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Q13237

- KGP2_HUMAN

UniProt

Q13237 - KGP2_HUMAN

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Protein
cGMP-dependent protein kinase 2
Gene
PRKG2, PRKGR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Binding of cGMP results in enzyme activation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei482 – 4821ATP By similarity
Active sitei576 – 5761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 285118cGMP 1
Add
BLAST
Nucleotide bindingi286 – 417132cGMP 2
Add
BLAST
Nucleotide bindingi459 – 4679ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cGMP binding Source: UniProtKB-KW
  3. cGMP-dependent protein kinase activity Source: UniProtKB-EC
  4. protein kinase activity Source: ProtInc

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. circadian regulation of gene expression Source: Ensembl
  3. nitric oxide metabolic process Source: Reactome
  4. protein phosphorylation Source: ProtInc
  5. regulation of nitric-oxide synthase activity Source: Reactome
  6. signal transduction Source: ProtInc
  7. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.12. 2681.
ReactomeiREACT_111176. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
REACT_172761. Ca2+ pathway.
REACT_23767. cGMP effects.
SignaLinkiQ13237.

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-dependent protein kinase 2 (EC:2.7.11.12)
Short name:
cGK 2
Short name:
cGK2
Alternative name(s):
cGMP-dependent protein kinase II
Short name:
cGKII
Gene namesi
Name:PRKG2
Synonyms:PRKGR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:9416. PRKG2.

Subcellular locationi

Apical cell membrane; Lipid-anchor 1 Publication

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 762761cGMP-dependent protein kinase 2
PRO_0000086123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Post-translational modificationi

Myristoylation mediates membrane localization.

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ13237.
PRIDEiQ13237.

PTM databases

PhosphoSiteiQ13237.

Expressioni

Tissue specificityi

Highly concentrated in brain, lung and intestinal mucosa.

Gene expression databases

ArrayExpressiQ13237.
BgeeiQ13237.
CleanExiHS_PRKG2.
GenevestigatoriQ13237.

Organism-specific databases

HPAiCAB018739.
HPA007386.

Interactioni

Protein-protein interaction databases

BioGridi111579. 5 interactions.
IntActiQ13237. 2 interactions.
STRINGi9606.ENSP00000264399.

Structurei

3D structure databases

ProteinModelPortaliQ13237.
SMRiQ13237. Positions 77-399, 448-762.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini453 – 711259Protein kinase
Add
BLAST
Domaini712 – 76251AGC-kinase C-terminal
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233033.
HOVERGENiHBG006211.
InParanoidiQ13237.
KOiK07376.
OMAiNPPFSGI.
OrthoDBiEOG75B84Q.
PhylomeDBiQ13237.
TreeFamiTF313261.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSiPR00104. CGMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13237-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGNGSVKPKH SKHPDGHSGN LTTDALRNKV TELERELRRK DAEIQEREYH    50
LKELREQLSK QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASPDK 100
VPLEVHRKTS GLVSLHSRRG AKAGVSAEPT TRTYDLNKPP EFSFEKARVR 150
KDSSEKKLIT DALNKNQFLK RLDPQQIKDM VECMYGRNYQ QGSYIIKQGE 200
PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC TRTASVKAIT 250
NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300
CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ 350
KGEYFGEKAL ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY 400
LEGYVANLNR DDEKRHAKRS MSNWKLSKAL SLEMIQLKEK VARFSSSSPF 450
QNLEIIATLG VGGFGRVELV KVKNENVAFA MKCIRKKHIV DTKQQEHVYS 500
EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS ILRDRGSFDE 550
PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600
IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF 650
SGVDQMMTYN LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN 700
GINDIKKHRW LNGFNWEGLK ARSLPSPLQR ELKGPIDHSY FDKYPPEKGM 750
PPDELSGWDK DF 762
Length:762
Mass (Da):87,432
Last modified:November 1, 1996 - v1
Checksum:iFA7BA149906B5996
GO
Isoform 2 (identifier: Q13237-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-469: Missing.

Note: No experimental confirmation available.

Show »
Length:733
Mass (Da):84,398
Checksum:i913712AC4EC4F8BC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221T → S.
Corresponds to variant rs34956759 [ dbSNP | Ensembl ].
VAR_051633
Natural varianti106 – 1061H → R.1 Publication
Corresponds to variant rs34616910 [ dbSNP | Ensembl ].
VAR_040608
Natural varianti716 – 7161W → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040609

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei441 – 46929Missing in isoform 2.
VSP_055121Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 582QL → HG in BAA18934. 1 Publication
Sequence conflicti154 – 1541S → I in CAA76073. 1 Publication
Sequence conflicti388 – 3881N → D in BAG60035. 1 Publication
Sequence conflicti460 – 4601G → A in BAA18934. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94612 mRNA. Translation: CAA64318.1.
D70899 mRNA. Translation: BAA18934.1.
AK297673 mRNA. Translation: BAG60035.1.
AC098819 Genomic DNA. No translation available.
AC139722 Genomic DNA. No translation available.
Y16106
, Y16107, Y16108, Y16109, Y16110, Y16111, Y16112, Y16113, Y16114, Y16115, Y16116, Y16117, Y16118, Y16119, Y16120, Y16121, Y16122, Y16123 Genomic DNA. Translation: CAA76073.1.
CCDSiCCDS3589.1. [Q13237-1]
PIRiS68217.
RefSeqiNP_001269409.1. NM_001282480.1.
NP_001269410.1. NM_001282481.1.
NP_001269411.1. NM_001282482.1.
NP_001269412.1. NM_001282483.1.
NP_001269414.1. NM_001282485.1.
NP_006250.1. NM_006259.2.
XP_005263183.1. XM_005263126.1.
UniGeneiHs.232044.
Hs.570833.
Hs.739943.

Genome annotation databases

EnsembliENST00000264399; ENSP00000264399; ENSG00000138669.
ENST00000395578; ENSP00000378945; ENSG00000138669.
ENST00000418486; ENSP00000389038; ENSG00000138669.
GeneIDi5593.
KEGGihsa:5593.
UCSCiuc003hmh.2. human. [Q13237-1]

Polymorphism databases

DMDMi6226833.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94612 mRNA. Translation: CAA64318.1 .
D70899 mRNA. Translation: BAA18934.1 .
AK297673 mRNA. Translation: BAG60035.1 .
AC098819 Genomic DNA. No translation available.
AC139722 Genomic DNA. No translation available.
Y16106
, Y16107 , Y16108 , Y16109 , Y16110 , Y16111 , Y16112 , Y16113 , Y16114 , Y16115 , Y16116 , Y16117 , Y16118 , Y16119 , Y16120 , Y16121 , Y16122 , Y16123 Genomic DNA. Translation: CAA76073.1 .
CCDSi CCDS3589.1. [Q13237-1 ]
PIRi S68217.
RefSeqi NP_001269409.1. NM_001282480.1.
NP_001269410.1. NM_001282481.1.
NP_001269411.1. NM_001282482.1.
NP_001269412.1. NM_001282483.1.
NP_001269414.1. NM_001282485.1.
NP_006250.1. NM_006259.2.
XP_005263183.1. XM_005263126.1.
UniGenei Hs.232044.
Hs.570833.
Hs.739943.

3D structure databases

ProteinModelPortali Q13237.
SMRi Q13237. Positions 77-399, 448-762.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111579. 5 interactions.
IntActi Q13237. 2 interactions.
STRINGi 9606.ENSP00000264399.

Chemistry

BindingDBi Q13237.
ChEMBLi CHEMBL2896.
GuidetoPHARMACOLOGYi 1493.

PTM databases

PhosphoSitei Q13237.

Polymorphism databases

DMDMi 6226833.

Proteomic databases

PaxDbi Q13237.
PRIDEi Q13237.

Protocols and materials databases

DNASUi 5593.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264399 ; ENSP00000264399 ; ENSG00000138669 .
ENST00000395578 ; ENSP00000378945 ; ENSG00000138669 .
ENST00000418486 ; ENSP00000389038 ; ENSG00000138669 .
GeneIDi 5593.
KEGGi hsa:5593.
UCSCi uc003hmh.2. human. [Q13237-1 ]

Organism-specific databases

CTDi 5593.
GeneCardsi GC04M082009.
HGNCi HGNC:9416. PRKG2.
HPAi CAB018739.
HPA007386.
MIMi 601591. gene.
neXtProti NX_Q13237.
PharmGKBi PA33778.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233033.
HOVERGENi HBG006211.
InParanoidi Q13237.
KOi K07376.
OMAi NPPFSGI.
OrthoDBi EOG75B84Q.
PhylomeDBi Q13237.
TreeFami TF313261.

Enzyme and pathway databases

BRENDAi 2.7.11.12. 2681.
Reactomei REACT_111176. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
REACT_172761. Ca2+ pathway.
REACT_23767. cGMP effects.
SignaLinki Q13237.

Miscellaneous databases

GenomeRNAii 5593.
NextBioi 21704.
PROi Q13237.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13237.
Bgeei Q13237.
CleanExi HS_PRKG2.
Genevestigatori Q13237.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSi PR00104. CGMPKINASE.
SMARTi SM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase."
    Orstavik S., Solberg R., Taskn K., Nordahl M., Altherr M.R., Hansson V., Jahnsen T., Sandberg M.
    Biochem. Biophys. Res. Commun. 220:759-765(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells."
    Fujii M., Ogata T., Takahashi E., Yamada K., Nakabayashi K., Oishi M., Ayusawa D.
    FEBS Lett. 375:263-267(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Heart.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Characterization of the gene encoding the human type II cGMP-dependent protein kinase."
    Witczak O., Orstavik S., Natarajan V., Frengen E., Jahnsen T., Sandberg M.
    Biochem. Biophys. Res. Commun. 245:113-119(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-734.
  6. "N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II."
    Vaandrager A.B., Ehlert E.M., Jarchau T., Lohmann S.M., de Jonge H.R.
    J. Biol. Chem. 271:7025-7029(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-106 AND ARG-716.

Entry informationi

Entry nameiKGP2_HUMAN
AccessioniPrimary (citable) accession number: Q13237
Secondary accession number(s): B4DMX3
, E7EPE6, O00125, O60916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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