Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q13224

- NMDE2_HUMAN

UniProt

Q13224 - NMDE2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamate receptor ionotropic, NMDA 2B

Gene

GRIN2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271ZincBy similarity
Metal bindingi284 – 2841ZincBy similarity
Sitei615 – 6151Functional determinant of NMDA receptorsBy similarity

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. glycine binding Source: UniProtKB
  4. N-methyl-D-aspartate selective glutamate receptor activity Source: RefGenome
  5. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. behavioral response to pain Source: Ensembl
  3. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  4. glutamate receptor signaling pathway Source: ProtInc
  5. in utero embryonic development Source: Ensembl
  6. ionotropic glutamate receptor signaling pathway Source: RefGenome
  7. ion transmembrane transport Source: RefGenome
  8. learning Source: Ensembl
  9. learning or memory Source: ProtInc
  10. memory Source: Ensembl
  11. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  12. regulation of synaptic plasticity Source: Ensembl
  13. response to ethanol Source: UniProtKB
  14. sensory organ development Source: Ensembl
  15. startle response Source: Ensembl
  16. suckling behavior Source: Ensembl
  17. synaptic transmission Source: Reactome
  18. synaptic transmission, glutamatergic Source: RefGenome
  19. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinkiQ13224.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 2B
Short name:
GluN2B
Alternative name(s):
Glutamate [NMDA] receptor subunit epsilon-2
N-methyl D-aspartate receptor subtype 2B
Short name:
NMDAR2B
Short name:
NR2B
N-methyl-D-aspartate receptor subunit 3
Short name:
NR3
Short name:
hNR3
Gene namesi
Name:GRIN2B
Synonyms:NMDAR2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4586. GRIN2B.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. dendrite Source: RefGenome
  4. integral component of plasma membrane Source: ProtInc
  5. neuronal postsynaptic density Source: Ensembl
  6. neuron projection Source: BHF-UCL
  7. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
  8. plasma membrane Source: Reactome
  9. postsynaptic membrane Source: RefGenome
  10. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 6 (MRD6) [MIM:613970]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti553 – 5531P → L in MRD6. 1 Publication
VAR_069384
Natural varianti682 – 6821R → C in MRD6; analysis of agonist dose-response curves reveal no differences in the affinities of wild-type and mutant receptors for glutamate and glycine. 1 Publication
VAR_065900
A chromosomal aberrations involving GRIN2B has been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1.

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi613970. phenotype.
Orphaneti178469. Autosomal dominant non-syndromic intellectual disability.
3451. West syndrome.
PharmGKBiPA28980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 14841458Glutamate receptor ionotropic, NMDA 2BPRO_0000011577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi86 ↔ 321By similarity
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi688 – 6881N-linked (GlcNAc...)Sequence Analysis
Modified residuei962 – 9621PhosphotyrosineBy similarity
Modified residuei1039 – 10391PhosphotyrosineBy similarity
Modified residuei1109 – 11091PhosphotyrosineBy similarity
Modified residuei1133 – 11331PhosphotyrosineBy similarity
Modified residuei1155 – 11551PhosphotyrosineBy similarity
Modified residuei1303 – 13031Phosphoserine; by DAPK1By similarity
Modified residuei1474 – 14741PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ13224.
PeptideAtlasiQ13224.
PRIDEiQ13224.

PTM databases

PhosphoSiteiQ13224.

Expressioni

Tissue specificityi

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.1 Publication

Gene expression databases

BgeeiQ13224.
CleanExiHS_GRIN2B.
ExpressionAtlasiQ13224. baseline and differential.
GenevestigatoriQ13224.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 and NETO1 (By similarity). Interacts with MAGI3. Interacts with DAPK1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAMK2AQ9UQM73EBI-2256942,EBI-1383687
Dlg3Q629364EBI-2256942,EBI-349596From a different organism.
DLG4P783522EBI-2256942,EBI-80389
Dlg4P310162EBI-2256942,EBI-375655From a different organism.
PPP1CAP621392EBI-2256942,EBI-2008988From a different organism.

Protein-protein interaction databases

BioGridi109161. 25 interactions.
DIPiDIP-41002N.
IntActiQ13224. 13 interactions.
MINTiMINT-127466.
STRINGi9606.ENSP00000279593.

Structurei

Secondary structure

1
1484
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni423 – 4264
Beta strandi429 – 4313
Beta strandi440 – 4423
Helixi448 – 4536
Helixi461 – 47212
Helixi496 – 5027
Beta strandi507 – 5093
Helixi517 – 5204
Beta strandi529 – 5357
Helixi666 – 6705
Helixi673 – 6753
Turni678 – 6803
Helixi690 – 6989
Helixi700 – 7067
Helixi714 – 72310
Beta strandi724 – 7274
Helixi733 – 7408
Turni743 – 7453
Beta strandi757 – 7626
Helixi773 – 78513
Helixi789 – 7979

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S11model-A403-543[»]
B660-801[»]
1S2Smodel-A405-543[»]
B660-801[»]
2IPVmodel-X404-768[»]
ProteinModelPortaliQ13224.
SMRiQ13224. Positions 32-837.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 557531ExtracellularSequence AnalysisAdd
BLAST
Topological domaini579 – 63456CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini656 – 817162ExtracellularSequence AnalysisAdd
BLAST
Topological domaini839 – 1484646CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei558 – 57821HelicalSequence AnalysisAdd
BLAST
Transmembranei635 – 65521HelicalSequence AnalysisAdd
BLAST
Transmembranei818 – 83821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1292 – 130413Interaction with DAPK1By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1482 – 14843PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi984 – 9896Poly-His
Compositional biasi1361 – 13644Poly-His

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282132.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000113802.
HOVERGENiHBG052635.
InParanoidiQ13224.
KOiK05210.
OMAiCTNRSHL.
OrthoDBiEOG72ZCD1.
PhylomeDBiQ13224.
TreeFamiTF314731.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13224 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPRAECCSP KFWLVLAVLA VSGSRARSQK SPPSIGIAVI LVGTSDEVAI
60 70 80 90 100
KDAHEKDDFH HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA
110 120 130 140 150
DDTDQEAIAQ ILDFISAQTL TPILGIHGGS SMIMADKDES SMFFQFGPSI
160 170 180 190 200
EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ DFVNKIRSTI ENSFVGWELE
210 220 230 240 250
EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI FEVANSVGLT
260 270 280 290 300
GYGYTWIVPS LVAGDTDTVP AEFPTGLISV SYDEWDYGLP ARVRDGIAII
310 320 330 340 350
TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS
360 370 380 390 400
FSEDGYQMHP KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE
410 420 430 440 450
QEDDHLSIVT LEEAPFVIVE SVDPLSGTCM RNTVPCQKRI VTENKTDEEP
460 470 480 490 500
GYIKKCCKGF CIDILKKISK SVKFTYDLYL VTNGKHGKKI NGTWNGMIGE
510 520 530 540 550
VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR SNGTVSPSAF
560 570 580 590 600
LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF
610 620 630 640 650
TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL
660 670 680 690 700
AAFMIQEEYV DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA
710 720 730 740 750
EMHAYMGKFN QRGVDDALLS LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT
760 770 780 790 800
IGSGKVFAST GYGIAIQKDS GWKRQVDLAI LQLFGDGEME ELEALWLTGI
810 820 830 840 850
CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH LFYWQFRHCF
860 870 880 890 900
MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR
910 920 930 940 950
LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN
960 970 980 990 1000
NPPCEENLFS DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSASSI
1010 1020 1030 1040 1050
DGLYDCDNPP FTTQSRSISK KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS
1060 1070 1080 1090 1100
GHDDLIRSDV SDISTHTVTY GNIEGNAAKR RKQQYKDSLK KRPASAKSRR
1110 1120 1130 1140 1150
EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK ENSPHWEHVD
1160 1170 1180 1190 1200
LTDIYKERSD DFKRDSVSGG GPCTNRSHIK HGTGDKHGVV SGVPAPWEKN
1210 1220 1230 1240 1250
LTNVEWEDRS GGNFCRSCPS KLHNYSTTVT GQNSGRQACI RCEACKKAGN
1260 1270 1280 1290 1300
LYDISEDNSL QELDQPAAPV AVTSNASTTK YPQSPTNSKA QKKNRNKLRR
1310 1320 1330 1340 1350
QHSYDTFVDL QKEEAALAPR SVSLKDKGRF MDGSPYAHMF EMSAGESTFA
1360 1370 1380 1390 1400
NNKSSVPTAG HHHHNNPGGG YMLSKSLYPD RVTQNPFIPT FGDDQCLLHG
1410 1420 1430 1440 1450
SKSYFFRQPT VAGASKARPD FRALVTNKPV VSALHGAVPA RFQKDICIGN
1460 1470 1480
QSNPCVPNNK NPRAFNGSSN GHVYEKLSSI ESDV
Length:1,484
Mass (Da):166,367
Last modified:June 20, 2001 - v3
Checksum:i40AEB12BE6E50CEF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti434 – 4341V → A in AAD00659. 1 PublicationCurated
Sequence conflicti745 – 7451G → A in AAA69920. (PubMed:7959773)Curated
Sequence conflicti773 – 7731K → N in AAA69920. (PubMed:7959773)Curated
Sequence conflicti773 – 7731K → N in AAA74930. (PubMed:7959773)Curated
Sequence conflicti796 – 7961W → C in AAA69920. (PubMed:7959773)Curated
Sequence conflicti796 – 7961W → C in AAA74930. (PubMed:7959773)Curated
Sequence conflicti888 – 8881T → P in AAA69920. (PubMed:7959773)Curated
Sequence conflicti888 – 8881T → P in AAA74930. (PubMed:7959773)Curated
Sequence conflicti902 – 9021L → V in AAA69920. (PubMed:7959773)Curated
Sequence conflicti902 – 9021L → V in AAA74930. (PubMed:7959773)Curated
Sequence conflicti920 – 9212SA → RP in AAB60368. (PubMed:7999784)Curated
Sequence conflicti958 – 9581L → S in AAA69920. (PubMed:7959773)Curated
Sequence conflicti958 – 9581L → S in AAA74930. (PubMed:7959773)Curated
Sequence conflicti980 – 9823VYQ → DHY in AAA69920. (PubMed:7959773)Curated
Sequence conflicti1056 – 10561I → M in AAA69920. (PubMed:7959773)Curated
Sequence conflicti1167 – 11671V → I in AAB49993. (PubMed:8768735)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti407 – 4071S → N.1 Publication
VAR_011317
Natural varianti553 – 5531P → L in MRD6. 1 Publication
VAR_069384
Natural varianti682 – 6821R → C in MRD6; analysis of agonist dose-response curves reveal no differences in the affinities of wild-type and mutant receptors for glutamate and glycine. 1 Publication
VAR_065900

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90278 mRNA. Translation: AAB49993.1.
U88963 mRNA. Translation: AAD00659.1.
U11287 mRNA. Translation: AAB60368.1.
BC113618 mRNA. Translation: AAI13619.1.
BC113620 mRNA. Translation: AAI13621.1.
U28758 mRNA. Translation: AAA74930.1.
U28861 mRNA. Translation: AAA69919.1.
U28862 mRNA. Translation: AAA69920.1.
CCDSiCCDS8662.1.
PIRiI39066.
S52086.
RefSeqiNP_000825.2. NM_000834.3.
UniGeneiHs.654430.

Genome annotation databases

GeneIDi2904.
KEGGihsa:2904.
UCSCiuc001rbt.2. human.

Polymorphism databases

DMDMi14548162.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90278 mRNA. Translation: AAB49993.1 .
U88963 mRNA. Translation: AAD00659.1 .
U11287 mRNA. Translation: AAB60368.1 .
BC113618 mRNA. Translation: AAI13619.1 .
BC113620 mRNA. Translation: AAI13621.1 .
U28758 mRNA. Translation: AAA74930.1 .
U28861 mRNA. Translation: AAA69919.1 .
U28862 mRNA. Translation: AAA69920.1 .
CCDSi CCDS8662.1.
PIRi I39066.
S52086.
RefSeqi NP_000825.2. NM_000834.3.
UniGenei Hs.654430.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S11 model - A 403-543 [» ]
B 660-801 [» ]
1S2S model - A 405-543 [» ]
B 660-801 [» ]
2IPV model - X 404-768 [» ]
ProteinModelPortali Q13224.
SMRi Q13224. Positions 32-837.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109161. 25 interactions.
DIPi DIP-41002N.
IntActi Q13224. 13 interactions.
MINTi MINT-127466.
STRINGi 9606.ENSP00000279593.

Chemistry

BindingDBi Q13224.
ChEMBLi CHEMBL1907603.
DrugBanki DB00659. Acamprosate.
DB06151. Acetylcysteine.
DB00289. Atomoxetine.
DB00949. Felbamate.
DB00996. Gabapentin.
DB00502. Haloperidol.
DB06738. Ketobemidone.
DB01043. Memantine.
DB04896. Milnacipran.
DB00312. Pentobarbital.
DB00454. Pethidine.
DB01174. Phenobarbital.
DB00418. Secobarbital.
GuidetoPHARMACOLOGYi 457.

PTM databases

PhosphoSitei Q13224.

Polymorphism databases

DMDMi 14548162.

Proteomic databases

PaxDbi Q13224.
PeptideAtlasi Q13224.
PRIDEi Q13224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2904.
KEGGi hsa:2904.
UCSCi uc001rbt.2. human.

Organism-specific databases

CTDi 2904.
GeneCardsi GC12M013714.
H-InvDB HIX0036873.
HGNCi HGNC:4586. GRIN2B.
MIMi 138252. gene.
613970. phenotype.
neXtProti NX_Q13224.
Orphaneti 178469. Autosomal dominant non-syndromic intellectual disability.
3451. West syndrome.
PharmGKBi PA28980.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282132.
GeneTreei ENSGT00760000119186.
HOGENOMi HOG000113802.
HOVERGENi HBG052635.
InParanoidi Q13224.
KOi K05210.
OMAi CTNRSHL.
OrthoDBi EOG72ZCD1.
PhylomeDBi Q13224.
TreeFami TF314731.

Enzyme and pathway databases

Reactomei REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinki Q13224.

Miscellaneous databases

GeneWikii GRIN2B.
GenomeRNAii 2904.
NextBioi 11499.
PROi Q13224.
SOURCEi Search...

Gene expression databases

Bgeei Q13224.
CleanExi HS_GRIN2B.
ExpressionAtlasi Q13224. baseline and differential.
Genevestigatori Q13224.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein."
    Adams S.L., Foldes R.L., Kamboj R.K.
    Biochim. Biophys. Acta 1260:105-108(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-407.
    Tissue: Fetal brain.
  2. "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors."
    Hess S.D., Daggett L.P., Crona J., Deal C., Lu C.-C., Urrutia A., Chavez-Noriega L., Ellis S.B., Johnson E.C., Velicelebi G.
    J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Cloning of GRIN2B human subunit."
    Mandich P., Schito A.M., Pizzuti A., Ratti A.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12."
    Mandich P., Schito A.M., Bellone E., Antonacci R., Finelli P., Rocchi M., Ajmar F.
    Genomics 22:216-218(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-294 AND 661-1089.
  6. "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit."
    Schito A.M., Pizzuti A., Di Maria E., Schenone A., Ratti A., Defferrari R., Bellone E., Mancardi G.L., Ajmar F., Mandich P.
    Neurosci. Lett. 239:49-53(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."
    Wu Y., Dowbenko D., Spencer S., Laura R., Lee J., Gu Q., Lasky L.A.
    J. Biol. Chem. 275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAGI3.
  8. Cited for: CHROMOSOMAL TRANSLOCATIONS, VARIANT MRD6 CYS-682.
  9. Cited for: VARIANT MRD6 LEU-553.

Entry informationi

Entry nameiNMDE2_HUMAN
AccessioniPrimary (citable) accession number: Q13224
Secondary accession number(s): Q12919
, Q13220, Q13225, Q14CU4, Q9UM56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3