Reviewed, UniProtKB/Swiss-Prot Q13145 (BAMBI_HUMAN)

Names and origin

Protein names

Recommended name:
    BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
    Putative transmembrane protein NMA
    Non-metastatic gene A protein

Gene names

Name:	BAMBI
Synonyms:	NMA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Negatively regulates TGF-beta signaling.
Subcellular location	Membrane; Single-pass type I membrane proteinPotential.
Tissue specificity	High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
Developmental stage	Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.
Sequence similarities	Belongs to the BAMBI family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB integral to membrane Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20
	Chain	21 – 260	240	BMP and activin membrane-bound inhibitor homolog		PRO_0000020779
Regions
	Topological domain	21 – 152	132	Extracellular Potential
	Transmembrane	153 – 173	21	Potential
	Topological domain	174 – 260	87	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	87	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q13145-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 70C23268838CE8AB	FASTA	260	29,108
	10 20 30 40 50 60 MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN 70 80 90 100 110 120 SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA 130 140 150 160 170 180 SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN 190 200 210 220 230 240 KRLQDQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND 250 260 KILSLVHWGM YSGHGKLEFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts." Degen W.G.J., Weterman M.A., van Groningen J.J.M., Cornelissen I.M.A.H., Lemmers J.P.W.M., Agterbos M.A., van Kessel A.G., Swart G.W.M., Bloemers H.P.J. Int. J. Cancer 65:460-465(1996) [PubMed: 8621228] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-35.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U23070 mRNA. Translation: AAC50435.1. U29189, U29188 Genomic DNA. Translation: AAR02414.1. BT006820 mRNA. Translation: AAP35466.1. AL161936 Genomic DNA. Translation: CAC16002.1. BC019252 mRNA. Translation: AAH19252.1.
RefSeq	NP_036474.1.
UniGene	Hs.533336
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13145.
PTM databases
PhosphoSite	Q13145.
Genome annotation databases
Ensembl	ENSG00000095739. Homo sapiens. [Contig view]
GeneID	25805.
KEGG	hsa:25805.
Organism-specific databases
HGNC	HGNC:30251. BAMBI.
MIM	604444. gene.
PharmGKB	PA134909139.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q13145.
HOVERGEN	Q13145.
Gene expression databases
ArrayExpress	Q13145.
CleanEx	HS_BAMBI.
GermOnline	ENSG00000095739. Homo sapiens.
Family and domain databases
InterPro	IPR009345. BAMBI. [Graphical view]
PANTHER	PTHR15505. BAMBI. 1 hit.
Pfam	PF06211. BAMBI. 1 hit. [Graphical view]
PIRSF	PIRSF037456. BAMBI. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	47019.
SOURCE	Search...

Entry information

Entry name

BAMBI_HUMAN

Accession

Primary (citable) accession number: Q13145

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)