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Q13233

- M3K1_HUMAN

UniProt

Q13233 - M3K1_HUMAN

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Protein

Mitogen-activated protein kinase kinase kinase 1

Gene

MAP3K1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.

Enzyme regulationi

Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1272 – 12721ATPPROSITE-ProRule annotation
Active sitei1369 – 13691Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri338 – 36629SWIM-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 49250RING-typePROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi1249 – 12579ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. JUN kinase kinase activity Source: Ensembl
  3. MAP kinase kinase kinase activity Source: UniProtKB
  4. protein kinase activity Source: MGI
  5. protein kinase binding Source: UniProtKB
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. activation of MAPKK activity Source: GOC
  2. apoptotic mitochondrial changes Source: Ensembl
  3. cellular response to mechanical stimulus Source: UniProtKB
  4. epithelial cell morphogenesis Source: Ensembl
  5. eyelid development in camera-type eye Source: Ensembl
  6. Fc-epsilon receptor signaling pathway Source: Reactome
  7. innate immune response Source: Reactome
  8. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  9. positive regulation of actin filament polymerization Source: Ensembl
  10. protein phosphorylation Source: UniProtKB
  11. regulation of cell migration Source: Ensembl
  12. toll-like receptor 10 signaling pathway Source: Reactome
  13. toll-like receptor 2 signaling pathway Source: Reactome
  14. toll-like receptor 4 signaling pathway Source: Reactome
  15. toll-like receptor 5 signaling pathway Source: Reactome
  16. toll-like receptor 9 signaling pathway Source: Reactome
  17. toll-like receptor signaling pathway Source: Reactome
  18. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  19. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  20. transforming growth factor beta receptor signaling pathway Source: Ensembl
  21. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_163701. FCERI mediated MAPK activation.
REACT_24969. TRAF6 mediated NF-kB activation.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_27215. MyD88 cascade initiated on plasma membrane.
REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
SignaLinkiQ13233.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 1 (EC:2.7.11.25)
Alternative name(s):
MAPK/ERK kinase kinase 1
Short name:
MEK kinase 1
Short name:
MEKK 1
Gene namesi
Name:MAP3K1
Synonyms:MAPKKK1, MEKK, MEKK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6848. MAP3K1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891L → P in SRXY6; increases phosphorylation of the downstream target MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
VAR_065504
Natural varianti189 – 1891L → R in SRXY6; increases phosphorylation of the downstream targets MAPK14 and MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
VAR_065505
Natural varianti211 – 2111V → VIQ in SRXY6.
VAR_065506
Natural varianti616 – 6161G → R in SRXY6. 1 Publication
Corresponds to variant rs143853590 [ dbSNP | Ensembl ].
VAR_065507

Organism-specific databases

MIMi613762. phenotype.
Orphaneti242. 46,XY complete gonadal dysgenesis.
251510. 46,XY partial gonadal dysgenesis.
PharmGKBiPA30592.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 15121511Mitogen-activated protein kinase kinase kinase 1PRO_0000086240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei137 – 1371PhosphoserineBy similarity
Modified residuei154 – 1541Phosphoserine1 Publication
Modified residuei275 – 2751Phosphoserine1 Publication
Modified residuei292 – 2921Phosphoserine3 Publications
Modified residuei297 – 2971Phosphoserine1 Publication
Modified residuei300 – 3001Phosphoserine1 Publication
Modified residuei507 – 5071Phosphoserine1 Publication
Modified residuei1018 – 10181Phosphoserine1 Publication
Modified residuei1043 – 10431Phosphoserine1 Publication
Modified residuei1400 – 14001Phosphothreonine; by autocatalysisBy similarity
Modified residuei1412 – 14121Phosphothreonine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ13233.
PaxDbiQ13233.
PRIDEiQ13233.

2D gel databases

SWISS-2DPAGEQ13233.

PTM databases

PhosphoSiteiQ13233.

Expressioni

Gene expression databases

BgeeiQ13233.
CleanExiHS_MAP3K1.
GenevestigatoriQ13233.

Organism-specific databases

HPAiCAB004500.
HPA046509.

Interactioni

Subunit structurei

Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARRB2P321212EBI-49776,EBI-714559
BRAFP150562EBI-49776,EBI-365980
DCAF7P619627EBI-49776,EBI-359808
FLNBO753692EBI-49776,EBI-352089
MAP2K4P459853EBI-49776,EBI-447868
MAP4K2Q128512EBI-49776,EBI-49783
TRAF2Q129332EBI-49776,EBI-355744

Protein-protein interaction databases

BioGridi110378. 61 interactions.
DIPiDIP-27520N.
IntActiQ13233. 34 interactions.
MINTiMINT-143285.
STRINGi9606.ENSP00000382423.

Structurei

3D structure databases

ProteinModelPortaliQ13233.
SMRiQ13233. Positions 1248-1506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1243 – 1508266Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 54Poly-Ala
Compositional biasi25 – 295Poly-Gly
Compositional biasi36 – 416Poly-Ala
Compositional biasi422 – 43110Poly-Ser
Compositional biasi842 – 8476Poly-Ser
Compositional biasi942 – 9498Poly-Thr
Compositional biasi1182 – 11876Poly-Glu
Compositional biasi1216 – 12194Poly-Ile

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri338 – 36629SWIM-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 49250RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119077.
HOGENOMiHOG000113437.
HOVERGENiHBG006302.
InParanoidiQ13233.
KOiK04416.
OMAiSTHFTRM.
OrthoDBiEOG7MSMNV.
PhylomeDBiQ13233.
TreeFamiTF105112.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13233-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAGNRAS SSGFPGARAT SPEAGGGGGA LKASSAPAAA AGLLREAGSG
60 70 80 90 100
GRERADWRRR QLRKVRSVEL DQLPEQPLFL AASPPASSTS PSPEPADAAG
110 120 130 140 150
SGTGFQPVAV PPPHGAASRG GAHLTESVAA PDSGASSPAA AEPGEKRAPA
160 170 180 190 200
AEPSPAAAPA GREMENKETL KGLHKMDDRP EERMIREKLK ATCMPAWKHE
210 220 230 240 250
WLERRNRRGP VVVKPIPVKG DGSEMNHLAA ESPGEVQASA ASPASKGRRS
260 270 280 290 300
PSPGNSPSGR TVKSESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS
310 320 330 340 350
PEETNRRVNK VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCA
360 370 380 390 400
RGTFCIHLLF VMLRVFQLEP SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI
410 420 430 440 450
KAPSRNTIQK FVSRMSNSHT LSSSSTSTSS SENSIKDEEE QMCPICLLGM
460 470 480 490 500
LDEESLTVCE DGCRNKLHHH CMSIWAEECR RNREPLICPL CRSKWRSHDF
510 520 530 540 550
YSHELSSPVD SPSSLRAAQQ QTVQQQPLAG SRRNQESNFN LTHYGTQQIP
560 570 580 590 600
PAYKDLAEPW IQVFGMELVG CLFSRNWNVR EMALRRLSHD VSGALLLANG
610 620 630 640 650
ESTGNSGGSS GSSPSGGATS GSSQTSISGD VVEACCSVLS MVCADPVYKV
660 670 680 690 700
YVAALKTLRA MLVYTPCHSL AERIKLQRLL QPVVDTILVK CADANSRTSQ
710 720 730 740 750
LSISTLLELC KGQAGELAVG REILKAGSIG IGGVDYVLNC ILGNQTESNN
760 770 780 790 800
WQELLGRLCL IDRLLLEFPA EFYPHIVSTD VSQAEPVEIR YKKLLSLLTF
810 820 830 840 850
ALQSIDNSHS MVGKLSRRIY LSSARMVTTV PHVFSKLLEM LSVSSSTHFT
860 870 880 890 900
RMRRRLMAIA DEVEIAEAIQ LGVEDTLDGQ QDSFLQASVP NNYLETTENS
910 920 930 940 950
SPECTVHLEK TGKGLCATKL SASSEDISER LASISVGPSS STTTTTTTTE
960 970 980 990 1000
QPKPMVQTKG RPHSQCLNSS PLSHHSQLMF PALSTPSSST PSVPAGTATD
1010 1020 1030 1040 1050
VSKHRLQGFI PCRIPSASPQ TQRKFSLQFH RNCPENKDSD KLSPVFTQSR
1060 1070 1080 1090 1100
PLPSSNIHRP KPSRPTPGNT SKQGDPSKNS MTLDLNSSSK CDDSFGCSSN
1110 1120 1130 1140 1150
SSNAVIPSDE TVFTPVEEKC RLDVNTELNS SIEDLLEASM PSSDTTVTFK
1160 1170 1180 1190 1200
SEVAVLSPEK AENDDTYKDD VNHNQKCKEK MEAEEEEALA IAMAMSASQD
1210 1220 1230 1240 1250
ALPIVPQLQV ENGEDIIIIQ QDTPETLPGH TKAKQPYRED TEWLKGQQIG
1260 1270 1280 1290 1300
LGAFSSCYQA QDVGTGTLMA VKQVTYVRNT SSEQEEVVEA LREEIRMMSH
1310 1320 1330 1340 1350
LNHPNIIRML GATCEKSNYN LFIEWMAGGS VAHLLSKYGA FKESVVINYT
1360 1370 1380 1390 1400
EQLLRGLSYL HENQIIHRDV KGANLLIDST GQRLRIADFG AAARLASKGT
1410 1420 1430 1440 1450
GAGEFQGQLL GTIAFMAPEV LRGQQYGRSC DVWSVGCAII EMACAKPPWN
1460 1470 1480 1490 1500
AEKHSNHLAL IFKIASATTA PSIPSHLSPG LRDVALRCLE LQPQDRPPSR
1510
ELLKHPVFRT TW
Length:1,512
Mass (Da):164,470
Last modified:December 16, 2008 - v4
Checksum:i5CB78242295411D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201T → P in AAC97073. (PubMed:9808624)Curated
Sequence conflicti37 – 371P → R in AAC97073. (PubMed:9808624)Curated
Sequence conflicti120 – 1201G → R in AAC97073. (PubMed:9808624)Curated
Sequence conflicti351 – 3511R → H in AAC97073. (PubMed:9808624)Curated
Sequence conflicti845 – 8451S → SV in AAC97073. (PubMed:9808624)Curated
Sequence conflicti859 – 8591I → Y in AAC97073. (PubMed:9808624)Curated
Sequence conflicti878 – 90225DGQQD…ENSSP → QRQQHNSFCRHLFPTTIWKP QRTVPL in AAC97073. (PubMed:9808624)CuratedAdd
BLAST
Sequence conflicti933 – 9331S → R in AAC97073. (PubMed:9808624)Curated
Sequence conflicti1097 – 10971C → L in AAC97073. (PubMed:9808624)Curated
Sequence conflicti1104 – 11074AVIP → CCYT in AAC97073. (PubMed:9808624)Curated
Sequence conflicti1200 – 12001D → V in AAC97073. (PubMed:9808624)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921S → N.1 Publication
VAR_040680
Natural varianti189 – 1891L → P in SRXY6; increases phosphorylation of the downstream target MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
VAR_065504
Natural varianti189 – 1891L → R in SRXY6; increases phosphorylation of the downstream targets MAPK14 and MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
VAR_065505
Natural varianti211 – 2111V → VIQ in SRXY6.
VAR_065506
Natural varianti443 – 4431C → S.1 Publication
VAR_040681
Natural varianti616 – 6161G → R in SRXY6. 1 Publication
Corresponds to variant rs143853590 [ dbSNP | Ensembl ].
VAR_065507
Natural varianti806 – 8061D → N.
Corresponds to variant rs702689 [ dbSNP | Ensembl ].
VAR_051636
Natural varianti906 – 9061V → I.
Corresponds to variant rs832582 [ dbSNP | Ensembl ].
VAR_051637

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008937 Genomic DNA. No translation available.
AF042838 mRNA. Translation: AAC97073.1.
U29671 Genomic DNA. Translation: AAB05828.1.
CCDSiCCDS43318.1.
PIRiG01887.
RefSeqiNP_005912.1. NM_005921.1.
UniGeneiHs.653654.

Genome annotation databases

EnsembliENST00000399503; ENSP00000382423; ENSG00000095015.
GeneIDi4214.
KEGGihsa:4214.
UCSCiuc003jqw.4. human.

Polymorphism databases

DMDMi218512139.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008937 Genomic DNA. No translation available.
AF042838 mRNA. Translation: AAC97073.1 .
U29671 Genomic DNA. Translation: AAB05828.1 .
CCDSi CCDS43318.1.
PIRi G01887.
RefSeqi NP_005912.1. NM_005921.1.
UniGenei Hs.653654.

3D structure databases

ProteinModelPortali Q13233.
SMRi Q13233. Positions 1248-1506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110378. 61 interactions.
DIPi DIP-27520N.
IntActi Q13233. 34 interactions.
MINTi MINT-143285.
STRINGi 9606.ENSP00000382423.

Chemistry

BindingDBi Q13233.
ChEMBLi CHEMBL3956.
GuidetoPHARMACOLOGYi 2069.

PTM databases

PhosphoSitei Q13233.

Polymorphism databases

DMDMi 218512139.

2D gel databases

SWISS-2DPAGE Q13233.

Proteomic databases

MaxQBi Q13233.
PaxDbi Q13233.
PRIDEi Q13233.

Protocols and materials databases

DNASUi 4214.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399503 ; ENSP00000382423 ; ENSG00000095015 .
GeneIDi 4214.
KEGGi hsa:4214.
UCSCi uc003jqw.4. human.

Organism-specific databases

CTDi 4214.
GeneCardsi GC05P056110.
GeneReviewsi MAP3K1.
H-InvDB HIX0024789.
HGNCi HGNC:6848. MAP3K1.
HPAi CAB004500.
HPA046509.
MIMi 600982. gene.
613762. phenotype.
neXtProti NX_Q13233.
Orphaneti 242. 46,XY complete gonadal dysgenesis.
251510. 46,XY partial gonadal dysgenesis.
PharmGKBi PA30592.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119077.
HOGENOMi HOG000113437.
HOVERGENi HBG006302.
InParanoidi Q13233.
KOi K04416.
OMAi STHFTRM.
OrthoDBi EOG7MSMNV.
PhylomeDBi Q13233.
TreeFami TF105112.

Enzyme and pathway databases

Reactomei REACT_163701. FCERI mediated MAPK activation.
REACT_24969. TRAF6 mediated NF-kB activation.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_27215. MyD88 cascade initiated on plasma membrane.
REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
SignaLinki Q13233.

Miscellaneous databases

GeneWikii MAP3K1.
GenomeRNAii 4214.
NextBioi 16613.
PROi Q13233.
SOURCEi Search...

Gene expression databases

Bgeei Q13233.
CleanExi HS_MAP3K1.
Genevestigatori Q13233.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50966. ZF_SWIM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension."
    Xia Y., Wu Z., Su B., Murray B., Karin M.
    Genes Dev. 12:3369-3381(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-1512, FUNCTION, INTERACTION WITH MAP2K4.
  3. "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5."
    Vinik B.S., Kay E.S., Fiedorek F.T. Jr.
    Mamm. Genome 6:782-783(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1238-1274.
    Tissue: Leukocyte.
  4. "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."
    Rui H.L., Fan E., Zhou H.M., Xu Z., Zhang Y., Lin S.C.
    J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXIN1.
  5. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
    Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
    J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXIN1.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154 AND SER-1043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)."
    Enomoto A., Kido N., Ito M., Morita A., Matsumoto Y., Takamatsu N., Hosoi Y., Miyagawa K.
    Oncogene 27:1930-1938(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STK38.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292; SER-297; SER-300; SER-507 AND SER-1018, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275 AND SER-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-92 AND SER-443.
  13. "Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination."
    Pearlman A., Loke J., Le Caignec C., White S., Chin L., Friedman A., Warr N., Willan J., Brauer D., Farmer C., Brooks E., Oddoux C., Riley B., Shajahan S., Camerino G., Homfray T., Crosby A.H., Couper J.
    , David A., Greenfield A., Sinclair A., Ostrer H.
    Am. J. Hum. Genet. 87:898-904(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SRXY6 PRO-189; ARG-189; ILE-GLN-211 INS AND ARG-616, CHARACTERIZATION OF VARIANTS SRXY6 PRO-189 AND ARG-189.

Entry informationi

Entry nameiM3K1_HUMAN
AccessioniPrimary (citable) accession number: Q13233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 150 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3