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Q13151

- ROA0_HUMAN

UniProt

Q13151 - ROA0_HUMAN

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Protein

Heterogeneous nuclear ribonucleoprotein A0

Gene

HNRNPA0

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.1 Publication

GO - Molecular functioni

  1. AU-rich element binding Source: UniProtKB
  2. nucleotide binding Source: InterPro
  3. poly(A) RNA binding Source: UniProtKB
  4. protein kinase binding Source: UniProtKB
  5. RNA binding Source: ProtInc

GO - Biological processi

  1. 3'-UTR-mediated mRNA stabilization Source: UniProtKB
  2. gene expression Source: Reactome
  3. inflammatory response Source: UniProtKB
  4. mRNA processing Source: ProtInc
  5. mRNA splicing, via spliceosome Source: Reactome
  6. response to lipopolysaccharide Source: UniProtKB
  7. RNA splicing Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_125. Processing of Capped Intron-Containing Pre-mRNA.
REACT_467. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A0
Short name:
hnRNP A0
Gene namesi
Name:HNRNPA0
Synonyms:HNRPA0
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5030. HNRNPA0.

Subcellular locationi

Nucleus By similarity
Note: Component of ribonucleosomes.By similarity

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: ProtInc
  3. ribonucleoprotein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Heterogeneous nuclear ribonucleoprotein A0PRO_0000081826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei84 – 841Phosphoserine; by MAPKAPK21 Publication
Modified residuei133 – 1331N6-acetyllysineBy similarity
Modified residuei188 – 1881Phosphoserine1 Publication
Modified residuei291 – 2911Dimethylated arginine1 Publication

Post-translational modificationi

Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.2 Publications
Arg-291 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ13151.
PaxDbiQ13151.
PeptideAtlasiQ13151.
PRIDEiQ13151.

2D gel databases

REPRODUCTION-2DPAGEQ13151.
SWISS-2DPAGEQ13151.

PTM databases

PhosphoSiteiQ13151.

Expressioni

Gene expression databases

BgeeiQ13151.
CleanExiHS_HNRNPA0.
GenevestigatoriQ13151.

Organism-specific databases

HPAiHPA036569.

Interactioni

Protein-protein interaction databases

BioGridi116149. 89 interactions.
IntActiQ13151. 27 interactions.
MINTiMINT-5001237.
STRINGi9606.ENSP00000316042.

Structurei

3D structure databases

ProteinModelPortaliQ13151.
SMRiQ13151. Positions 2-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8680RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini98 – 17578RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 305115Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiQ13151.
KOiK12894.
OMAiPKEDIHA.
OrthoDBiEOG715Q6V.
PhylomeDBiQ13151.
TreeFamiTF351342.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13151-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENSQLCKLF IGGLNVQTSE SGLRGHFEAF GTLTDCVVVV NPQTKRSRCF
60 70 80 90 100
GFVTYSNVEE ADAAMAASPH AVDGNTVELK RAVSREDSAR PGAHAKVKKL
110 120 130 140 150
FVGGLKGDVA EGDLIEHFSQ FGTVEKAEII ADKQSGKKRG FGFVYFQNHD
160 170 180 190 200
AADKAAVVKF HPIQGHRVEV KKAVPKEDIY SGGGGGGSRS SRGGRGGRGR
210 220 230 240 250
GGGRDQNGLS KGGGGGYNSY GGYGGGGGGG YNAYGGGGGG SSYGGSDYGN
260 270 280 290 300
GFGGFGSYSQ HQSSYGPMKS GGGGGGGGSS WGGRSNSGPY RGGYGGGGGY

GGSSF
Length:305
Mass (Da):30,841
Last modified:November 1, 1996 - v1
Checksum:i9A976A39345AA149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23803 mRNA. Translation: AAA65094.1.
CR456986 mRNA. Translation: CAG33267.1.
CH471062 Genomic DNA. Translation: EAW62182.1.
BC001008 mRNA. Translation: AAH01008.1.
BC007271 mRNA. Translation: AAH07271.1.
BC009284 mRNA. Translation: AAH09284.1.
BC011972 mRNA. Translation: AAH11972.1.
BC012980 mRNA. Translation: AAH12980.1.
BC018949 mRNA. Translation: AAH18949.1.
BC019271 mRNA. Translation: AAH19271.1.
BC028976 mRNA. Translation: AAH28976.1.
BC030249 mRNA. Translation: AAH30249.1.
CCDSiCCDS4193.1.
RefSeqiNP_006796.1. NM_006805.3.
UniGeneiHs.645902.
Hs.96996.

Genome annotation databases

EnsembliENST00000314940; ENSP00000316042; ENSG00000177733.
GeneIDi10949.
KEGGihsa:10949.
UCSCiuc003lbt.3. human.

Polymorphism databases

DMDMi8134660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23803 mRNA. Translation: AAA65094.1 .
CR456986 mRNA. Translation: CAG33267.1 .
CH471062 Genomic DNA. Translation: EAW62182.1 .
BC001008 mRNA. Translation: AAH01008.1 .
BC007271 mRNA. Translation: AAH07271.1 .
BC009284 mRNA. Translation: AAH09284.1 .
BC011972 mRNA. Translation: AAH11972.1 .
BC012980 mRNA. Translation: AAH12980.1 .
BC018949 mRNA. Translation: AAH18949.1 .
BC019271 mRNA. Translation: AAH19271.1 .
BC028976 mRNA. Translation: AAH28976.1 .
BC030249 mRNA. Translation: AAH30249.1 .
CCDSi CCDS4193.1.
RefSeqi NP_006796.1. NM_006805.3.
UniGenei Hs.645902.
Hs.96996.

3D structure databases

ProteinModelPortali Q13151.
SMRi Q13151. Positions 2-182.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116149. 89 interactions.
IntActi Q13151. 27 interactions.
MINTi MINT-5001237.
STRINGi 9606.ENSP00000316042.

PTM databases

PhosphoSitei Q13151.

Polymorphism databases

DMDMi 8134660.

2D gel databases

REPRODUCTION-2DPAGE Q13151.
SWISS-2DPAGE Q13151.

Proteomic databases

MaxQBi Q13151.
PaxDbi Q13151.
PeptideAtlasi Q13151.
PRIDEi Q13151.

Protocols and materials databases

DNASUi 10949.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314940 ; ENSP00000316042 ; ENSG00000177733 .
GeneIDi 10949.
KEGGi hsa:10949.
UCSCi uc003lbt.3. human.

Organism-specific databases

CTDi 10949.
GeneCardsi GC05M137114.
HGNCi HGNC:5030. HNRNPA0.
HPAi HPA036569.
MIMi 609409. gene.
neXtProti NX_Q13151.
PharmGKBi PA162391106.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00760000118873.
HOGENOMi HOG000234442.
HOVERGENi HBG002295.
InParanoidi Q13151.
KOi K12894.
OMAi PKEDIHA.
OrthoDBi EOG715Q6V.
PhylomeDBi Q13151.
TreeFami TF351342.

Enzyme and pathway databases

Reactomei REACT_125. Processing of Capped Intron-Containing Pre-mRNA.
REACT_467. mRNA Splicing - Major Pathway.

Miscellaneous databases

GeneWikii HNRNPA0.
GenomeRNAii 10949.
NextBioi 41601.
PROi Q13151.
SOURCEi Search...

Gene expression databases

Bgeei Q13151.
CleanExi HS_HNRNPA0.
Genevestigatori Q13151.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel, low abundance hnRNP protein: A0."
    Myer V.E., Steitz J.A.
    RNA 1:171-182(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 143-154 AND 287-305.
    Tissue: Placenta.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Eye, Lung, Muscle, Placenta and Skin.
  5. Cited for: PROTEIN SEQUENCE OF 9-24; 99-126; 140-154; 173-189 AND 285-305, METHYLATION AT ARG-291, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma and Ovarian carcinoma.
  6. "Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs."
    Rousseau S., Morrice N., Peggie M., Campbell D.G., Gaestel M., Cohen P.
    EMBO J. 21:6505-6514(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization."
    Reinhardt H.C., Hasskamp P., Schmedding I., Morandell S., van Vugt M.A., Wang X., Linding R., Ong S.E., Weaver D., Carr S.A., Yaffe M.B.
    Mol. Cell 40:34-49(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING, PHOSPHORYLATION AT SER-84 BY MAPKAPK2.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiROA0_HUMAN
AccessioniPrimary (citable) accession number: Q13151
Secondary accession number(s): Q6IB18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3