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Q13145 (BAMBI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Non-metastatic gene A protein
Putative transmembrane protein NMA
Gene names
Name:BAMBI
Synonyms:NMA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negatively regulates TGF-beta signaling.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

Developmental stage

Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.

Sequence similarities

Belongs to the BAMBI family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration

Inferred from direct assay PubMed 19328798. Source: BHF-UCL

negative regulation of transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 14660579. Source: BHF-UCL

positive regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 18838381. Source: BHF-UCL

positive regulation of catenin import into nucleus

Inferred from mutant phenotype PubMed 18838381. Source: BHF-UCL

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 18838381. Source: BHF-UCL

positive regulation of epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 19328798. Source: BHF-UCL

positive regulation of protein binding

Inferred from mutant phenotype PubMed 18838381. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 18838381. Source: BHF-UCL

regulation of cell shape

Inferred from mutant phenotype PubMed 19328798. Source: BHF-UCL

transforming growth factor beta receptor signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 10942595. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 18756595. Source: BHF-UCL

   Molecular_functionfrizzled binding

Inferred from physical interaction PubMed 18838381. Source: BHF-UCL

type II transforming growth factor beta receptor binding

Traceable author statement PubMed 18756595. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.5
Chain21 – 260240BMP and activin membrane-bound inhibitor homolog
PRO_0000020779

Regions

Topological domain21 – 152132Extracellular Potential
Transmembrane153 – 17321Helical; Potential
Topological domain174 – 26087Cytoplasmic Potential

Amino acid modifications

Glycosylation871N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q13145 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 70C23268838CE8AB

FASTA26029,108
        10         20         30         40         50         60 
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN 

        70         80         90        100        110        120 
SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA 

       130        140        150        160        170        180 
SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN 

       190        200        210        220        230        240 
KRLQDQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND 

       250        260 
KILSLVHWGM YSGHGKLEFV 

« Hide

References

« Hide 'large scale' references
[1]"Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts."
Degen W.G.J., Weterman M.A., van Groningen J.J.M., Cornelissen I.M.A.H., Lemmers J.P.W.M., Agterbos M.A., van Kessel A.G., Swart G.W.M., Bloemers H.P.J.
Int. J. Cancer 65:460-465(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-35.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U23070 mRNA. Translation: AAC50435.1.
U29189, U29188 Genomic DNA. Translation: AAR02414.1.
BT006820 mRNA. Translation: AAP35466.1.
AL161936 Genomic DNA. Translation: CAC16002.1.
BC019252 mRNA. Translation: AAH19252.1.
RefSeqNP_036474.1. NM_012342.2.
UniGeneHs.533336.

3D structure databases

ProteinModelPortalQ13145.
SMRQ13145. Positions 27-115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117337. 11 interactions.
IntActQ13145. 2 interactions.
MINTMINT-1473447.
STRING9606.ENSP00000364683.

PTM databases

PhosphoSiteQ13145.

Polymorphism databases

DMDM2498645.

Proteomic databases

PaxDbQ13145.
PRIDEQ13145.

Protocols and materials databases

DNASU25805.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375533; ENSP00000364683; ENSG00000095739.
GeneID25805.
KEGGhsa:25805.
UCSCuc001iuj.1. human.

Organism-specific databases

CTD25805.
GeneCardsGC10P029006.
HGNCHGNC:30251. BAMBI.
HPAHPA010866.
MIM604444. gene.
neXtProtNX_Q13145.
PharmGKBPA134909139.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46186.
HOGENOMHOG000095174.
HOVERGENHBG050659.
InParanoidQ13145.
KOK10162.
OMAAKQAQNH.
OrthoDBEOG7CZK6Q.
PhylomeDBQ13145.
TreeFamTF333466.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
SignaLinkQ13145.

Gene expression databases

ArrayExpressQ13145.
BgeeQ13145.
CleanExHS_BAMBI.
GenevestigatorQ13145.

Family and domain databases

InterProIPR009345. BMP/activin_membr-bound_inhib.
[Graphical view]
PANTHERPTHR15505. PTHR15505. 1 hit.
PfamPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFPIRSF037456. BAMBI. 1 hit.
ProtoNetSearch...

Other

GeneWikiBAMBI.
GenomeRNAi25805.
NextBio47019.
PROQ13145.
SOURCESearch...

Entry information

Entry nameBAMBI_HUMAN
AccessionPrimary (citable) accession number: Q13145
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM