G protein pathway suppressor 2 - Homo sapiens (Human)

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Q13227 (GPS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
G protein pathway suppressor 2
Short name=GPS-2

Gene names

Name:

GPS2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Subunit structure	Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.
Tissue specificity	Widely expressed. Ref.1
Sequence caution	The sequence CAB75677.2 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	JNK cascade Traceable author statement Ref.1. Source: ProtInc cell cycle Traceable author statement Ref.1. Source: ProtInc inactivation of MAPK activity Traceable author statement Ref.1. Source: ProtInc negative regulation of JNK cascade Inferred from direct assay Ref.6. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.6. Source: UniProtKB
Cellular_component	transcriptional repressor complex Inferred from direct assay PubMed 12628926. Source: UniProtKB
Molecular_function	GTPase inhibitor activity Traceable author statement Ref.1. Source: ProtInc transcription corepressor activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TAK1L	P57077	2	EBI-713355,EBI-748831
vif	P12504	2	EBI-713355,EBI-779991	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 327

327

G protein pathway suppressor 2

PRO_0000087565

Regions

Compositional bias

32 – 35

Poly-Glu

Natural variations

Natural variant

306

T → A.
Corresponds to variant rs2292065 [ dbSNP | Ensembl ].

VAR_021972

Secondary structure

327

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q13227 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: AE65DA578C978C9B
Show »

FASTA

327

36,689

        10         20         30         40         50         60 
MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER RKKKEMEERM 

        70         80         90        100        110        120 
SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR RRKEQSDLTT LTSAAYQQSL 

       130        140        150        160        170        180 
TVHTGTHLLS MQGSPGGHNR PGTLMAADRA KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF 

       190        200        210        220        230        240 
QGSPGGAYGT AQPPPHYGPT QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ 

       250        260        270        280        290        300 
TGFLQPGGAL SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK 

       310        320 
SGFAATSQPG PRLPFIQHSQ NPRFYHK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells." Spain B.H., Bowdish K.S., Pacal A., Flueckiger Staub S., Koo D., Chang K.-Y.R., Xie W., Colicelli J. Mol. Cell. Biol. 16:6698-6706(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.
[6]	"The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2." Zhang J., Kalkum M., Chait B.T., Roeder R.G. Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, COMPONENT OF THE N-COR COMPLEX WITH NCOR1; NCOR2; TBL1X; TBL1R AND HDAC3.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U28963 mRNA. Translation: AAB60432.1.
BT006998 mRNA. Translation: AAP35644.1.
CR541723 mRNA. Translation: CAG46524.1.
CR541750 mRNA. Translation: CAG46550.1.
AL122080 mRNA. Translation: CAB59255.1.
AL157493 mRNA. Translation: CAB75677.2. Sequence problems.
BC013652 mRNA. Translation: AAH13652.1.
BC103901 mRNA. Translation: AAI03902.1.
BC103903 mRNA. Translation: AAI03904.1.
BC107738 mRNA. Translation: AAI07739.1.

IPI

IPI00012301.

PIR

T34562.

RefSeq

NP_004480.1. NM_004489.4.

UniGene

Hs.438219.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2L5G	NMR	-	A	53-90	[»]

ProteinModelPortal

Q13227.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-34427N.

IntAct

Q13227. 16 interactions.

MINT

MINT-153910.

STRING

9606.ENSP00000319371.

PTM databases

PhosphoSite

Q13227.

Polymorphism databases

DMDM

6226623.

Proteomic databases

PaxDb

Q13227.

PRIDE

Q13227.

Protocols and materials databases

DNASU

2874.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000380728; ENSP00000370104; ENSG00000132522.
ENST00000389167; ENSP00000379841; ENSG00000132522.

GeneID

2874.

KEGG

hsa:2874.

UCSC

uc002gfw.1. human.

Organism-specific databases

CTD

2874.

GeneCards

GC17M007215.

HGNC

HGNC:4550. GPS2.

MIM

601935. gene.

neXtProt

NX_Q13227.

PharmGKB

PA28945.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG46035.

HOGENOM

HOG000112796.

HOVERGEN

HBG005905.

InParanoid

Q13227.

K15307.

OMA

YAVHSHF.

OrthoDB

EOG4F1X3S.

PhylomeDB

Q13227.

Gene expression databases

ArrayExpress

Q13227.

Bgee

Q13227.

CleanEx

HS_GPS2.

Genevestigator

Q13227.

GermOnline

ENSG00000132522. Homo sapiens.

Family and domain databases

InterPro

IPR026094. GPS2.
[Graphical view]

PANTHER

PTHR22654. PTHR22654. 1 hit.

ProtoNet

Search...

Other

GenomeRNAi

2874.

NextBio

11345.

SOURCE

Search...

Entry information

Entry name

GPS2_HUMAN

Accession

Primary (citable) accession number: Q13227
Secondary accession number(s): Q6FHM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents