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Q13227

- GPS2_HUMAN

UniProt

Q13227 - GPS2_HUMAN

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Protein
G protein pathway suppressor 2
Gene
GPS2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

GO - Molecular functioni

  1. GTPase inhibitor activity Source: ProtInc
  2. protein binding Source: UniProtKB
  3. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. JNK cascade Source: ProtInc
  2. cell cycle Source: ProtInc
  3. inactivation of MAPK activity Source: ProtInc
  4. negative regulation of JNK cascade Source: UniProtKB
  5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G protein pathway suppressor 2
Short name:
GPS-2
Gene namesi
Name:GPS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4550. GPS2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
  2. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327G protein pathway suppressor 2
PRO_0000087565Add
BLAST

Proteomic databases

MaxQBiQ13227.
PaxDbiQ13227.
PRIDEiQ13227.

PTM databases

PhosphoSiteiQ13227.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ13227.
CleanExiHS_GPS2.
GenevestigatoriQ13227.

Interactioni

Subunit structurei

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-713355,EBI-6863748From a different organism.
MAP3K7CLP570772EBI-713355,EBI-748831
vifP125042EBI-713355,EBI-779991From a different organism.

Protein-protein interaction databases

BioGridi109132. 32 interactions.
DIPiDIP-34427N.
IntActiQ13227. 19 interactions.
MINTiMINT-153910.
STRINGi9606.ENSP00000319371.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi57 – 8933

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L5GNMR-A53-90[»]
ProteinModelPortaliQ13227.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 354Poly-Glu

Phylogenomic databases

eggNOGiNOG46035.
HOGENOMiHOG000112796.
HOVERGENiHBG005905.
InParanoidiQ13227.
KOiK15307.
OMAiKHIMRER.
PhylomeDBiQ13227.
TreeFamiTF329067.

Family and domain databases

InterProiIPR026094. GPS2.
[Graphical view]
PANTHERiPTHR22654. PTHR22654. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13227-1 [UniParc]FASTAAdd to Basket

« Hide

MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER    50
RKKKEMEERM SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR 100
RRKEQSDLTT LTSAAYQQSL TVHTGTHLLS MQGSPGGHNR PGTLMAADRA 150
KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF QGSPGGAYGT AQPPPHYGPT 200
QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ TGFLQPGGAL 250
SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK 300
SGFAATSQPG PRLPFIQHSQ NPRFYHK 327
Length:327
Mass (Da):36,689
Last modified:May 30, 2000 - v3
Checksum:iAE65DA578C978C9B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 3061T → A.
Corresponds to variant rs2292065 [ dbSNP | Ensembl ].
VAR_021972

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28963 mRNA. Translation: AAB60432.1.
BT006998 mRNA. Translation: AAP35644.1.
CR541723 mRNA. Translation: CAG46524.1.
CR541750 mRNA. Translation: CAG46550.1.
AL122080 mRNA. Translation: CAB59255.1.
AL157493 mRNA. Translation: CAB75677.2. Sequence problems.
BC013652 mRNA. Translation: AAH13652.1.
BC103901 mRNA. Translation: AAI03902.1.
BC103903 mRNA. Translation: AAI03904.1.
BC107738 mRNA. Translation: AAI07739.1.
CCDSiCCDS11100.1.
PIRiT34562.
RefSeqiNP_004480.1. NM_004489.4.
UniGeneiHs.438219.

Genome annotation databases

EnsembliENST00000380728; ENSP00000370104; ENSG00000132522.
ENST00000389167; ENSP00000379841; ENSG00000132522.
GeneIDi2874.
KEGGihsa:2874.
UCSCiuc002gfw.1. human.

Polymorphism databases

DMDMi6226623.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28963 mRNA. Translation: AAB60432.1 .
BT006998 mRNA. Translation: AAP35644.1 .
CR541723 mRNA. Translation: CAG46524.1 .
CR541750 mRNA. Translation: CAG46550.1 .
AL122080 mRNA. Translation: CAB59255.1 .
AL157493 mRNA. Translation: CAB75677.2 . Sequence problems.
BC013652 mRNA. Translation: AAH13652.1 .
BC103901 mRNA. Translation: AAI03902.1 .
BC103903 mRNA. Translation: AAI03904.1 .
BC107738 mRNA. Translation: AAI07739.1 .
CCDSi CCDS11100.1.
PIRi T34562.
RefSeqi NP_004480.1. NM_004489.4.
UniGenei Hs.438219.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L5G NMR - A 53-90 [» ]
ProteinModelPortali Q13227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109132. 32 interactions.
DIPi DIP-34427N.
IntActi Q13227. 19 interactions.
MINTi MINT-153910.
STRINGi 9606.ENSP00000319371.

PTM databases

PhosphoSitei Q13227.

Polymorphism databases

DMDMi 6226623.

Proteomic databases

MaxQBi Q13227.
PaxDbi Q13227.
PRIDEi Q13227.

Protocols and materials databases

DNASUi 2874.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380728 ; ENSP00000370104 ; ENSG00000132522 .
ENST00000389167 ; ENSP00000379841 ; ENSG00000132522 .
GeneIDi 2874.
KEGGi hsa:2874.
UCSCi uc002gfw.1. human.

Organism-specific databases

CTDi 2874.
GeneCardsi GC17M007215.
HGNCi HGNC:4550. GPS2.
MIMi 601935. gene.
neXtProti NX_Q13227.
PharmGKBi PA28945.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46035.
HOGENOMi HOG000112796.
HOVERGENi HBG005905.
InParanoidi Q13227.
KOi K15307.
OMAi KHIMRER.
PhylomeDBi Q13227.
TreeFami TF329067.

Miscellaneous databases

GeneWikii GPS2_(gene).
GenomeRNAii 2874.
NextBioi 11345.
PROi Q13227.
SOURCEi Search...

Gene expression databases

Bgeei Q13227.
CleanExi HS_GPS2.
Genevestigatori Q13227.

Family and domain databases

InterProi IPR026094. GPS2.
[Graphical view ]
PANTHERi PTHR22654. PTHR22654. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells."
    Spain B.H., Bowdish K.S., Pacal A., Flueckiger Staub S., Koo D., Chang K.-Y.R., Xie W., Colicelli J.
    Mol. Cell. Biol. 16:6698-6706(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  6. "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
    Zhang J., Kalkum M., Chait B.T., Roeder R.G.
    Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, COMPONENT OF THE N-COR COMPLEX WITH NCOR1; NCOR2; TBL1X; TBL1R AND HDAC3.

Entry informationi

Entry nameiGPS2_HUMAN
AccessioniPrimary (citable) accession number: Q13227
Secondary accession number(s): Q6FHM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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