98

1

N-linked (GlcNAc...) Potential

Glycosylation

223

1

N-linked (GlcNAc...) Potential

Glycosylation

397

1

N-linked (GlcNAc...) Potential

Glycosylation

515

1

N-linked (GlcNAc...) Potential

Disulfide bond

67 ↔ 109

By similarity

Disulfide bond

140

Interchain Ref.5

Disulfide bond

289 ↔ 291

By similarity

Disulfide bond

378 ↔ 394

By similarity

Disulfide bond

432 ↔ 439

By similarity

Natural variations

Alternative sequence

887 – 906

20

NSNGK…QVPKG → KKRQPEFSPTSQCPSAHVQL in isoform Beta.

VSP_002024

Alternative sequence

907 – 1194

288

Missing in isoform Beta.

VSP_002025

Natural variant

34

1

S → Y.
Corresponds to variant rs12190109 [ dbSNP | Ensembl ].

VAR_028184

Natural variant

285

1

R → K.
Corresponds to variant rs7760248 [ dbSNP | Ensembl ].

VAR_028185

Natural variant

593

1

S → P. Ref.1
Corresponds to variant rs1047005 [ dbSNP | Ensembl ].

VAR_055875

Natural variant

696

1

R → W in a colorectal cancer sample; somatic mutation. Ref.7

VAR_036194

Natural variant

741

1

E → D.
Corresponds to variant rs3025919 [ dbSNP | Ensembl ].

VAR_028186

Natural variant

884

1

G → E.
Corresponds to variant rs362936 [ dbSNP | Ensembl ].

VAR_028187

Natural variant

929

1

V → I.
Corresponds to variant rs2941 [ dbSNP | Ensembl ].

VAR_024482

Natural variant

993

1

S → P. Ref.1 Ref.2
Corresponds to variant rs6923492 [ dbSNP | Ensembl ].

VAR_028188

Secondary structure

1

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1194

Helix Strand Turn

Details...

Beta strand

39 – 41

3

Beta strand

44 – 51

8

Helix

59 – 61

3

Turn

62 – 65

4

Turn

72 – 75

4

Helix

76 – 90

15

Beta strand

93 – 96

4

Beta strand

101 – 107

7

Helix

112 – 123

12

Beta strand

156 – 160

5

Helix

165 – 175

11

Helix

176 – 178

3

Beta strand

182 – 186

5

Helix

190 – 193

4

Turn

195 – 197

3

Beta strand

201 – 205

5

Helix

209 – 221

13

Beta strand

226 – 234

9

Helix

235 – 250

16

Beta strand

254 – 261

8

Helix

267 – 278

12

Turn

279 – 284

6

Beta strand

286 – 290

5

Helix

293 – 306

14

Beta strand

313 – 316

4

Turn

318 – 322

5

Helix

324 – 327

4

Helix

331 – 334

4

Beta strand

338 – 342

5

Helix

348 – 354

7

Turn

359 – 361

3

Helix

368 – 375

8

Beta strand

391 – 393

3

Turn

400 – 403

4

Helix

410 – 431

22

Helix

440 – 442

3

Helix

447 – 455

9

Beta strand

458 – 460

3

Beta strand

466 – 468

3

Beta strand

478 – 486

9

Beta strand

492 – 501

10

Beta strand

504 – 507

4

Turn

509 – 511

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified November 2, 2010. Version 3. Checksum: 0A633505F6D51909	FASTA	1,194	132,357
	10 20 30 40 50 60 MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL FSVHHQPPAE 70 80 90 100 110 120 KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT LGSEIRDSCW HSSVALEQSI 130 140 150 160 170 180 EFIRDSLISI RDEKDGINRC LPDGQSLPPG RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI 190 200 210 220 230 240 PQIAYSATSI DLSDKTLYKY FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG 250 260 270 280 290 300 MDAFKELAAQ EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 310 320 330 340 350 360 SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF DDYFLKLRLD 370 380 390 400 410 420 TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL EENYVQDSKM GFVINAIYAM 430 440 450 460 470 480 AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD 490 500 510 520 530 540 IMNLQYTEAN RYDYVHVGTW HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE 550 560 570 580 590 600 VSCCWICTAC KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS 610 620 630 640 650 660 CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA KPTTTSCYLQ 670 680 690 700 710 720 RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF MSAWAQVIIA SILISVQLTL 730 740 750 760 770 780 VVTLIIMEPP MPILSYPSIK EVYLICNTSN LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN 790 800 810 820 830 840 FNEAKYIAFT MYTTCIIWLA FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA 850 860 870 880 890 900 KPERNVRSAF TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNANSNG KSVSWSEPGG 910 920 930 940 950 960 GQVPKGQHMW HRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDTS TKTLYNVEEE 970 980 990 1000 1010 1020 EDAQPIRFSP PGSPSMVVHR RVPSAATTPP LPSHLTAEET PLFLAEPALP KGLPPPLQQQ 1030 1040 1050 1060 1070 1080 QQPPPQQKSL MDQLQGVVSN FSTAIPDFHA VLAGPGGPGN GLRSLYPPPP PPQHLQMLPL 1090 1100 1110 1120 1130 1140 QLSTFGEELV SPPADDDDDS ERFKLLQEYV YEHEREGNTE EDELEEEEED LQAASKLTPD 1150 1160 1170 1180 1190 DSPALTPPSP FRDSVASGSS VPSSPVSESV LCTPPNVSYA SVILRDYKQS SSTL
	Isoform Beta [UniParc]. Checksum: D63470CF9A15361E	FASTA	906	101,323
	10 20 30 40 50 60 MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL FSVHHQPPAE 70 80 90 100 110 120 KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT LGSEIRDSCW HSSVALEQSI 130 140 150 160 170 180 EFIRDSLISI RDEKDGINRC LPDGQSLPPG RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI 190 200 210 220 230 240 PQIAYSATSI DLSDKTLYKY FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG 250 260 270 280 290 300 MDAFKELAAQ EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 310 320 330 340 350 360 SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF DDYFLKLRLD 370 380 390 400 410 420 TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL EENYVQDSKM GFVINAIYAM 430 440 450 460 470 480 AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD 490 500 510 520 530 540 IMNLQYTEAN RYDYVHVGTW HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE 550 560 570 580 590 600 VSCCWICTAC KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS 610 620 630 640 650 660 CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA KPTTTSCYLQ 670 680 690 700 710 720 RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF MSAWAQVIIA SILISVQLTL 730 740 750 760 770 780 VVTLIIMEPP MPILSYPSIK EVYLICNTSN LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN 790 800 810 820 830 840 FNEAKYIAFT MYTTCIIWLA FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA 850 860 870 880 890 900 KPERNVRSAF TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNAKKRQ PEFSPTSQCP SAHVQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter." Desai M.A., Burnett J.P., Mayne N.G., Schoepp D.D. Mol. Pharmacol. 48:648-657(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANTS PRO-593 AND PRO-993.
[2]	"Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants." Stephan D., Bon C., Holzwarth J.A., Galvan M., Pruss R.M. Neuropharmacology 35:1649-1660(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANT PRO-993.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). Tissue: Testis.
[5]	"Cys-140 is critical for metabotropic glutamate receptor-1 dimerization." Ray K., Hauschild B.C. J. Biol. Chem. 275:34245-34251(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERCHAIN DISULFIDE BOND.
[6]	"Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1." Guergueltcheva V., Azmanov D.N., Angelicheva D., Smith K.R., Chamova T., Florez L., Bynevelt M., Nguyen T., Cherninkova S., Bojinova V., Kaprelyan A., Angelova L., Morar B., Chandler D., Kaneva R., Bahlo M., Tournev I., Kalaydjieva L. Am. J. Hum. Genet. 91:553-564(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SCAR13.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-696.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U31215 mRNA. Translation: AAA87843.1.
U31216 mRNA. Translation: AAA87844.1.
L76627 mRNA. Translation: AAB05337.1.
L76631 mRNA. Translation: AAB05338.1.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71181.1.
AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71182.1.
AL096867, AL592423, AL035698 Genomic DNA. Translation: CAI20335.1.
AL096867, AL035698, AL592423 Genomic DNA. Translation: CAI20336.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22468.1.
AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22469.1.
BC136280 mRNA. Translation: AAI36281.1.

IPI

IPI00012363.
IPI00514867.

RefSeq

NP_000829.2. NM_000838.3.
NP_001107801.1. NM_001114329.1.

UniGene

Hs.32945.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3KS9	X-ray	1.90	A/B	28-518	[»]

ProteinModelPortal

Q13255.

SMR

Q13255. Positions 35-582.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-2806316.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

Q13255.

Polymorphism databases

DMDM

311033443.

Proteomic databases

PaxDb

Q13255.

PRIDE

Q13255.

Protocols and materials databases

DNASU

2911.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000282753; ENSP00000282753; ENSG00000152822.
ENST00000361719; ENSP00000354896; ENSG00000152822.
ENST00000392299; ENSP00000376119; ENSG00000152822.
ENST00000492807; ENSP00000424095; ENSG00000152822.
ENST00000507907; ENSP00000425599; ENSG00000152822.

GeneID

2911.

KEGG

hsa:2911.

UCSC

uc003qll.2. human.
uc010khw.1. human.

Organism-specific databases

CTD

2911.

GeneCards

GC06P146390.

HGNC

HGNC:4593. GRM1.

HPA

HPA015701.

MIM

604473. gene.
614831. phenotype.

neXtProt

NX_Q13255.

PharmGKB

PA28990.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG295200.

HOVERGEN

HBG107965.

InParanoid

Q13255.

KO

K04604.

OMA

CTPPNVS.

PhylomeDB

Q13255.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q13255.

Bgee

Q13255.

Genevestigator

Q13255.

Family and domain databases

InterPro

IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
[Graphical view]

Pfam

PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]

PRINTS

PR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.

PROSITE

PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q13255.

ChEMBL

CHEMBL3772.

DrugBank

DB00659. Acamprosate.
DB00142. L-Glutamic Acid.

EvolutionaryTrace

Q13255.

GenomeRNAi

2911.

NextBio

11539.

SOURCE

Search...

Entry information

Entry name

GRM1_HUMAN

Accession

Primary (citable) accession number: Q13255
Secondary accession number(s): B9EG79 , Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 123 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.