UniProtKB - Q13207 (TBX2_HUMAN)
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Protein
T-box transcription factor TBX2
Gene
TBX2
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 109 – 287 | T-boxPROSITE-ProRule annotationAdd BLAST | 179 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: UniProtKB
- transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- aorta morphogenesis Source: BHF-UCL
- atrioventricular canal development Source: BHF-UCL
- cardiac muscle tissue development Source: BHF-UCL
- cell aging Source: UniProtKB
- cellular senescence Source: UniProtKB
- developmental growth involved in morphogenesis Source: Ensembl
- embryonic camera-type eye morphogenesis Source: BHF-UCL
- embryonic digit morphogenesis Source: BHF-UCL
- embryonic heart tube development Source: UniProtKB
- endocardial cushion morphogenesis Source: BHF-UCL
- heart looping Source: UniProtKB
- mammary placode formation Source: Ensembl
- muscle cell fate determination Source: BHF-UCL
- negative regulation of cardiac chamber formation Source: BHF-UCL
- negative regulation of heart looping Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- Notch signaling pathway Source: Ensembl
- outflow tract morphogenesis Source: BHF-UCL
- outflow tract septum morphogenesis Source: BHF-UCL
- palate development Source: Ensembl
- pharynx development Source: BHF-UCL
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of cell proliferation Source: UniProtKB
- regulation of heart contraction Source: UniProtKB
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
SignaLinki | Q13207. |
SIGNORi | Q13207. |
Names & Taxonomyi
Protein namesi | Recommended name: T-box transcription factor TBX2Short name: T-box protein 2 |
Gene namesi | Name:TBX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000121068.13. |
HGNCi | HGNC:11597. TBX2. |
MIMi | 600747. gene. |
neXtProti | NX_Q13207. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6909. |
MalaCardsi | TBX2. |
OpenTargetsi | ENSG00000121068. |
Orphaneti | 261279. 17q23.1q23.2 microdeletion syndrome. |
PharmGKBi | PA36360. |
Polymorphism and mutation databases
BioMutai | TBX2. |
DMDMi | 294862490. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184426 | 1 – 712 | T-box transcription factor TBX2Add BLAST | 712 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 336 | PhosphoserineBy similarity | 1 | |
Modified residuei | 342 | PhosphoserineBy similarity | 1 | |
Modified residuei | 360 | PhosphoserineBy similarity | 1 | |
Modified residuei | 653 | PhosphoserineCombined sources | 1 | |
Modified residuei | 657 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q13207. |
PaxDbi | Q13207. |
PeptideAtlasi | Q13207. |
PRIDEi | Q13207. |
PTM databases
iPTMneti | Q13207. |
PhosphoSitePlusi | Q13207. |
Expressioni
Tissue specificityi
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Gene expression databases
Bgeei | ENSG00000121068. |
CleanExi | HS_TBX2. |
ExpressionAtlasi | Q13207. baseline and differential. |
Genevisiblei | Q13207. HS. |
Organism-specific databases
HPAi | CAB013636. HPA008586. |
Interactioni
Subunit structurei
Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
PML | P29590 | 2 | EBI-2853051,EBI-295890 |
Protein-protein interaction databases
BioGridi | 112772. 6 interactors. |
IntActi | Q13207. 6 interactors. |
MINTi | Q13207. |
STRINGi | 9606.ENSP00000240328. |
Structurei
3D structure databases
ProteinModelPortali | Q13207. |
SMRi | Q13207. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 518 – 601 | Repression domain 1 (RD1)Add BLAST | 84 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 87 | Ala-richAdd BLAST | 60 | |
Compositional biasi | 461 – 538 | Gly-richAdd BLAST | 78 | |
Compositional biasi | 581 – 603 | Ala-richAdd BLAST | 23 |
Domaini
The repression domain 1 (RD1) is necessary for its interaction with PML.1 Publication
Phylogenomic databases
eggNOGi | KOG3585. Eukaryota. ENOG410XSTS. LUCA. |
GeneTreei | ENSGT00760000118897. |
HOGENOMi | HOG000038046. |
HOVERGENi | HBG000412. |
InParanoidi | Q13207. |
KOi | K10176. |
OMAi | PLFIHPG. |
OrthoDBi | EOG091G0I8R. |
PhylomeDBi | Q13207. |
TreeFami | TF106341. |
Family and domain databases
CDDi | cd00182. TBOX. 1 hit. |
Gene3Di | 2.60.40.820. 1 hit. |
InterProi | View protein in InterPro IPR008967. p53-like_TF_DNA-bd. IPR036960. T-box_sf. IPR022582. TBX. IPR002070. TF_Brachyury. IPR001699. TF_T-box. IPR018186. TF_T-box_CS. |
PANTHERi | PTHR11267. PTHR11267. 1 hit. |
Pfami | View protein in Pfam PF00907. T-box. 1 hit. PF12598. TBX. 1 hit. |
PRINTSi | PR00938. BRACHYURY. PR00937. TBOX. |
SMARTi | View protein in SMART SM00425. TBOX. 1 hit. |
SUPFAMi | SSF49417. SSF49417. 1 hit. |
PROSITEi | View protein in PROSITE PS01283. TBOX_1. 1 hit. PS01264. TBOX_2. 1 hit. PS50252. TBOX_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q13207-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK
60 70 80 90 100
PLPDPGLAGA AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE
110 120 130 140 150
VEDDPKVTLE AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK
160 170 180 190 200
YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM
210 220 230 240 250
AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF
260 270 280 290 300
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT
310 320 330 340 350
LPSLRLYEEH CKPERDGAES DASSCDPPPA REPPTSPGAA PSPLRLHRAR
360 370 380 390 400
AEEKSCAADS DPEPERLSEE RAGAPLGRSP APDSASPTRL TEPERARERR
410 420 430 440 450
SPERGKEPAE SGGDGPFGLR SLEKERAEAR RKDEGRKEAA EGKEQGLAPL
460 470 480 490 500
VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF LHPGQFTMGP
510 520 530 540 550
GAFSAMGMGH LLASVAGGGN GGGGGPGTAA GLDAGGLGPA ASAASTAAPF
560 570 580 590 600
PFHLSQHMLA SQGIPMPTFG GLFPYPYTYM AAAAAAASAL PATSAAAAAA
610 620 630 640 650
AAAGSLSRSP FLGSARPRLR FSPYQIPVTI PPSTSLLTTG LASEGSKAAG
660 670 680 690 700
GNSREPSPLP ELALRKVGAP SRGALSPSGS AKEAANELQS IQRLVSGLES
710
QRALSPGRES PK
Sequence cautioni
The sequence AAH52566 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | A → T in AAA73861 (PubMed:8530034).Curated | 1 | |
Sequence conflicti | 165 | Y → D in AAB36216 (PubMed:8597636).Curated | 1 | |
Sequence conflicti | 175 – 178 | AGKA → TDKT in AAB36216 (PubMed:8597636).Curated | 4 | |
Sequence conflicti | 373 | G → R in AAA73861 (PubMed:8530034).Curated | 1 | |
Sequence conflicti | 401 | S → C in AAA73861 (PubMed:8530034).Curated | 1 | |
Sequence conflicti | 427 | A → P in AAA73861 (PubMed:8530034).Curated | 1 | |
Sequence conflicti | 689 | Q → L in AAA73861 (PubMed:8530034).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28049 mRNA. Translation: AAA73861.1. Frameshift. AC005746 Genomic DNA. No translation available. BC052566 mRNA. Translation: AAH52566.1. Different initiation. S81264 mRNA. Translation: AAB36216.1. |
CCDSi | CCDS11627.2. |
PIRi | G01840. |
RefSeqi | NP_005985.3. NM_005994.3. |
UniGenei | Hs.531085. |
Genome annotation databases
Ensembli | ENST00000240328; ENSP00000240328; ENSG00000121068. |
GeneIDi | 6909. |
KEGGi | hsa:6909. |
UCSCi | uc010wox.3. human. |
Similar proteinsi
Entry informationi
Entry namei | TBX2_HUMAN | |
Accessioni | Q13207Primary (citable) accession number: Q13207 Secondary accession number(s): Q16424, Q7Z647 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 20, 2010 | |
Last modified: | March 28, 2018 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |