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Q13145

- BAMBI_HUMAN

UniProt

Q13145 - BAMBI_HUMAN

Protein

BMP and activin membrane-bound inhibitor homolog

Gene

BAMBI

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Negatively regulates TGF-beta signaling.

    GO - Molecular functioni

    1. frizzled binding Source: BHF-UCL
    2. type II transforming growth factor beta receptor binding Source: BHF-UCL

    GO - Biological processi

    1. cell migration Source: BHF-UCL
    2. negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
    3. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
    4. positive regulation of catenin import into nucleus Source: BHF-UCL
    5. positive regulation of cell proliferation Source: BHF-UCL
    6. positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
    7. positive regulation of protein binding Source: BHF-UCL
    8. positive regulation of transcription, DNA-templated Source: BHF-UCL
    9. regulation of cell shape Source: BHF-UCL
    10. transforming growth factor beta receptor signaling pathway Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_120727. Downregulation of TGF-beta receptor signaling.
    SignaLinkiQ13145.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BMP and activin membrane-bound inhibitor homolog
    Alternative name(s):
    Non-metastatic gene A protein
    Putative transmembrane protein NMA
    Gene namesi
    Name:BAMBI
    Synonyms:NMA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:30251. BAMBI.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909139.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 260240BMP and activin membrane-bound inhibitor homologPRO_0000020779Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ13145.
    PaxDbiQ13145.
    PRIDEiQ13145.

    PTM databases

    PhosphoSiteiQ13145.

    Expressioni

    Tissue specificityi

    High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

    Developmental stagei

    Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.

    Gene expression databases

    ArrayExpressiQ13145.
    BgeeiQ13145.
    CleanExiHS_BAMBI.
    GenevestigatoriQ13145.

    Organism-specific databases

    HPAiHPA010866.

    Interactioni

    Protein-protein interaction databases

    BioGridi117337. 11 interactions.
    IntActiQ13145. 5 interactions.
    MINTiMINT-1473447.
    STRINGi9606.ENSP00000364683.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13145.
    SMRiQ13145. Positions 27-115.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 152132ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini174 – 26087CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BAMBI family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46186.
    HOGENOMiHOG000095174.
    HOVERGENiHBG050659.
    InParanoidiQ13145.
    KOiK10162.
    OMAiCQAKQAQ.
    OrthoDBiEOG7CZK6Q.
    PhylomeDBiQ13145.
    TreeFamiTF333466.

    Family and domain databases

    InterProiIPR009345. BAMBI.
    [Graphical view]
    PANTHERiPTHR15505:SF0. PTHR15505:SF0. 1 hit.
    PfamiPF06211. BAMBI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037456. BAMBI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13145-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA    50
    CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH 100
    EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF 150
    RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG 200
    HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND KILSLVHWGM 250
    YSGHGKLEFV 260
    Length:260
    Mass (Da):29,108
    Last modified:November 1, 1997 - v1
    Checksum:i70C23268838CE8AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23070 mRNA. Translation: AAC50435.1.
    U29189, U29188 Genomic DNA. Translation: AAR02414.1.
    BT006820 mRNA. Translation: AAP35466.1.
    AL161936 Genomic DNA. Translation: CAC16002.1.
    BC019252 mRNA. Translation: AAH19252.1.
    CCDSiCCDS7162.1.
    RefSeqiNP_036474.1. NM_012342.2.
    UniGeneiHs.533336.

    Genome annotation databases

    EnsembliENST00000375533; ENSP00000364683; ENSG00000095739.
    GeneIDi25805.
    KEGGihsa:25805.
    UCSCiuc001iuj.1. human.

    Polymorphism databases

    DMDMi2498645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23070 mRNA. Translation: AAC50435.1 .
    U29189 , U29188 Genomic DNA. Translation: AAR02414.1 .
    BT006820 mRNA. Translation: AAP35466.1 .
    AL161936 Genomic DNA. Translation: CAC16002.1 .
    BC019252 mRNA. Translation: AAH19252.1 .
    CCDSi CCDS7162.1.
    RefSeqi NP_036474.1. NM_012342.2.
    UniGenei Hs.533336.

    3D structure databases

    ProteinModelPortali Q13145.
    SMRi Q13145. Positions 27-115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117337. 11 interactions.
    IntActi Q13145. 5 interactions.
    MINTi MINT-1473447.
    STRINGi 9606.ENSP00000364683.

    PTM databases

    PhosphoSitei Q13145.

    Polymorphism databases

    DMDMi 2498645.

    Proteomic databases

    MaxQBi Q13145.
    PaxDbi Q13145.
    PRIDEi Q13145.

    Protocols and materials databases

    DNASUi 25805.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375533 ; ENSP00000364683 ; ENSG00000095739 .
    GeneIDi 25805.
    KEGGi hsa:25805.
    UCSCi uc001iuj.1. human.

    Organism-specific databases

    CTDi 25805.
    GeneCardsi GC10P029006.
    HGNCi HGNC:30251. BAMBI.
    HPAi HPA010866.
    MIMi 604444. gene.
    neXtProti NX_Q13145.
    PharmGKBi PA134909139.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46186.
    HOGENOMi HOG000095174.
    HOVERGENi HBG050659.
    InParanoidi Q13145.
    KOi K10162.
    OMAi CQAKQAQ.
    OrthoDBi EOG7CZK6Q.
    PhylomeDBi Q13145.
    TreeFami TF333466.

    Enzyme and pathway databases

    Reactomei REACT_120727. Downregulation of TGF-beta receptor signaling.
    SignaLinki Q13145.

    Miscellaneous databases

    GeneWikii BAMBI.
    GenomeRNAii 25805.
    NextBioi 47019.
    PROi Q13145.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13145.
    Bgeei Q13145.
    CleanExi HS_BAMBI.
    Genevestigatori Q13145.

    Family and domain databases

    InterProi IPR009345. BAMBI.
    [Graphical view ]
    PANTHERi PTHR15505:SF0. PTHR15505:SF0. 1 hit.
    Pfami PF06211. BAMBI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037456. BAMBI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts."
      Degen W.G.J., Weterman M.A., van Groningen J.J.M., Cornelissen I.M.A.H., Lemmers J.P.W.M., Agterbos M.A., van Kessel A.G., Swart G.W.M., Bloemers H.P.J.
      Int. J. Cancer 65:460-465(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-35.

    Entry informationi

    Entry nameiBAMBI_HUMAN
    AccessioniPrimary (citable) accession number: Q13145
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3