Q131J1 (KHSE_RHOPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	RPD_4029

Organism

Rhodopseudomonas palustris (strain BisB5) [Complete proteome] [HAMAP]

Taxonomic identifier

316057 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_0000300805

Sequences

	Sequence		Length	Mass (Da)
	Q131J1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 2574FAABCE6122CC	FASTA	326	35,808
	10 20 30 40 50 60 MAVYTDVAAD ELADFLKAYE IGDLLSYKGI AEGVENSNFL LHTTRGHFIL TLYEKRVAAD 70 80 90 100 110 120 DLPYFLSLMA HLAARGVSCP QPATNRAGEV CGTLSGRPAV IINFLEGVWP RRPNLAHCAG 130 140 150 160 170 180 VGEAMAKMHR AGLDYPSYRS NPLSVTGWRP LFNIAASRAD EIQPGLRDFI AAELDYLEGN 190 200 210 220 230 240 WPDQLPTGVI HADLFPDNVF FIGDKLSGLI DFPFSCNDIL AYDVAICLNA WCFEPDLSFN 250 260 270 280 290 300 VTKARALLNA YQRERALSEA EQAALPLLAR GAAMRFLLTR LVDFLDVPAG ALVRPKDPLE 310 320 YVRKLRFQQN VAGIRDYGVE AAGAVA

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisB5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BisB5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000283 Genomic DNA. Translation: ABE41248.1.
RefSeq	YP_571149.1. NC_007958.1.
3D structure databases
ProteinModelPortal	Q131J1.
SMR	Q131J1. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	Q131J1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4024546.
GenomeReviews	Gene locus RPD_4029 in contig CP000283_GR.
KEGG	rpd:RPD_4029.
PATRIC	23283237. VBIRhoPal120395_4172.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	RPAL316057:RPD_4029-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHOPS

Accession

Primary (citable) accession number: Q131J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 31, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program