Reviewed,
UniProtKB/Swiss-Prot Q13202 (DUS8_HUMAN)
Last modified
November 25, 2008.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity protein phosphatase 8 EC=3.1.3.48 EC=3.1.3.16 Alternative name(s): Dual specificity protein phosphatase hVH-5 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 625 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. A phosphoprotein + H(2)O = a protein + phosphate. |
| Subcellular location | |
| Tissue specificity | Abundant in brain, heart and skeletal muscle. |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Hydrolase Protein phosphatase |
Gene Ontology (GO) | |
| Biological process | inactivation of MAPK activity Ref.1 Traceable author statement. Source: ProtInc protein amino acid dephosphorylation Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cytoplasm Ref.1 Traceable author statement. Source: ProtInc nucleusInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 625 | 625 | Dual specificity protein phosphatase 8 | PRO_0000094810 | |||||
Regions | |||||||||
| Domain | 23 – 138 | 116 | Rhodanese | ||||||
| Domain | 162 – 430 | 269 | Tyrosine-protein phosphatase | ||||||
| Compositional bias | 310 – 550 | 241 | Pro-rich | ||||||
Sites | |||||||||
| Active site | 246 | 1 | Phosphocysteine intermediate By similarity | ||||||
Sequences
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References
| [1] | "hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase." Martell K.J., Seasholtz A.F., Kwak S.P., Clemens K.K., Dixon J.E. J. Neurochem. 65:1823-1833(1995) [PubMed: 7561881] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U27193 mRNA. Translation: AAA83151.1. | |
| RefSeq | NP_004411.2. |
| UniGene | Hs.41688 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MKP based on UniProtKB Q16828. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000184545. Homo sapiens. [Contig view] |
| GeneID | 1850. |
| KEGG | hsa:1850. |
Organism-specific databases | |
| H-InvDB | HIX0026159. |
| HGNC | HGNC:3074. DUSP8. |
| MIM | 602038. gene. |
| PharmGKB | PA27531. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q13202. |
| HOVERGEN | Q13202. |
Gene expression databases | |
| ArrayExpress | Q13202. |
| CleanEx | HS_DUSP8. |
| GermOnline | ENSG00000184545. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008343. MAPK_phosph. IPR001763. Rhodanese-like. IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000340. Tyr_Pase_dual_specific. [Graphical view] |
| Pfam | PF00782. DSPc. 1 hit. [Graphical view] |
| PRINTS | PR01764. MAPKPHPHTASE. |
| SMART | SM00195. DSPc. 1 hit. SM00450. RHOD. 1 hit. [Graphical view] |
| PROSITE | PS50206. RHODANESE_3. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q13202. |
| NextBio | 7579. |
| SOURCE | Search... |
Entry information
| Entry name | DUS8_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13202 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


