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Protein

Selenium-binding protein 1

Gene

SELENBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).By similarity

GO - Molecular functioni

  • selenium binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Selenium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143416-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenium-binding protein 1
Alternative name(s):
56 kDa selenium-binding protein
Short name:
SBP56
Short name:
SP56
Gene namesi
Name:SELENBP1
Synonyms:SBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10719. SELENBP1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8991.
OpenTargetsiENSG00000143416.
PharmGKBiPA35641.

Polymorphism and mutation databases

BioMutaiSELENBP1.
DMDMi148840437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001746332 – 472Selenium-binding protein 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei111PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei467PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.1 Publication
The N-terminus is blocked.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13228.
PaxDbiQ13228.
PeptideAtlasiQ13228.
PRIDEiQ13228.

2D gel databases

REPRODUCTION-2DPAGEIPI00012303.
Q13228.
UCD-2DPAGEQ13228.

PTM databases

iPTMnetiQ13228.
PhosphoSitePlusiQ13228.
SwissPalmiQ13228.

Expressioni

Tissue specificityi

Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients.5 Publications

Inductioni

Down-regulated by androgen in prostate cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000143416.
CleanExiHS_SELENBP1.
ExpressionAtlasiQ13228. baseline and differential.
GenevisibleiQ13228. HS.

Organism-specific databases

HPAiCAB008366.
HPA005741.
HPA011731.

Interactioni

Subunit structurei

Interacts with USP33.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-711619,EBI-358993
USP33Q8TEY7-25EBI-711619,EBI-719307

Protein-protein interaction databases

BioGridi114472. 63 interactors.
IntActiQ13228. 11 interactors.
MINTiMINT-5005535.
STRINGi9606.ENSP00000357861.

Structurei

3D structure databases

ProteinModelPortaliQ13228.
SMRiQ13228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenium-binding protein family.Curated

Phylogenomic databases

eggNOGiKOG0918. Eukaryota.
ENOG410XP4F. LUCA.
GeneTreeiENSGT00390000014244.
HOGENOMiHOG000263885.
HOVERGENiHBG017779.
InParanoidiQ13228.
KOiK17285.
OMAiIDIPGKL.
OrthoDBiEOG091G061L.
PhylomeDBiQ13228.
TreeFamiTF315241.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR008826. Se-bd.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR23300. PTHR23300. 1 hit.
PfamiPF05694. SBP56. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATKCGNCGP GYSTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD
60 70 80 90 100
PKSPQYCQVI HRLPMPNLKD ELHHSGWNTC SSCFGDSTKS RTKLVLPSLI
110 120 130 140 150
SSRIYVVDVG SEPRAPKLHK VIEPKDIHAK CELAFLHTSH CLASGEVMIS
160 170 180 190 200
SLGDVKGNGK GGFVLLDGET FEVKGTWERP GGAAPLGYDF WYQPRHNVMI
210 220 230 240 250
STEWAAPNVL RDGFNPADVE AGLYGSHLYV WDWQRHEIVQ TLSLKDGLIP
260 270 280 290 300
LEIRFLHNPD AAQGFVGCAL SSTIQRFYKN EGGTWSVEKV IQVPPKKVKG
310 320 330 340 350
WLLPEMPGLI TDILLSLDDR FLYFSNWLHG DLRQYDISDP QRPRLTGQLF
360 370 380 390 400
LGGSIVKGGP VQVLEDEELK SQPEPLVVKG KRVAGGPQMI QLSLDGKRLY
410 420 430 440 450
ITTSLYSAWD KQFYPDLIRE GSVMLQVDVD TVKGGLKLNP NFLVDFGKEP
460 470
LGPALAHELR YPGGDCSSDI WI
Length:472
Mass (Da):52,391
Last modified:May 29, 2007 - v2
Checksum:i6DC68F9B45FEC1BC
GO
Isoform 2 (identifier: Q13228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:408
Mass (Da):45,349
Checksum:i7765636B7CE8ACA7
GO
Isoform 3 (identifier: Q13228-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-120: Missing.

Show »
Length:410
Mass (Da):45,469
Checksum:i966714583DDE49F3
GO
Isoform 4 (identifier: Q13228-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRLEWGPRPAALPWPAGMCAAERAEGAFTLQSVAQPMRPIAST

Show »
Length:514
Mass (Da):56,866
Checksum:iB0D47E495DD73E67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80C → Y in AAB02395 (PubMed:9027582).Curated1
Sequence conflicti92T → N in AAB02395 (PubMed:9027582).Curated1
Sequence conflicti114 – 116RAP → GPQ in AAB02395 (PubMed:9027582).Curated3
Sequence conflicti135F → C in AAB02395 (PubMed:9027582).Curated1
Sequence conflicti260 – 262DAA → SAT in AAB02395 (PubMed:9027582).Curated3
Sequence conflicti270 – 273LSST → SAPN in AAB02395 (PubMed:9027582).Curated4
Sequence conflicti278Y → C in BAG59258 (PubMed:14702039).Curated1
Sequence conflicti280 – 282NEG → TRE in AAB02395 (PubMed:9027582).Curated3
Sequence conflicti305 – 306EM → GV in AAB02395 (PubMed:9027582).Curated2
Sequence conflicti410D → E in AAB02395 (PubMed:9027582).Curated1
Sequence conflicti442F → C in AAB02395 (PubMed:9027582).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0384401 – 64Missing in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_0551261M → MRLEWGPRPAALPWPAGMCA AERAEGAFTLQSVAQPMRPI AST in isoform 4. 1 Publication1
Alternative sequenceiVSP_04542559 – 120Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29091 mRNA. Translation: AAB02395.1.
CR456852 mRNA. Translation: CAG33133.1.
AK296661 mRNA. Translation: BAG59258.1.
AK303815 mRNA. Translation: BAG64765.1.
AK315643 mRNA. Translation: BAG38010.1.
AL391069 Genomic DNA. Translation: CAH70328.1.
CH471121 Genomic DNA. Translation: EAW53443.1.
CH471121 Genomic DNA. Translation: EAW53445.1.
BC009084 mRNA. Translation: AAH09084.1.
BC032997 mRNA. Translation: AAH32997.1.
CCDSiCCDS58027.1. [Q13228-3]
CCDS60266.1. [Q13228-4]
CCDS995.1. [Q13228-1]
PIRiG01872.
RefSeqiNP_001245217.1. NM_001258288.1. [Q13228-3]
NP_001245218.1. NM_001258289.1. [Q13228-4]
NP_003935.2. NM_003944.3. [Q13228-1]
UniGeneiHs.632460.

Genome annotation databases

EnsembliENST00000368868; ENSP00000357861; ENSG00000143416. [Q13228-1]
ENST00000426705; ENSP00000397261; ENSG00000143416. [Q13228-4]
ENST00000447402; ENSP00000413960; ENSG00000143416. [Q13228-3]
GeneIDi8991.
KEGGihsa:8991.
UCSCiuc010pcy.4. human. [Q13228-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29091 mRNA. Translation: AAB02395.1.
CR456852 mRNA. Translation: CAG33133.1.
AK296661 mRNA. Translation: BAG59258.1.
AK303815 mRNA. Translation: BAG64765.1.
AK315643 mRNA. Translation: BAG38010.1.
AL391069 Genomic DNA. Translation: CAH70328.1.
CH471121 Genomic DNA. Translation: EAW53443.1.
CH471121 Genomic DNA. Translation: EAW53445.1.
BC009084 mRNA. Translation: AAH09084.1.
BC032997 mRNA. Translation: AAH32997.1.
CCDSiCCDS58027.1. [Q13228-3]
CCDS60266.1. [Q13228-4]
CCDS995.1. [Q13228-1]
PIRiG01872.
RefSeqiNP_001245217.1. NM_001258288.1. [Q13228-3]
NP_001245218.1. NM_001258289.1. [Q13228-4]
NP_003935.2. NM_003944.3. [Q13228-1]
UniGeneiHs.632460.

3D structure databases

ProteinModelPortaliQ13228.
SMRiQ13228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114472. 63 interactors.
IntActiQ13228. 11 interactors.
MINTiMINT-5005535.
STRINGi9606.ENSP00000357861.

PTM databases

iPTMnetiQ13228.
PhosphoSitePlusiQ13228.
SwissPalmiQ13228.

Polymorphism and mutation databases

BioMutaiSELENBP1.
DMDMi148840437.

2D gel databases

REPRODUCTION-2DPAGEIPI00012303.
Q13228.
UCD-2DPAGEQ13228.

Proteomic databases

EPDiQ13228.
PaxDbiQ13228.
PeptideAtlasiQ13228.
PRIDEiQ13228.

Protocols and materials databases

DNASUi8991.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368868; ENSP00000357861; ENSG00000143416. [Q13228-1]
ENST00000426705; ENSP00000397261; ENSG00000143416. [Q13228-4]
ENST00000447402; ENSP00000413960; ENSG00000143416. [Q13228-3]
GeneIDi8991.
KEGGihsa:8991.
UCSCiuc010pcy.4. human. [Q13228-1]

Organism-specific databases

CTDi8991.
DisGeNETi8991.
GeneCardsiSELENBP1.
HGNCiHGNC:10719. SELENBP1.
HPAiCAB008366.
HPA005741.
HPA011731.
MIMi604188. gene.
neXtProtiNX_Q13228.
OpenTargetsiENSG00000143416.
PharmGKBiPA35641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0918. Eukaryota.
ENOG410XP4F. LUCA.
GeneTreeiENSGT00390000014244.
HOGENOMiHOG000263885.
HOVERGENiHBG017779.
InParanoidiQ13228.
KOiK17285.
OMAiIDIPGKL.
OrthoDBiEOG091G061L.
PhylomeDBiQ13228.
TreeFamiTF315241.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143416-MONOMER.

Miscellaneous databases

ChiTaRSiSELENBP1. human.
GeneWikiiSELENBP1.
GenomeRNAii8991.
PROiQ13228.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143416.
CleanExiHS_SELENBP1.
ExpressionAtlasiQ13228. baseline and differential.
GenevisibleiQ13228. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR008826. Se-bd.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR23300. PTHR23300. 1 hit.
PfamiPF05694. SBP56. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSBP1_HUMAN
AccessioniPrimary (citable) accession number: Q13228
Secondary accession number(s): A6NML9
, A6PVW9, B2RDR3, B4DKP6, B4E1F3, Q49AQ8, Q96GX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 29, 2007
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.