Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoside diphosphate kinase 3

Gene

NME3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291ATPBy similarity
Binding sitei77 – 771ATPBy similarity
Binding sitei105 – 1051ATPBy similarity
Binding sitei111 – 1111ATPBy similarity
Binding sitei122 – 1221ATPBy similarity
Binding sitei132 – 1321ATPBy similarity
Active sitei135 – 1351Pros-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Apoptosis, Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 3 (EC:2.7.4.6)
Short name:
NDK 3
Short name:
NDP kinase 3
Alternative name(s):
DR-nm23
Nucleoside diphosphate kinase C
Short name:
NDPKC
nm23-H3
Gene namesi
Name:NME3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7851. NME3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intracellular Source: GO_Central
  • mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31656.

Polymorphism and mutation databases

BioMutaiNME3.
DMDMi21264477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Nucleoside diphosphate kinase 3PRO_0000137123Add
BLAST

Proteomic databases

EPDiQ13232.
MaxQBiQ13232.
PaxDbiQ13232.
PeptideAtlasiQ13232.
PRIDEiQ13232.

PTM databases

iPTMnetiQ13232.
PhosphoSiteiQ13232.

Expressioni

Developmental stagei

Preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells.

Gene expression databases

BgeeiENSG00000103024.
CleanExiHS_NME3.
ExpressionAtlasiQ13232. baseline and differential.
GenevisibleiQ13232. HS.

Organism-specific databases

HPAiHPA041113.
HPA052733.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NME1P155314EBI-713684,EBI-741141
SGTAO437654EBI-713684,EBI-347996
UBQLN1Q9UMX03EBI-713684,EBI-741480
UBQLN1Q9UMX0-23EBI-713684,EBI-10173939

Protein-protein interaction databases

BioGridi110896. 20 interactions.
DIPiDIP-49960N.
IntActiQ13232. 10 interactions.
MINTiMINT-1429907.
STRINGi9606.ENSP00000219302.

Structurei

Secondary structure

1
169
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 213Combined sources
Beta strandi23 – 286Combined sources
Helixi30 – 345Combined sources
Helixi38 – 4811Combined sources
Beta strandi51 – 588Combined sources
Helixi62 – 687Combined sources
Helixi70 – 723Combined sources
Helixi78 – 858Combined sources
Beta strandi90 – 978Combined sources
Helixi100 – 1089Combined sources
Helixi113 – 1153Combined sources
Helixi121 – 1255Combined sources
Helixi129 – 1313Combined sources
Beta strandi133 – 1364Combined sources
Helixi140 – 15011Combined sources
Helixi153 – 1553Combined sources
Helixi164 – 1674Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZS6X-ray2.30A/B/D1-169[»]
ProteinModelPortaliQ13232.
SMRiQ13232. Positions 18-169.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13232.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiQ13232.
KOiK00940.
OMAiCVEVGRN.
OrthoDBiEOG091G0PLD.
PhylomeDBiQ13232.
TreeFamiTF106373.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICLVLTIFA NLFPAACTGA HERTFLAVKP DGVQRRLVGE IVRRFERKGF
60 70 80 90 100
KLVALKLVQA SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV
110 120 130 140 150
VRTSRALIGA TNPADAPPGT IRGDFCIEVG KNLIHGSDSV ESARREIALW
160
FRADELLCWE DSAGHWLYE
Length:169
Mass (Da):19,015
Last modified:May 27, 2002 - v2
Checksum:iCCA41A122A37202D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601A → S in AAA85097 (PubMed:7638209).Curated
Sequence conflicti131 – 1311Missing in AAA85097 (PubMed:7638209).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29656 mRNA. Translation: AAA85097.1.
AE006639 Genomic DNA. Translation: AAK61291.1.
BC000250 mRNA. Translation: AAH00250.1.
CCDSiCCDS10443.1.
PIRiI39074.
RefSeqiNP_002504.2. NM_002513.2.
UniGeneiHs.514065.

Genome annotation databases

EnsembliENST00000219302; ENSP00000219302; ENSG00000103024.
GeneIDi4832.
KEGGihsa:4832.
UCSCiuc002cmm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29656 mRNA. Translation: AAA85097.1.
AE006639 Genomic DNA. Translation: AAK61291.1.
BC000250 mRNA. Translation: AAH00250.1.
CCDSiCCDS10443.1.
PIRiI39074.
RefSeqiNP_002504.2. NM_002513.2.
UniGeneiHs.514065.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZS6X-ray2.30A/B/D1-169[»]
ProteinModelPortaliQ13232.
SMRiQ13232. Positions 18-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110896. 20 interactions.
DIPiDIP-49960N.
IntActiQ13232. 10 interactions.
MINTiMINT-1429907.
STRINGi9606.ENSP00000219302.

PTM databases

iPTMnetiQ13232.
PhosphoSiteiQ13232.

Polymorphism and mutation databases

BioMutaiNME3.
DMDMi21264477.

Proteomic databases

EPDiQ13232.
MaxQBiQ13232.
PaxDbiQ13232.
PeptideAtlasiQ13232.
PRIDEiQ13232.

Protocols and materials databases

DNASUi4832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219302; ENSP00000219302; ENSG00000103024.
GeneIDi4832.
KEGGihsa:4832.
UCSCiuc002cmm.4. human.

Organism-specific databases

CTDi4832.
GeneCardsiNME3.
HGNCiHGNC:7851. NME3.
HPAiHPA041113.
HPA052733.
MIMi601817. gene.
neXtProtiNX_Q13232.
PharmGKBiPA31656.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiQ13232.
KOiK00940.
OMAiCVEVGRN.
OrthoDBiEOG091G0PLD.
PhylomeDBiQ13232.
TreeFamiTF106373.

Miscellaneous databases

ChiTaRSiNME3. human.
EvolutionaryTraceiQ13232.
GeneWikiiNME3.
GenomeRNAii4832.
PROiQ13232.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103024.
CleanExiHS_NME3.
ExpressionAtlasiQ13232. baseline and differential.
GenevisibleiQ13232. HS.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDK3_HUMAN
AccessioniPrimary (citable) accession number: Q13232
Secondary accession number(s): Q9BWH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 27, 2002
Last modified: September 7, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.