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Reviewed, UniProtKB/Swiss-Prot Q13207 (TBX2_HUMAN)

Last modified June 16, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    T-box transcription factor TBX2
      Short name=T-box protein 2
Gene names
Name: TBX2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length702 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

Sequence similarities

Contains 1 T-box DNA-binding domain.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological processcell aging

Inferred from direct assay. Source: UniProtKB

positive regulation of cell proliferation

Inferred from direct assay. Source: UniProtKB

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsequence-specific DNA binding

Inferred from direct assay. Source: UniProtKB

transcription repressor activity

Inferred from direct assay. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 702702T-box transcription factor TBX2
PRO_0000184426

Regions

DNA binding99 – 277179T-box
Compositional bias18 – 7760Ala-rich
Compositional bias451 – 52878Gly-rich
Compositional bias571 – 59323Ala-rich

Experimental info

Sequence conflict1551Y → D in AAB36216. Ref.3
Sequence conflict165 – 1684AGKA → TDKT in AAB36216. Ref.3
Sequence conflict3631G → R in AAA73861. Ref.1
Sequence conflict3911S → C in AAA73861. Ref.1
Sequence conflict4171A → P in AAA73861. Ref.1
Sequence conflict6791Q → L in AAA73861. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q13207-1 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: 9288DC56A0AB4EEE

FASTA70274,068
        10         20         30         40         50         60 
MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK PLPDPGLAGA AAAAAAAAAA 

        70         80         90        100        110        120 
AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK LGTEMVITKS 

       130        140        150        160        170        180 
GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP 

       190        200        210        220        230        240 
DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF 

       250        260        270        280        290        300 
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT LPSLRLYEEH 

       310        320        330        340        350        360 
CKPERDGAES DASSCDPPPA REPPTSPGAA PSPLRLHRAR AEEKSCAADS DPEPERLSEE 

       370        380        390        400        410        420 
RAGAPLGRSP APDSASPTRL TEPERARERR SPERGKEPAE SGGDGPFGLR SLEKERAEAR 

       430        440        450        460        470        480 
RKDEGRKEAA EGKEQGLAPL VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF 

       490        500        510        520        530        540 
LHPGQFTMGP GAFSAMGMGH LLASVAGGGN GGGGGPGTAA GLDAGGLGPA ASAASTAAPF 

       550        560        570        580        590        600 
PFHLSQHMLA SQGIPMPTFG GLFPYPYTYM AAAAAAASAL PATSAAAAAA AAAGSLSRSP 

       610        620        630        640        650        660 
FLGSARPRLR FSPYQIPVTI PPSTSLLTTG LASEGSKAAG GNSREPSPLP ELALRKVGAP 

       670        680        690        700 
SRGALSPSGS AKEAANELQS IQRLVSGLES QRALSPGRES PK

« Hide

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References

« Hide 'large scale' references
[1]"Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene."
Campbell C., Goodrich K., Casey G., Beatty B.
Genomics 28:255-260(1995) [PubMed: 8530034] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family."
Law D.J., Gebuhr T., Garvey N., Agulnik S.I., Silver L.M.
Mamm. Genome 6:793-797(1995) [PubMed: 8597636] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-245.
Tissue: Fetal kidney.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U28049 mRNA. Translation: AAA73861.1.
BC052566 mRNA. Translation: AAH52566.1.
S81264 mRNA. Translation: AAB36216.1.
IPIIPI00297902.
PIRG01840.
RefSeqNP_005985.3.
UniGeneHs.705451

3D structure databases

HSSPHSSP built from PDB template 1H6F based on UniProtKB O15119.
SMRQ13207. Positions 92-277.
ModBaseSearch...

PTM databases

PhosphoSiteQ13207.

Genome annotation databases

EnsemblENSG00000121068. Homo sapiens. [Contig view]
GeneID6909.
KEGGhsa:6909.

Organism-specific databases

GeneCardsGC17P056832.
H-InvDBHIX0014057.
HGNCHGNC:11597. TBX2.
HPACAB013636.
HPA008586.
MIM600747. gene.
PharmGKBPA36360.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ13207.
HOVERGENQ13207.
OMAQ13207. GSNSREP.

Gene expression databases

ArrayExpressQ13207.
BgeeQ13207.
CleanExHS_TBX2.
GermOnlineENSG00000121068. Homo sapiens.

Family and domain databases

InterProIPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
Gene3DG3DSA:2.60.40.820. TF_T-box. 1 hit.
PANTHERPTHR11267. TF_T-box. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00938. BRACHYURY.
PR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio27019.
SOURCESearch...

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Entry information

Entry nameTBX2_HUMAN
AccessionPrimary (citable) accession number: Q13207
Secondary accession number(s): Q16424, Q7Z647
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 16, 2004
Last modified: June 16, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents