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Q13202

- DUS8_HUMAN

UniProt

Q13202 - DUS8_HUMAN

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Protein

Dual specificity protein phosphatase 8

Gene

DUSP8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei246 – 2461Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  3. protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. inactivation of MAPK activity Source: ProtInc
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiQ13202.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 8 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity protein phosphatase hVH-5
Gene namesi
Name:DUSP8
Synonyms:C11orf81, VH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3074. DUSP8.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625Dual specificity protein phosphatase 8PRO_0000094810Add
BLAST

Proteomic databases

MaxQBiQ13202.
PaxDbiQ13202.
PRIDEiQ13202.

PTM databases

PhosphoSiteiQ13202.

Expressioni

Tissue specificityi

Abundant in brain, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ13202.
CleanExiHS_DUSP8.
GenevestigatoriQ13202.

Organism-specific databases

HPAiHPA020071.

Interactioni

Protein-protein interaction databases

BioGridi108183. 3 interactions.
IntActiQ13202. 3 interactions.
MINTiMINT-8247399.
STRINGi9606.ENSP00000329539.

Structurei

Secondary structure

1
625
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi162 – 1654
Beta strandi168 – 1714
Helixi173 – 1764
Helixi179 – 1846
Beta strandi187 – 1926
Beta strandi195 – 1973
Helixi205 – 2073
Beta strandi208 – 2103
Beta strandi215 – 2184
Helixi222 – 2243
Helixi225 – 23713
Beta strandi241 – 2455
Beta strandi247 – 2515
Helixi252 – 26514
Helixi269 – 27911
Helixi287 – 30620

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JMKX-ray1.90A/B160-310[»]
ProteinModelPortaliQ13202.
SMRiQ13202. Positions 14-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 138116RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini162 – 430269Tyrosine-protein phosphataseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi310 – 550241Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000082452.
HOVERGENiHBG005541.
InParanoidiQ13202.
KOiK04459.
OMAiDGRHSWH.
OrthoDBiEOG747PJD.
PhylomeDBiQ13202.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13202-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS WHVLSSVNIC
60 70 80 90 100
CSKLVKRRLQ QGKVTIAELI QPAARSQVEA TEPQDVVVYD QSTRDASVLA
110 120 130 140 150
ADSFLSILLS KLDGCFDSVA ILTGGFATFS SCFPGLCEGK PAALLPMSLS
160 170 180 190 200
QPCLPVPSVG LTRILPHLYL GSQKDVLNKD LMTQNGISYV LNASNSCPKP
210 220 230 240 250
DFICESRFMR VPINDNYCEK LLPWLDKSIE FIDKAKLSSC QVIVHCLAGI
260 270 280 290 300
SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL
310 320 330 340 350
KLLAALQGDP GTPSGTPEPP PSPAAGAPLP RLPPPTSESA ATGNAAAREG
360 370 380 390 400
GLSAGGEPPA PPTPPATSAL QQGLRGLHLS SDRLQDTNRL KRSFSLDIKS
410 420 430 440 450
AYAPSRRPDG PGPPDPGEAP KLCKLDSPSG AALGLSSPSP DSPDAAPEAR
460 470 480 490 500
PRPRRRPRPP AGSPARSPAH SLGLNFGDAA RQTPRHGLSA LSAPGLPGPG
510 520 530 540 550
QPAGPGAWAP PLDSPGTPSP DGPWCFSPEG AQGAGGVLFA PFGRAGAPGP
560 570 580 590 600
GGGSDLRRRE AARAEPRDAR TGWPEEPAPE TQFKRRSCQM EFEEGMVEGR
610 620
ARGEELAALG KQASFSGSVE VIEVS
Length:625
Mass (Da):65,827
Last modified:February 10, 2009 - v2
Checksum:iC7C808407B724FFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991S → T in AAA83151. (PubMed:7561881)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27193 mRNA. Translation: AAA83151.1.
AP006285 Genomic DNA. No translation available.
BC038231 mRNA. Translation: AAH38231.1.
BC045110 mRNA. Translation: AAH45110.1.
CCDSiCCDS7724.1.
RefSeqiNP_004411.2. NM_004420.2.
UniGeneiHs.41688.

Genome annotation databases

EnsembliENST00000331588; ENSP00000329539; ENSG00000184545.
ENST00000397374; ENSP00000380530; ENSG00000184545.
GeneIDi1850.
KEGGihsa:1850.
UCSCiuc001lts.2. human.

Polymorphism databases

DMDMi223590200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27193 mRNA. Translation: AAA83151.1 .
AP006285 Genomic DNA. No translation available.
BC038231 mRNA. Translation: AAH38231.1 .
BC045110 mRNA. Translation: AAH45110.1 .
CCDSi CCDS7724.1.
RefSeqi NP_004411.2. NM_004420.2.
UniGenei Hs.41688.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JMK X-ray 1.90 A/B 160-310 [» ]
ProteinModelPortali Q13202.
SMRi Q13202. Positions 14-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108183. 3 interactions.
IntActi Q13202. 3 interactions.
MINTi MINT-8247399.
STRINGi 9606.ENSP00000329539.

PTM databases

PhosphoSitei Q13202.

Polymorphism databases

DMDMi 223590200.

Proteomic databases

MaxQBi Q13202.
PaxDbi Q13202.
PRIDEi Q13202.

Protocols and materials databases

DNASUi 1850.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331588 ; ENSP00000329539 ; ENSG00000184545 .
ENST00000397374 ; ENSP00000380530 ; ENSG00000184545 .
GeneIDi 1850.
KEGGi hsa:1850.
UCSCi uc001lts.2. human.

Organism-specific databases

CTDi 1850.
GeneCardsi GC11M001531.
H-InvDB HIX0026159.
HGNCi HGNC:3074. DUSP8.
HPAi HPA020071.
MIMi 602038. gene.
neXtProti NX_Q13202.
PharmGKBi PA27531.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000118902.
HOGENOMi HOG000082452.
HOVERGENi HBG005541.
InParanoidi Q13202.
KOi K04459.
OMAi DGRHSWH.
OrthoDBi EOG747PJD.
PhylomeDBi Q13202.
TreeFami TF105122.

Enzyme and pathway databases

SignaLinki Q13202.

Miscellaneous databases

GenomeRNAii 1850.
NextBioi 7579.
PROi Q13202.
SOURCEi Search...

Gene expression databases

Bgeei Q13202.
CleanExi HS_DUSP8.
Genevestigatori Q13202.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase."
    Martell K.J., Seasholtz A.F., Kwak S.P., Clemens K.K., Dixon J.E.
    J. Neurochem. 65:1823-1833(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.

Entry informationi

Entry nameiDUS8_HUMAN
AccessioniPrimary (citable) accession number: Q13202
Secondary accession number(s): Q86SS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3