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Protein

Translation initiation factor eIF-2B subunit epsilon

Gene

EIF2B5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: UniProtKB
  • translation initiation factor activity Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB

GO - Biological processi

  • aging Source: Ensembl
  • astrocyte development Source: UniProtKB
  • astrocyte differentiation Source: UniProtKB
  • cellular response to drug Source: UniProtKB
  • hippocampus development Source: Ensembl
  • myelination Source: UniProtKB
  • negative regulation of translational initiation in response to stress Source: UniProtKB
  • oligodendrocyte development Source: UniProtKB
  • ovarian follicle development Source: UniProtKB
  • positive regulation of apoptotic process Source: Ensembl
  • positive regulation of translational initiation Source: UniProtKB
  • response to endoplasmic reticulum stress Source: UniProtKB
  • response to glucose Source: UniProtKB
  • response to heat Source: UniProtKB
  • response to lithium ion Source: Ensembl
  • response to peptide hormone Source: UniProtKB
  • translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145191-MONOMER.
ReactomeiR-HSA-72731. Recycling of eIF2:GDP.
SIGNORiQ13144.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit epsilon
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit epsilon
Gene namesi
Name:EIF2B5
Synonyms:EIF2BE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3261. EIF2B5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • eukaryotic translation initiation factor 2B complex Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Leukodystrophy with vanishing white matter (VWM)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
See also OMIM:603896
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06845762D → V in VWM. 1 Publication1
Natural variantiVAR_06845868L → S in VWM. 1 PublicationCorresponds to variant rs113994044dbSNPEnsembl.1
Natural variantiVAR_01232373V → G in VWM. 1 PublicationCorresponds to variant rs113994045dbSNPEnsembl.1
Natural variantiVAR_06845974A → T in VWM. 1 PublicationCorresponds to variant rs113994046dbSNPEnsembl.1
Natural variantiVAR_01229191T → A in VWM. 1 PublicationCorresponds to variant rs28939717dbSNPEnsembl.1
Natural variantiVAR_012324106L → F in VWM. 1 PublicationCorresponds to variant rs113994048dbSNPEnsembl.1
Natural variantiVAR_068460113R → C in VWM. 1 PublicationCorresponds to variant rs113994050dbSNPEnsembl.1
Natural variantiVAR_012292113R → H in VWM; with ovarian failure. 3 PublicationsCorresponds to variant rs113994049dbSNPEnsembl.1
Natural variantiVAR_016845195R → C in VWM; with ovarian failure. 1 PublicationCorresponds to variant rs113994055dbSNPEnsembl.1
Natural variantiVAR_016846195R → H in VWM; Cree leukoencephalopathy type. 1 PublicationCorresponds to variant rs113994054dbSNPEnsembl.1
Natural variantiVAR_068461269R → G in VWM. 1 PublicationCorresponds to variant rs113994058dbSNPEnsembl.1
Natural variantiVAR_068462269R → Q in VWM. 1 PublicationCorresponds to variant rs113994057dbSNPEnsembl.1
Natural variantiVAR_068463270D → H in VWM. 1 PublicationCorresponds to variant rs397514646dbSNPEnsembl.1
Natural variantiVAR_012325299R → H in VWM. 1 PublicationCorresponds to variant rs113994060dbSNPEnsembl.1
Natural variantiVAR_068464310C → F in VWM. 1 PublicationCorresponds to variant rs113994062dbSNPEnsembl.1
Natural variantiVAR_068465315R → C in VWM. 1 PublicationCorresponds to variant rs113994063dbSNPEnsembl.1
Natural variantiVAR_012326315R → G in VWM. 1 PublicationCorresponds to variant rs113994063dbSNPEnsembl.1
Natural variantiVAR_012327315R → H in VWM. 1 PublicationCorresponds to variant rs113994064dbSNPEnsembl.1
Natural variantiVAR_068466335C → R in VWM. 1 PublicationCorresponds to variant rs113994067dbSNPEnsembl.1
Natural variantiVAR_068467335C → S in VWM. 1 Publication1
Natural variantiVAR_012328339R → P in VWM. 2 PublicationsCorresponds to variant rs113994069dbSNPEnsembl.1
Natural variantiVAR_012329339R → Q in VWM. 1 PublicationCorresponds to variant rs113994069dbSNPEnsembl.1
Natural variantiVAR_012330339R → W in VWM. 1 PublicationCorresponds to variant rs113994068dbSNPEnsembl.1
Natural variantiVAR_068468376N → D in VWM. 1 Publication1
Natural variantiVAR_012293386G → V in VWM. 2 PublicationsCorresponds to variant rs113994074dbSNPEnsembl.1
Natural variantiVAR_012331430V → A in VWM. 1 PublicationCorresponds to variant rs113994079dbSNPEnsembl.1
Natural variantiVAR_068469447S → L in VWM. 1 PublicationCorresponds to variant rs113994080dbSNPEnsembl.1
Natural variantiVAR_012294628W → R in VWM. 1 PublicationCorresponds to variant rs28937596dbSNPEnsembl.1
Natural variantiVAR_012333650E → K in VWM. 1 PublicationCorresponds to variant rs113994085dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Leukodystrophy

Organism-specific databases

DisGeNETi8893.
MalaCardsiEIF2B5.
MIMi603896. phenotype.
OpenTargetsiENSG00000145191.
Orphaneti157713. Congenital or early infantile CACH syndrome.
99854. Cree leukoencephalopathy.
157719. Juvenile or adult CACH syndrome.
157716. Late infantile CACH syndrome.
99853. Ovarioleukodystrophy.
PharmGKBiPA27692.

Polymorphism and mutation databases

BioMutaiEIF2B5.
DMDMi160359049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001560732 – 721Translation initiation factor eIF-2B subunit epsilonAdd BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei19Omega-N-methylarginineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei130PhosphoserineBy similarity1
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei322PhosphothreonineBy similarity1
Modified residuei450PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei532PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei544Phosphoserine; by DYRK2Combined sources1
Modified residuei717PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function.By similarity1 Publication
Polyubiquitinated, probably by NEDD4.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13144.
MaxQBiQ13144.
PaxDbiQ13144.
PeptideAtlasiQ13144.
PRIDEiQ13144.

PTM databases

iPTMnetiQ13144.
PhosphoSitePlusiQ13144.

Expressioni

Gene expression databases

BgeeiENSG00000145191.
CleanExiHS_EIF2B5.
ExpressionAtlasiQ13144. baseline and differential.
GenevisibleiQ13144. HS.

Organism-specific databases

HPAiCAB015412.
HPA064370.
HPA069303.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Interacts with RGS2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114410. 34 interactors.
IntActiQ13144. 5 interactors.
MINTiMINT-3027192.
STRINGi9606.ENSP00000273783.

Structurei

Secondary structure

1721
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi548 – 567Combined sources20
Helixi571 – 584Combined sources14
Helixi589 – 602Combined sources14
Helixi603 – 607Combined sources5
Helixi614 – 635Combined sources22
Helixi639 – 655Combined sources17
Helixi657 – 662Combined sources6
Helixi663 – 672Combined sources10
Helixi678 – 685Combined sources8
Helixi693 – 697Combined sources5
Helixi701 – 714Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JUIX-ray2.00A548-721[»]
ProteinModelPortaliQ13144.
SMRiQ13144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13144.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini543 – 720W2PROSITE-ProRule annotationAdd BLAST178

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi505 – 509Poly-Glu5

Sequence similaritiesi

Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1461. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00510000047568.
HOGENOMiHOG000216610.
HOVERGENiHBG051460.
InParanoidiQ13144.
KOiK03240.
OMAiESEQSMD.
OrthoDBiEOG091G065U.
PhylomeDBiQ13144.
TreeFamiTF101509.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep.
IPR016021. MIF4-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVVAPPG VVVSRANKRS GAGPGGSGGG GARGAEEEPP PPLQAVLVAD
60 70 80 90 100
SFDRRFFPIS KDQPRVLLPL ANVALIDYTL EFLTATGVQE TFVFCCWKAA
110 120 130 140 150
QIKEHLLKSK WCRPTSLNVV RIITSELYRS LGDVLRDVDA KALVRSDFLL
160 170 180 190 200
VYGDVISNIN ITRALEEHRL RRKLEKNVSV MTMIFKESSP SHPTRCHEDN
210 220 230 240 250
VVVAVDSTTN RVLHFQKTQG LRRFAFPLSL FQGSSDGVEV RYDLLDCHIS
260 270 280 290 300
ICSPQVAQLF TDNFDYQTRD DFVRGLLVNE EILGNQIHMH VTAKEYGARV
310 320 330 340 350
SNLHMYSAVC ADVIRRWVYP LTPEANFTDS TTQSCTHSRH NIYRGPEVSL
360 370 380 390 400
GHGSILEENV LLGSGTVIGS NCFITNSVIG PGCHIGDNVV LDQTYLWQGV
410 420 430 440 450
RVAAGAQIHQ SLLCDNAEVK ERVTLKPRSV LTSQVVVGPN ITLPEGSVIS
460 470 480 490 500
LHPPDAEEDE DDGEFSDDSG ADQEKDKVKM KGYNPAEVGA AGKGYLWKAA
510 520 530 540 550
GMNMEEEEEL QQNLWGLKIN MEEESESESE QSMDSEEPDS RGGSPQMDDI
560 570 580 590 600
KVFQNEVLGT LQRGKEENIS CDNLVLEINS LKYAYNISLK EVMQVLSHVV
610 620 630 640 650
LEFPLQQMDS PLDSSRYCAL LLPLLKAWSP VFRNYIKRAA DHLEALAAIE
660 670 680 690 700
DFFLEHEALG ISMAKVLMAF YQLEILAEET ILSWFSQRDT TDKGQQLRKN
710 720
QQLQRFIQWL KEAEEESSED D
Length:721
Mass (Da):80,380
Last modified:October 23, 2007 - v3
Checksum:i08B39D3A5EE7D905
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06845762D → V in VWM. 1 Publication1
Natural variantiVAR_06845868L → S in VWM. 1 PublicationCorresponds to variant rs113994044dbSNPEnsembl.1
Natural variantiVAR_01232373V → G in VWM. 1 PublicationCorresponds to variant rs113994045dbSNPEnsembl.1
Natural variantiVAR_06845974A → T in VWM. 1 PublicationCorresponds to variant rs113994046dbSNPEnsembl.1
Natural variantiVAR_01229191T → A in VWM. 1 PublicationCorresponds to variant rs28939717dbSNPEnsembl.1
Natural variantiVAR_012324106L → F in VWM. 1 PublicationCorresponds to variant rs113994048dbSNPEnsembl.1
Natural variantiVAR_068460113R → C in VWM. 1 PublicationCorresponds to variant rs113994050dbSNPEnsembl.1
Natural variantiVAR_012292113R → H in VWM; with ovarian failure. 3 PublicationsCorresponds to variant rs113994049dbSNPEnsembl.1
Natural variantiVAR_016845195R → C in VWM; with ovarian failure. 1 PublicationCorresponds to variant rs113994055dbSNPEnsembl.1
Natural variantiVAR_016846195R → H in VWM; Cree leukoencephalopathy type. 1 PublicationCorresponds to variant rs113994054dbSNPEnsembl.1
Natural variantiVAR_048919200N → T.Corresponds to variant rs2971409dbSNPEnsembl.1
Natural variantiVAR_068461269R → G in VWM. 1 PublicationCorresponds to variant rs113994058dbSNPEnsembl.1
Natural variantiVAR_068462269R → Q in VWM. 1 PublicationCorresponds to variant rs113994057dbSNPEnsembl.1
Natural variantiVAR_068463270D → H in VWM. 1 PublicationCorresponds to variant rs397514646dbSNPEnsembl.1
Natural variantiVAR_012325299R → H in VWM. 1 PublicationCorresponds to variant rs113994060dbSNPEnsembl.1
Natural variantiVAR_068464310C → F in VWM. 1 PublicationCorresponds to variant rs113994062dbSNPEnsembl.1
Natural variantiVAR_068465315R → C in VWM. 1 PublicationCorresponds to variant rs113994063dbSNPEnsembl.1
Natural variantiVAR_012326315R → G in VWM. 1 PublicationCorresponds to variant rs113994063dbSNPEnsembl.1
Natural variantiVAR_012327315R → H in VWM. 1 PublicationCorresponds to variant rs113994064dbSNPEnsembl.1
Natural variantiVAR_068466335C → R in VWM. 1 PublicationCorresponds to variant rs113994067dbSNPEnsembl.1
Natural variantiVAR_068467335C → S in VWM. 1 Publication1
Natural variantiVAR_012328339R → P in VWM. 2 PublicationsCorresponds to variant rs113994069dbSNPEnsembl.1
Natural variantiVAR_012329339R → Q in VWM. 1 PublicationCorresponds to variant rs113994069dbSNPEnsembl.1
Natural variantiVAR_012330339R → W in VWM. 1 PublicationCorresponds to variant rs113994068dbSNPEnsembl.1
Natural variantiVAR_068468376N → D in VWM. 1 Publication1
Natural variantiVAR_012293386G → V in VWM. 2 PublicationsCorresponds to variant rs113994074dbSNPEnsembl.1
Natural variantiVAR_012331430V → A in VWM. 1 PublicationCorresponds to variant rs113994079dbSNPEnsembl.1
Natural variantiVAR_068469447S → L in VWM. 1 PublicationCorresponds to variant rs113994080dbSNPEnsembl.1
Natural variantiVAR_012332587I → V.5 PublicationsCorresponds to variant rs843358dbSNPEnsembl.1
Natural variantiVAR_012294628W → R in VWM. 1 PublicationCorresponds to variant rs28937596dbSNPEnsembl.1
Natural variantiVAR_012333650E → K in VWM. 1 PublicationCorresponds to variant rs113994085dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091646 mRNA. Translation: BAC03712.1.
AC131235 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78299.1.
BC013590 mRNA. Translation: AAH13590.1.
U23028 mRNA. Translation: AAC50646.1.
CCDSiCCDS3252.1.
RefSeqiNP_003898.2. NM_003907.2.
UniGeneiHs.283551.

Genome annotation databases

EnsembliENST00000273783; ENSP00000273783; ENSG00000145191.
GeneIDi8893.
KEGGihsa:8893.
UCSCiuc003fmp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mendelian genes eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (EIF2B5)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091646 mRNA. Translation: BAC03712.1.
AC131235 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78299.1.
BC013590 mRNA. Translation: AAH13590.1.
U23028 mRNA. Translation: AAC50646.1.
CCDSiCCDS3252.1.
RefSeqiNP_003898.2. NM_003907.2.
UniGeneiHs.283551.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JUIX-ray2.00A548-721[»]
ProteinModelPortaliQ13144.
SMRiQ13144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114410. 34 interactors.
IntActiQ13144. 5 interactors.
MINTiMINT-3027192.
STRINGi9606.ENSP00000273783.

PTM databases

iPTMnetiQ13144.
PhosphoSitePlusiQ13144.

Polymorphism and mutation databases

BioMutaiEIF2B5.
DMDMi160359049.

Proteomic databases

EPDiQ13144.
MaxQBiQ13144.
PaxDbiQ13144.
PeptideAtlasiQ13144.
PRIDEiQ13144.

Protocols and materials databases

DNASUi8893.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273783; ENSP00000273783; ENSG00000145191.
GeneIDi8893.
KEGGihsa:8893.
UCSCiuc003fmp.4. human.

Organism-specific databases

CTDi8893.
DisGeNETi8893.
GeneCardsiEIF2B5.
GeneReviewsiEIF2B5.
H-InvDBHIX0003921.
HGNCiHGNC:3261. EIF2B5.
HPAiCAB015412.
HPA064370.
HPA069303.
MalaCardsiEIF2B5.
MIMi603896. phenotype.
603945. gene.
neXtProtiNX_Q13144.
OpenTargetsiENSG00000145191.
Orphaneti157713. Congenital or early infantile CACH syndrome.
99854. Cree leukoencephalopathy.
157719. Juvenile or adult CACH syndrome.
157716. Late infantile CACH syndrome.
99853. Ovarioleukodystrophy.
PharmGKBiPA27692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1461. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00510000047568.
HOGENOMiHOG000216610.
HOVERGENiHBG051460.
InParanoidiQ13144.
KOiK03240.
OMAiESEQSMD.
OrthoDBiEOG091G065U.
PhylomeDBiQ13144.
TreeFamiTF101509.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145191-MONOMER.
ReactomeiR-HSA-72731. Recycling of eIF2:GDP.
SIGNORiQ13144.

Miscellaneous databases

ChiTaRSiEIF2B5. human.
EvolutionaryTraceiQ13144.
GeneWikiiEIF2B5.
GenomeRNAii8893.
PROiQ13144.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145191.
CleanExiHS_EIF2B5.
ExpressionAtlasiQ13144. baseline and differential.
GenevisibleiQ13144. HS.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep.
IPR016021. MIF4-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BE_HUMAN
AccessioniPrimary (citable) accession number: Q13144
Secondary accession number(s): Q541Z1, Q96D04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 167 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.