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Q13227

- GPS2_HUMAN

UniProt

Q13227 - GPS2_HUMAN

Protein

G protein pathway suppressor 2

Gene

GPS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    Functioni

    Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

    GO - Molecular functioni

    1. GTPase inhibitor activity Source: ProtInc
    2. protein binding Source: UniProtKB
    3. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: ProtInc
    2. inactivation of MAPK activity Source: ProtInc
    3. JNK cascade Source: ProtInc
    4. negative regulation of JNK cascade Source: UniProtKB
    5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein pathway suppressor 2
    Short name:
    GPS-2
    Gene namesi
    Name:GPS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4550. GPS2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: Ensembl
    2. transcriptional repressor complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28945.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327G protein pathway suppressor 2PRO_0000087565Add
    BLAST

    Proteomic databases

    MaxQBiQ13227.
    PaxDbiQ13227.
    PRIDEiQ13227.

    PTM databases

    PhosphoSiteiQ13227.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiQ13227.
    CleanExiHS_GPS2.
    GenevestigatoriQ13227.

    Interactioni

    Subunit structurei

    Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q9WMX22EBI-713355,EBI-6863748From a different organism.
    MAP3K7CLP570772EBI-713355,EBI-748831
    vifP125042EBI-713355,EBI-779991From a different organism.

    Protein-protein interaction databases

    BioGridi109132. 32 interactions.
    DIPiDIP-34427N.
    IntActiQ13227. 19 interactions.
    MINTiMINT-153910.
    STRINGi9606.ENSP00000319371.

    Structurei

    Secondary structure

    1
    327
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi57 – 8933

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L5GNMR-A53-90[»]
    ProteinModelPortaliQ13227.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 354Poly-Glu

    Phylogenomic databases

    eggNOGiNOG46035.
    HOGENOMiHOG000112796.
    HOVERGENiHBG005905.
    InParanoidiQ13227.
    KOiK15307.
    OMAiKHIMRER.
    PhylomeDBiQ13227.
    TreeFamiTF329067.

    Family and domain databases

    InterProiIPR026094. GPS2.
    [Graphical view]
    PANTHERiPTHR22654. PTHR22654. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q13227-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER    50
    RKKKEMEERM SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR 100
    RRKEQSDLTT LTSAAYQQSL TVHTGTHLLS MQGSPGGHNR PGTLMAADRA 150
    KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF QGSPGGAYGT AQPPPHYGPT 200
    QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ TGFLQPGGAL 250
    SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK 300
    SGFAATSQPG PRLPFIQHSQ NPRFYHK 327
    Length:327
    Mass (Da):36,689
    Last modified:May 30, 2000 - v3
    Checksum:iAE65DA578C978C9B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti306 – 3061T → A.
    Corresponds to variant rs2292065 [ dbSNP | Ensembl ].
    VAR_021972

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28963 mRNA. Translation: AAB60432.1.
    BT006998 mRNA. Translation: AAP35644.1.
    CR541723 mRNA. Translation: CAG46524.1.
    CR541750 mRNA. Translation: CAG46550.1.
    AL122080 mRNA. Translation: CAB59255.1.
    AL157493 mRNA. Translation: CAB75677.2. Sequence problems.
    BC013652 mRNA. Translation: AAH13652.1.
    BC103901 mRNA. Translation: AAI03902.1.
    BC103903 mRNA. Translation: AAI03904.1.
    BC107738 mRNA. Translation: AAI07739.1.
    CCDSiCCDS11100.1.
    PIRiT34562.
    RefSeqiNP_004480.1. NM_004489.4.
    UniGeneiHs.438219.

    Genome annotation databases

    EnsembliENST00000380728; ENSP00000370104; ENSG00000132522.
    ENST00000389167; ENSP00000379841; ENSG00000132522.
    GeneIDi2874.
    KEGGihsa:2874.
    UCSCiuc002gfw.1. human.

    Polymorphism databases

    DMDMi6226623.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28963 mRNA. Translation: AAB60432.1 .
    BT006998 mRNA. Translation: AAP35644.1 .
    CR541723 mRNA. Translation: CAG46524.1 .
    CR541750 mRNA. Translation: CAG46550.1 .
    AL122080 mRNA. Translation: CAB59255.1 .
    AL157493 mRNA. Translation: CAB75677.2 . Sequence problems.
    BC013652 mRNA. Translation: AAH13652.1 .
    BC103901 mRNA. Translation: AAI03902.1 .
    BC103903 mRNA. Translation: AAI03904.1 .
    BC107738 mRNA. Translation: AAI07739.1 .
    CCDSi CCDS11100.1.
    PIRi T34562.
    RefSeqi NP_004480.1. NM_004489.4.
    UniGenei Hs.438219.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L5G NMR - A 53-90 [» ]
    ProteinModelPortali Q13227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109132. 32 interactions.
    DIPi DIP-34427N.
    IntActi Q13227. 19 interactions.
    MINTi MINT-153910.
    STRINGi 9606.ENSP00000319371.

    PTM databases

    PhosphoSitei Q13227.

    Polymorphism databases

    DMDMi 6226623.

    Proteomic databases

    MaxQBi Q13227.
    PaxDbi Q13227.
    PRIDEi Q13227.

    Protocols and materials databases

    DNASUi 2874.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380728 ; ENSP00000370104 ; ENSG00000132522 .
    ENST00000389167 ; ENSP00000379841 ; ENSG00000132522 .
    GeneIDi 2874.
    KEGGi hsa:2874.
    UCSCi uc002gfw.1. human.

    Organism-specific databases

    CTDi 2874.
    GeneCardsi GC17M007215.
    HGNCi HGNC:4550. GPS2.
    MIMi 601935. gene.
    neXtProti NX_Q13227.
    PharmGKBi PA28945.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46035.
    HOGENOMi HOG000112796.
    HOVERGENi HBG005905.
    InParanoidi Q13227.
    KOi K15307.
    OMAi KHIMRER.
    PhylomeDBi Q13227.
    TreeFami TF329067.

    Miscellaneous databases

    GeneWikii GPS2_(gene).
    GenomeRNAii 2874.
    NextBioi 11345.
    PROi Q13227.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13227.
    CleanExi HS_GPS2.
    Genevestigatori Q13227.

    Family and domain databases

    InterProi IPR026094. GPS2.
    [Graphical view ]
    PANTHERi PTHR22654. PTHR22654. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells."
      Spain B.H., Bowdish K.S., Pacal A., Flueckiger Staub S., Koo D., Chang K.-Y.R., Xie W., Colicelli J.
      Mol. Cell. Biol. 16:6698-6706(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    6. "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
      Zhang J., Kalkum M., Chait B.T., Roeder R.G.
      Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, COMPONENT OF THE N-COR COMPLEX WITH NCOR1; NCOR2; TBL1X; TBL1R AND HDAC3.

    Entry informationi

    Entry nameiGPS2_HUMAN
    AccessioniPrimary (citable) accession number: Q13227
    Secondary accession number(s): Q6FHM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3