Q13228 (SBP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenium-binding protein 1

Alternative name(s):
56 kDa selenium-binding protein
Short name=SBP56
Short name=SP56

Gene names

Name:	SELENBP1
Synonyms:	SBP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport By similarity.
Subunit structure	Interacts with USP33. Ref.13
Subcellular location	Nucleus. Cytoplasm › cytosol. Membrane; Peripheral membrane protein By similarity. Note: May associate with Golgi membrane. May associate with the membrane of autophagosomes By similarity. Ref.9 Ref.10
Tissue specificity	Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12
Induction	Down-regulated by androgen in prostate cancer cells. Ref.8
Post-translational modification	Phosphorylated Probable. Ref.9 The N-terminus is blocked By similarity.
Sequence similarities	Belongs to the selenium-binding protein family.
Sequence caution	The sequence BAG59258.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing
Ligand	Selenium
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from direct assay. Source: HPA
Molecular_function	selenium binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
USP33	Q8TEY7-2	5	EBI-711619,EBI-719307

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13228-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13228-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Isoform 3 (identifier: Q13228-3)

The sequence of this isoform differs from the canonical sequence as follows:
     59-120: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Selenium-binding protein 1		PRO_0000174633
Amino acid modifications
	Modified residue	467	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 64	64	Missing in isoform 2.		VSP_038440
	Alternative sequence	59 – 120	62	Missing in isoform 3.		VSP_045425
Experimental info
	Sequence conflict	80	1	C → Y in AAB02395. Ref.1
	Sequence conflict	92	1	T → N in AAB02395. Ref.1
	Sequence conflict	114 – 116	3	RAP → GPQ in AAB02395. Ref.1
	Sequence conflict	135	1	F → C in AAB02395. Ref.1
	Sequence conflict	260 – 262	3	DAA → SAT in AAB02395. Ref.1
	Sequence conflict	270 – 273	4	LSST → SAPN in AAB02395. Ref.1
	Sequence conflict	278	1	Y → C in BAG59258. Ref.3
	Sequence conflict	280 – 282	3	NEG → TRE in AAB02395. Ref.1
	Sequence conflict	305 – 306	2	EM → GV in AAB02395. Ref.1
	Sequence conflict	410	1	D → E in AAB02395. Ref.1
	Sequence conflict	442	1	F → C in AAB02395. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: 6DC68F9B45FEC1BC	FASTA	472	52,391
	10 20 30 40 50 60 MATKCGNCGP GYSTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD PKSPQYCQVI 70 80 90 100 110 120 HRLPMPNLKD ELHHSGWNTC SSCFGDSTKS RTKLVLPSLI SSRIYVVDVG SEPRAPKLHK 130 140 150 160 170 180 VIEPKDIHAK CELAFLHTSH CLASGEVMIS SLGDVKGNGK GGFVLLDGET FEVKGTWERP 190 200 210 220 230 240 GGAAPLGYDF WYQPRHNVMI STEWAAPNVL RDGFNPADVE AGLYGSHLYV WDWQRHEIVQ 250 260 270 280 290 300 TLSLKDGLIP LEIRFLHNPD AAQGFVGCAL SSTIQRFYKN EGGTWSVEKV IQVPPKKVKG 310 320 330 340 350 360 WLLPEMPGLI TDILLSLDDR FLYFSNWLHG DLRQYDISDP QRPRLTGQLF LGGSIVKGGP 370 380 390 400 410 420 VQVLEDEELK SQPEPLVVKG KRVAGGPQMI QLSLDGKRLY ITTSLYSAWD KQFYPDLIRE 430 440 450 460 470 GSVMLQVDVD TVKGGLKLNP NFLVDFGKEP LGPALAHELR YPGGDCSSDI WI
	Isoform 2 [UniParc]. Checksum: 7765636B7CE8ACA7	FASTA	408	45,349
	10 20 30 40 50 60 MPNLKDELHH SGWNTCSSCF GDSTKSRTKL VLPSLISSRI YVVDVGSEPR APKLHKVIEP 70 80 90 100 110 120 KDIHAKCELA FLHTSHCLAS GEVMISSLGD VKGNGKGGFV LLDGETFEVK GTWERPGGAA 130 140 150 160 170 180 PLGYDFWYQP RHNVMISTEW AAPNVLRDGF NPADVEAGLY GSHLYVWDWQ RHEIVQTLSL 190 200 210 220 230 240 KDGLIPLEIR FLHNPDAAQG FVGCALSSTI QRFYKNEGGT WSVEKVIQVP PKKVKGWLLP 250 260 270 280 290 300 EMPGLITDIL LSLDDRFLYF SNWLHGDLRQ YDISDPQRPR LTGQLFLGGS IVKGGPVQVL 310 320 330 340 350 360 EDEELKSQPE PLVVKGKRVA GGPQMIQLSL DGKRLYITTS LYSAWDKQFY PDLIREGSVM 370 380 390 400 LQVDVDTVKG GLKLNPNFLV DFGKEPLGPA LAHELRYPGG DCSSDIWI
	Isoform 3 [UniParc]. Checksum: 966714583DDE49F3	FASTA	410	45,469
	10 20 30 40 50 60 MATKCGNCGP GYSTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD PKSPQYCQVI 70 80 90 100 110 120 EPKDIHAKCE LAFLHTSHCL ASGEVMISSL GDVKGNGKGG FVLLDGETFE VKGTWERPGG 130 140 150 160 170 180 AAPLGYDFWY QPRHNVMIST EWAAPNVLRD GFNPADVEAG LYGSHLYVWD WQRHEIVQTL 190 200 210 220 230 240 SLKDGLIPLE IRFLHNPDAA QGFVGCALSS TIQRFYKNEG GTWSVEKVIQ VPPKKVKGWL 250 260 270 280 290 300 LPEMPGLITD ILLSLDDRFL YFSNWLHGDL RQYDISDPQR PRLTGQLFLG GSIVKGGPVQ 310 320 330 340 350 360 VLEDEELKSQ PEPLVVKGKR VAGGPQMIQL SLDGKRLYIT TSLYSAWDKQ FYPDLIREGS 370 380 390 400 410 VMLQVDVDTV KGGLKLNPNF LVDFGKEPLG PALAHELRYP GGDCSSDIWI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein." Chang P.W.G., Tsui S.K.W., Liew C., Lee C., Waye M.M.Y., Fung K. J. Cell. Biochem. 64:217-224(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Colon, Lung and Synovial cell.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Colon and Testis.
[7]	Lubec G., Vishwanath V. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 255-276, MASS SPECTROMETRY. Tissue: Brain and Cajal-Retzius cell.
[8]	"Differential expression and androgen regulation of the human selenium-binding protein gene hSP56 in prostate cancer cells." Yang M., Sytkowski A.J. Cancer Res. 58:3150-3153(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[9]	"Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas." Chen G., Wang H., Miller C.T., Thomas D.G., Gharib T.G., Misek D.E., Giordano T.J., Orringer M.B., Hanash S.M., Beer D.G. J. Pathol. 202:321-329(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PHOSPHORYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
[10]	"Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia." Glatt S.J., Everall I.P., Kremen W.S., Corbeil J., Sasik R., Khanlou N., Han M., Liew C.-C., Tsuang M.T. Proc. Natl. Acad. Sci. U.S.A. 102:15533-15538(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[11]	"Selenium binding protein 1 in ovarian cancer." Huang K.-C., Park D.C., Ng S.-K., Lee J.Y., Ni X., Ng W.-C., Bandera C.A., Welch W.R., Berkowitz R.S., Mok S.C., Ng S.-W. Int. J. Cancer 118:2433-2440(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
[12]	"Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival." Kim H., Kang H.J., You K.T., Kim S.H., Lee K.Y., Kim T.I., Kim C., Song S.Y., Kim H.-J., Lee C., Kim H. Proteomics 6:3466-3476(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
[13]	"Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner." Jeong J.Y., Wang Y., Sytkowski A.J. Biochem. Biophys. Res. Commun. 379:583-588(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH USP33.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U29091 mRNA. Translation: AAB02395.1. CR456852 mRNA. Translation: CAG33133.1. AK296661 mRNA. Translation: BAG59258.1. Sequence problems. AK303815 mRNA. Translation: BAG64765.1. AK315643 mRNA. Translation: BAG38010.1. AL391069 Genomic DNA. Translation: CAH70328.1. CH471121 Genomic DNA. Translation: EAW53443.1. CH471121 Genomic DNA. Translation: EAW53445.1. BC009084 mRNA. Translation: AAH09084.1. BC032997 mRNA. Translation: AAH32997.1.
IPI	IPI00012303. IPI00954180.
PIR	G01872.
RefSeq	NP_001245217.1. NM_001258288.1. NP_001245218.1. NM_001258289.1. NP_003935.2. NM_003944.3.
UniGene	Hs.632460.
3D structure databases
ProteinModelPortal	Q13228.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13228. 8 interactions.
MINT	MINT-5005535.
STRING	9606.ENSP00000357861.
Polymorphism databases
DMDM	148840437.
2D gel databases
REPRODUCTION-2DPAGE	IPI00012303. Q13228.
UCD-2DPAGE	Q13228.
Proteomic databases
PaxDb	Q13228.
PRIDE	Q13228.
Protocols and materials databases
DNASU	8991.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368868; ENSP00000357861; ENSG00000143416. ENST00000435071; ENSP00000408263; ENSG00000143416. ENST00000447402; ENSP00000413960; ENSG00000143416.
GeneID	8991.
KEGG	hsa:8991.
UCSC	uc001exx.3. human.
Organism-specific databases
CTD	8991.
GeneCards	GC01M151339.
HGNC	HGNC:10719. SELENBP1.
HPA	CAB008366. HPA005741. HPA011731.
MIM	604188. gene.
neXtProt	NX_Q13228.
PharmGKB	PA35641.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84363.
HOGENOM	HOG000263885.
HOVERGEN	HBG017779.
InParanoid	Q13228.
OMA	STEWGAP.
OrthoDB	EOG4Z8XW7.
PhylomeDB	Q13228.
Gene expression databases
ArrayExpress	Q13228.
Bgee	Q13228.
CleanEx	HS_SELENBP1.
Genevestigator	Q13228.
GermOnline	ENSG00000143416. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR008826. Se-bd. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
PANTHER	PTHR23300. PTHR23300. 1 hit.
Pfam	PF05694. SBP56. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SELENBP1. human.
GenomeRNAi	8991.
NextBio	33715.
SOURCE	Search...

Entry information

Entry name

SBP1_HUMAN

Accession

Primary (citable) accession number: Q13228
Secondary accession number(s): A6NML9 , B2RDR3, B4DKP6, B4E1F3, Q49AQ8, Q96GX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.