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Protein

G protein pathway suppressor 2

Gene

GPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

GO - Molecular functioni

  1. GTPase inhibitor activity Source: ProtInc
  2. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: ProtInc
  2. chromatin organization Source: Reactome
  3. inactivation of MAPK activity Source: ProtInc
  4. JNK cascade Source: ProtInc
  5. negative regulation of JNK cascade Source: UniProtKB
  6. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_228222. HDACs deacetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein pathway suppressor 2
Short name:
GPS-2
Gene namesi
Name:GPS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4550. GPS2.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327G protein pathway suppressor 2PRO_0000087565Add
BLAST

Proteomic databases

MaxQBiQ13227.
PaxDbiQ13227.
PRIDEiQ13227.

PTM databases

PhosphoSiteiQ13227.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ13227.
CleanExiHS_GPS2.
ExpressionAtlasiQ13227. baseline and differential.
GenevestigatoriQ13227.

Interactioni

Subunit structurei

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-713355,EBI-6863748From a different organism.
MAP3K7CLP570772EBI-713355,EBI-748831
vifP125042EBI-713355,EBI-779991From a different organism.

Protein-protein interaction databases

BioGridi109132. 60 interactions.
DIPiDIP-34427N.
IntActiQ13227. 19 interactions.
MINTiMINT-153910.
STRINGi9606.ENSP00000319371.

Structurei

Secondary structure

1
327
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi57 – 8933Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L5GNMR-A53-90[»]
ProteinModelPortaliQ13227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 354Poly-Glu

Phylogenomic databases

eggNOGiNOG46035.
GeneTreeiENSGT00390000004049.
HOGENOMiHOG000112796.
HOVERGENiHBG005905.
InParanoidiQ13227.
KOiK15307.
OMAiKHIMRER.
PhylomeDBiQ13227.
TreeFamiTF329067.

Family and domain databases

InterProiIPR026094. GPS2.
[Graphical view]
PANTHERiPTHR22654. PTHR22654. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13227-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER
60 70 80 90 100
RKKKEMEERM SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR
110 120 130 140 150
RRKEQSDLTT LTSAAYQQSL TVHTGTHLLS MQGSPGGHNR PGTLMAADRA
160 170 180 190 200
KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF QGSPGGAYGT AQPPPHYGPT
210 220 230 240 250
QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ TGFLQPGGAL
260 270 280 290 300
SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK
310 320
SGFAATSQPG PRLPFIQHSQ NPRFYHK
Length:327
Mass (Da):36,689
Last modified:May 30, 2000 - v3
Checksum:iAE65DA578C978C9B
GO
Isoform 2 (identifier: Q13227-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-327: SGFAATSQPGPRLPFIQHSQNPRFYHK → TAP

Note: No experimental confirmation available.

Show »
Length:303
Mass (Da):33,907
Checksum:i92B89119643D2D42
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 3061T → A.
Corresponds to variant rs2292065 [ dbSNP | Ensembl ].
VAR_021972

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei301 – 32727SGFAA…RFYHK → TAP in isoform 2. 1 PublicationVSP_057012Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28963 mRNA. Translation: AAB60432.1.
BT006998 mRNA. Translation: AAP35644.1.
AK301877 mRNA. Translation: BAG63313.1.
CR541723 mRNA. Translation: CAG46524.1.
CR541750 mRNA. Translation: CAG46550.1.
AL122080 mRNA. Translation: CAB59255.1.
AL157493 mRNA. Translation: CAB75677.2. Sequence problems.
AC026954 Genomic DNA. No translation available.
BC013652 mRNA. Translation: AAH13652.1.
BC103901 mRNA. Translation: AAI03902.1.
BC103903 mRNA. Translation: AAI03904.1.
BC107738 mRNA. Translation: AAI07739.1.
CCDSiCCDS11100.1. [Q13227-1]
PIRiT34562.
RefSeqiNP_004480.1. NM_004489.4. [Q13227-1]
UniGeneiHs.438219.

Genome annotation databases

EnsembliENST00000380728; ENSP00000370104; ENSG00000132522. [Q13227-1]
ENST00000389167; ENSP00000379841; ENSG00000132522. [Q13227-1]
GeneIDi2874.
KEGGihsa:2874.
UCSCiuc002gfw.1. human. [Q13227-1]

Polymorphism databases

DMDMi6226623.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28963 mRNA. Translation: AAB60432.1.
BT006998 mRNA. Translation: AAP35644.1.
AK301877 mRNA. Translation: BAG63313.1.
CR541723 mRNA. Translation: CAG46524.1.
CR541750 mRNA. Translation: CAG46550.1.
AL122080 mRNA. Translation: CAB59255.1.
AL157493 mRNA. Translation: CAB75677.2. Sequence problems.
AC026954 Genomic DNA. No translation available.
BC013652 mRNA. Translation: AAH13652.1.
BC103901 mRNA. Translation: AAI03902.1.
BC103903 mRNA. Translation: AAI03904.1.
BC107738 mRNA. Translation: AAI07739.1.
CCDSiCCDS11100.1. [Q13227-1]
PIRiT34562.
RefSeqiNP_004480.1. NM_004489.4. [Q13227-1]
UniGeneiHs.438219.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L5GNMR-A53-90[»]
ProteinModelPortaliQ13227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109132. 60 interactions.
DIPiDIP-34427N.
IntActiQ13227. 19 interactions.
MINTiMINT-153910.
STRINGi9606.ENSP00000319371.

PTM databases

PhosphoSiteiQ13227.

Polymorphism databases

DMDMi6226623.

Proteomic databases

MaxQBiQ13227.
PaxDbiQ13227.
PRIDEiQ13227.

Protocols and materials databases

DNASUi2874.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380728; ENSP00000370104; ENSG00000132522. [Q13227-1]
ENST00000389167; ENSP00000379841; ENSG00000132522. [Q13227-1]
GeneIDi2874.
KEGGihsa:2874.
UCSCiuc002gfw.1. human. [Q13227-1]

Organism-specific databases

CTDi2874.
GeneCardsiGC17M007215.
HGNCiHGNC:4550. GPS2.
MIMi601935. gene.
neXtProtiNX_Q13227.
PharmGKBiPA28945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46035.
GeneTreeiENSGT00390000004049.
HOGENOMiHOG000112796.
HOVERGENiHBG005905.
InParanoidiQ13227.
KOiK15307.
OMAiKHIMRER.
PhylomeDBiQ13227.
TreeFamiTF329067.

Enzyme and pathway databases

ReactomeiREACT_228222. HDACs deacetylate histones.

Miscellaneous databases

GeneWikiiGPS2_(gene).
GenomeRNAii2874.
NextBioi11345.
PROiQ13227.
SOURCEiSearch...

Gene expression databases

BgeeiQ13227.
CleanExiHS_GPS2.
ExpressionAtlasiQ13227. baseline and differential.
GenevestigatoriQ13227.

Family and domain databases

InterProiIPR026094. GPS2.
[Graphical view]
PANTHERiPTHR22654. PTHR22654. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells."
    Spain B.H., Bowdish K.S., Pacal A., Flueckiger Staub S., Koo D., Chang K.-Y.R., Xie W., Colicelli J.
    Mol. Cell. Biol. 16:6698-6706(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.
  8. "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
    Zhang J., Kalkum M., Chait B.T., Roeder R.G.
    Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, COMPONENT OF THE N-COR COMPLEX WITH NCOR1; NCOR2; TBL1X; TBL1R AND HDAC3.

Entry informationi

Entry nameiGPS2_HUMAN
AccessioniPrimary (citable) accession number: Q13227
Secondary accession number(s): B4DXA1, Q6FHM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: March 4, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.