cGMP-dependent protein kinase 2 - Homo sapiens (Human)

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Q13237 (KGP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
cGMP-dependent protein kinase 2
Short name=cGK 2
Short name=cGK2
EC=2.7.11.12

Alternative name(s):
cGMP-dependent protein kinase II
Short name=cGKII

Gene names

Name:	PRKG2
Synonyms:	PRKGR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	762 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Binding of cGMP results in enzyme activation.
Tissue specificity	Highly concentrated in brain, lung and intestinal mucosa.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 cyclic nucleotide-binding domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding cGMP cGMP-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Nitration
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	platelet activation Traceable author statement. Source: Reactome signal transduction Traceable author statement. Source: ProtInc
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cGMP binding Inferred from electronic annotation. Source: UniProtKB-KW cGMP-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 762

762

cGMP-dependent protein kinase 2

PRO_0000086123

Regions

Domain

453 – 711

259

Protein kinase

Domain

712 – 762

AGC-kinase C-terminal

Nucleotide binding

168 – 285

118

cGMP 1

Nucleotide binding

286 – 417

132

cGMP 2

Nucleotide binding

459 – 467

ATP By similarity

Sites

Active site

576

Proton acceptor By similarity

Binding site

482

ATP By similarity

Amino acid modifications

Modified residue

354

Nitrated tyrosine Ref.4

Natural variations

Natural variant

T → S.
Corresponds to variant rs34956759 [ dbSNP | Ensembl ].

VAR_051633

Natural variant

106

H → R. Ref.5
Corresponds to variant rs34616910 [ dbSNP | Ensembl ].

VAR_040608

Natural variant

716

W → R in a colorectal adenocarcinoma sample; somatic mutation. Ref.5

VAR_040609

Experimental info

Sequence conflict

57 – 58

QL → HG in BAA18934. Ref.2

Sequence conflict

154

S → I in CAA76073. Ref.3

Sequence conflict

460

G → A in BAA18934. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q13237 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FA7BA149906B5996
Show »

FASTA

762

87,432

        10         20         30         40         50         60 
MGNGSVKPKH SKHPDGHSGN LTTDALRNKV TELERELRRK DAEIQEREYH LKELREQLSK 

        70         80         90        100        110        120 
QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASPDK VPLEVHRKTS GLVSLHSRRG 

       130        140        150        160        170        180 
AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 

       190        200        210        220        230        240 
VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 

       250        260        270        280        290        300 
TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 

       310        320        330        340        350        360 
CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 

       370        380        390        400        410        420 
ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 

       430        440        450        460        470        480 
MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 

       490        500        510        520        530        540 
MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 

       550        560        570        580        590        600 
ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 

       610        620        630        640        650        660 
IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGVDQMMTYN 

       670        680        690        700        710        720 
LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 

       730        740        750        760 
ARSLPSPLQR ELKGPIDHSY FDKYPPEKGM PPDELSGWDK DF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase." Orstavik S., Solberg R., Taskn K., Nordahl M., Altherr M.R., Hansson V., Jahnsen T., Sandberg M. Biochem. Biophys. Res. Commun. 220:759-765(1996) [PubMed: 8607838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells." Fujii M., Ogata T., Takahashi E., Yamada K., Nakabayashi K., Oishi M., Ayusawa D. FEBS Lett. 375:263-267(1995) [PubMed: 7498513] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Characterization of the gene encoding the human type II cGMP-dependent protein kinase." Witczak O., Orstavik S., Natarajan V., Frengen E., Jahnsen T., Sandberg M. Biochem. Biophys. Res. Commun. 245:113-119(1998) [PubMed: 9535793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-734.
[4]	"The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry." Zhan X., Desiderio D.M. Biochem. Biophys. Res. Commun. 325:1180-1186(2004) [PubMed: 15555551] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-354, MASS SPECTROMETRY. Tissue: Pituitary.
[5]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-106 AND ARG-716.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94612 mRNA. Translation: CAA64318.1. D70899 mRNA. Translation: BAA18934.1. Y16106 Y16123 Genomic DNA. Translation: CAA76073.1.
IPI	IPI00012322.
PIR	S68217.
RefSeq	NP_006250.1. NM_006259.1.
UniGene	Hs.570833.
3D structure databases
ProteinModelPortal	Q13237.
SMR	Q13237. Positions 119-403, 447-762.
ModBase	Search...
Protein-protein interaction databases
STRING	Q13237.
PTM databases
PhosphoSite	Q13237.
Polymorphism databases
DMDM	6226833.
Proteomic databases
PRIDE	Q13237.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264399; ENSP00000264399; ENSG00000138669. ENST00000395578; ENSP00000378945; ENSG00000138669.
GeneID	5593.
KEGG	hsa:5593.
UCSC	uc003hmh.1. human.
Organism-specific databases
CTD	5593.
GeneCards	GC04M082009.
H-InvDB	HIX0031503.
HGNC	HGNC:9416. PRKG2.
HPA	CAB018739. HPA007386.
MIM	601591. gene.
neXtProt	NX_Q13237.
PharmGKB	PA33778.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07432.
GeneTree	ENSGT00550000074358.
HOGENOM	HBG755340.
HOVERGEN	HBG006211.
InParanoid	Q13237.
OMA	TKQQEHI.
OrthoDB	EOG4V6ZFZ.
PhylomeDB	Q13237.
Enzyme and pathway databases
BRENDA	2.7.11.12. 2681.
Reactome	REACT_111217. Metabolism. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q13237.
Bgee	Q13237.
CleanEx	HS_PRKG2.
Genevestigator	Q13237.
GermOnline	ENSG00000138669. Homo sapiens.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR016232. cGMP-dependent_protein_kinase. IPR002374. cGMP_dep_kinase. IPR018490. cNMP-bd-like. IPR018488. cNMP-bd_CS. IPR000595. cNMP-bd_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR014710. RmlC-like_jellyroll. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits.
KO	K07376.
Pfam	PF00027. cNMP_binding. 2 hits. PF00069. Pkinase. 1 hit. [Graphical view]
PIRSF	PIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTS	PR00104. CGMPKINASE.
SMART	SM00100. cNMP. 2 hits. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF51206. cNMP_binding. 2 hits. SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00888. CNMP_BINDING_1. 2 hits. PS00889. CNMP_BINDING_2. 2 hits. PS50042. CNMP_BINDING_3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	21704.
SOURCE	Search...

Entry information

Entry name

KGP2_HUMAN

Accession

Primary (citable) accession number: Q13237
Secondary accession number(s): O00125, O60916

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human and mouse protein kinases: classification and index

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents