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Q13233

- M3K1_HUMAN

UniProt

Q13233 - M3K1_HUMAN

Protein

Mitogen-activated protein kinase kinase kinase 1

Gene

MAP3K1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 4 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1272 – 12721ATPPROSITE-ProRule annotation
    Active sitei1369 – 13691Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri338 – 36629SWIM-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri443 – 49250RING-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi1249 – 12579ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. JUN kinase kinase activity Source: Ensembl
    3. MAP kinase kinase kinase activity Source: UniProtKB
    4. protein binding Source: IntAct
    5. protein kinase activity Source: MGI
    6. protein kinase binding Source: UniProtKB
    7. zinc ion binding Source: InterPro

    GO - Biological processi

    1. activation of MAPKK activity Source: GOC
    2. apoptotic mitochondrial changes Source: Ensembl
    3. cellular response to mechanical stimulus Source: UniProtKB
    4. epithelial cell morphogenesis Source: Ensembl
    5. eyelid development in camera-type eye Source: Ensembl
    6. Fc-epsilon receptor signaling pathway Source: Reactome
    7. innate immune response Source: Reactome
    8. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    9. positive regulation of actin filament polymerization Source: Ensembl
    10. protein phosphorylation Source: UniProtKB
    11. regulation of cell migration Source: Ensembl
    12. toll-like receptor 10 signaling pathway Source: Reactome
    13. toll-like receptor 2 signaling pathway Source: Reactome
    14. toll-like receptor 4 signaling pathway Source: Reactome
    15. toll-like receptor 5 signaling pathway Source: Reactome
    16. toll-like receptor 9 signaling pathway Source: Reactome
    17. toll-like receptor signaling pathway Source: Reactome
    18. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    19. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
    20. transforming growth factor beta receptor signaling pathway Source: Ensembl
    21. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_163701. FCERI mediated MAPK activation.
    REACT_24969. TRAF6 mediated NF-kB activation.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_27215. MyD88 cascade initiated on plasma membrane.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    SignaLinkiQ13233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 1 (EC:2.7.11.25)
    Alternative name(s):
    MAPK/ERK kinase kinase 1
    Short name:
    MEK kinase 1
    Short name:
    MEKK 1
    Gene namesi
    Name:MAP3K1
    Synonyms:MAPKKK1, MEKK, MEKK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6848. MAP3K1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Involvement in diseasei

    46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti189 – 1891L → P in SRXY6; increases phosphorylation of the downstream target MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
    VAR_065504
    Natural varianti189 – 1891L → R in SRXY6; increases phosphorylation of the downstream targets MAPK14 and MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
    VAR_065505
    Natural varianti211 – 2111V → VIQ in SRXY6.
    VAR_065506
    Natural varianti616 – 6161G → R in SRXY6. 1 Publication
    Corresponds to variant rs143853590 [ dbSNP | Ensembl ].
    VAR_065507

    Organism-specific databases

    MIMi613762. phenotype.
    Orphaneti242. 46,XY complete gonadal dysgenesis.
    251510. 46,XY partial gonadal dysgenesis.
    PharmGKBiPA30592.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 15121511Mitogen-activated protein kinase kinase kinase 1PRO_0000086240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei137 – 1371PhosphoserineBy similarity
    Modified residuei154 – 1541Phosphoserine1 Publication
    Modified residuei275 – 2751Phosphoserine1 Publication
    Modified residuei292 – 2921Phosphoserine3 Publications
    Modified residuei297 – 2971Phosphoserine1 Publication
    Modified residuei300 – 3001Phosphoserine1 Publication
    Modified residuei507 – 5071Phosphoserine1 Publication
    Modified residuei1018 – 10181Phosphoserine1 Publication
    Modified residuei1043 – 10431Phosphoserine1 Publication
    Modified residuei1400 – 14001Phosphothreonine; by autocatalysisBy similarity
    Modified residuei1412 – 14121Phosphothreonine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13233.
    PaxDbiQ13233.
    PRIDEiQ13233.

    2D gel databases

    SWISS-2DPAGEQ13233.

    PTM databases

    PhosphoSiteiQ13233.

    Expressioni

    Gene expression databases

    BgeeiQ13233.
    CleanExiHS_MAP3K1.
    GenevestigatoriQ13233.

    Organism-specific databases

    HPAiCAB004500.
    HPA046509.

    Interactioni

    Subunit structurei

    Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARRB2P321212EBI-49776,EBI-714559
    BRAFP150562EBI-49776,EBI-365980
    DCAF7P619627EBI-49776,EBI-359808
    FLNBO753692EBI-49776,EBI-352089
    MAP2K4P459853EBI-49776,EBI-447868
    MAP4K2Q128512EBI-49776,EBI-49783
    TRAF2Q129332EBI-49776,EBI-355744

    Protein-protein interaction databases

    BioGridi110378. 61 interactions.
    DIPiDIP-27520N.
    IntActiQ13233. 34 interactions.
    MINTiMINT-143285.
    STRINGi9606.ENSP00000382423.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13233.
    SMRiQ13233. Positions 443-495, 1227-1505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1243 – 1508266Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 54Poly-Ala
    Compositional biasi25 – 295Poly-Gly
    Compositional biasi36 – 416Poly-Ala
    Compositional biasi422 – 43110Poly-Ser
    Compositional biasi842 – 8476Poly-Ser
    Compositional biasi942 – 9498Poly-Thr
    Compositional biasi1182 – 11876Poly-Glu
    Compositional biasi1216 – 12194Poly-Ile

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri338 – 36629SWIM-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri443 – 49250RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000113437.
    HOVERGENiHBG006302.
    InParanoidiQ13233.
    KOiK04416.
    OMAiSTHFTRM.
    OrthoDBiEOG7MSMNV.
    PhylomeDBiQ13233.
    TreeFamiTF105112.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR007527. Znf_SWIM.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    PS50966. ZF_SWIM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13233-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAGNRAS SSGFPGARAT SPEAGGGGGA LKASSAPAAA AGLLREAGSG     50
    GRERADWRRR QLRKVRSVEL DQLPEQPLFL AASPPASSTS PSPEPADAAG 100
    SGTGFQPVAV PPPHGAASRG GAHLTESVAA PDSGASSPAA AEPGEKRAPA 150
    AEPSPAAAPA GREMENKETL KGLHKMDDRP EERMIREKLK ATCMPAWKHE 200
    WLERRNRRGP VVVKPIPVKG DGSEMNHLAA ESPGEVQASA ASPASKGRRS 250
    PSPGNSPSGR TVKSESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS 300
    PEETNRRVNK VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCA 350
    RGTFCIHLLF VMLRVFQLEP SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI 400
    KAPSRNTIQK FVSRMSNSHT LSSSSTSTSS SENSIKDEEE QMCPICLLGM 450
    LDEESLTVCE DGCRNKLHHH CMSIWAEECR RNREPLICPL CRSKWRSHDF 500
    YSHELSSPVD SPSSLRAAQQ QTVQQQPLAG SRRNQESNFN LTHYGTQQIP 550
    PAYKDLAEPW IQVFGMELVG CLFSRNWNVR EMALRRLSHD VSGALLLANG 600
    ESTGNSGGSS GSSPSGGATS GSSQTSISGD VVEACCSVLS MVCADPVYKV 650
    YVAALKTLRA MLVYTPCHSL AERIKLQRLL QPVVDTILVK CADANSRTSQ 700
    LSISTLLELC KGQAGELAVG REILKAGSIG IGGVDYVLNC ILGNQTESNN 750
    WQELLGRLCL IDRLLLEFPA EFYPHIVSTD VSQAEPVEIR YKKLLSLLTF 800
    ALQSIDNSHS MVGKLSRRIY LSSARMVTTV PHVFSKLLEM LSVSSSTHFT 850
    RMRRRLMAIA DEVEIAEAIQ LGVEDTLDGQ QDSFLQASVP NNYLETTENS 900
    SPECTVHLEK TGKGLCATKL SASSEDISER LASISVGPSS STTTTTTTTE 950
    QPKPMVQTKG RPHSQCLNSS PLSHHSQLMF PALSTPSSST PSVPAGTATD 1000
    VSKHRLQGFI PCRIPSASPQ TQRKFSLQFH RNCPENKDSD KLSPVFTQSR 1050
    PLPSSNIHRP KPSRPTPGNT SKQGDPSKNS MTLDLNSSSK CDDSFGCSSN 1100
    SSNAVIPSDE TVFTPVEEKC RLDVNTELNS SIEDLLEASM PSSDTTVTFK 1150
    SEVAVLSPEK AENDDTYKDD VNHNQKCKEK MEAEEEEALA IAMAMSASQD 1200
    ALPIVPQLQV ENGEDIIIIQ QDTPETLPGH TKAKQPYRED TEWLKGQQIG 1250
    LGAFSSCYQA QDVGTGTLMA VKQVTYVRNT SSEQEEVVEA LREEIRMMSH 1300
    LNHPNIIRML GATCEKSNYN LFIEWMAGGS VAHLLSKYGA FKESVVINYT 1350
    EQLLRGLSYL HENQIIHRDV KGANLLIDST GQRLRIADFG AAARLASKGT 1400
    GAGEFQGQLL GTIAFMAPEV LRGQQYGRSC DVWSVGCAII EMACAKPPWN 1450
    AEKHSNHLAL IFKIASATTA PSIPSHLSPG LRDVALRCLE LQPQDRPPSR 1500
    ELLKHPVFRT TW 1512
    Length:1,512
    Mass (Da):164,470
    Last modified:December 16, 2008 - v4
    Checksum:i5CB78242295411D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201T → P in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti37 – 371P → R in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti120 – 1201G → R in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti351 – 3511R → H in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti845 – 8451S → SV in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti859 – 8591I → Y in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti878 – 90225DGQQD…ENSSP → QRQQHNSFCRHLFPTTIWKP QRTVPL in AAC97073. (PubMed:9808624)CuratedAdd
    BLAST
    Sequence conflicti933 – 9331S → R in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti1097 – 10971C → L in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti1104 – 11074AVIP → CCYT in AAC97073. (PubMed:9808624)Curated
    Sequence conflicti1200 – 12001D → V in AAC97073. (PubMed:9808624)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921S → N.1 Publication
    VAR_040680
    Natural varianti189 – 1891L → P in SRXY6; increases phosphorylation of the downstream target MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
    VAR_065504
    Natural varianti189 – 1891L → R in SRXY6; increases phosphorylation of the downstream targets MAPK14 and MAPK3/MAPK1 compared to wild-type and enhances binding of RHOA to the mutant MAP3K1 complex. 1 Publication
    VAR_065505
    Natural varianti211 – 2111V → VIQ in SRXY6.
    VAR_065506
    Natural varianti443 – 4431C → S.1 Publication
    VAR_040681
    Natural varianti616 – 6161G → R in SRXY6. 1 Publication
    Corresponds to variant rs143853590 [ dbSNP | Ensembl ].
    VAR_065507
    Natural varianti806 – 8061D → N.
    Corresponds to variant rs702689 [ dbSNP | Ensembl ].
    VAR_051636
    Natural varianti906 – 9061V → I.
    Corresponds to variant rs832582 [ dbSNP | Ensembl ].
    VAR_051637

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008937 Genomic DNA. No translation available.
    AF042838 mRNA. Translation: AAC97073.1.
    U29671 Genomic DNA. Translation: AAB05828.1.
    CCDSiCCDS43318.1.
    PIRiG01887.
    RefSeqiNP_005912.1. NM_005921.1.
    UniGeneiHs.653654.

    Genome annotation databases

    EnsembliENST00000399503; ENSP00000382423; ENSG00000095015.
    GeneIDi4214.
    KEGGihsa:4214.
    UCSCiuc003jqw.4. human.

    Polymorphism databases

    DMDMi218512139.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008937 Genomic DNA. No translation available.
    AF042838 mRNA. Translation: AAC97073.1 .
    U29671 Genomic DNA. Translation: AAB05828.1 .
    CCDSi CCDS43318.1.
    PIRi G01887.
    RefSeqi NP_005912.1. NM_005921.1.
    UniGenei Hs.653654.

    3D structure databases

    ProteinModelPortali Q13233.
    SMRi Q13233. Positions 443-495, 1227-1505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110378. 61 interactions.
    DIPi DIP-27520N.
    IntActi Q13233. 34 interactions.
    MINTi MINT-143285.
    STRINGi 9606.ENSP00000382423.

    Chemistry

    BindingDBi Q13233.
    ChEMBLi CHEMBL3956.
    GuidetoPHARMACOLOGYi 2069.

    PTM databases

    PhosphoSitei Q13233.

    Polymorphism databases

    DMDMi 218512139.

    2D gel databases

    SWISS-2DPAGE Q13233.

    Proteomic databases

    MaxQBi Q13233.
    PaxDbi Q13233.
    PRIDEi Q13233.

    Protocols and materials databases

    DNASUi 4214.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399503 ; ENSP00000382423 ; ENSG00000095015 .
    GeneIDi 4214.
    KEGGi hsa:4214.
    UCSCi uc003jqw.4. human.

    Organism-specific databases

    CTDi 4214.
    GeneCardsi GC05P056110.
    GeneReviewsi MAP3K1.
    H-InvDB HIX0024789.
    HGNCi HGNC:6848. MAP3K1.
    HPAi CAB004500.
    HPA046509.
    MIMi 600982. gene.
    613762. phenotype.
    neXtProti NX_Q13233.
    Orphaneti 242. 46,XY complete gonadal dysgenesis.
    251510. 46,XY partial gonadal dysgenesis.
    PharmGKBi PA30592.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000113437.
    HOVERGENi HBG006302.
    InParanoidi Q13233.
    KOi K04416.
    OMAi STHFTRM.
    OrthoDBi EOG7MSMNV.
    PhylomeDBi Q13233.
    TreeFami TF105112.

    Enzyme and pathway databases

    Reactomei REACT_163701. FCERI mediated MAPK activation.
    REACT_24969. TRAF6 mediated NF-kB activation.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_27215. MyD88 cascade initiated on plasma membrane.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    SignaLinki Q13233.

    Miscellaneous databases

    GeneWikii MAP3K1.
    GenomeRNAii 4214.
    NextBioi 16613.
    PROi Q13233.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13233.
    CleanExi HS_MAP3K1.
    Genevestigatori Q13233.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR007527. Znf_SWIM.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    PS50966. ZF_SWIM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension."
      Xia Y., Wu Z., Su B., Murray B., Karin M.
      Genes Dev. 12:3369-3381(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-1512, FUNCTION, INTERACTION WITH MAP2K4.
    3. "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5."
      Vinik B.S., Kay E.S., Fiedorek F.T. Jr.
      Mamm. Genome 6:782-783(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1238-1274.
      Tissue: Leukocyte.
    4. "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."
      Rui H.L., Fan E., Zhou H.M., Xu Z., Zhang Y., Lin S.C.
      J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AXIN1.
    5. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
      Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
      J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AXIN1.
    6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154 AND SER-1043, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)."
      Enomoto A., Kido N., Ito M., Morita A., Matsumoto Y., Takamatsu N., Hosoi Y., Miyagawa K.
      Oncogene 27:1930-1938(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STK38.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292; SER-297; SER-300; SER-507 AND SER-1018, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275 AND SER-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-92 AND SER-443.
    13. "Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination."
      Pearlman A., Loke J., Le Caignec C., White S., Chin L., Friedman A., Warr N., Willan J., Brauer D., Farmer C., Brooks E., Oddoux C., Riley B., Shajahan S., Camerino G., Homfray T., Crosby A.H., Couper J.
      , David A., Greenfield A., Sinclair A., Ostrer H.
      Am. J. Hum. Genet. 87:898-904(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SRXY6 PRO-189; ARG-189; ILE-GLN-211 INS AND ARG-616, CHARACTERIZATION OF VARIANTS SRXY6 PRO-189 AND ARG-189.

    Entry informationi

    Entry nameiM3K1_HUMAN
    AccessioniPrimary (citable) accession number: Q13233
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 149 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3