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Protein

Serine/arginine-rich splicing factor 5

Gene

SRSF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 5
Alternative name(s):
Delayed-early protein HRS
Pre-mRNA-splicing factor SRP40
Splicing factor, arginine/serine-rich 5
Gene namesi
Name:SRSF5
Synonyms:HRS, SFRS5, SRP40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100650.15
HGNCiHGNC:10787 SRSF5
MIMi600914 gene
neXtProtiNX_Q13243

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6430
OpenTargetsiENSG00000100650
PharmGKBiPA35703

Polymorphism and mutation databases

BioMutaiSRSF5
DMDMi3929378

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819271 – 272Serine/arginine-rich splicing factor 5Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1
Modified residuei167N6-acetyllysineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13243
PaxDbiQ13243
PeptideAtlasiQ13243
PRIDEiQ13243

PTM databases

iPTMnetiQ13243
PhosphoSitePlusiQ13243
SwissPalmiQ13243

Expressioni

Gene expression databases

BgeeiENSG00000100650
CleanExiHS_SFRS5
ExpressionAtlasiQ13243 baseline and differential
GenevisibleiQ13243 HS

Organism-specific databases

HPAiHPA043484
HPA056523

Interactioni

Subunit structurei

Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.By similarity1 Publication

Protein-protein interaction databases

BioGridi112328, 118 interactors
CORUMiQ13243
DIPiDIP-46894N
IntActiQ13243, 36 interactors
MINTiQ13243
STRINGi9606.ENSP00000377892

Structurei

3D structure databases

ProteinModelPortaliQ13243
SMRiQ13243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 74RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini108 – 181RRM 2PROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 83Gly-rich (hinge region)6
Compositional biasi182 – 267Arg/Ser-rich (RS domain)Add BLAST86

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00910000144049
HOVERGENiHBG002295
InParanoidiQ13243
KOiK12893
OMAiCRVMTGF
OrthoDBiEOG091G0R9W
PhylomeDBiQ13243
TreeFamiTF351335

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform SRP40-1 (identifier: Q13243-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA
60 70 80 90 100
DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN
110 120 130 140 150
APPVRTENRL IVENLSSRVS WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE
160 170 180 190 200
FASYGDLKNA IEKLSGKEIN GRKIKLIEGS KRHSRSRSRS RSRTRSSSRS
210 220 230 240 250
RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ KRGSSSRSKS
260 270
PASVDRQRSR SRSRSRSVDS GN
Length:272
Mass (Da):31,264
Last modified:November 1, 1996 - v1
Checksum:iF13AD79845ECBB16
GO
Isoform SRP40-2 (identifier: Q13243-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-107: NAPPVRTE → YVKGGWLH
     108-272: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:107
Mass (Da):12,528
Checksum:i131B3E530F96F528
GO
Isoform SRP40-3 (identifier: Q13243-4)
Sequence is not available
Length:
Mass (Da):
Isoform SRP40-4 (identifier: Q13243-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-45: Missing.

Note: No experimental confirmation available.
Show »
Length:269
Mass (Da):30,858
Checksum:iEB51CB5B0F51BD78
GO

Sequence cautioni

The sequence AAC39543 differs from that shown. Reason: Frameshift at positions 113 and 140.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014713160A → S. Corresponds to variant dbSNP:rs1057683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00586343 – 45Missing in isoform SRP40-4. Curated3
Alternative sequenceiVSP_005864100 – 107NAPPVRTE → YVKGGWLH in isoform SRP40-2. 5 Publications8
Alternative sequenceiVSP_005865108 – 272Missing in isoform SRP40-2. 5 PublicationsAdd BLAST165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30826 mRNA Translation: AAA93070.1
U30884 mRNA Translation: AAA93074.1
U30827 mRNA Translation: AAB60405.1
BT007089 mRNA Translation: AAP35752.1
AK311805 mRNA Translation: BAG34748.1
CR542167 mRNA Translation: CAG46964.1
CR542182 mRNA Translation: CAG46979.1
BX640605 mRNA Translation: CAE45711.1
AB451250 mRNA Translation: BAG70064.1
BC018823 mRNA Translation: AAH18823.1
BC040209 mRNA Translation: AAH40209.1
AF020307 Genomic DNA Translation: AAC39543.1 Frameshift.
CCDSiCCDS32109.1 [Q13243-1]
PIRiS59042
RefSeqiNP_001034554.1, NM_001039465.1 [Q13243-1]
NP_001307143.1, NM_001320214.1 [Q13243-1]
NP_008856.2, NM_006925.4 [Q13243-1]
UniGeneiHs.632326

Genome annotation databases

EnsembliENST00000394366; ENSP00000377892; ENSG00000100650 [Q13243-1]
ENST00000553521; ENSP00000452123; ENSG00000100650 [Q13243-1]
ENST00000553635; ENSP00000451391; ENSG00000100650 [Q13243-3]
ENST00000557154; ENSP00000451088; ENSG00000100650 [Q13243-1]
GeneIDi6430
KEGGihsa:6430
UCSCiuc001xll.4 human [Q13243-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSRSF5_HUMAN
AccessioniPrimary (citable) accession number: Q13243
Secondary accession number(s): O14797
, Q16662, Q49AD6, Q6FGE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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