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Q13202 (DUS8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 8

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Dual specificity protein phosphatase hVH-5
Gene names
Name:DUSP8
Synonyms:C11orf81, VH5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Abundant in brain, heart and skeletal muscle. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 rhodanese domain.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 625625Dual specificity protein phosphatase 8
PRO_0000094810

Regions

Domain23 – 138116Rhodanese
Domain162 – 430269Tyrosine-protein phosphatase
Compositional bias310 – 550241Pro-rich

Sites

Active site2461Phosphocysteine intermediate By similarity

Experimental info

Sequence conflict2991S → T in AAA83151. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q13202 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: C7C808407B724FFC

FASTA62565,827
        10         20         30         40         50         60 
MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS WHVLSSVNIC CSKLVKRRLQ 

        70         80         90        100        110        120 
QGKVTIAELI QPAARSQVEA TEPQDVVVYD QSTRDASVLA ADSFLSILLS KLDGCFDSVA 

       130        140        150        160        170        180 
ILTGGFATFS SCFPGLCEGK PAALLPMSLS QPCLPVPSVG LTRILPHLYL GSQKDVLNKD 

       190        200        210        220        230        240 
LMTQNGISYV LNASNSCPKP DFICESRFMR VPINDNYCEK LLPWLDKSIE FIDKAKLSSC 

       250        260        270        280        290        300 
QVIVHCLAGI SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL 

       310        320        330        340        350        360 
KLLAALQGDP GTPSGTPEPP PSPAAGAPLP RLPPPTSESA ATGNAAAREG GLSAGGEPPA 

       370        380        390        400        410        420 
PPTPPATSAL QQGLRGLHLS SDRLQDTNRL KRSFSLDIKS AYAPSRRPDG PGPPDPGEAP 

       430        440        450        460        470        480 
KLCKLDSPSG AALGLSSPSP DSPDAAPEAR PRPRRRPRPP AGSPARSPAH SLGLNFGDAA 

       490        500        510        520        530        540 
RQTPRHGLSA LSAPGLPGPG QPAGPGAWAP PLDSPGTPSP DGPWCFSPEG AQGAGGVLFA 

       550        560        570        580        590        600 
PFGRAGAPGP GGGSDLRRRE AARAEPRDAR TGWPEEPAPE TQFKRRSCQM EFEEGMVEGR 

       610        620 
ARGEELAALG KQASFSGSVE VIEVS 

« Hide

References

« Hide 'large scale' references
[1]"hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase."
Martell K.J., Seasholtz A.F., Kwak S.P., Clemens K.K., Dixon J.E.
J. Neurochem. 65:1823-1833(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U27193 mRNA. Translation: AAA83151.1.
AP006285 Genomic DNA. No translation available.
BC038231 mRNA. Translation: AAH38231.1.
BC045110 mRNA. Translation: AAH45110.1.
RefSeqNP_004411.2. NM_004420.2.
UniGeneHs.41688.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4JMKX-ray1.90A/B160-310[»]
ProteinModelPortalQ13202.
SMRQ13202. Positions 14-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108183. 3 interactions.
IntActQ13202. 3 interactions.
MINTMINT-8247399.
STRING9606.ENSP00000329539.

PTM databases

PhosphoSiteQ13202.

Polymorphism databases

DMDM223590200.

Proteomic databases

PaxDbQ13202.
PRIDEQ13202.

Protocols and materials databases

DNASU1850.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331588; ENSP00000329539; ENSG00000184545.
ENST00000397374; ENSP00000380530; ENSG00000184545.
GeneID1850.
KEGGhsa:1850.
UCSCuc001lts.2. human.

Organism-specific databases

CTD1850.
GeneCardsGC11M001531.
H-InvDBHIX0026159.
HGNCHGNC:3074. DUSP8.
HPAHPA020071.
MIM602038. gene.
neXtProtNX_Q13202.
PharmGKBPA27531.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000082452.
HOVERGENHBG005541.
InParanoidQ13202.
KOK04459.
OMARDARTGW.
OrthoDBEOG747PJD.
PhylomeDBQ13202.
TreeFamTF105122.

Enzyme and pathway databases

SignaLinkQ13202.

Gene expression databases

BgeeQ13202.
CleanExHS_DUSP8.
GenevestigatorQ13202.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR01764. MAPKPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi1850.
NextBio7579.
PROQ13202.
SOURCESearch...

Entry information

Entry nameDUS8_HUMAN
AccessionPrimary (citable) accession number: Q13202
Secondary accession number(s): Q86SS8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 10, 2009
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM