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Protein

Heterogeneous nuclear ribonucleoprotein A0

Gene

HNRNPA0

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.1 Publication

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A0
Short name:
hnRNP A0
Gene namesi
Name:HNRNPA0
Synonyms:HNRPA0
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177733.6
HGNCiHGNC:5030 HNRNPA0
MIMi609409 gene
neXtProtiNX_Q13151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10949
OpenTargetsiENSG00000177733
PharmGKBiPA162391106

Polymorphism and mutation databases

BioMutaiHNRNPA0
DMDMi8134660

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818261 – 305Heterogeneous nuclear ribonucleoprotein A0Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei84Phosphoserine; by MAPKAPK21 Publication1
Cross-linki96Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei133N6-acetyllysineBy similarity1
Modified residuei139Omega-N-methylarginineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188PhosphoserineCombined sources1
Modified residuei284Omega-N-methylarginineCombined sources1
Modified residuei291Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei291Dimethylated arginine; alternate1 Publication1
Modified residuei291Omega-N-methylarginine; alternateCombined sources1

Post-translational modificationi

Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.1 Publication
Arg-291 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13151
MaxQBiQ13151
PaxDbiQ13151
PeptideAtlasiQ13151
PRIDEiQ13151
ProteomicsDBi59192

2D gel databases

REPRODUCTION-2DPAGEiQ13151
SWISS-2DPAGEiQ13151

PTM databases

iPTMnetiQ13151
PhosphoSitePlusiQ13151
SwissPalmiQ13151

Expressioni

Gene expression databases

BgeeiENSG00000177733
CleanExiHS_HNRNPA0
GenevisibleiQ13151 HS

Organism-specific databases

HPAiHPA036569
HPA059404

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116149, 103 interactors
IntActiQ13151, 41 interactors
MINTiQ13151
STRINGi9606.ENSP00000316042

Structurei

3D structure databases

ProteinModelPortaliQ13151
SMRiQ13151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 86RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini98 – 175RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 305Gly-richAdd BLAST115

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQWQ Eukaryota
ENOG4111C8J LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
HOVERGENiHBG002295
InParanoidiQ13151
KOiK12894
OMAiRGMRGNQ
OrthoDBiEOG091G1CPI
PhylomeDBiQ13151
TreeFamiTF351342

Family and domain databases

CDDicd12326 RRM1_hnRNPA0, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034801 hnRNPA0_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

Q13151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSQLCKLF IGGLNVQTSE SGLRGHFEAF GTLTDCVVVV NPQTKRSRCF
60 70 80 90 100
GFVTYSNVEE ADAAMAASPH AVDGNTVELK RAVSREDSAR PGAHAKVKKL
110 120 130 140 150
FVGGLKGDVA EGDLIEHFSQ FGTVEKAEII ADKQSGKKRG FGFVYFQNHD
160 170 180 190 200
AADKAAVVKF HPIQGHRVEV KKAVPKEDIY SGGGGGGSRS SRGGRGGRGR
210 220 230 240 250
GGGRDQNGLS KGGGGGYNSY GGYGGGGGGG YNAYGGGGGG SSYGGSDYGN
260 270 280 290 300
GFGGFGSYSQ HQSSYGPMKS GGGGGGGGSS WGGRSNSGPY RGGYGGGGGY

GGSSF
Length:305
Mass (Da):30,841
Last modified:November 1, 1996 - v1
Checksum:i9A976A39345AA149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23803 mRNA Translation: AAA65094.1
CR456986 mRNA Translation: CAG33267.1
CH471062 Genomic DNA Translation: EAW62182.1
BC001008 mRNA Translation: AAH01008.1
BC007271 mRNA Translation: AAH07271.1
BC009284 mRNA Translation: AAH09284.1
BC011972 mRNA Translation: AAH11972.1
BC012980 mRNA Translation: AAH12980.1
BC018949 mRNA Translation: AAH18949.1
BC019271 mRNA Translation: AAH19271.1
BC028976 mRNA Translation: AAH28976.1
BC030249 mRNA Translation: AAH30249.1
CCDSiCCDS4193.1
RefSeqiNP_006796.1, NM_006805.3
UniGeneiHs.645902
Hs.96996

Genome annotation databases

EnsembliENST00000314940; ENSP00000316042; ENSG00000177733
GeneIDi10949
KEGGihsa:10949
UCSCiuc003lbt.4 human

Similar proteinsi

Entry informationi

Entry nameiROA0_HUMAN
AccessioniPrimary (citable) accession number: Q13151
Secondary accession number(s): Q6IB18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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