Nucleoside diphosphate kinase 3 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q13232 (NDK3_HUMAN)

Last modified November 25, 2008. Version 79. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase 3
      Short name=NDP kinase 3
      Short name=NDK 3
    EC=2.7.4.6
Alternative name(s):
    Nucleoside diphosphate kinase C
      Short name=NDPKC
    nm23-H3
    DR-nm23

Gene names

Name:

NME3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Developmental stage	Preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells.
Sequence similarities	Belongs to the NDK family.

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Ontologies

Keywords
Biological process	Apoptosis Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro induction of apoptosis Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytosol Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 169

169

Nucleoside diphosphate kinase 3

PRO_0000137123

Sites

Active site

135

Pros-phosphohistidine intermediate By similarity

Binding site

ATP By similarity

Binding site

ATP By similarity

Binding site

105

ATP By similarity

Binding site

111

ATP By similarity

Binding site

122

ATP By similarity

Binding site

132

ATP By similarity

Experimental info

Sequence conflict

A → S in AAA85097. Ref.1

Sequence conflict

131

Missing in AAA85097. Ref.1

Secondary structure

169

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q13232-1 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: CCA41A122A37202D
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FASTA

169

19,015

        10         20         30         40         50         60 
MICLVLTIFA NLFPAACTGA HERTFLAVKP DGVQRRLVGE IVRRFERKGF KLVALKLVQA 

        70         80         90        100        110        120 
SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV VRTSRALIGA TNPADAPPGT 

       130        140        150        160 
IRGDFCIEVG KNLIHGSDSV ESARREIALW FRADELLCWE DSAGHWLYE

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells." Venturelli D., Martinez R., Melotti P., Casella I., Peschle C., Cucco C., Spampinato G., Darzynkiewicz Z., Calabretta B. Proc. Natl. Acad. Sci. U.S.A. 92:7435-7439(1995) [PubMed: 7638209] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

U29656 mRNA. Translation: AAA85097.1.
AE006639 Genomic DNA. Translation: AAK61291.1.
BC000250 mRNA. Translation: AAH00250.1.

PIR

I39074.

RefSeq

NP_002504.2.

UniGene

Hs.514065

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZS6	X-ray	2.30	A/B/D	1-169	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13232.

Proteomic databases

PeptideAtlas

Q13232.

Genome annotation databases

Ensembl

ENSG00000103024. Homo sapiens. [Contig view]

GeneID

4832.

KEGG

hsa:4832.

Organism-specific databases

H-InvDB

HIX0012691.

HGNC

HGNC:7851. NME3.

MIM

601817. gene.

PharmGKB

PA31656.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q13232.

HOVERGEN

Q13232.

Enzyme and pathway databases

Reactome

REACT_1698. Nucleotide metabolism.

Gene expression databases

CleanEx

HS_NME3.

GermOnline

ENSG00000103024. Homo sapiens.

Family and domain databases

InterPro

IPR001564. Nuc_diP_kinase_core.
[Graphical view]

Gene3D

G3DSA:3.30.70.141. NDK. 1 hit.

PANTHER

PTHR11349. Nuc_diP_kinase_core. 1 hit.

Pfam

PF00334. NDK. 1 hit.
[Graphical view]

PRINTS

PR01243. NUCDPKINASE.

ProDom

PD001018. NDK. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00562. NDK. 1 hit.
[Graphical view]

PROSITE

PS00469. NDP_KINASES. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

18622.

SOURCE

Search...

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Entry information

Entry name

NDK3_HUMAN

Accession

Primary (citable) accession number: Q13232
Secondary accession number(s): Q9BWH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	May 27, 2002
Last modified:	November 25, 2008
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents