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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

BAMBI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates TGF-beta signaling.

GO - Molecular functioni

  • frizzled binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

  • cell migration Source: BHF-UCL
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  • positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of catenin import into nucleus Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
  • positive regulation of protein binding Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • regulation of cell shape Source: BHF-UCL
  • transforming growth factor beta receptor signaling pathway Source: Ensembl

Enzyme and pathway databases

ReactomeiR-HSA-2173788. Downregulation of TGF-beta receptor signaling.
SignaLinkiQ13145.
SIGNORiQ13145.

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Non-metastatic gene A protein
Putative transmembrane protein NMA
Gene namesi
Name:BAMBI
Synonyms:NMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000095739.10.
HGNCiHGNC:30251. BAMBI.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 152ExtracellularSequence analysisAdd BLAST132
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 260CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25805.
OpenTargetsiENSG00000095739.
PharmGKBiPA134909139.

Polymorphism and mutation databases

BioMutaiBAMBI.
DMDMi2498645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000002077921 – 260BMP and activin membrane-bound inhibitor homologAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ13145.
PaxDbiQ13145.
PeptideAtlasiQ13145.
PRIDEiQ13145.

PTM databases

iPTMnetiQ13145.
PhosphoSitePlusiQ13145.

Expressioni

Tissue specificityi

High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

Developmental stagei

Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.

Gene expression databases

BgeeiENSG00000095739.
CleanExiHS_BAMBI.
GenevisibleiQ13145. HS.

Organism-specific databases

HPAiHPA010819.
HPA010866.

Interactioni

GO - Molecular functioni

  • frizzled binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi117337. 10 interactors.
IntActiQ13145. 5 interactors.
MINTiMINT-1473447.
STRINGi9606.ENSP00000364683.

Structurei

3D structure databases

ProteinModelPortaliQ13145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAMBI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU1. Eukaryota.
ENOG4110R2C. LUCA.
GeneTreeiENSGT00390000014168.
HOGENOMiHOG000095174.
HOVERGENiHBG050659.
InParanoidiQ13145.
KOiK10162.
OMAiVTGHENC.
OrthoDBiEOG091G0PAE.
PhylomeDBiQ13145.
TreeFamiTF333466.

Family and domain databases

InterProiView protein in InterPro
IPR009345. BAMBI.
PANTHERiPTHR15505:SF4. PTHR15505:SF4. 1 hit.
PfamiView protein in Pfam
PF06211. BAMBI. 1 hit.
PIRSFiPIRSF037456. BAMBI. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND KILSLVHWGM
260
YSGHGKLEFV
Length:260
Mass (Da):29,108
Last modified:November 1, 1997 - v1
Checksum:i70C23268838CE8AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23070 mRNA. Translation: AAC50435.1.
U29189, U29188 Genomic DNA. Translation: AAR02414.1.
BT006820 mRNA. Translation: AAP35466.1.
AL161936 Genomic DNA. No translation available.
BC019252 mRNA. Translation: AAH19252.1.
CCDSiCCDS7162.1.
RefSeqiNP_036474.1. NM_012342.2.
UniGeneiHs.533336.

Genome annotation databases

EnsembliENST00000375533; ENSP00000364683; ENSG00000095739.
GeneIDi25805.
KEGGihsa:25805.
UCSCiuc001iuj.2. human.

Similar proteinsi

Entry informationi

Entry nameiBAMBI_HUMAN
AccessioniPrimary (citable) accession number: Q13145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families