Q13145 (BAMBI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BMP and activin membrane-bound inhibitor homolog

Alternative name(s):
Non-metastatic gene A protein
Putative transmembrane protein NMA

Gene names

Name:	BAMBI
Synonyms:	NMA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Negatively regulates TGF-beta signaling.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
Developmental stage	Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.
Sequence similarities	Belongs to the BAMBI family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cell migration Inferred from direct assay. Source: BHF-UCL negative regulation of transforming growth factor beta receptor signaling pathway Inferred from direct assay. Source: BHF-UCL positive regulation of canonical Wnt receptor signaling pathway Inferred from direct assay. Source: BHF-UCL positive regulation of catenin import into nucleus Inferred from mutant phenotype. Source: BHF-UCL positive regulation of cell proliferation Inferred from mutant phenotype. Source: BHF-UCL positive regulation of epithelial to mesenchymal transition Inferred from mutant phenotype. Source: BHF-UCL positive regulation of protein binding Inferred from mutant phenotype. Source: BHF-UCL positive regulation of transcription, DNA-dependent Inferred from direct assay. Source: BHF-UCL regulation of cell shape Inferred from mutant phenotype. Source: BHF-UCL
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: BHF-UCL
Molecular function	frizzled binding Inferred from physical interaction. Source: BHF-UCL type II transforming growth factor beta receptor binding Traceable author statement. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.5
	Chain	21 – 260	240	BMP and activin membrane-bound inhibitor homolog		PRO_0000020779
Regions
	Topological domain	21 – 152	132	Extracellular Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Topological domain	174 – 260	87	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	87	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q13145 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 70C23268838CE8AB	FASTA	260	29,108
	10 20 30 40 50 60 MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN 70 80 90 100 110 120 SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA 130 140 150 160 170 180 SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN 190 200 210 220 230 240 KRLQDQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND 250 260 KILSLVHWGM YSGHGKLEFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts." Degen W.G.J., Weterman M.A., van Groningen J.J.M., Cornelissen I.M.A.H., Lemmers J.P.W.M., Agterbos M.A., van Kessel A.G., Swart G.W.M., Bloemers H.P.J. Int. J. Cancer 65:460-465(1996) [PubMed: 8621228] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-35.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23070 mRNA. Translation: AAC50435.1. U29189, U29188 Genomic DNA. Translation: AAR02414.1. BT006820 mRNA. Translation: AAP35466.1. AL161936 Genomic DNA. Translation: CAC16002.1. BC019252 mRNA. Translation: AAH19252.1.
IPI	IPI00011899.
RefSeq	NP_036474.1. NM_012342.2.
UniGene	Hs.533336.
3D structure databases
ProteinModelPortal	Q13145.
SMR	Q13145. Positions 28-115.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13145. 1 interaction.
MINT	MINT-1473447.
STRING	Q13145.
Polymorphism databases
DMDM	2498645.
Proteomic databases
PRIDE	Q13145.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375533; ENSP00000364683; ENSG00000095739.
GeneID	25805.
KEGG	hsa:25805.
UCSC	uc001iuj.1. human.
Organism-specific databases
CTD	25805.
GeneCards	GC10P029006.
H-InvDB	HIX0008734.
HGNC	HGNC:30251. BAMBI.
HPA	HPA010866.
MIM	604444. gene.
neXtProt	NX_Q13145.
PharmGKB	PA134909139.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08309.
HOGENOM	HBG717755.
HOVERGEN	HBG050659.
InParanoid	Q13145.
OMA	SPLTHGC.
OrthoDB	EOG4868D6.
PhylomeDB	Q13145.
Enzyme and pathway databases
Pathway_Interaction_DB	bmppathway. BMP receptor signaling. tgfbrpathway. TGF-beta receptor signaling.
Gene expression databases
ArrayExpress	Q13145.
Bgee	Q13145.
CleanEx	HS_BAMBI.
Genevestigator	Q13145.
GermOnline	ENSG00000095739. Homo sapiens.
Family and domain databases
InterPro	IPR009345. BMP/activin_membr-bound_inhib. [Graphical view]
KO	K10162.
PANTHER	PTHR15505. BAMBI. 1 hit.
Pfam	PF06211. BAMBI. 1 hit. [Graphical view]
PIRSF	PIRSF037456. BAMBI. 1 hit.
ProtoNet	Search...
Other
NextBio	47019.
SOURCE	Search...

Entry information

Entry name

BAMBI_HUMAN

Accession

Primary (citable) accession number: Q13145

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.