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Protein

TAR DNA-binding protein 43

Gene

TARDBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.2 Publications

GO - Molecular functioni

  • double-stranded DNA binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • mRNA 3'-UTR binding Source: BHF-UCL
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: BHF-UCL
  • mRNA processing Source: UniProtKB-KW
  • negative regulation by host of viral transcription Source: BHF-UCL
  • negative regulation of gene expression Source: CACAO
  • negative regulation of protein phosphorylation Source: CACAO
  • nuclear fragmentation involved in apoptotic nuclear change Source: CACAO
  • nuclear inner membrane organization Source: CACAO
  • positive regulation of transcription from RNA polymerase II promoter Source: GOC
  • regulation of cell cycle Source: CACAO
  • RNA splicing Source: BHF-UCL
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120948-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TAR DNA-binding protein 43
Short name:
TDP-43
Gene namesi
Name:TARDBP
Synonyms:TDP43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11571. TARDBP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Amyotrophic lateral sclerosis 10 (ALS10)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
See also OMIM:612069
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045657169D → G in ALS10. 1 PublicationCorresponds to variant rs80356717dbSNPEnsembl.1
Natural variantiVAR_058611267N → S in ALS10; also in a patient with frontotemporal dementia. 1 PublicationCorresponds to variant rs80356718dbSNPEnsembl.1
Natural variantiVAR_045658287G → S in ALS10. 2 PublicationsCorresponds to variant rs80356719dbSNPEnsembl.1
Natural variantiVAR_045659290G → A in ALS10. 1 PublicationCorresponds to variant rs121908395dbSNPEnsembl.1
Natural variantiVAR_045660294G → A in ALS10. 2 PublicationsCorresponds to variant rs80356721dbSNPEnsembl.1
Natural variantiVAR_058612294G → V in ALS10; a patient with bulbar signs and dementia. 1 PublicationCorresponds to variant rs80356721dbSNPEnsembl.1
Natural variantiVAR_058613295G → R in ALS10. 1 PublicationCorresponds to variant rs80356723dbSNPEnsembl.1
Natural variantiVAR_058614295G → S in ALS10; also in patients with frontotemporal lobar degeneration with motor neuron disease. 1 PublicationCorresponds to variant rs80356723dbSNPEnsembl.1
Natural variantiVAR_045661298G → S in ALS10. 1 PublicationCorresponds to variant rs4884357dbSNPEnsembl.1
Natural variantiVAR_045662315A → T in ALS10. 2 PublicationsCorresponds to variant rs80356726dbSNPEnsembl.1
Natural variantiVAR_045663331Q → K in ALS10; impedes the development of normal limb and tail buds and increases the number of apoptotic nuclei when expressed in chick embryos; does not affect the interaction with ATNX2. 2 PublicationsCorresponds to variant rs80356727dbSNPEnsembl.1
Natural variantiVAR_058615332S → N in ALS10. 1 PublicationCorresponds to variant rs80356728dbSNPEnsembl.1
Natural variantiVAR_058616335G → D in ALS10. 1 PublicationCorresponds to variant rs80356729dbSNPEnsembl.1
Natural variantiVAR_045664337M → V in ALS10; impedes the development of normal limb and tail buds and increases the number of apoptotic nuclei when expressed in chick embryos. 2 PublicationsCorresponds to variant rs80356730dbSNPEnsembl.1
Natural variantiVAR_062767343Q → R in ALS10. 1 PublicationCorresponds to variant rs80356731dbSNPEnsembl.1
Natural variantiVAR_045665348G → C in ALS10. 1 PublicationCorresponds to variant rs80356733dbSNPEnsembl.1
Natural variantiVAR_067499357G → R in ALS10. 1 Publication1
Natural variantiVAR_045666361R → S in ALS10. 1 PublicationCorresponds to variant rs80356735dbSNPEnsembl.1
Natural variantiVAR_067500361R → T in ALS10. 1 Publication1
Natural variantiVAR_058617379S → C in ALS10. 1 PublicationCorresponds to variant rs80356739dbSNPEnsembl.1
Natural variantiVAR_058618379S → P in ALS10. 2 PublicationsCorresponds to variant rs80356738dbSNPEnsembl.1
Natural variantiVAR_045667382A → T in ALS10. 4 PublicationsCorresponds to variant rs367543041dbSNPEnsembl.1
Natural variantiVAR_045668390N → D in ALS10. 1 PublicationCorresponds to variant rs80356741dbSNPEnsembl.1
Natural variantiVAR_045669390N → S in ALS10. 1 PublicationCorresponds to variant rs80356742dbSNPEnsembl.1
Natural variantiVAR_058619393S → L in ALS10. 1 PublicationCorresponds to variant rs80356743dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi106 – 175Missing : Completely abolishes RNA binding. 1 PublicationAdd BLAST70
Mutagenesisi106 – 111LIVLGL → DIDLGD: Completely abolishes RNA binding. 1 Publication6
Mutagenesisi106 – 111Missing : Completely abolishes RNA binding. 1 Publication6
Mutagenesisi147 – 149FGF → LGL: Highly reduces binding to RNA and DNA. 1 Publication3
Mutagenesisi193 – 257Missing : Alters but does not abolish RNA binding. 1 PublicationAdd BLAST65

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi23435.
MalaCardsiTARDBP.
MIMi612069. phenotype.
OpenTargetsiENSG00000120948.
Orphaneti803. Amyotrophic lateral sclerosis.
275872. Frontotemporal dementia with motor neuron disease.
PharmGKBiPA36336.

Chemistry databases

ChEMBLiCHEMBL2362981.

Polymorphism and mutation databases

BioMutaiTARDBP.
DMDMi20140568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819721 – 414TAR DNA-binding protein 43Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei183PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei293Omega-N-methylarginineCombined sources1

Post-translational modificationi

Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.
Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.2 Publications
Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13148.
MaxQBiQ13148.
PaxDbiQ13148.
PeptideAtlasiQ13148.
PRIDEiQ13148.

PTM databases

iPTMnetiQ13148.
PhosphoSitePlusiQ13148.
SwissPalmiQ13148.

Expressioni

Tissue specificityi

Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

Gene expression databases

BgeeiENSG00000120948.
CleanExiHS_TARDBP.
ExpressionAtlasiQ13148. baseline and differential.
GenevisibleiQ13148. HS.

Organism-specific databases

HPAiCAB003703.
HPA017284.

Interactioni

Subunit structurei

Homodimer. Interacts with BRDT (By similarity). Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent (PubMed:20740007). Interacts with MATR3 (PubMed:24686783). Interacts with UBQLN2 (PubMed:23541532). Interacts with HNRNPA2B1 (PubMed:19429692).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself17EBI-372899,EBI-372899
Q9WMX22EBI-372899,EBI-710918From a different organism.
IRAK2O431872EBI-372899,EBI-447733

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi117003. 329 interactors.
DIPiDIP-31167N.
IntActiQ13148. 36 interactors.
MINTiMINT-5002768.
STRINGi9606.ENSP00000240185.

Structurei

Secondary structure

1414
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 13Combined sources9
Beta strandi16 – 18Combined sources3
Beta strandi22 – 24Combined sources3
Helixi28 – 34Combined sources7
Beta strandi40 – 44Combined sources5
Turni46 – 48Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi60 – 62Combined sources3
Beta strandi72 – 76Combined sources5
Beta strandi106 – 110Combined sources5
Helixi117 – 124Combined sources8
Turni125 – 127Combined sources3
Beta strandi130 – 137Combined sources8
Turni139 – 141Combined sources3
Beta strandi144 – 154Combined sources11
Helixi155 – 162Combined sources8
Beta strandi166 – 168Combined sources3
Beta strandi171 – 176Combined sources6
Beta strandi193 – 197Combined sources5
Beta strandi200 – 202Combined sources3
Helixi204 – 210Combined sources7
Turni212 – 214Combined sources3
Beta strandi219 – 221Combined sources3
Beta strandi231 – 233Combined sources3
Helixi237 – 242Combined sources6
Turni243 – 245Combined sources3
Beta strandi247 – 250Combined sources4
Beta strandi253 – 258Combined sources6
Beta strandi263 – 265Combined sources3
Beta strandi312 – 314Combined sources3
Turni315 – 318Combined sources4
Beta strandi319 – 321Combined sources3
Helixi322 – 344Combined sources23
Beta strandi348 – 350Combined sources3
Beta strandi356 – 358Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF0NMR-A193-267[»]
2CQGNMR-A96-185[»]
2N2CNMR-A307-349[»]
2N3XNMR-A311-360[»]
2N4GNMR-A311-360[»]
2N4HNMR-A311-360[»]
2N4PNMR-A1-77[»]
4BS2NMR-A102-269[»]
4IUFX-ray2.75A103-179[»]
4Y00X-ray3.00A/B/C/D101-191[»]
4Y0FX-ray2.65A/B101-191[»]
ProteinModelPortaliQ13148.
SMRiQ13148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13148.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 200RRM 1PROSITE-ProRule annotationAdd BLAST97
Domaini191 – 262RRM 2PROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 414Interaction with UBQLN21 PublicationAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 413Gly-richAdd BLAST140

Domaini

The RRM domains can bind to both DNA and RNA.By similarity

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFJS. Eukaryota.
ENOG410ZYQJ. LUCA.
GeneTreeiENSGT00850000132362.
HOGENOMiHOG000254792.
HOVERGENiHBG058671.
InParanoidiQ13148.
OMAiKHNSSRQ.
OrthoDBiEOG091G0BJZ.
PhylomeDBiQ13148.
TreeFamiTF315657.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13148-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC
60 70 80 90 100
MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV
110 120 130 140 150
QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV
160 170 180 190 200
RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE
210 220 230 240 250
DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII
260 270 280 290 300
KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG
310 320 330 340 350
NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS
360 370 380 390 400
GNNQNQGNMQ REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG
410
FGSSMDSKSS GWGM
Length:414
Mass (Da):44,740
Last modified:November 1, 1996 - v1
Checksum:i8E09A1206FB4EF4A
GO
Isoform 2 (identifier: Q13148-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSEYIRVTEDENDEPIEI → MPQMLAGEIWCMLSTIQK
     19-134: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):31,808
Checksum:i22F381E08083AB08
GO

Sequence cautioni

The sequence ABO32290 differs from that shown. Probable cloning artifact.Curated
The sequence ABO32292 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200E → G in BAD96474 (Ref. 5) Curated1
Sequence conflicti278G → V in BAG35326 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04565690A → V.3 PublicationsCorresponds to variant rs80356715dbSNPEnsembl.1
Natural variantiVAR_045657169D → G in ALS10. 1 PublicationCorresponds to variant rs80356717dbSNPEnsembl.1
Natural variantiVAR_058611267N → S in ALS10; also in a patient with frontotemporal dementia. 1 PublicationCorresponds to variant rs80356718dbSNPEnsembl.1
Natural variantiVAR_045658287G → S in ALS10. 2 PublicationsCorresponds to variant rs80356719dbSNPEnsembl.1
Natural variantiVAR_045659290G → A in ALS10. 1 PublicationCorresponds to variant rs121908395dbSNPEnsembl.1
Natural variantiVAR_045660294G → A in ALS10. 2 PublicationsCorresponds to variant rs80356721dbSNPEnsembl.1
Natural variantiVAR_058612294G → V in ALS10; a patient with bulbar signs and dementia. 1 PublicationCorresponds to variant rs80356721dbSNPEnsembl.1
Natural variantiVAR_058613295G → R in ALS10. 1 PublicationCorresponds to variant rs80356723dbSNPEnsembl.1
Natural variantiVAR_058614295G → S in ALS10; also in patients with frontotemporal lobar degeneration with motor neuron disease. 1 PublicationCorresponds to variant rs80356723dbSNPEnsembl.1
Natural variantiVAR_045661298G → S in ALS10. 1 PublicationCorresponds to variant rs4884357dbSNPEnsembl.1
Natural variantiVAR_045662315A → T in ALS10. 2 PublicationsCorresponds to variant rs80356726dbSNPEnsembl.1
Natural variantiVAR_045663331Q → K in ALS10; impedes the development of normal limb and tail buds and increases the number of apoptotic nuclei when expressed in chick embryos; does not affect the interaction with ATNX2. 2 PublicationsCorresponds to variant rs80356727dbSNPEnsembl.1
Natural variantiVAR_058615332S → N in ALS10. 1 PublicationCorresponds to variant rs80356728dbSNPEnsembl.1
Natural variantiVAR_058616335G → D in ALS10. 1 PublicationCorresponds to variant rs80356729dbSNPEnsembl.1
Natural variantiVAR_045664337M → V in ALS10; impedes the development of normal limb and tail buds and increases the number of apoptotic nuclei when expressed in chick embryos. 2 PublicationsCorresponds to variant rs80356730dbSNPEnsembl.1
Natural variantiVAR_062767343Q → R in ALS10. 1 PublicationCorresponds to variant rs80356731dbSNPEnsembl.1
Natural variantiVAR_045665348G → C in ALS10. 1 PublicationCorresponds to variant rs80356733dbSNPEnsembl.1
Natural variantiVAR_067499357G → R in ALS10. 1 Publication1
Natural variantiVAR_045666361R → S in ALS10. 1 PublicationCorresponds to variant rs80356735dbSNPEnsembl.1
Natural variantiVAR_067500361R → T in ALS10. 1 Publication1
Natural variantiVAR_058617379S → C in ALS10. 1 PublicationCorresponds to variant rs80356739dbSNPEnsembl.1
Natural variantiVAR_058618379S → P in ALS10. 2 PublicationsCorresponds to variant rs80356738dbSNPEnsembl.1
Natural variantiVAR_045667382A → T in ALS10. 4 PublicationsCorresponds to variant rs367543041dbSNPEnsembl.1
Natural variantiVAR_045668390N → D in ALS10. 1 PublicationCorresponds to variant rs80356741dbSNPEnsembl.1
Natural variantiVAR_045669390N → S in ALS10. 1 PublicationCorresponds to variant rs80356742dbSNPEnsembl.1
Natural variantiVAR_058619393S → L in ALS10. 1 PublicationCorresponds to variant rs80356743dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564061 – 18MSEYI…EPIEI → MPQMLAGEIWCMLSTIQK in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05640719 – 134Missing in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23731 mRNA. Translation: AAA70033.1.
EF434181 mRNA. Translation: ABO32290.1. Sequence problems.
EF434182 mRNA. Translation: ABO32291.1.
EF434183 mRNA. Translation: ABO32292.1. Sequence problems.
AK295920 mRNA. Translation: BAG58707.1.
AK312416 mRNA. Translation: BAG35326.1.
CR533534 mRNA. Translation: CAG38565.1.
AK222754 mRNA. Translation: BAD96474.1.
AL050265 mRNA. Translation: CAB43367.1.
AL109811 Genomic DNA. Translation: CAI22098.1.
CH471130 Genomic DNA. Translation: EAW71670.1.
BC071657 mRNA. Translation: AAH71657.1.
BC095435 mRNA. Translation: AAH95435.1.
CCDSiCCDS122.1. [Q13148-1]
PIRiI38977.
RefSeqiNP_031401.1. NM_007375.3. [Q13148-1]
XP_016856352.1. XM_017000863.1. [Q13148-1]
XP_016856353.1. XM_017000864.1. [Q13148-1]
XP_016856354.1. XM_017000865.1. [Q13148-1]
XP_016856355.1. XM_017000866.1. [Q13148-1]
XP_016856356.1. XM_017000867.1. [Q13148-1]
XP_016856357.1. XM_017000868.1. [Q13148-1]
UniGeneiHs.300624.

Genome annotation databases

EnsembliENST00000240185; ENSP00000240185; ENSG00000120948. [Q13148-1]
GeneIDi23435.
KEGGihsa:23435.
UCSCiuc001art.4. human. [Q13148-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23731 mRNA. Translation: AAA70033.1.
EF434181 mRNA. Translation: ABO32290.1. Sequence problems.
EF434182 mRNA. Translation: ABO32291.1.
EF434183 mRNA. Translation: ABO32292.1. Sequence problems.
AK295920 mRNA. Translation: BAG58707.1.
AK312416 mRNA. Translation: BAG35326.1.
CR533534 mRNA. Translation: CAG38565.1.
AK222754 mRNA. Translation: BAD96474.1.
AL050265 mRNA. Translation: CAB43367.1.
AL109811 Genomic DNA. Translation: CAI22098.1.
CH471130 Genomic DNA. Translation: EAW71670.1.
BC071657 mRNA. Translation: AAH71657.1.
BC095435 mRNA. Translation: AAH95435.1.
CCDSiCCDS122.1. [Q13148-1]
PIRiI38977.
RefSeqiNP_031401.1. NM_007375.3. [Q13148-1]
XP_016856352.1. XM_017000863.1. [Q13148-1]
XP_016856353.1. XM_017000864.1. [Q13148-1]
XP_016856354.1. XM_017000865.1. [Q13148-1]
XP_016856355.1. XM_017000866.1. [Q13148-1]
XP_016856356.1. XM_017000867.1. [Q13148-1]
XP_016856357.1. XM_017000868.1. [Q13148-1]
UniGeneiHs.300624.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF0NMR-A193-267[»]
2CQGNMR-A96-185[»]
2N2CNMR-A307-349[»]
2N3XNMR-A311-360[»]
2N4GNMR-A311-360[»]
2N4HNMR-A311-360[»]
2N4PNMR-A1-77[»]
4BS2NMR-A102-269[»]
4IUFX-ray2.75A103-179[»]
4Y00X-ray3.00A/B/C/D101-191[»]
4Y0FX-ray2.65A/B101-191[»]
ProteinModelPortaliQ13148.
SMRiQ13148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117003. 329 interactors.
DIPiDIP-31167N.
IntActiQ13148. 36 interactors.
MINTiMINT-5002768.
STRINGi9606.ENSP00000240185.

Chemistry databases

ChEMBLiCHEMBL2362981.

PTM databases

iPTMnetiQ13148.
PhosphoSitePlusiQ13148.
SwissPalmiQ13148.

Polymorphism and mutation databases

BioMutaiTARDBP.
DMDMi20140568.

Proteomic databases

EPDiQ13148.
MaxQBiQ13148.
PaxDbiQ13148.
PeptideAtlasiQ13148.
PRIDEiQ13148.

Protocols and materials databases

DNASUi23435.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240185; ENSP00000240185; ENSG00000120948. [Q13148-1]
GeneIDi23435.
KEGGihsa:23435.
UCSCiuc001art.4. human. [Q13148-1]

Organism-specific databases

CTDi23435.
DisGeNETi23435.
GeneCardsiTARDBP.
GeneReviewsiTARDBP.
HGNCiHGNC:11571. TARDBP.
HPAiCAB003703.
HPA017284.
MalaCardsiTARDBP.
MIMi605078. gene.
612069. phenotype.
neXtProtiNX_Q13148.
OpenTargetsiENSG00000120948.
Orphaneti803. Amyotrophic lateral sclerosis.
275872. Frontotemporal dementia with motor neuron disease.
PharmGKBiPA36336.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJS. Eukaryota.
ENOG410ZYQJ. LUCA.
GeneTreeiENSGT00850000132362.
HOGENOMiHOG000254792.
HOVERGENiHBG058671.
InParanoidiQ13148.
OMAiKHNSSRQ.
OrthoDBiEOG091G0BJZ.
PhylomeDBiQ13148.
TreeFamiTF315657.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120948-MONOMER.

Miscellaneous databases

ChiTaRSiTARDBP. human.
EvolutionaryTraceiQ13148.
GeneWikiiTARDBP.
GenomeRNAii23435.
PROiQ13148.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120948.
CleanExiHS_TARDBP.
ExpressionAtlasiQ13148. baseline and differential.
GenevisibleiQ13148. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTADBP_HUMAN
AccessioniPrimary (citable) accession number: Q13148
Secondary accession number(s): A4GUK4
, A4GUK5, A4GUK6, B2R629, B4DJ45, E2PU12, Q53H27, Q6FI92, Q96DJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.