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Protein

Interleukin-2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • interleukin-2 receptor binding Source: UniProtKB
  • kinase activator activity Source: UniProtKB

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell-cell signaling Source: UniProtKB
  • immune response Source: UniProtKB
  • natural killer cell activation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • T cell differentiation Source: UniProtKB

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation
Biological processAdaptive immunityUniRule annotation, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2UniRule annotation
Short name:
IL-2UniRule annotation
Gene namesi
Name:IL2UniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-KW

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500903146821 – 156Interleukin-2UniRule annotationAdd BLAST136

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PeptideAtlasiQ13169.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • interleukin-2 receptor binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliQ13169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

HOGENOMiHOG000048727.
HOVERGENiHBG007496.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
PANTHERiPTHR10078:SF32. PTHR10078:SF32. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00424. INTERLEUKIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALILALVTNS APTSSSTKKT KKTQLQLEHL LLDLQMILNG
60 70 80 90 100
INNYKNPKLT RMLTFKFYMP KKATELKQLQ CLEEELKPLE EVLNLAQSKN
110 120 130 140 150
FHLRPRDLIS NINVIVLELK GSETTFMCEY ADETATIVEF LNRWITFCQS

IISTLT
Length:156
Mass (Da):18,002
Last modified:November 1, 1996 - v1
Checksum:i8E0452D43B336389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25676 mRNA. Translation: AAA70092.1.
UniGeneiHs.89679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25676 mRNA. Translation: AAA70092.1.
UniGeneiHs.89679.

3D structure databases

ProteinModelPortaliQ13169.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ13169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000048727.
HOVERGENiHBG007496.

Miscellaneous databases

ChiTaRSiIL2. human.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
PANTHERiPTHR10078:SF32. PTHR10078:SF32. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00424. INTERLEUKIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ13169_HUMAN
AccessioniPrimary (citable) accession number: Q13169
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.