Q131U9 (AROE_RHOPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	RPD_3919

Organism

Rhodopseudomonas palustris (strain BisB5) [Complete proteome] [HAMAP]

Taxonomic identifier

316057 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325157
Regions
	Nucleotide binding	133 – 137	5	NADP By similarity
Sites
	Active site	73	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q131U9 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 915472D64E224548	FASTA	283	30,200
	10 20 30 40 50 60 MTQPTSQAHI AACLIGWPAA HSRSPLIHHY WLRKLGIEGG YSIESVPPEG FAEFVLHLKT 70 80 90 100 110 120 HGYSGANVTI PHKERALQLT VPDQRACAVG AANTLYYDGS VLRSTNTDVE GFISNLDASA 130 140 150 160 170 180 PGWDRTPHAV VLGAGGSSRA VVFGLLERGI QRIALANRSI ERARALADLF GERVVPIAWT 190 200 210 220 230 240 DAPAALPGAG LLVNTTSLGM KGQPSLDLDL EPLPADATVA DLVYVPLETE LLSEARARGL 250 260 270 280 RTADGLGMLL HQAVRGFELW FGARPEVTSE LRALVEADLV AHA

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisB5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BisB5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000283 Genomic DNA. Translation: ABE41140.1.
RefSeq	YP_571041.1. NC_007958.1.
3D structure databases
ProteinModelPortal	Q131U9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q131U9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4024435.
GenomeReviews	Gene locus RPD_3919 in contig CP000283_GR.
KEGG	rpd:RPD_3919.
PATRIC	23283017. VBIRhoPal120395_4062.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	LHLKTHG.
ProtClustDB	CLSK820486.
Enzyme and pathway databases
BioCyc	RPAL316057:RPD_3919-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_RHOPS

Accession

Primary (citable) accession number: Q131U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 31, 2006
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program