Q13183 (S13A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 13 member 2

Alternative name(s):
Na(+)/dicarboxylate cotransporter 1
Short name=NaDC-1
Renal sodium/dicarboxylate cotransporter

Gene names

Name:	SLC13A2
Synonyms:	NADC1, SDCT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	592 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	low affinity sodium:dicarboxylate symporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13183-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13183-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     77-77: E → EIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 592	592	Solute carrier family 13 member 2		PRO_0000172488
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	274 – 294	21	Helical; Potential
	Transmembrane	324 – 344	21	Helical; Potential
	Transmembrane	371 – 391	21	Helical; Potential
	Transmembrane	450 – 470	21	Helical; Potential
	Transmembrane	482 – 502	21	Helical; Potential
	Transmembrane	511 – 531	21	Helical; Potential
	Transmembrane	545 – 565	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 44	44	Missing in isoform 2.		VSP_046426
	Alternative sequence	77	1	E → EIIQRPFPSSFESPGECQSV GMSVTASHNLGGTVGDSRVF PPLSHVSTCQ in isoform 2.		VSP_046427
	Natural variant	44	1	L → F. Corresponds to variant rs45443898 [ dbSNP | Ensembl ].		VAR_029254
	Natural variant	45	1	M → L. Corresponds to variant rs16964363 [ dbSNP | Ensembl ].		VAR_052000
	Natural variant	254	1	F → L. Corresponds to variant rs11568461 [ dbSNP | Ensembl ].		VAR_029255
	Natural variant	310	1	A → P. Corresponds to variant rs11568441 [ dbSNP | Ensembl ].		VAR_029256
	Natural variant	385	1	P → S. Corresponds to variant rs45546232 [ dbSNP | Ensembl ].		VAR_020399
	Natural variant	477	1	V → M. Corresponds to variant rs11568476 [ dbSNP | Ensembl ].		VAR_029257
	Natural variant	550	1	I → V. Ref.2 Ref.5 Corresponds to variant rs11567842 [ dbSNP | Ensembl ].		VAR_020400
Experimental info
	Sequence conflict	307	1	Q → R in BAG60623. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 41137D6621A0872A	FASTA	592	64,410
	10 20 30 40 50 60 MATCWQALWA YRSYLIVFFV PILLLPLPIL VPSKEAYCAY AIILMALFWC TEALPLAVTA 70 80 90 100 110 120 LFPLILFPMM GIVDASEVAV EYLKDSNLLF FGGLLVAIAV EHWNLHKRIA LRVLLIVGVR 130 140 150 160 170 180 PAPLILGFML VTAFLSMWIS NTATSAMMVP IAHAVLDQLH SSQASSNVEE GSNNPTFELQ 190 200 210 220 230 240 EPSPQKEVTK LDNGQALPVT SASSEGRAHL SQKHLHLTQC MSLCVCYSAS IGGIATLTGT 250 260 270 280 290 300 APNLVLQGQI NSLFPQNGNV VNFASWFSFA FPTMVILLLL AWLWLQILFL GFNFRKNFGI 310 320 330 340 350 360 GEKMQEQQQA AYCVIQTEHR LLGPMTFAEK AISILFVILV LLWFTREPGF FLGWGNLAFP 370 380 390 400 410 420 NAKGESMVSD GTVAIFIGII MFIIPSKFPG LTQDPENPGK LKAPLGLLDW KTVNQKMPWN 430 440 450 460 470 480 IVLLLGGGYA LAKGSERSGL SEWLGNKLTP LQSVPAPAIA IILSLLVATF TECTSNVATT 490 500 510 520 530 540 TIFLPILASM AQAICLHPLY VMLPCTLATS LAFMLPVATP PNAIVFSFGD LKVLDMARAG 550 560 570 580 590 FLLNIIGVLI IALAINSWGI PLFSLHSFPS WAQSNTTAQC LPSLANTTTP SP
	Isoform 2 [UniParc]. Checksum: 51635628BF7A3AC3	FASTA	597	64,468
	10 20 30 40 50 60 MALFWCTEAL PLAVTALFPL ILFPMMGIVD ASEIIQRPFP SSFESPGECQ SVGMSVTASH 70 80 90 100 110 120 NLGGTVGDSR VFPPLSHVST CQVAVEYLKD SNLLFFGGLL VAIAVEHWNL HKRIALRVLL 130 140 150 160 170 180 IVGVRPAPLI LGFMLVTAFL SMWISNTATS AMMVPIAHAV LDQLHSSQAS SNVEEGSNNP 190 200 210 220 230 240 TFELQEPSPQ KEVTKLDNGQ ALPVTSASSE GRAHLSQKHL HLTQCMSLCV CYSASIGGIA 250 260 270 280 290 300 TLTGTAPNLV LQGQINSLFP QNGNVVNFAS WFSFAFPTMV ILLLLAWLWL QILFLGFNFR 310 320 330 340 350 360 KNFGIGEKMQ EQQQAAYCVI QTEHRLLGPM TFAEKAISIL FVILVLLWFT REPGFFLGWG 370 380 390 400 410 420 NLAFPNAKGE SMVSDGTVAI FIGIIMFIIP SKFPGLTQDP ENPGKLKAPL GLLDWKTVNQ 430 440 450 460 470 480 KMPWNIVLLL GGGYALAKGS ERSGLSEWLG NKLTPLQSVP APAIAIILSL LVATFTECTS 490 500 510 520 530 540 NVATTTIFLP ILASMAQAIC LHPLYVMLPC TLATSLAFML PVATPPNAIV FSFGDLKVLD 550 560 570 580 590 MARAGFLLNI IGVLIIALAI NSWGIPLFSL HSFPSWAQSN TTAQCLPSLA NTTTPSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney." Pajor A.M. Am. J. Physiol. 270:F642-F648(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-550. Tissue: Kidney.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls." Okamoto N., Aruga S., Matsuzaki S., Takahashi S., Matsushita K., Kitamura T. Int. J. Urol. 14:344-349(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT VAL-550.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U26209 mRNA. Translation: AAA98504.1. AK298388 mRNA. Translation: BAG60623.1. AK314684 mRNA. Translation: BAG37236.1. AC015917 Genomic DNA. No translation available. BC096277 mRNA. Translation: AAH96277.1. BC096278 mRNA. Translation: AAH96278.1. BC096279 mRNA. Translation: AAH96279.1.
IPI	IPI00011981. IPI00908933.
RefSeq	NP_001139447.1. NM_001145975.1. NP_003975.1. NM_003984.3.
UniGene	Hs.102307.
3D structure databases
ProteinModelPortal	Q13183.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000316202.
PTM databases
PhosphoSite	Q13183.
Polymorphism databases
DMDM	2499523.
Proteomic databases
PaxDb	Q13183.
PRIDE	Q13183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314669; ENSP00000316202; ENSG00000007216. ENST00000444914; ENSP00000392411; ENSG00000007216. ENST00000572344; ENSP00000458829; ENSG00000262654.
GeneID	9058.
KEGG	hsa:9058.
UCSC	uc002hbh.3. human.
Organism-specific databases
CTD	9058.
GeneCards	GC17P026800.
HGNC	HGNC:10917. SLC13A2.
HPA	HPA014963.
MIM	604148. gene.
neXtProt	NX_Q13183.
PharmGKB	PA382.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0471.
HOGENOM	HOG000278432.
HOVERGEN	HBG055339.
InParanoid	Q13183.
KO	K14445.
OrthoDB	EOG4QZ7KW.
PhylomeDB	Q13183.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_20633. Bile salt and organic anion SLC transporters.
Gene expression databases
ArrayExpress	Q13183.
Bgee	Q13183.
CleanEx	HS_SLC13A2.
Genevestigator	Q13183.
Family and domain databases
InterPro	IPR001898. Na/sul_symport. [Graphical view]
Pfam	PF00939. Na_sulph_symp. 1 hit. [Graphical view]
PROSITE	PS01271. NA_SULFATE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00139. Succinic acid.
GenomeRNAi	9058.
NextBio	33945.
SOURCE	Search...

Entry information

Entry name

S13A2_HUMAN

Accession

Primary (citable) accession number: Q13183
Secondary accession number(s): B2RBI9 , B4DPL1, E7ETH5, Q4VAR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.