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Q13224

- NMDE2_HUMAN

UniProt

Q13224 - NMDE2_HUMAN

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Protein

Glutamate receptor ionotropic, NMDA 2B

Gene
GRIN2B, NMDAR2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271Zinc By similarity
Metal bindingi284 – 2841Zinc By similarity
Sitei615 – 6151Functional determinant of NMDA receptors By similarity

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. glycine binding Source: UniProtKB
  4. N-methyl-D-aspartate selective glutamate receptor activity Source: RefGenome
  5. protein binding Source: UniProtKB
  6. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. behavioral response to pain Source: Ensembl
  3. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  4. glutamate receptor signaling pathway Source: ProtInc
  5. in utero embryonic development Source: Ensembl
  6. ionotropic glutamate receptor signaling pathway Source: RefGenome
  7. ion transmembrane transport Source: RefGenome
  8. learning Source: Ensembl
  9. learning or memory Source: ProtInc
  10. memory Source: Ensembl
  11. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  12. regulation of synaptic plasticity Source: Ensembl
  13. response to ethanol Source: UniProtKB
  14. sensory organ development Source: Ensembl
  15. startle response Source: Ensembl
  16. suckling behavior Source: Ensembl
  17. synaptic transmission Source: Reactome
  18. synaptic transmission, glutamatergic Source: RefGenome
  19. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinkiQ13224.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 2B
Short name:
GluN2B
Alternative name(s):
Glutamate [NMDA] receptor subunit epsilon-2
N-methyl D-aspartate receptor subtype 2B
Short name:
NMDAR2B
Short name:
NR2B
N-methyl-D-aspartate receptor subunit 3
Short name:
NR3
Short name:
hNR3
Gene namesi
Name:GRIN2B
Synonyms:NMDAR2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4586. GRIN2B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 557531Extracellular Reviewed predictionAdd
BLAST
Transmembranei558 – 57821Helical; Reviewed predictionAdd
BLAST
Topological domaini579 – 63456Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei635 – 65521Helical; Reviewed predictionAdd
BLAST
Topological domaini656 – 817162Extracellular Reviewed predictionAdd
BLAST
Transmembranei818 – 83821Helical; Reviewed predictionAdd
BLAST
Topological domaini839 – 1484646Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. dendrite Source: RefGenome
  4. integral component of plasma membrane Source: ProtInc
  5. neuron projection Source: BHF-UCL
  6. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
  7. plasma membrane Source: Reactome
  8. postsynaptic density Source: Ensembl
  9. postsynaptic membrane Source: RefGenome
  10. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 6 (MRD6) [MIM:613970]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti553 – 5531P → L in MRD6. 1 Publication
VAR_069384
Natural varianti682 – 6821R → C in MRD6; analysis of agonist dose-response curves reveal no differences in the affinities of wild-type and mutant receptors for glutamate and glycine. 1 Publication
VAR_065900
A chromosomal aberrations involving GRIN2B has been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1.

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi613970. phenotype.
Orphaneti178469. Autosomal dominant nonsyndromic intellectual disability.
3451. West syndrome.
PharmGKBiPA28980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 14841458Glutamate receptor ionotropic, NMDA 2BPRO_0000011577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi86 ↔ 321 By similarity
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi542 – 5421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi688 – 6881N-linked (GlcNAc...) Reviewed prediction
Modified residuei962 – 9621Phosphotyrosine By similarity
Modified residuei1039 – 10391Phosphotyrosine By similarity
Modified residuei1109 – 11091Phosphotyrosine By similarity
Modified residuei1133 – 11331Phosphotyrosine By similarity
Modified residuei1155 – 11551Phosphotyrosine By similarity
Modified residuei1303 – 13031Phosphoserine; by DAPK1 By similarity
Modified residuei1474 – 14741Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ13224.
PeptideAtlasiQ13224.
PRIDEiQ13224.

PTM databases

PhosphoSiteiQ13224.

Expressioni

Tissue specificityi

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.1 Publication

Gene expression databases

ArrayExpressiQ13224.
BgeeiQ13224.
CleanExiHS_GRIN2B.
GenevestigatoriQ13224.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 and NETO1 By similarity. Interacts with MAGI3. Interacts with DAPK1 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CAMK2AQ9UQM73EBI-2256942,EBI-1383687
Dlg3Q629364EBI-2256942,EBI-349596From a different organism.
DLG4P783522EBI-2256942,EBI-80389
Dlg4P310162EBI-2256942,EBI-375655From a different organism.
PPP1CAP621392EBI-2256942,EBI-2008988From a different organism.

Protein-protein interaction databases

BioGridi109161. 25 interactions.
DIPiDIP-41002N.
IntActiQ13224. 11 interactions.
MINTiMINT-127466.
STRINGi9606.ENSP00000279593.

Structurei

Secondary structure

1
1484
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni423 – 4264
Beta strandi429 – 4313
Beta strandi440 – 4423
Helixi448 – 4536
Helixi461 – 47212
Helixi496 – 5027
Beta strandi507 – 5093
Helixi517 – 5204
Beta strandi529 – 5357
Helixi666 – 6705
Helixi673 – 6753
Turni678 – 6803
Helixi690 – 6989
Helixi700 – 7067
Helixi714 – 72310
Beta strandi724 – 7274
Helixi733 – 7408
Turni743 – 7453
Beta strandi757 – 7626
Helixi773 – 78513
Helixi789 – 7979

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S11model-A403-543[»]
B660-801[»]
1S2Smodel-A405-543[»]
B660-801[»]
2IPVmodel-X404-768[»]
ProteinModelPortaliQ13224.
SMRiQ13224. Positions 32-836.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1292 – 130413Interaction with DAPK1 By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1482 – 14843PDZ-binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi984 – 9896Poly-His
Compositional biasi1361 – 13644Poly-His

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282132.
HOGENOMiHOG000113802.
HOVERGENiHBG052635.
InParanoidiQ13224.
KOiK05210.
OMAiCTNRSHL.
OrthoDBiEOG72ZCD1.
PhylomeDBiQ13224.
TreeFamiTF314731.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13224-1 [UniParc]FASTAAdd to Basket

« Hide

MKPRAECCSP KFWLVLAVLA VSGSRARSQK SPPSIGIAVI LVGTSDEVAI     50
KDAHEKDDFH HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA 100
DDTDQEAIAQ ILDFISAQTL TPILGIHGGS SMIMADKDES SMFFQFGPSI 150
EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ DFVNKIRSTI ENSFVGWELE 200
EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI FEVANSVGLT 250
GYGYTWIVPS LVAGDTDTVP AEFPTGLISV SYDEWDYGLP ARVRDGIAII 300
TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS 350
FSEDGYQMHP KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE 400
QEDDHLSIVT LEEAPFVIVE SVDPLSGTCM RNTVPCQKRI VTENKTDEEP 450
GYIKKCCKGF CIDILKKISK SVKFTYDLYL VTNGKHGKKI NGTWNGMIGE 500
VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR SNGTVSPSAF 550
LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF 600
TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL 650
AAFMIQEEYV DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA 700
EMHAYMGKFN QRGVDDALLS LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT 750
IGSGKVFAST GYGIAIQKDS GWKRQVDLAI LQLFGDGEME ELEALWLTGI 800
CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH LFYWQFRHCF 850
MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR 900
LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN 950
NPPCEENLFS DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSASSI 1000
DGLYDCDNPP FTTQSRSISK KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS 1050
GHDDLIRSDV SDISTHTVTY GNIEGNAAKR RKQQYKDSLK KRPASAKSRR 1100
EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK ENSPHWEHVD 1150
LTDIYKERSD DFKRDSVSGG GPCTNRSHIK HGTGDKHGVV SGVPAPWEKN 1200
LTNVEWEDRS GGNFCRSCPS KLHNYSTTVT GQNSGRQACI RCEACKKAGN 1250
LYDISEDNSL QELDQPAAPV AVTSNASTTK YPQSPTNSKA QKKNRNKLRR 1300
QHSYDTFVDL QKEEAALAPR SVSLKDKGRF MDGSPYAHMF EMSAGESTFA 1350
NNKSSVPTAG HHHHNNPGGG YMLSKSLYPD RVTQNPFIPT FGDDQCLLHG 1400
SKSYFFRQPT VAGASKARPD FRALVTNKPV VSALHGAVPA RFQKDICIGN 1450
QSNPCVPNNK NPRAFNGSSN GHVYEKLSSI ESDV 1484
Length:1,484
Mass (Da):166,367
Last modified:June 20, 2001 - v3
Checksum:i40AEB12BE6E50CEF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti407 – 4071S → N.1 Publication
VAR_011317
Natural varianti553 – 5531P → L in MRD6. 1 Publication
VAR_069384
Natural varianti682 – 6821R → C in MRD6; analysis of agonist dose-response curves reveal no differences in the affinities of wild-type and mutant receptors for glutamate and glycine. 1 Publication
VAR_065900

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti434 – 4341V → A in AAD00659. 1 Publication
Sequence conflicti745 – 7451G → A in AAA69920. 1 Publication
Sequence conflicti773 – 7731K → N in AAA69920. 1 Publication
Sequence conflicti773 – 7731K → N in AAA74930. 1 Publication
Sequence conflicti796 – 7961W → C in AAA69920. 1 Publication
Sequence conflicti796 – 7961W → C in AAA74930. 1 Publication
Sequence conflicti888 – 8881T → P in AAA69920. 1 Publication
Sequence conflicti888 – 8881T → P in AAA74930. 1 Publication
Sequence conflicti902 – 9021L → V in AAA69920. 1 Publication
Sequence conflicti902 – 9021L → V in AAA74930. 1 Publication
Sequence conflicti920 – 9212SA → RP in AAB60368. 1 Publication
Sequence conflicti958 – 9581L → S in AAA69920. 1 Publication
Sequence conflicti958 – 9581L → S in AAA74930. 1 Publication
Sequence conflicti980 – 9823VYQ → DHY in AAA69920. 1 Publication
Sequence conflicti1056 – 10561I → M in AAA69920. 1 Publication
Sequence conflicti1167 – 11671V → I in AAB49993. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90278 mRNA. Translation: AAB49993.1.
U88963 mRNA. Translation: AAD00659.1.
U11287 mRNA. Translation: AAB60368.1.
BC113618 mRNA. Translation: AAI13619.1.
BC113620 mRNA. Translation: AAI13621.1.
U28758 mRNA. Translation: AAA74930.1.
U28861 mRNA. Translation: AAA69919.1.
U28862 mRNA. Translation: AAA69920.1.
CCDSiCCDS8662.1.
PIRiI39066.
S52086.
RefSeqiNP_000825.2. NM_000834.3.
UniGeneiHs.654430.

Genome annotation databases

EnsembliENST00000609686; ENSP00000477455; ENSG00000273079.
GeneIDi2904.
KEGGihsa:2904.
UCSCiuc001rbt.2. human.

Polymorphism databases

DMDMi14548162.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90278 mRNA. Translation: AAB49993.1 .
U88963 mRNA. Translation: AAD00659.1 .
U11287 mRNA. Translation: AAB60368.1 .
BC113618 mRNA. Translation: AAI13619.1 .
BC113620 mRNA. Translation: AAI13621.1 .
U28758 mRNA. Translation: AAA74930.1 .
U28861 mRNA. Translation: AAA69919.1 .
U28862 mRNA. Translation: AAA69920.1 .
CCDSi CCDS8662.1.
PIRi I39066.
S52086.
RefSeqi NP_000825.2. NM_000834.3.
UniGenei Hs.654430.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S11 model - A 403-543 [» ]
B 660-801 [» ]
1S2S model - A 405-543 [» ]
B 660-801 [» ]
2IPV model - X 404-768 [» ]
ProteinModelPortali Q13224.
SMRi Q13224. Positions 32-836.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109161. 25 interactions.
DIPi DIP-41002N.
IntActi Q13224. 11 interactions.
MINTi MINT-127466.
STRINGi 9606.ENSP00000279593.

Chemistry

BindingDBi Q13224.
ChEMBLi CHEMBL2094124.
DrugBanki DB00949. Felbamate.
DB00502. Haloperidol.
DB00142. L-Glutamic Acid.
DB00836. Loperamide.
DB01043. Memantine.
GuidetoPHARMACOLOGYi 457.

PTM databases

PhosphoSitei Q13224.

Polymorphism databases

DMDMi 14548162.

Proteomic databases

PaxDbi Q13224.
PeptideAtlasi Q13224.
PRIDEi Q13224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000609686 ; ENSP00000477455 ; ENSG00000273079 .
GeneIDi 2904.
KEGGi hsa:2904.
UCSCi uc001rbt.2. human.

Organism-specific databases

CTDi 2904.
GeneCardsi GC12M013714.
H-InvDB HIX0036873.
HGNCi HGNC:4586. GRIN2B.
MIMi 138252. gene.
613970. phenotype.
neXtProti NX_Q13224.
Orphaneti 178469. Autosomal dominant nonsyndromic intellectual disability.
3451. West syndrome.
PharmGKBi PA28980.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282132.
HOGENOMi HOG000113802.
HOVERGENi HBG052635.
InParanoidi Q13224.
KOi K05210.
OMAi CTNRSHL.
OrthoDBi EOG72ZCD1.
PhylomeDBi Q13224.
TreeFami TF314731.

Enzyme and pathway databases

Reactomei REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinki Q13224.

Miscellaneous databases

GeneWikii GRIN2B.
GenomeRNAii 2904.
NextBioi 11499.
PROi Q13224.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13224.
Bgeei Q13224.
CleanExi HS_GRIN2B.
Genevestigatori Q13224.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein."
    Adams S.L., Foldes R.L., Kamboj R.K.
    Biochim. Biophys. Acta 1260:105-108(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-407.
    Tissue: Fetal brain.
  2. "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors."
    Hess S.D., Daggett L.P., Crona J., Deal C., Lu C.-C., Urrutia A., Chavez-Noriega L., Ellis S.B., Johnson E.C., Velicelebi G.
    J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Cloning of GRIN2B human subunit."
    Mandich P., Schito A.M., Pizzuti A., Ratti A.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12."
    Mandich P., Schito A.M., Bellone E., Antonacci R., Finelli P., Rocchi M., Ajmar F.
    Genomics 22:216-218(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-294 AND 661-1089.
  6. "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit."
    Schito A.M., Pizzuti A., Di Maria E., Schenone A., Ratti A., Defferrari R., Bellone E., Mancardi G.L., Ajmar F., Mandich P.
    Neurosci. Lett. 239:49-53(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."
    Wu Y., Dowbenko D., Spencer S., Laura R., Lee J., Gu Q., Lasky L.A.
    J. Biol. Chem. 275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAGI3.
  8. Cited for: CHROMOSOMAL TRANSLOCATIONS, VARIANT MRD6 CYS-682.
  9. Cited for: VARIANT MRD6 LEU-553.

Entry informationi

Entry nameiNMDE2_HUMAN
AccessioniPrimary (citable) accession number: Q13224
Secondary accession number(s): Q12919
, Q13220, Q13225, Q14CU4, Q9UM56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: September 3, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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