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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

BAMBI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates TGF-beta signaling.

GO - Molecular functioni

  1. frizzled binding Source: BHF-UCL
  2. type II transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

  1. cell migration Source: BHF-UCL
  2. negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  3. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  4. positive regulation of catenin import into nucleus Source: BHF-UCL
  5. positive regulation of cell proliferation Source: BHF-UCL
  6. positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
  7. positive regulation of protein binding Source: BHF-UCL
  8. positive regulation of transcription, DNA-templated Source: BHF-UCL
  9. regulation of cell shape Source: BHF-UCL
  10. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_120727. Downregulation of TGF-beta receptor signaling.
SignaLinkiQ13145.

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Non-metastatic gene A protein
Putative transmembrane protein NMA
Gene namesi
Name:BAMBI
Synonyms:NMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:30251. BAMBI.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 152132ExtracellularSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Topological domaini174 – 26087CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909139.

Polymorphism and mutation databases

BioMutaiBAMBI.
DMDMi2498645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 260240BMP and activin membrane-bound inhibitor homologPRO_0000020779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ13145.
PaxDbiQ13145.
PRIDEiQ13145.

PTM databases

PhosphoSiteiQ13145.

Expressioni

Tissue specificityi

High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

Developmental stagei

Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.

Gene expression databases

BgeeiQ13145.
CleanExiHS_BAMBI.
GenevestigatoriQ13145.

Organism-specific databases

HPAiHPA010866.

Interactioni

Protein-protein interaction databases

BioGridi117337. 11 interactions.
IntActiQ13145. 5 interactions.
MINTiMINT-1473447.
STRINGi9606.ENSP00000364683.

Structurei

3D structure databases

ProteinModelPortaliQ13145.
SMRiQ13145. Positions 27-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAMBI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46186.
GeneTreeiENSGT00390000014168.
HOGENOMiHOG000095174.
HOVERGENiHBG050659.
InParanoidiQ13145.
KOiK10162.
OMAiAKQAQNH.
OrthoDBiEOG7CZK6Q.
PhylomeDBiQ13145.
TreeFamiTF333466.

Family and domain databases

InterProiIPR009345. BAMBI.
[Graphical view]
PANTHERiPTHR15505:SF0. PTHR15505:SF0. 1 hit.
PfamiPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFiPIRSF037456. BAMBI. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND KILSLVHWGM
260
YSGHGKLEFV
Length:260
Mass (Da):29,108
Last modified:November 1, 1997 - v1
Checksum:i70C23268838CE8AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23070 mRNA. Translation: AAC50435.1.
U29189, U29188 Genomic DNA. Translation: AAR02414.1.
BT006820 mRNA. Translation: AAP35466.1.
AL161936 Genomic DNA. Translation: CAC16002.1.
BC019252 mRNA. Translation: AAH19252.1.
CCDSiCCDS7162.1.
RefSeqiNP_036474.1. NM_012342.2.
UniGeneiHs.533336.

Genome annotation databases

EnsembliENST00000375533; ENSP00000364683; ENSG00000095739.
GeneIDi25805.
KEGGihsa:25805.
UCSCiuc001iuj.1. human.

Polymorphism and mutation databases

BioMutaiBAMBI.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23070 mRNA. Translation: AAC50435.1.
U29189, U29188 Genomic DNA. Translation: AAR02414.1.
BT006820 mRNA. Translation: AAP35466.1.
AL161936 Genomic DNA. Translation: CAC16002.1.
BC019252 mRNA. Translation: AAH19252.1.
CCDSiCCDS7162.1.
RefSeqiNP_036474.1. NM_012342.2.
UniGeneiHs.533336.

3D structure databases

ProteinModelPortaliQ13145.
SMRiQ13145. Positions 27-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117337. 11 interactions.
IntActiQ13145. 5 interactions.
MINTiMINT-1473447.
STRINGi9606.ENSP00000364683.

PTM databases

PhosphoSiteiQ13145.

Polymorphism and mutation databases

BioMutaiBAMBI.
DMDMi2498645.

Proteomic databases

MaxQBiQ13145.
PaxDbiQ13145.
PRIDEiQ13145.

Protocols and materials databases

DNASUi25805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375533; ENSP00000364683; ENSG00000095739.
GeneIDi25805.
KEGGihsa:25805.
UCSCiuc001iuj.1. human.

Organism-specific databases

CTDi25805.
GeneCardsiGC10P028967.
HGNCiHGNC:30251. BAMBI.
HPAiHPA010866.
MIMi604444. gene.
neXtProtiNX_Q13145.
PharmGKBiPA134909139.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46186.
GeneTreeiENSGT00390000014168.
HOGENOMiHOG000095174.
HOVERGENiHBG050659.
InParanoidiQ13145.
KOiK10162.
OMAiAKQAQNH.
OrthoDBiEOG7CZK6Q.
PhylomeDBiQ13145.
TreeFamiTF333466.

Enzyme and pathway databases

ReactomeiREACT_120727. Downregulation of TGF-beta receptor signaling.
SignaLinkiQ13145.

Miscellaneous databases

ChiTaRSiBAMBI. human.
GeneWikiiBAMBI.
GenomeRNAii25805.
NextBioi47019.
PROiQ13145.
SOURCEiSearch...

Gene expression databases

BgeeiQ13145.
CleanExiHS_BAMBI.
GenevestigatoriQ13145.

Family and domain databases

InterProiIPR009345. BAMBI.
[Graphical view]
PANTHERiPTHR15505:SF0. PTHR15505:SF0. 1 hit.
PfamiPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFiPIRSF037456. BAMBI. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts."
    Degen W.G.J., Weterman M.A., van Groningen J.J.M., Cornelissen I.M.A.H., Lemmers J.P.W.M., Agterbos M.A., van Kessel A.G., Swart G.W.M., Bloemers H.P.J.
    Int. J. Cancer 65:460-465(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.

Entry informationi

Entry nameiBAMBI_HUMAN
AccessioniPrimary (citable) accession number: Q13145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 29, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.