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Q13227 (GPS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G protein pathway suppressor 2

Short name=GPS-2
Gene names
Name:GPS2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Subunit structure

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

Tissue specificity

Widely expressed. Ref.1

Sequence caution

The sequence CAB75677.2 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q9WMX22EBI-713355,EBI-6863748From a different organism.
MAP3K7CLP570772EBI-713355,EBI-748831
vifP125042EBI-713355,EBI-779991From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327G protein pathway suppressor 2
PRO_0000087565

Regions

Compositional bias32 – 354Poly-Glu

Natural variations

Natural variant3061T → A.
Corresponds to variant rs2292065 [ dbSNP | Ensembl ].
VAR_021972

Secondary structure

... 327
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q13227 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: AE65DA578C978C9B

FASTA32736,689
        10         20         30         40         50         60 
MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER RKKKEMEERM 

        70         80         90        100        110        120 
SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR RRKEQSDLTT LTSAAYQQSL 

       130        140        150        160        170        180 
TVHTGTHLLS MQGSPGGHNR PGTLMAADRA KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF 

       190        200        210        220        230        240 
QGSPGGAYGT AQPPPHYGPT QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ 

       250        260        270        280        290        300 
TGFLQPGGAL SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK 

       310        320 
SGFAATSQPG PRLPFIQHSQ NPRFYHK 

« Hide

References

« Hide 'large scale' references
[1]"Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells."
Spain B.H., Bowdish K.S., Pacal A., Flueckiger Staub S., Koo D., Chang K.-Y.R., Xie W., Colicelli J.
Mol. Cell. Biol. 16:6698-6706(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix.
[6]"The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
Zhang J., Kalkum M., Chait B.T., Roeder R.G.
Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, COMPONENT OF THE N-COR COMPLEX WITH NCOR1; NCOR2; TBL1X; TBL1R AND HDAC3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U28963 mRNA. Translation: AAB60432.1.
BT006998 mRNA. Translation: AAP35644.1.
CR541723 mRNA. Translation: CAG46524.1.
CR541750 mRNA. Translation: CAG46550.1.
AL122080 mRNA. Translation: CAB59255.1.
AL157493 mRNA. Translation: CAB75677.2. Sequence problems.
BC013652 mRNA. Translation: AAH13652.1.
BC103901 mRNA. Translation: AAI03902.1.
BC103903 mRNA. Translation: AAI03904.1.
BC107738 mRNA. Translation: AAI07739.1.
PIRT34562.
RefSeqNP_004480.1. NM_004489.4.
UniGeneHs.438219.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2L5GNMR-A53-90[»]
ProteinModelPortalQ13227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109132. 32 interactions.
DIPDIP-34427N.
IntActQ13227. 19 interactions.
MINTMINT-153910.
STRING9606.ENSP00000319371.

PTM databases

PhosphoSiteQ13227.

Polymorphism databases

DMDM6226623.

Proteomic databases

PaxDbQ13227.
PRIDEQ13227.

Protocols and materials databases

DNASU2874.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380728; ENSP00000370104; ENSG00000132522.
ENST00000389167; ENSP00000379841; ENSG00000132522.
GeneID2874.
KEGGhsa:2874.
UCSCuc002gfw.1. human.

Organism-specific databases

CTD2874.
GeneCardsGC17M007215.
HGNCHGNC:4550. GPS2.
MIM601935. gene.
neXtProtNX_Q13227.
PharmGKBPA28945.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46035.
HOGENOMHOG000112796.
HOVERGENHBG005905.
InParanoidQ13227.
KOK15307.
OMAKHIMRER.
PhylomeDBQ13227.
TreeFamTF329067.

Gene expression databases

BgeeQ13227.
CleanExHS_GPS2.
GenevestigatorQ13227.

Family and domain databases

InterProIPR026094. GPS2.
[Graphical view]
PANTHERPTHR22654. PTHR22654. 1 hit.
ProtoNetSearch...

Other

GeneWikiGPS2_(gene).
GenomeRNAi2874.
NextBio11345.
PROQ13227.
SOURCESearch...

Entry information

Entry nameGPS2_HUMAN
AccessionPrimary (citable) accession number: Q13227
Secondary accession number(s): Q6FHM8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM