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Q13219

- PAPP1_HUMAN

UniProt

Q13219 - PAPP1_HUMAN

Protein

Pappalysin-1

Gene

PAPPA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 3 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.3 Publications

    Catalytic activityi

    Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Enzyme regulationi

    Inhibited by complexation with the proform of PRG2.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi562 – 5621Zinc; catalyticPROSITE-ProRule annotation
    Active sitei563 – 5631PROSITE-ProRule annotation
    Metal bindingi566 – 5661Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi572 – 5721Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. endopeptidase activity Source: Ensembl
    2. metallopeptidase activity Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: InterPro
    2. cellular protein metabolic process Source: Reactome
    3. female pregnancy Source: UniProtKB
    4. response to follicle-stimulating hormone Source: Ensembl
    5. response to glucocorticoid Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000119398-MONOMER.
    ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Protein family/group databases

    MEROPSiM43.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pappalysin-1 (EC:3.4.24.79)
    Alternative name(s):
    Insulin-like growth factor-dependent IGF-binding protein 4 protease
    Short name:
    IGF-dependent IGFBP-4 protease
    Short name:
    IGFBP-4ase
    Pregnancy-associated plasma protein A
    Short name:
    PAPP-A
    Gene namesi
    Name:PAPPA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8602. PAPPA.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: Ensembl
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32935.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 80582 PublicationsPRO_0000029245Add
    BLAST
    Chaini81 – 16271547Pappalysin-1PRO_0000029246Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi144 ↔ 2351 PublicationPROSITE-ProRule annotation
    Disulfide bondi327 ↔ 6221 PublicationPROSITE-ProRule annotation
    Disulfide bondi332 ↔ 6571 PublicationPROSITE-ProRule annotation
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi402 – 4021N-linked (GlcNAc...)1 Publication
    Disulfide bondi414 ↔ 4281 PublicationPROSITE-ProRule annotation
    Disulfide bondi424 ↔ 4401 PublicationPROSITE-ProRule annotation
    Glycosylationi429 – 4291N-linked (GlcNAc...)1 Publication
    Disulfide bondi457 ↔ 4731 PublicationPROSITE-ProRule annotation
    Disulfide bondi461 – 461Interchain (with C-51 in PRG2 proform)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi474 ↔ 4851 PublicationPROSITE-ProRule annotation
    Glycosylationi480 – 4801N-linked (GlcNAc...)1 Publication
    Disulfide bondi583 ↔ 600Or C-583 with C-6121 PublicationPROSITE-ProRule annotation
    Disulfide bondi587 ↔ 612Or C-587 with C-6001 PublicationPROSITE-ProRule annotation
    Glycosylationi601 – 6011N-linked (GlcNAc...)1 Publication
    Glycosylationi619 – 6191N-linked (GlcNAc...)1 Publication
    Disulfide bondi710 ↔ 8781 PublicationPROSITE-ProRule annotation
    Disulfide bondi713 ↔ 8811 PublicationPROSITE-ProRule annotation
    Glycosylationi725 – 7251N-linked (GlcNAc...)1 Publication
    Disulfide bondi732 – 732Interchain (with C-169 in PRG2 proform)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi753 ↔ 8351 PublicationPROSITE-ProRule annotation
    Disulfide bondi775 ↔ 7811 PublicationPROSITE-ProRule annotation
    Glycosylationi825 – 8251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi947 ↔ 9751 PublicationPROSITE-ProRule annotation
    Disulfide bondi960 ↔ 9711 PublicationPROSITE-ProRule annotation
    Disulfide bondi983 ↔ 9901 PublicationPROSITE-ProRule annotation
    Disulfide bondi999 ↔ 10111 PublicationPROSITE-ProRule annotation
    Glycosylationi1026 – 10261N-linked (GlcNAc...)1 Publication
    Disulfide bondi1036 ↔ 10701 PublicationPROSITE-ProRule annotation
    Disulfide bondi1051 ↔ 11391 PublicationPROSITE-ProRule annotation
    Disulfide bondi1192 ↔ 12051 PublicationPROSITE-ProRule annotation
    Disulfide bondi1210 – 1210Interchain1 PublicationPROSITE-ProRule annotation
    Disulfide bondi1215 ↔ 12691 PublicationPROSITE-ProRule annotation
    Glycosylationi1222 – 12221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1226 – 12261N-linked (GlcNAc...)1 Publication
    Disulfide bondi1227 ↔ 12381 PublicationPROSITE-ProRule annotation
    Disulfide bondi1242 ↔ 12801 PublicationPROSITE-ProRule annotation
    Disulfide bondi1285 ↔ 13291 PublicationPROSITE-ProRule annotation
    Disulfide bondi1300 ↔ 13101 PublicationPROSITE-ProRule annotation
    Disulfide bondi1314 ↔ 13421 PublicationPROSITE-ProRule annotation
    Glycosylationi1323 – 13231N-linked (GlcNAc...)1 Publication
    Disulfide bondi1346 ↔ 13991 PublicationPROSITE-ProRule annotation
    Disulfide bondi1362 ↔ 13731 PublicationPROSITE-ProRule annotation
    Disulfide bondi1377 ↔ 14101 PublicationPROSITE-ProRule annotation
    Disulfide bondi1415 ↔ 14581 PublicationPROSITE-ProRule annotation
    Disulfide bondi1428 ↔ 14381 PublicationPROSITE-ProRule annotation
    Disulfide bondi1442 ↔ 14711 PublicationPROSITE-ProRule annotation
    Glycosylationi1465 – 14651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1478 ↔ 15391 PublicationPROSITE-ProRule annotation
    Disulfide bondi1492 ↔ 15021 PublicationPROSITE-ProRule annotation
    Disulfide bondi1506 ↔ 15541 PublicationPROSITE-ProRule annotation
    Glycosylationi1519 – 15191N-linked (GlcNAc...)1 Publication
    Disulfide bondi1558 ↔ 15761 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    There appear to be no free sulfhydryl groups.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ13219.
    PRIDEiQ13219.

    PTM databases

    PhosphoSiteiQ13219.

    Miscellaneous databases

    PMAP-CutDBQ13219.

    Expressioni

    Tissue specificityi

    High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.4 Publications

    Developmental stagei

    Present in serum and placenta during pregnancy; levels increase throughout pregnancy.2 Publications

    Inductioni

    By 8-bromoadenosine-3',5'-phosphate.1 Publication

    Gene expression databases

    ArrayExpressiQ13219.
    BgeeiQ13219.
    CleanExiHS_PAPPA.
    GenevestigatoriQ13219.

    Organism-specific databases

    HPAiCAB016724.
    HPA001667.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.3 Publications

    Protein-protein interaction databases

    BioGridi111104. 8 interactions.
    IntActiQ13219. 7 interactions.
    MINTiMINT-1193478.
    STRINGi9606.ENSP00000330658.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13219.
    SMRiQ13219. Positions 543-660, 1287-1506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1213 – 128270Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1283 – 134462Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1345 – 141268Sushi 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1413 – 147361Sushi 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1476 – 155681Sushi 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni272 – 583312MetalloproteaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 8461Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M43B family.Curated
    Contains 5 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG128309.
    HOGENOMiHOG000067833.
    HOVERGENiHBG053501.
    InParanoidiQ13219.
    KOiK07762.
    OMAiGIQIYTL.
    OrthoDBiEOG7HB58B.
    PhylomeDBiQ13219.
    TreeFamiTF331636.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    3.40.390.10. 3 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR006558. LamG-like.
    IPR024079. MetalloPept_cat_dom.
    IPR011936. Myxo_disulph_rpt.
    IPR000800. Notch_dom.
    IPR008754. Peptidase_M43.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00066. Notch. 2 hits.
    PF05572. Peptidase_M43. 1 hit.
    PF00084. Sushi. 3 hits.
    [Graphical view]
    SMARTiSM00032. CCP. 4 hits.
    SM00560. LamGL. 1 hit.
    SM00004. NL. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57535. SSF57535. 4 hits.
    TIGRFAMsiTIGR02232. myxo_disulf_rpt. 1 hit.
    PROSITEiPS50923. SUSHI. 5 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13219-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLWSWVLHL GLLSAALGCG LAERPRRARR DPRAGRPPRP AAGPATCATR     50
    AARGRRASPP PPPPPGGAWE AVRVPRRRQQ REARGATEEP SPPSRALYFS 100
    GRGEQLRLRA DLELPRDAFT LQVWLRAEGG QRSPAVITGL YDKCSYISRD 150
    RGWVVGIHTI SDQDNKDPRY FFSLKTDRAR QVTTINAHRS YLPGQWVYLA 200
    ATYDGQFMKL YVNGAQVATS GEQVGGIFSP LTQKCKVLML GGSALNHNYR 250
    GYIEHFSLWK VARTQREILS DMETHGAHTA LPQLLLQENW DNVKHAWSPM 300
    KDGSSPKVEF SNAHGFLLDT SLEPPLCGQT LCDNTEVIAS YNQLSSFRQP 350
    KVVRYRVVNL YEDDHKNPTV TREQVDFQHH QLAEAFKQYN ISWELDVLEV 400
    SNSSLRRRLI LANCDISKIG DENCDPECNH TLTGHDGGDC RHLRHPAFVK 450
    KQHNGVCDMD CNYERFNFDG GECCDPEITN VTQTCFDPDS PHRAYLDVNE 500
    LKNILKLDGS THLNIFFAKS SEEELAGVAT WPWDKEALMH LGGIVLNPSF 550
    YGMPGHTHTM IHEIGHSLGL YHVFRGISEI QSCSDPCMET EPSFETGDLC 600
    NDTNPAPKHK SCGDPGPGND TCGFHSFFNT PYNNFMSYAD DDCTDSFTPN 650
    QVARMHCYLD LVYQGWQPSR KPAPVALAPQ VLGHTTDSVT LEWFPPIDGH 700
    FFERELGSAC HLCLEGRILV QYASNASSPM PCSPSGHWSP REAEGHPDVE 750
    QPCKSSVRTW SPNSAVNPHT VPPACPEPQG CYLELEFLYP LVPESLTIWV 800
    TFVSTDWDSS GAVNDIKLLA VSGKNISLGP QNVFCDVPLT IRLWDVGEEV 850
    YGIQIYTLDE HLEIDAAMLT STADTPLCLQ CKPLKYKVVR DPPLQMDVAS 900
    ILHLNRKFVD MDLNLGSVYQ YWVITISGTE ESEPSPAVTY IHGSGYCGDG 950
    IIQKDQGEQC DDMNKINGDG CSLFCRQEVS FNCIDEPSRC YFHDGDGVCE 1000
    EFEQKTSIKD CGVYTPQGFL DQWASNASVS HQDQQCPGWV IIGQPAASQV 1050
    CRTKVIDLSE GISQHAWYPC TISYPYSQLA QTTFWLRAYF SQPMVAAAVI 1100
    VHLVTDGTYY GDQKQETISV QLLDTKDQSH DLGLHVLSCR NNPLIIPVVH 1150
    DLSQPFYHSQ AVRVSFSSPL VAISGVALRS FDNFDPVTLS SCQRGETYSP 1200
    AEQSCVHFAC EKTDCPELAV ENASLNCSSS DRYHGAQCTV SCRTGYVLQI 1250
    RRDDELIKSQ TGPSVTVTCT EGKWNKQVAC EPVDCSIPDH HQVYAASFSC 1300
    PEGTTFGSQC SFQCRHPAQL KGNNSLLTCM EDGLWSFPEA LCELMCLAPP 1350
    PVPNADLQTA RCRENKHKVG SFCKYKCKPG YHVPGSSRKS KKRAFKTQCT 1400
    QDGSWQEGAC VPVTCDPPPP KFHGLYQCTN GFQFNSECRI KCEDSDASQG 1450
    LGSNVIHCRK DGTWNGSFHV CQEMQGQCSV PNELNSNLKL QCPDGYAIGS 1500
    ECATSCLDHN SESIILPMNV TVRDIPHWLN PTRVERVVCT AGLKWYPHPA 1550
    LIHCVKGCEP FMGDNYCDAI NNRAFCNYDG GDCCTSTVKT KKVTPFPMSC 1600
    DLQGDCACRD PQAQEHSRKD LRGYSHG 1627
    Length:1,627
    Mass (Da):180,973
    Last modified:February 10, 2009 - v3
    Checksum:i202ECA62C1107207
    GO

    Sequence cautioni

    The sequence AAC50543.1 differs from that shown. Reason: Frameshift at positions 51 and 67.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1071R → RV in AAC50543. (PubMed:8620868)Curated
    Sequence conflicti107 – 1071R → RV in CAA48341. (PubMed:7508748)Curated
    Sequence conflicti511 – 5122TH → RD AA sequence (PubMed:7508748)Curated
    Sequence conflicti1622 – 16221R → Q in AAH78657. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51S → I.
    Corresponds to variant rs417012 [ dbSNP | Ensembl ].
    VAR_057091
    Natural varianti325 – 3251P → L.
    Corresponds to variant rs445159 [ dbSNP | Ensembl ].
    VAR_057092
    Natural varianti944 – 9441S → R.2 Publications
    Corresponds to variant rs117124330 [ dbSNP | Ensembl ].
    VAR_011419
    Natural varianti1224 – 12241S → Y.2 Publications
    Corresponds to variant rs7020782 [ dbSNP | Ensembl ].
    VAR_018726

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28727 mRNA. Translation: AAC50543.1. Frameshift.
    AL353141, AL137024, AL691426 Genomic DNA. Translation: CAI16083.1.
    AL691426, AL137024, AL353141 Genomic DNA. Translation: CAI16715.1.
    BC078657 mRNA. Translation: AAH78657.1.
    X68280 mRNA. Translation: CAA48341.1.
    CCDSiCCDS6813.1.
    PIRiS65464.
    RefSeqiNP_002572.2. NM_002581.3.
    UniGeneiHs.643599.

    Genome annotation databases

    EnsembliENST00000328252; ENSP00000330658; ENSG00000182752.
    GeneIDi5069.
    KEGGihsa:5069.
    UCSCiuc004bjn.3. human.

    Polymorphism databases

    DMDMi223590248.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28727 mRNA. Translation: AAC50543.1 . Frameshift.
    AL353141 , AL137024 , AL691426 Genomic DNA. Translation: CAI16083.1 .
    AL691426 , AL137024 , AL353141 Genomic DNA. Translation: CAI16715.1 .
    BC078657 mRNA. Translation: AAH78657.1 .
    X68280 mRNA. Translation: CAA48341.1 .
    CCDSi CCDS6813.1.
    PIRi S65464.
    RefSeqi NP_002572.2. NM_002581.3.
    UniGenei Hs.643599.

    3D structure databases

    ProteinModelPortali Q13219.
    SMRi Q13219. Positions 543-660, 1287-1506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111104. 8 interactions.
    IntActi Q13219. 7 interactions.
    MINTi MINT-1193478.
    STRINGi 9606.ENSP00000330658.

    Protein family/group databases

    MEROPSi M43.004.

    PTM databases

    PhosphoSitei Q13219.

    Polymorphism databases

    DMDMi 223590248.

    Proteomic databases

    PaxDbi Q13219.
    PRIDEi Q13219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328252 ; ENSP00000330658 ; ENSG00000182752 .
    GeneIDi 5069.
    KEGGi hsa:5069.
    UCSCi uc004bjn.3. human.

    Organism-specific databases

    CTDi 5069.
    GeneCardsi GC09P118916.
    H-InvDB HIX0025885.
    HGNCi HGNC:8602. PAPPA.
    HPAi CAB016724.
    HPA001667.
    MIMi 176385. gene.
    neXtProti NX_Q13219.
    PharmGKBi PA32935.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG128309.
    HOGENOMi HOG000067833.
    HOVERGENi HBG053501.
    InParanoidi Q13219.
    KOi K07762.
    OMAi GIQIYTL.
    OrthoDBi EOG7HB58B.
    PhylomeDBi Q13219.
    TreeFami TF331636.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000119398-MONOMER.
    Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Miscellaneous databases

    ChiTaRSi PAPPA. human.
    GeneWikii Pregnancy-associated_plasma_protein_A.
    GenomeRNAii 5069.
    NextBioi 19534.
    PMAP-CutDB Q13219.
    PROi Q13219.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13219.
    Bgeei Q13219.
    CleanExi HS_PAPPA.
    Genevestigatori Q13219.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    3.40.390.10. 3 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR006558. LamG-like.
    IPR024079. MetalloPept_cat_dom.
    IPR011936. Myxo_disulph_rpt.
    IPR000800. Notch_dom.
    IPR008754. Peptidase_M43.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00066. Notch. 2 hits.
    PF05572. Peptidase_M43. 1 hit.
    PF00084. Sushi. 3 hits.
    [Graphical view ]
    SMARTi SM00032. CCP. 4 hits.
    SM00560. LamGL. 1 hit.
    SM00004. NL. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57535. SSF57535. 4 hits.
    TIGRFAMsi TIGR02232. myxo_disulf_rpt. 1 hit.
    PROSITEi PS50923. SUSHI. 5 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete cDNA sequence of the preproform of human pregnancy-associated plasma protein-A. Evidence for expression in the brain and induction by cAMP."
      Haaning J., Oxvig C., Overgaard M.T., Ebbesen P., Kristensen T., Sottrup-Jensen L.
      Eur. J. Biochem. 237:159-163(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, VARIANT ARG-944.
      Tissue: Placenta.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-1224.
      Tissue: Placenta.
    4. "Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA."
      Kristensen T., Oxvig C., Sand O., Moller N.P.H., Sottrup-Jensen L.
      Biochemistry 33:1592-1598(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-1627, PROTEIN SEQUENCE OF 81-98; 117-126; 210-224; 466-485; 507-519; 576-593; 609-621; 718-736; 742-754; 1006-1017; 1259-1273; 1369-1374; 1389-1398; 1490-1509; 1524-1533 AND 1537-1544, VARIANT ARG-944, TISSUE SPECIFICITY.
      Tissue: Placenta and Serum.
    5. "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein."
      Oxvig C., Sand O., Kristensen T., Gleich G.J., Sottrup-Jensen L.
      J. Biol. Chem. 268:12243-12246(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 81-89; 117-126; 210-224; 460-485; 507-519; 576-593; 718-736; 742-754; 1259-1273; 1369-1374; 1490-1509; 1524-1533 AND 1537-1544, SUBUNIT, INTERCHAIN DISULFIDE BOND.
      Tissue: Serum.
    6. "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites."
      Overgaard M.T., Sorensen E.S., Stachowiak D., Boldt H.B., Kristensen L., Sottrup-Jensen L., Oxvig C.
      J. Biol. Chem. 278:2106-2117(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-402; ASN-429; ASN-480; ASN-601; ASN-619; ASN-725; ASN-1026; ASN-1226; ASN-1323 AND ASN-1519, DISULFIDE BONDS.
    7. "The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A."
      Lawrence J.B., Oxvig C., Overgaard M.T., Sottrup-Jensen L., Gleich G.J., Hays L.G., Yates J.R. III, Conover C.A.
      Proc. Natl. Acad. Sci. U.S.A. 96:3149-3153(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fibroblast.
    8. "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor."
      Overgaard M.T., Haaning J., Boldt H.B., Olsen I.M., Laursen L.S., Christiansen M., Gleich G.J., Sottrup-Jensen L., Conover C.A., Oxvig C.
      J. Biol. Chem. 275:31128-31133(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, ENZYME REGULATION.
    9. "Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta."
      Bonno M., Oxvig C., Kephart G.M., Wagner J.M., Kristensen T., Sottrup-Jensen L., Gleich G.J.
      Lab. Invest. 71:560-566(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. "Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues."
      Overgaard M.T., Oxvig C., Christiansen M., Lawrence J.B., Conover C.A., Gleich G.J., Sottrup-Jensen L., Haaning J.
      Biol. Reprod. 61:1083-1089(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    11. "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."
      Oxvig C., Haaning J., Kristensen L., Wagner J.M., Rubin I., Stigbrand T., Gleich G.J., Sottrup-Jensen L.
      J. Biol. Chem. 270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    12. "Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A."
      Laursen L.S., Overgaard M.T., Soe R., Boldt H.B., Sottrup-Jensen L., Giudice L.C., Conover C.A., Oxvig C.
      FEBS Lett. 504:36-40(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene."
      Frosk P., Weiler T., Nylen E., Sudha T., Greenberg C.R., Morgan K., Fujiwara T.M., Wrogemann K.
      Am. J. Hum. Genet. 70:663-672(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TYR-1224.

    Entry informationi

    Entry nameiPAPP1_HUMAN
    AccessioniPrimary (citable) accession number: Q13219
    Secondary accession number(s): B1AMF9
    , Q08371, Q68G52, Q9UDK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 159 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3