SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q13253

- NOGG_HUMAN

UniProt

Q13253 - NOGG_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Noggin

Gene
NOG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.1 Publication

GO - Molecular functioni

  1. cytokine binding Source: BHF-UCL
  2. protein binding Source: IntAct
  3. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. axial mesoderm development Source: Ensembl
  2. BMP signaling pathway Source: Reactome
  3. cartilage development Source: UniProtKB-KW
  4. cell differentiation in hindbrain Source: BHF-UCL
  5. cellular response to BMP stimulus Source: Ensembl
  6. dorsal/ventral pattern formation Source: BHF-UCL
  7. embryonic digit morphogenesis Source: BHF-UCL
  8. embryonic skeletal joint morphogenesis Source: BHF-UCL
  9. embryonic skeletal system development Source: BHF-UCL
  10. endoderm formation Source: Ensembl
  11. epithelial to mesenchymal transition Source: UniProtKB
  12. face morphogenesis Source: Ensembl
  13. fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: BHF-UCL
  14. in utero embryonic development Source: Ensembl
  15. limb development Source: BHF-UCL
  16. lung morphogenesis Source: Ensembl
  17. mesoderm formation Source: Ensembl
  18. middle ear morphogenesis Source: BHF-UCL
  19. motor neuron axon guidance Source: Ensembl
  20. negative regulation of apoptotic signaling pathway Source: Ensembl
  21. negative regulation of astrocyte differentiation Source: UniProtKB
  22. negative regulation of BMP signaling pathway Source: UniProtKB
  23. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  24. negative regulation of cardiac muscle cell proliferation Source: UniProtKB
  25. negative regulation of cartilage development Source: Ensembl
  26. negative regulation of cell migration Source: BHF-UCL
  27. negative regulation of cytokine activity Source: BHF-UCL
  28. negative regulation of osteoblast differentiation Source: BHF-UCL
  29. negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  30. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  31. nervous system development Source: ProtInc
  32. neural plate morphogenesis Source: Ensembl
  33. neural tube closure Source: Ensembl
  34. notochord morphogenesis Source: Ensembl
  35. osteoblast differentiation Source: UniProtKB
  36. pituitary gland development Source: Ensembl
  37. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  38. positive regulation of epithelial cell proliferation Source: Ensembl
  39. positive regulation of glomerulus development Source: UniProtKB
  40. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  41. prostatic bud formation Source: Ensembl
  42. regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: BHF-UCL
  43. skeletal system development Source: ProtInc
  44. somatic stem cell maintenance Source: BHF-UCL
  45. somite development Source: Ensembl
  46. spinal cord development Source: Ensembl
  47. ureteric bud formation Source: Ensembl
  48. wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_12034. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Noggin
Gene namesi
Name:NOG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7866. NOG.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Symphalangism, proximal 1A (SYM1A) [MIM:185800]: A disease characterized by the hereditary absence of the proximal interphalangeal joints. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conductive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.
Note: The disease is caused by mutations affecting the gene represented in this entry.4 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351P → R in SYM1A and TCC. 2 Publications
VAR_011361
Natural varianti35 – 351P → S in SYM1A and BDB2. 2 Publications
Corresponds to variant rs28937580 [ dbSNP | Ensembl ].
VAR_018324
Natural varianti184 – 1841C → Y in SYM1A; sporadic; de novo mutation. 1 Publication
VAR_018325
Natural varianti189 – 1891G → C in SYM1A. 1 Publication
VAR_011362
Natural varianti205 – 2051W → C in SYM1A. 1 Publication
VAR_037605
Natural varianti220 – 2201I → N in SYM1A. 1 Publication
VAR_011364
Natural varianti222 – 2221Y → C in SYM1A and TCC. 2 Publications
VAR_011365
Natural varianti222 – 2221Y → D in SYM1A. 1 Publication
VAR_011366
Natural varianti223 – 2231P → L in SYM1A. 1 Publication
VAR_011367
Multiple synostoses syndrome 1 (SYNS1) [MIM:186500]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti217 – 2171W → G in SYNS1. 1 Publication
VAR_011363
Natural varianti232 – 2321C → W in SYNS1. 1 Publication
VAR_064541
Tarsal-carpal coalition syndrome (TCC) [MIM:186570]: Autosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges, short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1, and different mutations in NOG can result in either TCC or SYM1 in different families.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351P → R in SYM1A and TCC. 2 Publications
VAR_011361
Natural varianti204 – 2041R → L in TCC. 1 Publication
VAR_018326
Natural varianti222 – 2221Y → C in SYM1A and TCC. 2 Publications
VAR_011365
Stapes ankylosis with broad thumb and toes (SABTS) [MIM:184460]: Congenital autosomal dominant disorder that includes hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal anomalies but lacked carpal and tarsal fusion and symphalangism.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Brachydactyly B2 (BDB2) [MIM:611377]: A form of brachydactyly characterized by hypoplasia/aplasia of distal phalanges in combination with distal symphalangism, fusion of carpal/tarsal bones and partial cutaneous syndactyly.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351P → A in BDB2. 1 Publication
VAR_036997
Natural varianti35 – 351P → S in SYM1A and BDB2. 2 Publications
Corresponds to variant rs28937580 [ dbSNP | Ensembl ].
VAR_018324
Natural varianti36 – 361A → P in BDB2. 1 Publication
VAR_036998
Natural varianti48 – 481E → K in BDB2. 1 Publication
VAR_036999
Natural varianti167 – 1671R → G in BDB2. 1 Publication
VAR_037000
Natural varianti187 – 1871P → S in BDB2. 1 Publication
VAR_037001

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

MIMi184460. phenotype.
185800. phenotype.
186500. phenotype.
186570. phenotype.
611377. phenotype.
Orphaneti140908. Brachydactyly type B2.
3237. Multiple synostoses syndrome.
3250. Proximal symphalangism.
140917. Stapes ankylosis with broad thumbs and toes.
1412. Tarsal-carpal coalition syndrome.
PharmGKBiPA31670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 232205NogginPRO_0000019813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi155 ↔ 1921 Publication
Disulfide bondi178 ↔ 2281 Publication
Disulfide bondi184 ↔ 2301 Publication
Disulfide bondi207 ↔ 2151 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13253.
PRIDEiQ13253.

PTM databases

PhosphoSiteiQ13253.

Expressioni

Gene expression databases

BgeeiQ13253.
CleanExiHS_NOG.
GenevestigatoriQ13253.

Organism-specific databases

HPAiHPA061318.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BMP2P126432EBI-1035205,EBI-1029262

Protein-protein interaction databases

BioGridi114668. 2 interactions.
IntActiQ13253. 2 interactions.
MINTiMINT-3027418.
STRINGi9606.ENSP00000328181.

Structurei

Secondary structure

1
232
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 324
Helixi58 – 603
Helixi63 – 708
Helixi71 – 733
Turni76 – 783
Beta strandi79 – 824
Helixi99 – 10911
Helixi118 – 1214
Beta strandi129 – 1313
Helixi139 – 15315
Beta strandi158 – 1636
Beta strandi168 – 17710
Beta strandi185 – 1884
Beta strandi191 – 20717
Helixi210 – 2123
Beta strandi214 – 23118

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4UX-ray2.42A28-232[»]
ProteinModelPortaliQ13253.
SMRiQ13253. Positions 28-232.

Miscellaneous databases

EvolutionaryTraceiQ13253.

Family & Domainsi

Sequence similaritiesi

Belongs to the noggin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42124.
HOGENOMiHOG000089944.
HOVERGENiHBG006514.
InParanoidiQ13253.
KOiK04658.
OMAiRFWPRFV.
OrthoDBiEOG7XSTFS.
PhylomeDBiQ13253.
TreeFamiTF353745.

Family and domain databases

Gene3Di2.10.90.10. 2 hits.
InterProiIPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view]
PANTHERiPTHR10494. PTHR10494. 1 hit.
PfamiPF05806. Noggin. 1 hit.
[Graphical view]
PIRSFiPIRSF008129. Noggin. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13253-1 [UniParc]FASTAAdd to Basket

« Hide

MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP    50
DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED 100
LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW 150
SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL 200
TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC 232
Length:232
Mass (Da):25,774
Last modified:November 1, 1996 - v1
Checksum:iFCA0D8E1E2098580
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351P → A in BDB2. 1 Publication
VAR_036997
Natural varianti35 – 351P → R in SYM1A and TCC. 2 Publications
VAR_011361
Natural varianti35 – 351P → S in SYM1A and BDB2. 2 Publications
Corresponds to variant rs28937580 [ dbSNP | Ensembl ].
VAR_018324
Natural varianti36 – 361A → P in BDB2. 1 Publication
VAR_036998
Natural varianti48 – 481E → K in BDB2. 1 Publication
VAR_036999
Natural varianti167 – 1671R → G in BDB2. 1 Publication
VAR_037000
Natural varianti184 – 1841C → Y in SYM1A; sporadic; de novo mutation. 1 Publication
VAR_018325
Natural varianti187 – 1871P → S in BDB2. 1 Publication
VAR_037001
Natural varianti189 – 1891G → C in SYM1A. 1 Publication
VAR_011362
Natural varianti204 – 2041R → L in TCC. 1 Publication
VAR_018326
Natural varianti205 – 2051W → C in SYM1A. 1 Publication
VAR_037605
Natural varianti217 – 2171W → G in SYNS1. 1 Publication
VAR_011363
Natural varianti220 – 2201I → N in SYM1A. 1 Publication
VAR_011364
Natural varianti222 – 2221Y → C in SYM1A and TCC. 2 Publications
VAR_011365
Natural varianti222 – 2221Y → D in SYM1A. 1 Publication
VAR_011366
Natural varianti223 – 2231P → L in SYM1A. 1 Publication
VAR_011367
Natural varianti232 – 2321C → W in SYNS1. 1 Publication
VAR_064541

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31202 Genomic DNA. Translation: AAA83259.1.
BC034027 mRNA. Translation: AAH34027.1.
CCDSiCCDS11589.1.
RefSeqiNP_005441.1. NM_005450.4.
UniGeneiHs.248201.

Genome annotation databases

EnsembliENST00000332822; ENSP00000328181; ENSG00000183691.
GeneIDi9241.
KEGGihsa:9241.
UCSCiuc002iup.2. human.

Polymorphism databases

DMDMi15214099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31202 Genomic DNA. Translation: AAA83259.1 .
BC034027 mRNA. Translation: AAH34027.1 .
CCDSi CCDS11589.1.
RefSeqi NP_005441.1. NM_005450.4.
UniGenei Hs.248201.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M4U X-ray 2.42 A 28-232 [» ]
ProteinModelPortali Q13253.
SMRi Q13253. Positions 28-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114668. 2 interactions.
IntActi Q13253. 2 interactions.
MINTi MINT-3027418.
STRINGi 9606.ENSP00000328181.

PTM databases

PhosphoSitei Q13253.

Polymorphism databases

DMDMi 15214099.

Proteomic databases

PaxDbi Q13253.
PRIDEi Q13253.

Protocols and materials databases

DNASUi 9241.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332822 ; ENSP00000328181 ; ENSG00000183691 .
GeneIDi 9241.
KEGGi hsa:9241.
UCSCi uc002iup.2. human.

Organism-specific databases

CTDi 9241.
GeneCardsi GC17P054671.
HGNCi HGNC:7866. NOG.
HPAi HPA061318.
MIMi 184460. phenotype.
185800. phenotype.
186500. phenotype.
186570. phenotype.
602991. gene.
611377. phenotype.
neXtProti NX_Q13253.
Orphaneti 140908. Brachydactyly type B2.
3237. Multiple synostoses syndrome.
3250. Proximal symphalangism.
140917. Stapes ankylosis with broad thumbs and toes.
1412. Tarsal-carpal coalition syndrome.
PharmGKBi PA31670.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42124.
HOGENOMi HOG000089944.
HOVERGENi HBG006514.
InParanoidi Q13253.
KOi K04658.
OMAi RFWPRFV.
OrthoDBi EOG7XSTFS.
PhylomeDBi Q13253.
TreeFami TF353745.

Enzyme and pathway databases

Reactomei REACT_12034. Signaling by BMP.

Miscellaneous databases

EvolutionaryTracei Q13253.
GeneWikii Noggin_(protein).
GenomeRNAii 9241.
NextBioi 34645.
PROi Q13253.
SOURCEi Search...

Gene expression databases

Bgeei Q13253.
CleanExi HS_NOG.
Genevestigatori Q13253.

Family and domain databases

Gene3Di 2.10.90.10. 2 hits.
InterProi IPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view ]
PANTHERi PTHR10494. PTHR10494. 1 hit.
Pfami PF05806. Noggin. 1 hit.
[Graphical view ]
PIRSFi PIRSF008129. Noggin. 1 hit.
SUPFAMi SSF57501. SSF57501. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of mammalian noggin and its expression in the adult nervous system."
    Valenzuela D.M., Economides A.N., Rojas E., Lamb T.M., Nunez L., Jones P., Ip N.Y., Espinosa R. III, Brannan C.I., Gilbert D.J., Copeland N.G., Jenkins N.A., Le Beau M.M., Harland R.M., Yancopoulos G.D.
    J. Neurosci. 15:6077-6084(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta and Temporal cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin."
    Groppe J., Greenwald J., Wiater E., Rodriguez-Leon J., Economides A.N., Kwiatkowski W., Affolter M., Vale W.W., Belmonte J.C., Choe S.
    Nature 420:636-642(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 28-232 IN COMPLEX WITH BMP7, FUNCTION, SUBUNIT, DISULFIDE BONDS.
  4. Cited for: VARIANTS SYM1A ARG-35; CYS-189; ASN-220; CYS-222; ASP-222 AND LEU-223, VARIANT SYNS1 GLY-217.
  5. "Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome."
    Takahashi T., Takahashi I., Komatsu M., Sawaishi Y., Higashi K., Nishimura G., Saito H., Takada G.
    Clin. Genet. 60:447-451(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SYM1A TYR-184.
  6. "Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism."
    Dixon M.E., Armstrong P., Stevens D.B., Bamshad M.
    Genet. Med. 3:349-353(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TCC ARG-35; LEU-204 AND CYS-222.
  7. "Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin."
    Brown D.J., Kim T.B., Petty E.M., Downs C.A., Martin D.M., Strouse P.J., Moroi S.E., Milunsky J.M., Lesperance M.M.
    Am. J. Hum. Genet. 71:618-624(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SABTS.
  8. "Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism."
    Mangino M., Flex E., Digilio M.C., Giannotti A., Dallapiccola B.
    Hum. Mutat. 19:308-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SYM1A SER-35.
  9. "The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene."
    van den Ende J.J., Mattelaer P., Declau F., Vanhoenacker F., Claes J., Van Hul E., Baten E.
    Clin. Dysmorphol. 14:73-80(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SYM1A CYS-205.
  10. "A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN."
    Lehmann K., Seemann P., Silan F., Goecke T.O., Irgang S., Kjaer K.W., Kjaergaard S., Mahoney M.J., Morlot S., Reissner C., Kerr B., Wilkie A.O.M., Mundlos S.
    Am. J. Hum. Genet. 81:388-396(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS BDB2 ALA-35; SER-35; PRO-36; LYS-48; GLY-167 AND SER-187.
  11. "Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation."
    Rudnik-Schoneborn S., Takahashi T., Busse S., Schmidt T., Senderek J., Eggermann T., Zerres K.
    Am. J. Med. Genet. A 152:1540-1544(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SYNS1 TRP-232.

Entry informationi

Entry nameiNOGG_HUMAN
AccessioniPrimary (citable) accession number: Q13253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi