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Protein
Submitted name:

Interleukin 2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • interleukin-2 receptor binding Source: UniProtKB
  • kinase activator activity Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: UniProtKB
  • immune response Source: UniProtKB
  • natural killer cell activation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of phosphorylation Source: GOC
  • T cell differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 2Imported
Gene namesi
Name:IL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 156136Sequence analysisPRO_5004181807Add
BLAST

Proteomic databases

PRIDEiQ13169.

Interactioni

GO - Molecular functioni

  • interleukin-2 receptor binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliQ13169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000048727.
HOVERGENiHBG007496.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALILALVTNS APTSSSTKKT KKTQLQLEHL LLDLQMILNG
60 70 80 90 100
INNYKNPKLT RMLTFKFYMP KKATELKQLQ CLEEELKPLE EVLNLAQSKN
110 120 130 140 150
FHLRPRDLIS NINVIVLELK GSETTFMCEY ADETATIVEF LNRWITFCQS

IISTLT
Length:156
Mass (Da):18,002
Last modified:November 1, 1996 - v1
Checksum:i8E0452D43B336389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25676 mRNA. Translation: AAA70092.1.
UniGeneiHs.89679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25676 mRNA. Translation: AAA70092.1.
UniGeneiHs.89679.

3D structure databases

ProteinModelPortaliQ13169.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ13169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000048727.
HOVERGENiHBG007496.

Miscellaneous databases

ChiTaRSiIL2. human.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of human IL-2 from gene transferred mouse melanoma cells and its effect on the growth of mouse melanoma."
    Xu D., Wu Y., Chen J., Yu L., Zhong M., Hui Y., Qu H.
    Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 13:78-82(1993)
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Xu L.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ13169_HUMAN
AccessioniPrimary (citable) accession number: Q13169
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.