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Q13253

- NOGG_HUMAN

UniProt

Q13253 - NOGG_HUMAN

Protein

Noggin

Gene

NOG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.1 Publication

    GO - Molecular functioni

    1. cytokine binding Source: BHF-UCL
    2. protein binding Source: IntAct
    3. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. axial mesoderm development Source: Ensembl
    2. BMP signaling pathway Source: Reactome
    3. cartilage development Source: UniProtKB-KW
    4. cell differentiation in hindbrain Source: BHF-UCL
    5. cellular response to BMP stimulus Source: Ensembl
    6. dorsal/ventral pattern formation Source: BHF-UCL
    7. embryonic digit morphogenesis Source: BHF-UCL
    8. embryonic skeletal joint morphogenesis Source: BHF-UCL
    9. embryonic skeletal system development Source: BHF-UCL
    10. endoderm formation Source: Ensembl
    11. epithelial to mesenchymal transition Source: UniProtKB
    12. face morphogenesis Source: Ensembl
    13. fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: BHF-UCL
    14. in utero embryonic development Source: Ensembl
    15. limb development Source: BHF-UCL
    16. lung morphogenesis Source: Ensembl
    17. mesoderm formation Source: Ensembl
    18. middle ear morphogenesis Source: BHF-UCL
    19. motor neuron axon guidance Source: Ensembl
    20. negative regulation of apoptotic signaling pathway Source: Ensembl
    21. negative regulation of astrocyte differentiation Source: UniProtKB
    22. negative regulation of BMP signaling pathway Source: UniProtKB
    23. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    24. negative regulation of cardiac muscle cell proliferation Source: UniProtKB
    25. negative regulation of cartilage development Source: Ensembl
    26. negative regulation of cell migration Source: BHF-UCL
    27. negative regulation of cytokine activity Source: BHF-UCL
    28. negative regulation of osteoblast differentiation Source: BHF-UCL
    29. negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    30. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    31. nervous system development Source: ProtInc
    32. neural plate morphogenesis Source: Ensembl
    33. neural tube closure Source: Ensembl
    34. notochord morphogenesis Source: Ensembl
    35. osteoblast differentiation Source: UniProtKB
    36. pituitary gland development Source: Ensembl
    37. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    38. positive regulation of epithelial cell proliferation Source: Ensembl
    39. positive regulation of glomerulus development Source: UniProtKB
    40. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    41. prostatic bud formation Source: Ensembl
    42. regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: BHF-UCL
    43. skeletal system development Source: ProtInc
    44. somatic stem cell maintenance Source: BHF-UCL
    45. somite development Source: Ensembl
    46. spinal cord development Source: Ensembl
    47. ureteric bud formation Source: Ensembl
    48. wound healing Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Chondrogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_12034. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Noggin
    Gene namesi
    Name:NOG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7866. NOG.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Symphalangism, proximal 1A (SYM1A) [MIM:185800]: A disease characterized by the hereditary absence of the proximal interphalangeal joints. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conductive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351P → R in SYM1A and TCC. 2 Publications
    VAR_011361
    Natural varianti35 – 351P → S in SYM1A and BDB2. 2 Publications
    Corresponds to variant rs28937580 [ dbSNP | Ensembl ].
    VAR_018324
    Natural varianti184 – 1841C → Y in SYM1A; sporadic; de novo mutation. 1 Publication
    VAR_018325
    Natural varianti189 – 1891G → C in SYM1A. 1 Publication
    VAR_011362
    Natural varianti205 – 2051W → C in SYM1A. 1 Publication
    VAR_037605
    Natural varianti220 – 2201I → N in SYM1A. 1 Publication
    VAR_011364
    Natural varianti222 – 2221Y → C in SYM1A and TCC. 2 Publications
    VAR_011365
    Natural varianti222 – 2221Y → D in SYM1A. 1 Publication
    VAR_011366
    Natural varianti223 – 2231P → L in SYM1A. 1 Publication
    VAR_011367
    Multiple synostoses syndrome 1 (SYNS1) [MIM:186500]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti217 – 2171W → G in SYNS1. 1 Publication
    VAR_011363
    Natural varianti232 – 2321C → W in SYNS1. 1 Publication
    VAR_064541
    Tarsal-carpal coalition syndrome (TCC) [MIM:186570]: Autosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges, short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1, and different mutations in NOG can result in either TCC or SYM1 in different families.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351P → R in SYM1A and TCC. 2 Publications
    VAR_011361
    Natural varianti204 – 2041R → L in TCC. 1 Publication
    VAR_018326
    Natural varianti222 – 2221Y → C in SYM1A and TCC. 2 Publications
    VAR_011365
    Stapes ankylosis with broad thumb and toes (SABTS) [MIM:184460]: Congenital autosomal dominant disorder that includes hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal anomalies but lacked carpal and tarsal fusion and symphalangism.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Brachydactyly B2 (BDB2) [MIM:611377]: A form of brachydactyly characterized by hypoplasia/aplasia of distal phalanges in combination with distal symphalangism, fusion of carpal/tarsal bones and partial cutaneous syndactyly.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351P → A in BDB2. 1 Publication
    VAR_036997
    Natural varianti35 – 351P → S in SYM1A and BDB2. 2 Publications
    Corresponds to variant rs28937580 [ dbSNP | Ensembl ].
    VAR_018324
    Natural varianti36 – 361A → P in BDB2. 1 Publication
    VAR_036998
    Natural varianti48 – 481E → K in BDB2. 1 Publication
    VAR_036999
    Natural varianti167 – 1671R → G in BDB2. 1 Publication
    VAR_037000
    Natural varianti187 – 1871P → S in BDB2. 1 Publication
    VAR_037001

    Keywords - Diseasei

    Deafness, Disease mutation

    Organism-specific databases

    MIMi184460. phenotype.
    185800. phenotype.
    186500. phenotype.
    186570. phenotype.
    611377. phenotype.
    Orphaneti140908. Brachydactyly type B2.
    3237. Multiple synostoses syndrome.
    3250. Proximal symphalangism.
    140917. Stapes ankylosis with broad thumbs and toes.
    1412. Tarsal-carpal coalition syndrome.
    PharmGKBiPA31670.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 232205NogginPRO_0000019813Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 1921 Publication
    Disulfide bondi178 ↔ 2281 Publication
    Disulfide bondi184 ↔ 2301 Publication
    Disulfide bondi207 ↔ 2151 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ13253.
    PRIDEiQ13253.

    PTM databases

    PhosphoSiteiQ13253.

    Expressioni

    Gene expression databases

    BgeeiQ13253.
    CleanExiHS_NOG.
    GenevestigatoriQ13253.

    Organism-specific databases

    HPAiHPA061318.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BMP2P126432EBI-1035205,EBI-1029262

    Protein-protein interaction databases

    BioGridi114668. 2 interactions.
    IntActiQ13253. 2 interactions.
    MINTiMINT-3027418.
    STRINGi9606.ENSP00000328181.

    Structurei

    Secondary structure

    1
    232
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 324
    Helixi58 – 603
    Helixi63 – 708
    Helixi71 – 733
    Turni76 – 783
    Beta strandi79 – 824
    Helixi99 – 10911
    Helixi118 – 1214
    Beta strandi129 – 1313
    Helixi139 – 15315
    Beta strandi158 – 1636
    Beta strandi168 – 17710
    Beta strandi185 – 1884
    Beta strandi191 – 20717
    Helixi210 – 2123
    Beta strandi214 – 23118

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1M4UX-ray2.42A28-232[»]
    ProteinModelPortaliQ13253.
    SMRiQ13253. Positions 28-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13253.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the noggin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42124.
    HOGENOMiHOG000089944.
    HOVERGENiHBG006514.
    InParanoidiQ13253.
    KOiK04658.
    OMAiRFWPRFV.
    OrthoDBiEOG7XSTFS.
    PhylomeDBiQ13253.
    TreeFamiTF353745.

    Family and domain databases

    Gene3Di2.10.90.10. 2 hits.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR008717. Noggin.
    [Graphical view]
    PANTHERiPTHR10494. PTHR10494. 1 hit.
    PfamiPF05806. Noggin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF008129. Noggin. 1 hit.
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13253-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP    50
    DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED 100
    LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW 150
    SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL 200
    TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC 232
    Length:232
    Mass (Da):25,774
    Last modified:November 1, 1996 - v1
    Checksum:iFCA0D8E1E2098580
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351P → A in BDB2. 1 Publication
    VAR_036997
    Natural varianti35 – 351P → R in SYM1A and TCC. 2 Publications
    VAR_011361
    Natural varianti35 – 351P → S in SYM1A and BDB2. 2 Publications
    Corresponds to variant rs28937580 [ dbSNP | Ensembl ].
    VAR_018324
    Natural varianti36 – 361A → P in BDB2. 1 Publication
    VAR_036998
    Natural varianti48 – 481E → K in BDB2. 1 Publication
    VAR_036999
    Natural varianti167 – 1671R → G in BDB2. 1 Publication
    VAR_037000
    Natural varianti184 – 1841C → Y in SYM1A; sporadic; de novo mutation. 1 Publication
    VAR_018325
    Natural varianti187 – 1871P → S in BDB2. 1 Publication
    VAR_037001
    Natural varianti189 – 1891G → C in SYM1A. 1 Publication
    VAR_011362
    Natural varianti204 – 2041R → L in TCC. 1 Publication
    VAR_018326
    Natural varianti205 – 2051W → C in SYM1A. 1 Publication
    VAR_037605
    Natural varianti217 – 2171W → G in SYNS1. 1 Publication
    VAR_011363
    Natural varianti220 – 2201I → N in SYM1A. 1 Publication
    VAR_011364
    Natural varianti222 – 2221Y → C in SYM1A and TCC. 2 Publications
    VAR_011365
    Natural varianti222 – 2221Y → D in SYM1A. 1 Publication
    VAR_011366
    Natural varianti223 – 2231P → L in SYM1A. 1 Publication
    VAR_011367
    Natural varianti232 – 2321C → W in SYNS1. 1 Publication
    VAR_064541

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31202 Genomic DNA. Translation: AAA83259.1.
    BC034027 mRNA. Translation: AAH34027.1.
    CCDSiCCDS11589.1.
    RefSeqiNP_005441.1. NM_005450.4.
    UniGeneiHs.248201.

    Genome annotation databases

    EnsembliENST00000332822; ENSP00000328181; ENSG00000183691.
    GeneIDi9241.
    KEGGihsa:9241.
    UCSCiuc002iup.2. human.

    Polymorphism databases

    DMDMi15214099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31202 Genomic DNA. Translation: AAA83259.1 .
    BC034027 mRNA. Translation: AAH34027.1 .
    CCDSi CCDS11589.1.
    RefSeqi NP_005441.1. NM_005450.4.
    UniGenei Hs.248201.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1M4U X-ray 2.42 A 28-232 [» ]
    ProteinModelPortali Q13253.
    SMRi Q13253. Positions 28-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114668. 2 interactions.
    IntActi Q13253. 2 interactions.
    MINTi MINT-3027418.
    STRINGi 9606.ENSP00000328181.

    PTM databases

    PhosphoSitei Q13253.

    Polymorphism databases

    DMDMi 15214099.

    Proteomic databases

    PaxDbi Q13253.
    PRIDEi Q13253.

    Protocols and materials databases

    DNASUi 9241.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332822 ; ENSP00000328181 ; ENSG00000183691 .
    GeneIDi 9241.
    KEGGi hsa:9241.
    UCSCi uc002iup.2. human.

    Organism-specific databases

    CTDi 9241.
    GeneCardsi GC17P054671.
    HGNCi HGNC:7866. NOG.
    HPAi HPA061318.
    MIMi 184460. phenotype.
    185800. phenotype.
    186500. phenotype.
    186570. phenotype.
    602991. gene.
    611377. phenotype.
    neXtProti NX_Q13253.
    Orphaneti 140908. Brachydactyly type B2.
    3237. Multiple synostoses syndrome.
    3250. Proximal symphalangism.
    140917. Stapes ankylosis with broad thumbs and toes.
    1412. Tarsal-carpal coalition syndrome.
    PharmGKBi PA31670.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42124.
    HOGENOMi HOG000089944.
    HOVERGENi HBG006514.
    InParanoidi Q13253.
    KOi K04658.
    OMAi RFWPRFV.
    OrthoDBi EOG7XSTFS.
    PhylomeDBi Q13253.
    TreeFami TF353745.

    Enzyme and pathway databases

    Reactomei REACT_12034. Signaling by BMP.

    Miscellaneous databases

    EvolutionaryTracei Q13253.
    GeneWikii Noggin_(protein).
    GenomeRNAii 9241.
    NextBioi 34645.
    PROi Q13253.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13253.
    CleanExi HS_NOG.
    Genevestigatori Q13253.

    Family and domain databases

    Gene3Di 2.10.90.10. 2 hits.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR008717. Noggin.
    [Graphical view ]
    PANTHERi PTHR10494. PTHR10494. 1 hit.
    Pfami PF05806. Noggin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF008129. Noggin. 1 hit.
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of mammalian noggin and its expression in the adult nervous system."
      Valenzuela D.M., Economides A.N., Rojas E., Lamb T.M., Nunez L., Jones P., Ip N.Y., Espinosa R. III, Brannan C.I., Gilbert D.J., Copeland N.G., Jenkins N.A., Le Beau M.M., Harland R.M., Yancopoulos G.D.
      J. Neurosci. 15:6077-6084(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta and Temporal cortex.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin."
      Groppe J., Greenwald J., Wiater E., Rodriguez-Leon J., Economides A.N., Kwiatkowski W., Affolter M., Vale W.W., Belmonte J.C., Choe S.
      Nature 420:636-642(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 28-232 IN COMPLEX WITH BMP7, FUNCTION, SUBUNIT, DISULFIDE BONDS.
    4. Cited for: VARIANTS SYM1A ARG-35; CYS-189; ASN-220; CYS-222; ASP-222 AND LEU-223, VARIANT SYNS1 GLY-217.
    5. "Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome."
      Takahashi T., Takahashi I., Komatsu M., Sawaishi Y., Higashi K., Nishimura G., Saito H., Takada G.
      Clin. Genet. 60:447-451(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SYM1A TYR-184.
    6. "Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism."
      Dixon M.E., Armstrong P., Stevens D.B., Bamshad M.
      Genet. Med. 3:349-353(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS TCC ARG-35; LEU-204 AND CYS-222.
    7. "Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin."
      Brown D.J., Kim T.B., Petty E.M., Downs C.A., Martin D.M., Strouse P.J., Moroi S.E., Milunsky J.M., Lesperance M.M.
      Am. J. Hum. Genet. 71:618-624(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SABTS.
    8. "Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism."
      Mangino M., Flex E., Digilio M.C., Giannotti A., Dallapiccola B.
      Hum. Mutat. 19:308-308(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SYM1A SER-35.
    9. "The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene."
      van den Ende J.J., Mattelaer P., Declau F., Vanhoenacker F., Claes J., Van Hul E., Baten E.
      Clin. Dysmorphol. 14:73-80(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SYM1A CYS-205.
    10. "A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN."
      Lehmann K., Seemann P., Silan F., Goecke T.O., Irgang S., Kjaer K.W., Kjaergaard S., Mahoney M.J., Morlot S., Reissner C., Kerr B., Wilkie A.O.M., Mundlos S.
      Am. J. Hum. Genet. 81:388-396(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS BDB2 ALA-35; SER-35; PRO-36; LYS-48; GLY-167 AND SER-187.
    11. "Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation."
      Rudnik-Schoneborn S., Takahashi T., Busse S., Schmidt T., Senderek J., Eggermann T., Zerres K.
      Am. J. Med. Genet. A 152:1540-1544(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SYNS1 TRP-232.

    Entry informationi

    Entry nameiNOGG_HUMAN
    AccessioniPrimary (citable) accession number: Q13253
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3