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Q13255

- GRM1_HUMAN

UniProt

Q13255 - GRM1_HUMAN

Protein

Metabotropic glutamate receptor 1

Gene

GRM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.2 Publications

    Enzyme regulationi

    Signaling is inhibited by the antagonist LY341495. The LY341495 binding site partially overlaps with the glutamate binding site. Signaling is also inhibited by synthetic allosteric regulators, such as FITM (4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide) that bind in a pocket between the transmembrane helices.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741GlutamateCurated
    Binding sitei165 – 1651GlutamateCurated
    Binding sitei236 – 2361GlutamateBy similarity
    Binding sitei318 – 3181GlutamateBy similarity
    Binding sitei409 – 4091GlutamateBy similarity

    GO - Molecular functioni

    1. glutamate receptor activity Source: UniProtKB
    2. G-protein coupled receptor activity Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. activation of MAPKK activity Source: Ensembl
    3. cell death Source: UniProtKB-KW
    4. cellular response to electrical stimulus Source: Ensembl
    5. dimeric G-protein coupled receptor signaling pathway Source: UniProtKB
    6. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    7. G-protein coupled receptor signaling pathway Source: UniProtKB
    8. locomotory behavior Source: Ensembl
    9. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
    10. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RefGenome
    11. regulation of sensory perception of pain Source: Ensembl
    12. regulation of synaptic transmission, glutamatergic Source: RefGenome
    13. sensory perception of pain Source: Ensembl
    14. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    SignaLinkiQ13255.

    Protein family/group databases

    TCDBi9.A.14.7.1. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 1
    Short name:
    mGluR1
    Gene namesi
    Name:GRM1
    Synonyms:GPRC1A, MGLUR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4593. GRM1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. G-protein coupled receptor dimeric complex Source: UniProtKB
    3. G-protein coupled receptor homodimeric complex Source: FlyBase
    4. integral component of plasma membrane Source: UniProtKB
    5. nucleus Source: Ensembl
    6. plasma membrane Source: Reactome
    7. postsynaptic density Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13) [MIM:614831]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Neurodegeneration

    Organism-specific databases

    MIMi614831. phenotype.
    Orphaneti324262. Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency.
    PharmGKBiPA28990.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 11941176Metabotropic glutamate receptor 1PRO_0000012922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 109
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi140 – 140Interchain
    Glycosylationi223 – 2231N-linked (GlcNAc...)1 Publication
    Disulfide bondi289 ↔ 291By similarity
    Disulfide bondi378 ↔ 394
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi432 ↔ 439
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi657 ↔ 746

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ13255.
    PRIDEiQ13255.

    PTM databases

    PhosphoSiteiQ13255.

    Expressioni

    Tissue specificityi

    Detected in brain.

    Gene expression databases

    ArrayExpressiQ13255.
    BgeeiQ13255.
    GenevestigatoriQ13255.

    Organism-specific databases

    HPAiHPA015701.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KPNA1P522942EBI-8527352,EBI-358383

    Protein-protein interaction databases

    BioGridi109168. 6 interactions.
    IntActiQ13255. 2 interactions.
    MINTiMINT-2806316.

    Structurei

    Secondary structure

    1
    1194
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 413
    Beta strandi44 – 518
    Helixi59 – 613
    Turni62 – 654
    Turni72 – 754
    Helixi76 – 9015
    Beta strandi93 – 964
    Beta strandi101 – 1077
    Helixi112 – 12312
    Beta strandi156 – 1605
    Helixi165 – 17511
    Helixi176 – 1783
    Beta strandi182 – 1865
    Helixi190 – 1934
    Turni195 – 1973
    Beta strandi201 – 2055
    Helixi209 – 22113
    Beta strandi226 – 2349
    Helixi235 – 25016
    Beta strandi254 – 2618
    Helixi267 – 27812
    Turni279 – 2846
    Beta strandi286 – 2905
    Helixi293 – 30614
    Beta strandi313 – 3164
    Turni318 – 3225
    Helixi324 – 3274
    Helixi331 – 3344
    Beta strandi338 – 3425
    Helixi348 – 3547
    Turni359 – 3613
    Helixi368 – 3758
    Beta strandi391 – 3933
    Turni400 – 4034
    Helixi410 – 43122
    Helixi440 – 4423
    Helixi447 – 4559
    Beta strandi458 – 4603
    Beta strandi466 – 4683
    Beta strandi478 – 4869
    Beta strandi492 – 50110
    Beta strandi504 – 5074
    Turni509 – 5113
    Helixi591 – 61626
    Beta strandi618 – 6203
    Helixi621 – 6244
    Helixi628 – 64922
    Helixi654 – 68532
    Helixi703 – 72725
    Beta strandi732 – 7354
    Beta strandi738 – 7403
    Beta strandi742 – 7465
    Helixi750 – 77324
    Turni774 – 7763
    Helixi779 – 80729
    Helixi811 – 83929

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KS9X-ray1.90A/B28-518[»]
    4OR2X-ray2.80A/B581-860[»]
    ProteinModelPortaliQ13255.
    SMRiQ13255. Positions 35-846.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13255.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 592574Extracellular1 PublicationAdd
    BLAST
    Topological domaini616 – 62914Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini651 – 6588Extracellular1 Publication
    Topological domaini681 – 70323Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini728 – 75023Extracellular1 PublicationAdd
    BLAST
    Topological domaini773 – 78513Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini808 – 8158Extracellular1 Publication
    Topological domaini841 – 1194354Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei593 – 61523Helical; Name=1Add
    BLAST
    Transmembranei630 – 65021Helical; Name=2Add
    BLAST
    Transmembranei659 – 68022Helical; Name=3Add
    BLAST
    Transmembranei704 – 72724Helical; Name=4Add
    BLAST
    Transmembranei751 – 77222Helical; Name=5Add
    BLAST
    Transmembranei786 – 80722Helical; Name=6Add
    BLAST
    Transmembranei816 – 84025Helical; Name=7Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni186 – 1883Glutamate bindingCurated

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1014 – 103522Gln/Pro-richAdd
    BLAST
    Compositional biasi1067 – 108115Gln/Pro-richAdd
    BLAST
    Compositional biasi1095 – 113036Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi1142 – 119453Ser-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    HOVERGENiHBG107965.
    InParanoidiQ13255.
    KOiK04603.
    OMAiKTNETAC.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiQ13255.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001256. GPCR_3_mtglu_rcpt_1.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01051. MTABOTROPC1R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: Q13255-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL     50
    FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT 100
    LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGINRC LPDGQSLPPG 150
    RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY 200
    FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ 250
    EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 300
    SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF 350
    DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL 400
    EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL 450
    LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW 500
    HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC 550
    KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS 600
    CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA 650
    KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF 700
    MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN 750
    LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA 800
    FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF 850
    TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNANSNG KSVSWSEPGG 900
    GQVPKGQHMW HRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDTS 950
    TKTLYNVEEE EDAQPIRFSP PGSPSMVVHR RVPSAATTPP LPSHLTAEET 1000
    PLFLAEPALP KGLPPPLQQQ QQPPPQQKSL MDQLQGVVSN FSTAIPDFHA 1050
    VLAGPGGPGN GLRSLYPPPP PPQHLQMLPL QLSTFGEELV SPPADDDDDS 1100
    ERFKLLQEYV YEHEREGNTE EDELEEEEED LQAASKLTPD DSPALTPPSP 1150
    FRDSVASGSS VPSSPVSESV LCTPPNVSYA SVILRDYKQS SSTL 1194
    Length:1,194
    Mass (Da):132,357
    Last modified:November 2, 2010 - v3
    Checksum:i0A633505F6D51909
    GO
    Isoform Beta (identifier: Q13255-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         887-906: NSNGKSVSWSEPGGGQVPKG → KKRQPEFSPTSQCPSAHVQL
         907-1194: Missing.

    Show »
    Length:906
    Mass (Da):101,323
    Checksum:iD63470CF9A15361E
    GO
    Isoform 3 (identifier: Q13255-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         887-908: NSNGKSVSWSEPGGGQVPKGQH → KWRTGAQGTAYVAPPLCAREDQ
         909-1194: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:908
    Mass (Da):101,473
    Checksum:i214EC733A9D585B1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform Beta (identifier: Q13255-2)
    Sequence conflicti896 – 8961T → S in AAA87844. (PubMed:7476890)Curated
    Sequence conflicti904 – 9041V → A in AAA87844. (PubMed:7476890)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341S → Y.
    Corresponds to variant rs12190109 [ dbSNP | Ensembl ].
    VAR_028184
    Natural varianti285 – 2851R → K.
    Corresponds to variant rs7760248 [ dbSNP | Ensembl ].
    VAR_028185
    Natural varianti593 – 5931S → P.1 Publication
    Corresponds to variant rs1047005 [ dbSNP | Ensembl ].
    VAR_055875
    Natural varianti696 – 6961R → W in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036194
    Natural varianti741 – 7411E → D.
    Corresponds to variant rs3025919 [ dbSNP | Ensembl ].
    VAR_028186
    Natural varianti884 – 8841G → E.
    Corresponds to variant rs362936 [ dbSNP | Ensembl ].
    VAR_028187
    Natural varianti929 – 9291V → I.
    Corresponds to variant rs2941 [ dbSNP | Ensembl ].
    VAR_024482
    Natural varianti993 – 9931S → P.2 Publications
    Corresponds to variant rs6923492 [ dbSNP | Ensembl ].
    VAR_028188

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei887 – 90822NSNGK…PKGQH → KWRTGAQGTAYVAPPLCARE DQ in isoform 3. 1 PublicationVSP_055127Add
    BLAST
    Alternative sequencei887 – 90620NSNGK…QVPKG → KKRQPEFSPTSQCPSAHVQL in isoform Beta. 2 PublicationsVSP_002024Add
    BLAST
    Alternative sequencei907 – 1194288Missing in isoform Beta. 2 PublicationsVSP_002025Add
    BLAST
    Alternative sequencei909 – 1194286Missing in isoform 3. 1 PublicationVSP_055128Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31215 mRNA. Translation: AAA87843.1.
    U31216 mRNA. Translation: AAA87844.1.
    L76627 mRNA. Translation: AAB05337.1.
    L76631 mRNA. Translation: AAB05338.1.
    AL031769 Genomic DNA. No translation available.
    AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71181.1.
    AL592423, AL035698, AL096867 Genomic DNA. Translation: CAH71182.1.
    AL096867, AL592423, AL035698 Genomic DNA. Translation: CAI20335.1.
    AL096867, AL035698, AL592423 Genomic DNA. Translation: CAI20336.1.
    AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22468.1.
    AL035698, AL096867, AL592423 Genomic DNA. Translation: CAI22469.1.
    BC136280 mRNA. Translation: AAI36281.1.
    BC143779 mRNA. No translation available.
    CCDSiCCDS47497.1. [Q13255-2]
    CCDS5209.1. [Q13255-1]
    CCDS64548.1. [Q13255-3]
    RefSeqiNP_001264993.1. NM_001278064.1. [Q13255-1]
    NP_001264994.1. NM_001278065.1. [Q13255-2]
    NP_001264995.1. NM_001278066.1. [Q13255-2]
    NP_001264996.1. NM_001278067.1.
    XP_006715530.1. XM_006715467.1. [Q13255-2]
    UniGeneiHs.32945.

    Genome annotation databases

    EnsembliENST00000282753; ENSP00000282753; ENSG00000152822. [Q13255-1]
    ENST00000355289; ENSP00000347437; ENSG00000152822. [Q13255-3]
    ENST00000361719; ENSP00000354896; ENSG00000152822. [Q13255-1]
    ENST00000492807; ENSP00000424095; ENSG00000152822. [Q13255-2]
    ENST00000507907; ENSP00000425599; ENSG00000152822. [Q13255-2]
    GeneIDi2911.
    KEGGihsa:2911.
    UCSCiuc003qll.3. human. [Q13255-2]
    uc010khw.2. human. [Q13255-1]

    Polymorphism databases

    DMDMi311033443.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31215 mRNA. Translation: AAA87843.1 .
    U31216 mRNA. Translation: AAA87844.1 .
    L76627 mRNA. Translation: AAB05337.1 .
    L76631 mRNA. Translation: AAB05338.1 .
    AL031769 Genomic DNA. No translation available.
    AL592423 , AL035698 , AL096867 Genomic DNA. Translation: CAH71181.1 .
    AL592423 , AL035698 , AL096867 Genomic DNA. Translation: CAH71182.1 .
    AL096867 , AL592423 , AL035698 Genomic DNA. Translation: CAI20335.1 .
    AL096867 , AL035698 , AL592423 Genomic DNA. Translation: CAI20336.1 .
    AL035698 , AL096867 , AL592423 Genomic DNA. Translation: CAI22468.1 .
    AL035698 , AL096867 , AL592423 Genomic DNA. Translation: CAI22469.1 .
    BC136280 mRNA. Translation: AAI36281.1 .
    BC143779 mRNA. No translation available.
    CCDSi CCDS47497.1. [Q13255-2 ]
    CCDS5209.1. [Q13255-1 ]
    CCDS64548.1. [Q13255-3 ]
    RefSeqi NP_001264993.1. NM_001278064.1. [Q13255-1 ]
    NP_001264994.1. NM_001278065.1. [Q13255-2 ]
    NP_001264995.1. NM_001278066.1. [Q13255-2 ]
    NP_001264996.1. NM_001278067.1.
    XP_006715530.1. XM_006715467.1. [Q13255-2 ]
    UniGenei Hs.32945.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KS9 X-ray 1.90 A/B 28-518 [» ]
    4OR2 X-ray 2.80 A/B 581-860 [» ]
    ProteinModelPortali Q13255.
    SMRi Q13255. Positions 35-846.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109168. 6 interactions.
    IntActi Q13255. 2 interactions.
    MINTi MINT-2806316.

    Chemistry

    BindingDBi Q13255.
    ChEMBLi CHEMBL3772.
    DrugBanki DB00659. Acamprosate.
    DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 289.

    Protein family/group databases

    TCDBi 9.A.14.7.1. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q13255.

    Polymorphism databases

    DMDMi 311033443.

    Proteomic databases

    PaxDbi Q13255.
    PRIDEi Q13255.

    Protocols and materials databases

    DNASUi 2911.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282753 ; ENSP00000282753 ; ENSG00000152822 . [Q13255-1 ]
    ENST00000355289 ; ENSP00000347437 ; ENSG00000152822 . [Q13255-3 ]
    ENST00000361719 ; ENSP00000354896 ; ENSG00000152822 . [Q13255-1 ]
    ENST00000492807 ; ENSP00000424095 ; ENSG00000152822 . [Q13255-2 ]
    ENST00000507907 ; ENSP00000425599 ; ENSG00000152822 . [Q13255-2 ]
    GeneIDi 2911.
    KEGGi hsa:2911.
    UCSCi uc003qll.3. human. [Q13255-2 ]
    uc010khw.2. human. [Q13255-1 ]

    Organism-specific databases

    CTDi 2911.
    GeneCardsi GC06P146390.
    HGNCi HGNC:4593. GRM1.
    HPAi HPA015701.
    MIMi 604473. gene.
    614831. phenotype.
    neXtProti NX_Q13255.
    Orphaneti 324262. Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency.
    PharmGKBi PA28990.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295200.
    HOVERGENi HBG107965.
    InParanoidi Q13255.
    KOi K04603.
    OMAi KTNETAC.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi Q13255.
    TreeFami TF313240.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    SignaLinki Q13255.

    Miscellaneous databases

    EvolutionaryTracei Q13255.
    GeneWikii Metabotropic_glutamate_receptor_1.
    GenomeRNAii 2911.
    NextBioi 11539.
    PROi Q13255.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13255.
    Bgeei Q13255.
    Genevestigatori Q13255.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001256. GPCR_3_mtglu_rcpt_1.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01051. MTABOTROPC1R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter."
      Desai M.A., Burnett J.P., Mayne N.G., Schoepp D.D.
      Mol. Pharmacol. 48:648-657(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), FUNCTION, VARIANTS PRO-593 AND PRO-993.
    2. "Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants."
      Stephan D., Bon C., Holzwarth J.A., Galvan M., Pruss R.M.
      Neuropharmacology 35:1649-1660(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANT PRO-993.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 3).
      Tissue: Testis.
    5. Cited for: INVOLVEMENT IN SCAR13.
    6. "Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist."
      Structural genomics consortium (SGC)
      Submitted (JUL-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 28-518 IN COMPLEX WITH ANTAGONIST LY341495, GLYCOSYLATION AT ASN-223, DISULFIDE BONDS.
    7. "Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator."
      Wu H., Wang C., Gregory K.J., Han G.W., Cho H.P., Xia Y., Niswender C.M., Katritch V., Meiler J., Cherezov V., Conn P.J., Stevens R.C.
      Science 344:58-64(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 581-860 IN COMPLEX WITH ALLOSTERIC ANTAGONIST, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, DISULFIDE BOND, ENZYME REGULATION.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-696.

    Entry informationi

    Entry nameiGRM1_HUMAN
    AccessioniPrimary (citable) accession number: Q13255
    Secondary accession number(s): B9EG79
    , F8W805, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 139 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3