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Q13237

- KGP2_HUMAN

UniProt

Q13237 - KGP2_HUMAN

Protein

cGMP-dependent protein kinase 2

Gene

PRKG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Binding of cGMP results in enzyme activation.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei482 – 4821ATPPROSITE-ProRule annotation
    Active sitei576 – 5761Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi168 – 285118cGMP 1Add
    BLAST
    Nucleotide bindingi286 – 417132cGMP 2Add
    BLAST
    Nucleotide bindingi459 – 4679ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cGMP binding Source: UniProtKB-KW
    3. cGMP-dependent protein kinase activity Source: UniProtKB-EC
    4. protein kinase activity Source: ProtInc

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. circadian regulation of gene expression Source: Ensembl
    3. nitric oxide metabolic process Source: Reactome
    4. protein phosphorylation Source: ProtInc
    5. regulation of nitric-oxide synthase activity Source: Reactome
    6. signal transduction Source: ProtInc
    7. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, cGMP, cGMP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.12. 2681.
    ReactomeiREACT_111176. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
    REACT_172761. Ca2+ pathway.
    REACT_23767. cGMP effects.
    SignaLinkiQ13237.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-dependent protein kinase 2 (EC:2.7.11.12)
    Short name:
    cGK 2
    Short name:
    cGK2
    Alternative name(s):
    cGMP-dependent protein kinase II
    Short name:
    cGKII
    Gene namesi
    Name:PRKG2
    Synonyms:PRKGR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:9416. PRKG2.

    Subcellular locationi

    Apical cell membrane 1 Publication; Lipid-anchor 1 Publication

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33778.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 762761cGMP-dependent protein kinase 2PRO_0000086123Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine1 Publication

    Post-translational modificationi

    Myristoylation mediates membrane localization.1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    PaxDbiQ13237.
    PRIDEiQ13237.

    PTM databases

    PhosphoSiteiQ13237.

    Expressioni

    Tissue specificityi

    Highly concentrated in brain, lung and intestinal mucosa.

    Gene expression databases

    ArrayExpressiQ13237.
    BgeeiQ13237.
    CleanExiHS_PRKG2.
    GenevestigatoriQ13237.

    Organism-specific databases

    HPAiCAB018739.
    HPA007386.

    Interactioni

    Protein-protein interaction databases

    BioGridi111579. 5 interactions.
    IntActiQ13237. 3 interactions.
    STRINGi9606.ENSP00000264399.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13237.
    SMRiQ13237. Positions 77-399, 448-762.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini453 – 711259Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini712 – 76251AGC-kinase C-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233033.
    HOVERGENiHBG006211.
    InParanoidiQ13237.
    KOiK07376.
    OMAiNPPFSGI.
    OrthoDBiEOG75B84Q.
    PhylomeDBiQ13237.
    TreeFamiTF313261.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR000961. AGC-kinase_C.
    IPR016232. cGMP-dependent_protein_kinase.
    IPR002374. cGMP_dep_kinase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014710. RmlC-like_jellyroll.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000559. cGMP-dep_kinase. 1 hit.
    PRINTSiPR00104. CGMPKINASE.
    SMARTiSM00100. cNMP. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00888. CNMP_BINDING_1. 2 hits.
    PS00889. CNMP_BINDING_2. 2 hits.
    PS50042. CNMP_BINDING_3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13237-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNGSVKPKH SKHPDGHSGN LTTDALRNKV TELERELRRK DAEIQEREYH    50
    LKELREQLSK QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASPDK 100
    VPLEVHRKTS GLVSLHSRRG AKAGVSAEPT TRTYDLNKPP EFSFEKARVR 150
    KDSSEKKLIT DALNKNQFLK RLDPQQIKDM VECMYGRNYQ QGSYIIKQGE 200
    PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC TRTASVKAIT 250
    NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300
    CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ 350
    KGEYFGEKAL ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY 400
    LEGYVANLNR DDEKRHAKRS MSNWKLSKAL SLEMIQLKEK VARFSSSSPF 450
    QNLEIIATLG VGGFGRVELV KVKNENVAFA MKCIRKKHIV DTKQQEHVYS 500
    EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS ILRDRGSFDE 550
    PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600
    IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF 650
    SGVDQMMTYN LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN 700
    GINDIKKHRW LNGFNWEGLK ARSLPSPLQR ELKGPIDHSY FDKYPPEKGM 750
    PPDELSGWDK DF 762
    Length:762
    Mass (Da):87,432
    Last modified:November 1, 1996 - v1
    Checksum:iFA7BA149906B5996
    GO
    Isoform 2 (identifier: Q13237-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         441-469: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:733
    Mass (Da):84,398
    Checksum:i913712AC4EC4F8BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 582QL → HG in BAA18934. (PubMed:7498513)Curated
    Sequence conflicti154 – 1541S → I in CAA76073. (PubMed:9535793)Curated
    Sequence conflicti388 – 3881N → D in BAG60035. (PubMed:14702039)Curated
    Sequence conflicti460 – 4601G → A in BAA18934. (PubMed:7498513)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221T → S.
    Corresponds to variant rs34956759 [ dbSNP | Ensembl ].
    VAR_051633
    Natural varianti106 – 1061H → R.1 Publication
    Corresponds to variant rs34616910 [ dbSNP | Ensembl ].
    VAR_040608
    Natural varianti716 – 7161W → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040609

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei441 – 46929Missing in isoform 2. 1 PublicationVSP_055121Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94612 mRNA. Translation: CAA64318.1.
    D70899 mRNA. Translation: BAA18934.1.
    AK297673 mRNA. Translation: BAG60035.1.
    AC098819 Genomic DNA. No translation available.
    AC139722 Genomic DNA. No translation available.
    Y16106
    , Y16107, Y16108, Y16109, Y16110, Y16111, Y16112, Y16113, Y16114, Y16115, Y16116, Y16117, Y16118, Y16119, Y16120, Y16121, Y16122, Y16123 Genomic DNA. Translation: CAA76073.1.
    CCDSiCCDS3589.1. [Q13237-1]
    CCDS64005.1. [Q13237-2]
    PIRiS68217.
    RefSeqiNP_001269409.1. NM_001282480.1.
    NP_001269410.1. NM_001282481.1.
    NP_001269411.1. NM_001282482.1.
    NP_001269412.1. NM_001282483.1.
    NP_001269414.1. NM_001282485.1.
    NP_006250.1. NM_006259.2.
    XP_005263183.1. XM_005263126.1.
    UniGeneiHs.232044.
    Hs.570833.
    Hs.739943.

    Genome annotation databases

    EnsembliENST00000264399; ENSP00000264399; ENSG00000138669. [Q13237-1]
    ENST00000395578; ENSP00000378945; ENSG00000138669. [Q13237-1]
    GeneIDi5593.
    KEGGihsa:5593.
    UCSCiuc003hmh.2. human. [Q13237-1]

    Polymorphism databases

    DMDMi6226833.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94612 mRNA. Translation: CAA64318.1 .
    D70899 mRNA. Translation: BAA18934.1 .
    AK297673 mRNA. Translation: BAG60035.1 .
    AC098819 Genomic DNA. No translation available.
    AC139722 Genomic DNA. No translation available.
    Y16106
    , Y16107 , Y16108 , Y16109 , Y16110 , Y16111 , Y16112 , Y16113 , Y16114 , Y16115 , Y16116 , Y16117 , Y16118 , Y16119 , Y16120 , Y16121 , Y16122 , Y16123 Genomic DNA. Translation: CAA76073.1 .
    CCDSi CCDS3589.1. [Q13237-1 ]
    CCDS64005.1. [Q13237-2 ]
    PIRi S68217.
    RefSeqi NP_001269409.1. NM_001282480.1.
    NP_001269410.1. NM_001282481.1.
    NP_001269411.1. NM_001282482.1.
    NP_001269412.1. NM_001282483.1.
    NP_001269414.1. NM_001282485.1.
    NP_006250.1. NM_006259.2.
    XP_005263183.1. XM_005263126.1.
    UniGenei Hs.232044.
    Hs.570833.
    Hs.739943.

    3D structure databases

    ProteinModelPortali Q13237.
    SMRi Q13237. Positions 77-399, 448-762.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111579. 5 interactions.
    IntActi Q13237. 3 interactions.
    STRINGi 9606.ENSP00000264399.

    Chemistry

    BindingDBi Q13237.
    ChEMBLi CHEMBL2896.
    GuidetoPHARMACOLOGYi 1493.

    PTM databases

    PhosphoSitei Q13237.

    Polymorphism databases

    DMDMi 6226833.

    Proteomic databases

    PaxDbi Q13237.
    PRIDEi Q13237.

    Protocols and materials databases

    DNASUi 5593.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264399 ; ENSP00000264399 ; ENSG00000138669 . [Q13237-1 ]
    ENST00000395578 ; ENSP00000378945 ; ENSG00000138669 . [Q13237-1 ]
    GeneIDi 5593.
    KEGGi hsa:5593.
    UCSCi uc003hmh.2. human. [Q13237-1 ]

    Organism-specific databases

    CTDi 5593.
    GeneCardsi GC04M082009.
    HGNCi HGNC:9416. PRKG2.
    HPAi CAB018739.
    HPA007386.
    MIMi 601591. gene.
    neXtProti NX_Q13237.
    PharmGKBi PA33778.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233033.
    HOVERGENi HBG006211.
    InParanoidi Q13237.
    KOi K07376.
    OMAi NPPFSGI.
    OrthoDBi EOG75B84Q.
    PhylomeDBi Q13237.
    TreeFami TF313261.

    Enzyme and pathway databases

    BRENDAi 2.7.11.12. 2681.
    Reactomei REACT_111176. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
    REACT_172761. Ca2+ pathway.
    REACT_23767. cGMP effects.
    SignaLinki Q13237.

    Miscellaneous databases

    GenomeRNAii 5593.
    NextBioi 21704.
    PROi Q13237.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13237.
    Bgeei Q13237.
    CleanExi HS_PRKG2.
    Genevestigatori Q13237.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR000961. AGC-kinase_C.
    IPR016232. cGMP-dependent_protein_kinase.
    IPR002374. cGMP_dep_kinase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014710. RmlC-like_jellyroll.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000559. cGMP-dep_kinase. 1 hit.
    PRINTSi PR00104. CGMPKINASE.
    SMARTi SM00100. cNMP. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00888. CNMP_BINDING_1. 2 hits.
    PS00889. CNMP_BINDING_2. 2 hits.
    PS50042. CNMP_BINDING_3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase."
      Orstavik S., Solberg R., Taskn K., Nordahl M., Altherr M.R., Hansson V., Jahnsen T., Sandberg M.
      Biochem. Biophys. Res. Commun. 220:759-765(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells."
      Fujii M., Ogata T., Takahashi E., Yamada K., Nakabayashi K., Oishi M., Ayusawa D.
      FEBS Lett. 375:263-267(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Heart.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Characterization of the gene encoding the human type II cGMP-dependent protein kinase."
      Witczak O., Orstavik S., Natarajan V., Frengen E., Jahnsen T., Sandberg M.
      Biochem. Biophys. Res. Commun. 245:113-119(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-734.
    6. "N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II."
      Vaandrager A.B., Ehlert E.M., Jarchau T., Lohmann S.M., de Jonge H.R.
      J. Biol. Chem. 271:7025-7029(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-106 AND ARG-716.

    Entry informationi

    Entry nameiKGP2_HUMAN
    AccessioniPrimary (citable) accession number: Q13237
    Secondary accession number(s): B4DMX3
    , E7EPE6, O00125, O60916
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3