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Protein

Heterogeneous nuclear ribonucleoprotein A0

Gene

HNRNPA0

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.1 Publication

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177733-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A0
Short name:
hnRNP A0
Gene namesi
Name:HNRNPA0
Synonyms:HNRPA0
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5030. HNRNPA0.

Subcellular locationi

  • Nucleus By similarity

  • Note: Component of ribonucleosomes.By similarity

GO - Cellular componenti

  • intracellular ribonucleoprotein complex Source: UniProtKB-KW
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10949.
OpenTargetsiENSG00000177733.
PharmGKBiPA162391106.

Polymorphism and mutation databases

BioMutaiHNRNPA0.
DMDMi8134660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818261 – 305Heterogeneous nuclear ribonucleoprotein A0Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei84Phosphoserine; by MAPKAPK21 Publication1
Modified residuei133N6-acetyllysineBy similarity1
Modified residuei139Omega-N-methylarginineCombined sources1
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188PhosphoserineCombined sources1
Modified residuei284Omega-N-methylarginineCombined sources1
Modified residuei291Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei291Dimethylated arginine; alternate1 Publication1
Modified residuei291Omega-N-methylarginine; alternateCombined sources1

Post-translational modificationi

Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.1 Publication
Arg-291 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13151.
MaxQBiQ13151.
PaxDbiQ13151.
PeptideAtlasiQ13151.
PRIDEiQ13151.

2D gel databases

REPRODUCTION-2DPAGEQ13151.
SWISS-2DPAGEQ13151.

PTM databases

iPTMnetiQ13151.
PhosphoSitePlusiQ13151.
SwissPalmiQ13151.

Expressioni

Gene expression databases

BgeeiENSG00000177733.
CleanExiHS_HNRNPA0.
GenevisibleiQ13151. HS.

Organism-specific databases

HPAiHPA036569.
HPA059404.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116149. 101 interactors.
IntActiQ13151. 38 interactors.
MINTiMINT-5001237.
STRINGi9606.ENSP00000316042.

Structurei

3D structure databases

ProteinModelPortaliQ13151.
SMRiQ13151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 86RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini98 – 175RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 305Gly-richAdd BLAST115

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQWQ. Eukaryota.
ENOG4111C8J. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiQ13151.
KOiK12894.
OMAiPKEDIHA.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ13151.
TreeFamiTF351342.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSQLCKLF IGGLNVQTSE SGLRGHFEAF GTLTDCVVVV NPQTKRSRCF
60 70 80 90 100
GFVTYSNVEE ADAAMAASPH AVDGNTVELK RAVSREDSAR PGAHAKVKKL
110 120 130 140 150
FVGGLKGDVA EGDLIEHFSQ FGTVEKAEII ADKQSGKKRG FGFVYFQNHD
160 170 180 190 200
AADKAAVVKF HPIQGHRVEV KKAVPKEDIY SGGGGGGSRS SRGGRGGRGR
210 220 230 240 250
GGGRDQNGLS KGGGGGYNSY GGYGGGGGGG YNAYGGGGGG SSYGGSDYGN
260 270 280 290 300
GFGGFGSYSQ HQSSYGPMKS GGGGGGGGSS WGGRSNSGPY RGGYGGGGGY

GGSSF
Length:305
Mass (Da):30,841
Last modified:November 1, 1996 - v1
Checksum:i9A976A39345AA149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23803 mRNA. Translation: AAA65094.1.
CR456986 mRNA. Translation: CAG33267.1.
CH471062 Genomic DNA. Translation: EAW62182.1.
BC001008 mRNA. Translation: AAH01008.1.
BC007271 mRNA. Translation: AAH07271.1.
BC009284 mRNA. Translation: AAH09284.1.
BC011972 mRNA. Translation: AAH11972.1.
BC012980 mRNA. Translation: AAH12980.1.
BC018949 mRNA. Translation: AAH18949.1.
BC019271 mRNA. Translation: AAH19271.1.
BC028976 mRNA. Translation: AAH28976.1.
BC030249 mRNA. Translation: AAH30249.1.
CCDSiCCDS4193.1.
RefSeqiNP_006796.1. NM_006805.3.
UniGeneiHs.645902.
Hs.96996.

Genome annotation databases

EnsembliENST00000314940; ENSP00000316042; ENSG00000177733.
GeneIDi10949.
KEGGihsa:10949.
UCSCiuc003lbt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23803 mRNA. Translation: AAA65094.1.
CR456986 mRNA. Translation: CAG33267.1.
CH471062 Genomic DNA. Translation: EAW62182.1.
BC001008 mRNA. Translation: AAH01008.1.
BC007271 mRNA. Translation: AAH07271.1.
BC009284 mRNA. Translation: AAH09284.1.
BC011972 mRNA. Translation: AAH11972.1.
BC012980 mRNA. Translation: AAH12980.1.
BC018949 mRNA. Translation: AAH18949.1.
BC019271 mRNA. Translation: AAH19271.1.
BC028976 mRNA. Translation: AAH28976.1.
BC030249 mRNA. Translation: AAH30249.1.
CCDSiCCDS4193.1.
RefSeqiNP_006796.1. NM_006805.3.
UniGeneiHs.645902.
Hs.96996.

3D structure databases

ProteinModelPortaliQ13151.
SMRiQ13151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116149. 101 interactors.
IntActiQ13151. 38 interactors.
MINTiMINT-5001237.
STRINGi9606.ENSP00000316042.

PTM databases

iPTMnetiQ13151.
PhosphoSitePlusiQ13151.
SwissPalmiQ13151.

Polymorphism and mutation databases

BioMutaiHNRNPA0.
DMDMi8134660.

2D gel databases

REPRODUCTION-2DPAGEQ13151.
SWISS-2DPAGEQ13151.

Proteomic databases

EPDiQ13151.
MaxQBiQ13151.
PaxDbiQ13151.
PeptideAtlasiQ13151.
PRIDEiQ13151.

Protocols and materials databases

DNASUi10949.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314940; ENSP00000316042; ENSG00000177733.
GeneIDi10949.
KEGGihsa:10949.
UCSCiuc003lbt.4. human.

Organism-specific databases

CTDi10949.
DisGeNETi10949.
GeneCardsiHNRNPA0.
HGNCiHGNC:5030. HNRNPA0.
HPAiHPA036569.
HPA059404.
MIMi609409. gene.
neXtProtiNX_Q13151.
OpenTargetsiENSG00000177733.
PharmGKBiPA162391106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQWQ. Eukaryota.
ENOG4111C8J. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiQ13151.
KOiK12894.
OMAiPKEDIHA.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ13151.
TreeFamiTF351342.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177733-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

GeneWikiiHNRNPA0.
GenomeRNAii10949.
PROiQ13151.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177733.
CleanExiHS_HNRNPA0.
GenevisibleiQ13151. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROA0_HUMAN
AccessioniPrimary (citable) accession number: Q13151
Secondary accession number(s): Q6IB18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.