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Q13243

- SRSF5_HUMAN

UniProt

Q13243 - SRSF5_HUMAN

Protein

Serine/arginine-rich splicing factor 5

Gene

SRSF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: HGNC

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA 3'-end processing Source: Reactome
    3. mRNA export from nucleus Source: Reactome
    4. mRNA processing Source: ProtInc
    5. mRNA splice site selection Source: ProtInc
    6. mRNA splicing, via spliceosome Source: Reactome
    7. regulation of cell cycle Source: Ensembl
    8. response to wounding Source: Ensembl
    9. RNA splicing Source: Reactome
    10. termination of RNA polymerase II transcription Source: Reactome
    11. transcription from RNA polymerase II promoter Source: Reactome

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1597. Transport of Mature mRNA derived from an Intron-Containing Transcript.
    REACT_1849. mRNA 3'-end processing.
    REACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/arginine-rich splicing factor 5
    Alternative name(s):
    Delayed-early protein HRS
    Pre-mRNA-splicing factor SRP40
    Splicing factor, arginine/serine-rich 5
    Gene namesi
    Name:SRSF5
    Synonyms:HRS, SFRS5, SRP40
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:10787. SRSF5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nuclear speck Source: UniProtKB
    3. nucleolus Source: HPA
    4. nucleoplasm Source: Reactome
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35703.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Serine/arginine-rich splicing factor 5PRO_0000081927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei167 – 1671N6-acetyllysine1 Publication
    Modified residuei227 – 2271Phosphoserine1 Publication
    Modified residuei229 – 2291Phosphoserine1 Publication
    Modified residuei233 – 2331Phosphoserine1 Publication
    Modified residuei250 – 2501Phosphoserine2 Publications
    Modified residuei253 – 2531Phosphoserine2 Publications

    Post-translational modificationi

    Extensively phosphorylated on serine residues in the RS domain.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13243.
    PaxDbiQ13243.
    PRIDEiQ13243.

    PTM databases

    PhosphoSiteiQ13243.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13243.
    BgeeiQ13243.
    CleanExiHS_SFRS5.
    GenevestigatoriQ13243.

    Organism-specific databases

    HPAiHPA043484.
    HPA056523.

    Interactioni

    Subunit structurei

    Interacts (via RS domain) with PHF5A (via N-terminus) By similarity. Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi112328. 96 interactions.
    DIPiDIP-46894N.
    IntActiQ13243. 24 interactions.
    MINTiMINT-1400587.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13243.
    SMRiQ13243. Positions 4-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7471RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini108 – 18174RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi78 – 836Gly-rich (hinge region)
    Compositional biasi182 – 26786Arg/Ser-rich (RS domain)Add
    BLAST

    Sequence similaritiesi

    Belongs to the splicing factor SR family.Curated
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOVERGENiHBG002295.
    InParanoidiQ13243.
    KOiK12893.
    OMAiIIVELAM.
    OrthoDBiEOG7H1JPR.
    PhylomeDBiQ13243.
    TreeFamiTF351335.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 2 hits.
    [Graphical view]
    SMARTiSM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform SRP40-1 (identifier: Q13243-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA    50
    DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN 100
    APPVRTENRL IVENLSSRVS WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE 150
    FASYGDLKNA IEKLSGKEIN GRKIKLIEGS KRHSRSRSRS RSRTRSSSRS 200
    RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ KRGSSSRSKS 250
    PASVDRQRSR SRSRSRSVDS GN 272
    Length:272
    Mass (Da):31,264
    Last modified:November 1, 1996 - v1
    Checksum:iF13AD79845ECBB16
    GO
    Isoform SRP40-2 (identifier: Q13243-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         100-107: NAPPVRTE → YVKGGWLH
         108-272: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:107
    Mass (Da):12,528
    Checksum:i131B3E530F96F528
    GO
    Isoform SRP40-3 (identifier: Q13243-4)

    Sequence is not available
    Length:
    Mass (Da):
    Isoform SRP40-4 (identifier: Q13243-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-45: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:269
    Mass (Da):30,858
    Checksum:iEB51CB5B0F51BD78
    GO

    Sequence cautioni

    The sequence AAC39543.1 differs from that shown. Reason: Frameshift at positions 113 and 140.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti160 – 1601A → S.
    Corresponds to variant rs1057683 [ dbSNP | Ensembl ].
    VAR_014713

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei43 – 453Missing in isoform SRP40-4. CuratedVSP_005863
    Alternative sequencei100 – 1078NAPPVRTE → YVKGGWLH in isoform SRP40-2. 5 PublicationsVSP_005864
    Alternative sequencei108 – 272165Missing in isoform SRP40-2. 5 PublicationsVSP_005865Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30826 mRNA. Translation: AAA93070.1.
    U30884 mRNA. Translation: AAA93074.1.
    U30827 mRNA. Translation: AAB60405.1.
    BT007089 mRNA. Translation: AAP35752.1.
    AK311805 mRNA. Translation: BAG34748.1.
    CR542167 mRNA. Translation: CAG46964.1.
    CR542182 mRNA. Translation: CAG46979.1.
    BX640605 mRNA. Translation: CAE45711.1.
    AB451250 mRNA. Translation: BAG70064.1.
    BC018823 mRNA. Translation: AAH18823.1.
    BC040209 mRNA. Translation: AAH40209.1.
    AF020307 Genomic DNA. Translation: AAC39543.1. Frameshift.
    CCDSiCCDS32109.1. [Q13243-1]
    PIRiS59042.
    RefSeqiNP_001034554.1. NM_001039465.1. [Q13243-1]
    NP_008856.2. NM_006925.3. [Q13243-1]
    XP_005268055.1. XM_005267998.1. [Q13243-1]
    UniGeneiHs.632326.

    Genome annotation databases

    EnsembliENST00000394366; ENSP00000377892; ENSG00000100650. [Q13243-1]
    ENST00000553521; ENSP00000452123; ENSG00000100650. [Q13243-1]
    ENST00000553635; ENSP00000451391; ENSG00000100650. [Q13243-3]
    ENST00000557154; ENSP00000451088; ENSG00000100650. [Q13243-1]
    GeneIDi6430.
    KEGGihsa:6430.
    UCSCiuc001xll.3. human. [Q13243-1]
    uc001xln.1. human. [Q13243-2]

    Polymorphism databases

    DMDMi3929378.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30826 mRNA. Translation: AAA93070.1 .
    U30884 mRNA. Translation: AAA93074.1 .
    U30827 mRNA. Translation: AAB60405.1 .
    BT007089 mRNA. Translation: AAP35752.1 .
    AK311805 mRNA. Translation: BAG34748.1 .
    CR542167 mRNA. Translation: CAG46964.1 .
    CR542182 mRNA. Translation: CAG46979.1 .
    BX640605 mRNA. Translation: CAE45711.1 .
    AB451250 mRNA. Translation: BAG70064.1 .
    BC018823 mRNA. Translation: AAH18823.1 .
    BC040209 mRNA. Translation: AAH40209.1 .
    AF020307 Genomic DNA. Translation: AAC39543.1 . Frameshift.
    CCDSi CCDS32109.1. [Q13243-1 ]
    PIRi S59042.
    RefSeqi NP_001034554.1. NM_001039465.1. [Q13243-1 ]
    NP_008856.2. NM_006925.3. [Q13243-1 ]
    XP_005268055.1. XM_005267998.1. [Q13243-1 ]
    UniGenei Hs.632326.

    3D structure databases

    ProteinModelPortali Q13243.
    SMRi Q13243. Positions 4-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112328. 96 interactions.
    DIPi DIP-46894N.
    IntActi Q13243. 24 interactions.
    MINTi MINT-1400587.

    PTM databases

    PhosphoSitei Q13243.

    Polymorphism databases

    DMDMi 3929378.

    Proteomic databases

    MaxQBi Q13243.
    PaxDbi Q13243.
    PRIDEi Q13243.

    Protocols and materials databases

    DNASUi 6430.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394366 ; ENSP00000377892 ; ENSG00000100650 . [Q13243-1 ]
    ENST00000553521 ; ENSP00000452123 ; ENSG00000100650 . [Q13243-1 ]
    ENST00000553635 ; ENSP00000451391 ; ENSG00000100650 . [Q13243-3 ]
    ENST00000557154 ; ENSP00000451088 ; ENSG00000100650 . [Q13243-1 ]
    GeneIDi 6430.
    KEGGi hsa:6430.
    UCSCi uc001xll.3. human. [Q13243-1 ]
    uc001xln.1. human. [Q13243-2 ]

    Organism-specific databases

    CTDi 6430.
    GeneCardsi GC14P070234.
    HGNCi HGNC:10787. SRSF5.
    HPAi HPA043484.
    HPA056523.
    MIMi 600914. gene.
    neXtProti NX_Q13243.
    PharmGKBi PA35703.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0724.
    HOVERGENi HBG002295.
    InParanoidi Q13243.
    KOi K12893.
    OMAi IIVELAM.
    OrthoDBi EOG7H1JPR.
    PhylomeDBi Q13243.
    TreeFami TF351335.

    Enzyme and pathway databases

    Reactomei REACT_1597. Transport of Mature mRNA derived from an Intron-Containing Transcript.
    REACT_1849. mRNA 3'-end processing.
    REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    ChiTaRSi SRSF5. human.
    GeneWikii SFRS5.
    GenomeRNAii 6430.
    NextBioi 24973.
    PROi Q13243.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13243.
    Bgeei Q13243.
    CleanExi HS_SFRS5.
    Genevestigatori Q13243.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 2 hits.
    [Graphical view ]
    SMARTi SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors."
      Screaton G.R., Caceres J.F., Mayeda A., Bell M.V., Plebanski M., Jackson D.G., Bell J.I., Krainer A.R.
      EMBO J. 14:4336-4349(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SRP40-1 AND SRP40-2).
      Tissue: Colon.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SRP40-1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SRP40-2).
      Tissue: Testis.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SRP40-2).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SRP40-2).
      Tissue: Endometrial tumor.
    6. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SRP40-2).
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SRP40-1).
      Tissue: Skin and Testis.
    8. "Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes."
      Du K., Taub R.
      Gene 204:243-249(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-192, ALTERNATIVE SPLICING.
      Tissue: Thymus.
    9. "SR proteins: a conserved family of pre-mRNA splicing factors."
      Zahler A.M., Lane W.S., Stolk J.A., Roth M.B.
      Genes Dev. 6:837-847(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 130-158.
    10. Cited for: IDENTIFICATION IN A MRNA SPLICING COMPLEX WITH SRSF4; SNRNP70; SNRPA1; SRRM1 AND SRRM2.
    11. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250 AND SER-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227; SER-229; SER-233; SER-250 AND SER-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSRSF5_HUMAN
    AccessioniPrimary (citable) accession number: Q13243
    Secondary accession number(s): O14797
    , Q16662, Q49AD6, Q6FGE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 151 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3