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Q13137

- CACO2_HUMAN

UniProt

Q13137 - CACO2_HUMAN

Protein

Calcium-binding and coiled-coil domain-containing protein 2

Gene

CALCOCO2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. response to interferon-gamma Source: BHF-UCL
    2. viral process Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-binding and coiled-coil domain-containing protein 2
    Alternative name(s):
    Antigen nuclear dot 52 kDa protein
    Nuclear domain 10 protein NDP52
    Short name:
    Nuclear domain 10 protein 52
    Nuclear dot protein 52
    Gene namesi
    Name:CALCOCO2
    Synonyms:NDP52
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29912. CALCOCO2.

    Subcellular locationi

    Cytoplasmperinuclear region. Golgi apparatus. Cytoplasmcytoskeleton
    Note: According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytoskeleton Source: UniProtKB-SubCell
    3. Golgi apparatus Source: UniProtKB-SubCell
    4. intracellular membrane-bounded organelle Source: HPA
    5. membrane Source: UniProtKB
    6. nucleus Source: ProtInc
    7. perinuclear region of cytoplasm Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi400 – 4001C → A: Loss of interaction with MYO6. 1 Publication
    Mutagenesisi425 – 4251C → A: No effect on interaction with MYO6. 1 Publication

    Organism-specific databases

    PharmGKBiPA143485407.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Calcium-binding and coiled-coil domain-containing protein 2PRO_0000312337Add
    BLAST

    Proteomic databases

    MaxQBiQ13137.
    PaxDbiQ13137.
    PRIDEiQ13137.

    PTM databases

    PhosphoSiteiQ13137.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ13137.
    BgeeiQ13137.
    CleanExiHS_CALCOCO2.
    GenevestigatoriQ13137.

    Organism-specific databases

    HPAiHPA022989.
    HPA023019.
    HPA023195.

    Interactioni

    Subunit structurei

    Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q9WMX23EBI-739580,EBI-6863741From a different organism.
    MAVSQ7Z4343EBI-739580,EBI-995373
    MTPAPQ9NVV42EBI-739580,EBI-2556166
    TBK1Q9UHD25EBI-739580,EBI-356402

    Protein-protein interaction databases

    BioGridi115535. 77 interactions.
    DIPiDIP-57534N.
    IntActiQ13137. 76 interactions.
    MINTiMINT-270155.
    STRINGi9606.ENSP00000258947.

    Structurei

    Secondary structure

    1
    446
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi22 – 276
    Beta strandi30 – 323
    Beta strandi38 – 447
    Beta strandi55 – 606
    Helixi66 – 683
    Beta strandi70 – 745
    Beta strandi89 – 935
    Helixi95 – 973
    Beta strandi105 – 1106
    Beta strandi116 – 1194
    Beta strandi123 – 1264
    Beta strandi133 – 1353

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VVVX-ray1.35A21-141[»]
    3VVWX-ray2.50A21-141[»]
    4GXLX-ray2.02B368-381[»]
    4HANX-ray2.55C/D372-385[»]
    ProteinModelPortaliQ13137.
    SMRiQ13137. Positions 21-132, 420-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni395 – 44652Interaction with MYO6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili137 – 349213Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG87904.
    HOGENOMiHOG000050230.
    HOVERGENiHBG104102.
    InParanoidiQ13137.
    OMAiYYTFMWV.
    OrthoDBiEOG7RRF8H.
    PhylomeDBiQ13137.
    TreeFamiTF329501.

    Family and domain databases

    InterProiIPR012852. CoCoA.
    [Graphical view]
    PfamiPF07888. CALCOCO1. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13137-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYIPGGDVTC HYTFTQHFIP    50
    RRKDWIGIFR VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK 100
    DDEYYQFCYV DEDGVVRGAS IPFQFRPENE EDILVVTTQG EVEEIEQHNK 150
    ELCKENQELK DSCISLQKQN SDMQAELQKK QEELETLQSI NKKLELKVKE 200
    QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ EKEMEKLVQG 250
    DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ 300
    QELMDENFDL SKRLSENEII CNALQRQKER LEGENDLLKR ENSRLLSYMG 350
    LDFNSLPYQV PTSDEGGARQ NPGLAYGNPY SGIQESSSPS PLSIKKCPIC 400
    KADDICDHTL EQQQMQPLCF NCPICDKIFP ATEKQIFEDH VFCHSL 446
    Length:446
    Mass (Da):52,254
    Last modified:November 1, 1996 - v1
    Checksum:i609B121DA1A9DCB8
    GO
    Isoform 2 (identifier: Q13137-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         139-180: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:404
    Mass (Da):47,340
    Checksum:i096590EDA273DE3E
    GO
    Isoform 3 (identifier: Q13137-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-60: R → RCSLNQTIQLLITPDTGSIWHQ

    Note: No experimental confirmation available.

    Show »
    Length:467
    Mass (Da):54,605
    Checksum:iCF0B512C4C91DB91
    GO
    Isoform 4 (identifier: Q13137-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-60: R → RAFKCFQDKLEQELLKWRSQGQKLQ

    Note: No experimental confirmation available.

    Show »
    Length:470
    Mass (Da):55,188
    Checksum:iDC114D09C4737FEC
    GO
    Isoform 5 (identifier: Q13137-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-72: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:374
    Mass (Da):43,669
    Checksum:iF20EB9A4621F735A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021D → Y in BAG64382. (PubMed:14702039)Curated
    Sequence conflicti313 – 3131R → G in BAG56685. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401G → E.1 Publication
    Corresponds to variant rs550510 [ dbSNP | Ensembl ].
    VAR_037489
    Natural varianti227 – 2271G → R.
    Corresponds to variant rs2303016 [ dbSNP | Ensembl ].
    VAR_037490
    Natural varianti248 – 2481V → A.2 Publications
    Corresponds to variant rs2303015 [ dbSNP | Ensembl ].
    VAR_037491
    Natural varianti273 – 2731T → A.1 Publication
    Corresponds to variant rs17849804 [ dbSNP | Ensembl ].
    VAR_037492
    Natural varianti389 – 3891P → A.3 Publications
    Corresponds to variant rs10278 [ dbSNP | Ensembl ].
    VAR_037493

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7272Missing in isoform 5. 1 PublicationVSP_047414Add
    BLAST
    Alternative sequencei60 – 601R → RCSLNQTIQLLITPDTGSIW HQ in isoform 3. 1 PublicationVSP_046766
    Alternative sequencei60 – 601R → RAFKCFQDKLEQELLKWRSQ GQKLQ in isoform 4. 1 PublicationVSP_046767
    Alternative sequencei139 – 18042Missing in isoform 2. 1 PublicationVSP_044728Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22897 mRNA. Translation: AAA75297.1.
    AK293137 mRNA. Translation: BAG56685.1.
    AK293329 mRNA. Translation: BAG56845.1.
    AK298177 mRNA. Translation: BAG60448.1.
    AK303313 mRNA. Translation: BAG64382.1.
    AK314796 mRNA. Translation: BAG37327.1.
    CR456763 mRNA. Translation: CAG33044.1.
    AK222666 mRNA. Translation: BAD96386.1.
    AK223227 mRNA. Translation: BAD96947.1.
    AC068531 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94707.1.
    BC004130 mRNA. Translation: AAH04130.1.
    BC015893 mRNA. Translation: AAH15893.1.
    CCDSiCCDS11538.1. [Q13137-1]
    CCDS58558.1. [Q13137-3]
    CCDS58559.1. [Q13137-4]
    CCDS58560.1. [Q13137-2]
    CCDS58561.1. [Q13137-5]
    PIRiA56733.
    RefSeqiNP_001248319.1. NM_001261390.1. [Q13137-4]
    NP_001248320.1. NM_001261391.1. [Q13137-3]
    NP_001248322.1. NM_001261393.1. [Q13137-2]
    NP_001248324.1. NM_001261395.1. [Q13137-5]
    NP_005822.1. NM_005831.4. [Q13137-1]
    UniGeneiHs.514920.

    Genome annotation databases

    EnsembliENST00000258947; ENSP00000258947; ENSG00000136436. [Q13137-1]
    ENST00000416445; ENSP00000406974; ENSG00000136436. [Q13137-2]
    ENST00000448105; ENSP00000398523; ENSG00000136436. [Q13137-4]
    ENST00000508679; ENSP00000423437; ENSG00000136436. [Q13137-5]
    ENST00000509507; ENSP00000424352; ENSG00000136436. [Q13137-3]
    GeneIDi10241.
    KEGGihsa:10241.
    UCSCiuc002iof.4. human. [Q13137-1]

    Polymorphism databases

    DMDMi74735623.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22897 mRNA. Translation: AAA75297.1 .
    AK293137 mRNA. Translation: BAG56685.1 .
    AK293329 mRNA. Translation: BAG56845.1 .
    AK298177 mRNA. Translation: BAG60448.1 .
    AK303313 mRNA. Translation: BAG64382.1 .
    AK314796 mRNA. Translation: BAG37327.1 .
    CR456763 mRNA. Translation: CAG33044.1 .
    AK222666 mRNA. Translation: BAD96386.1 .
    AK223227 mRNA. Translation: BAD96947.1 .
    AC068531 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94707.1 .
    BC004130 mRNA. Translation: AAH04130.1 .
    BC015893 mRNA. Translation: AAH15893.1 .
    CCDSi CCDS11538.1. [Q13137-1 ]
    CCDS58558.1. [Q13137-3 ]
    CCDS58559.1. [Q13137-4 ]
    CCDS58560.1. [Q13137-2 ]
    CCDS58561.1. [Q13137-5 ]
    PIRi A56733.
    RefSeqi NP_001248319.1. NM_001261390.1. [Q13137-4 ]
    NP_001248320.1. NM_001261391.1. [Q13137-3 ]
    NP_001248322.1. NM_001261393.1. [Q13137-2 ]
    NP_001248324.1. NM_001261395.1. [Q13137-5 ]
    NP_005822.1. NM_005831.4. [Q13137-1 ]
    UniGenei Hs.514920.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VVV X-ray 1.35 A 21-141 [» ]
    3VVW X-ray 2.50 A 21-141 [» ]
    4GXL X-ray 2.02 B 368-381 [» ]
    4HAN X-ray 2.55 C/D 372-385 [» ]
    ProteinModelPortali Q13137.
    SMRi Q13137. Positions 21-132, 420-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115535. 77 interactions.
    DIPi DIP-57534N.
    IntActi Q13137. 76 interactions.
    MINTi MINT-270155.
    STRINGi 9606.ENSP00000258947.

    PTM databases

    PhosphoSitei Q13137.

    Polymorphism databases

    DMDMi 74735623.

    Proteomic databases

    MaxQBi Q13137.
    PaxDbi Q13137.
    PRIDEi Q13137.

    Protocols and materials databases

    DNASUi 10241.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258947 ; ENSP00000258947 ; ENSG00000136436 . [Q13137-1 ]
    ENST00000416445 ; ENSP00000406974 ; ENSG00000136436 . [Q13137-2 ]
    ENST00000448105 ; ENSP00000398523 ; ENSG00000136436 . [Q13137-4 ]
    ENST00000508679 ; ENSP00000423437 ; ENSG00000136436 . [Q13137-5 ]
    ENST00000509507 ; ENSP00000424352 ; ENSG00000136436 . [Q13137-3 ]
    GeneIDi 10241.
    KEGGi hsa:10241.
    UCSCi uc002iof.4. human. [Q13137-1 ]

    Organism-specific databases

    CTDi 10241.
    GeneCardsi GC17P046908.
    H-InvDB HIX0013950.
    HGNCi HGNC:29912. CALCOCO2.
    HPAi HPA022989.
    HPA023019.
    HPA023195.
    MIMi 604587. gene.
    neXtProti NX_Q13137.
    PharmGKBi PA143485407.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87904.
    HOGENOMi HOG000050230.
    HOVERGENi HBG104102.
    InParanoidi Q13137.
    OMAi YYTFMWV.
    OrthoDBi EOG7RRF8H.
    PhylomeDBi Q13137.
    TreeFami TF329501.

    Miscellaneous databases

    ChiTaRSi CALCOCO2. human.
    GeneWikii CALCOCO2.
    GenomeRNAii 10241.
    NextBioi 38796.
    PROi Q13137.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13137.
    Bgeei Q13137.
    CleanExi HS_CALCOCO2.
    Genevestigatori Q13137.

    Family and domain databases

    InterProi IPR012852. CoCoA.
    [Graphical view ]
    Pfami PF07888. CALCOCO1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment."
      Korioth F., Gieffers C., Maul G.G., Frey J.
      J. Cell Biol. 130:1-13(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), VARIANTS GLU-140; ALA-248 AND ALA-389.
      Tissue: Mammary gland, Neuroblastoma, Teratocarcinoma and Thymus.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-248.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-389.
      Tissue: Brain and Gastric mucosa.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-389.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-273.
      Tissue: Kidney and Skin.
    8. "Cellular localization, expression, and structure of the nuclear dot protein 52."
      Sternsdorf T., Jensen K., Zuchner D., Will H.
      J. Cell Biol. 138:435-448(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins."
      Di Y., Li J., Zhang Y., He X., Lu H., Xu D., Ling J., Huo K., Wan D., Li Y.Y., Gu J.
      J. Biochem. 133:713-718(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GEMIN4, SUBCELLULAR LOCATION.
    10. "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion."
      Morriswood B., Ryzhakov G., Puri C., Arden S.D., Roberts R., Dendrou C., Kendrick-Jones J., Buss F.
      J. Cell Sci. 120:2574-2585(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TAX1BP1 AND MYO6, MUTAGENESIS OF CYS-400 AND CYS-425.

    Entry informationi

    Entry nameiCACO2_HUMAN
    AccessioniPrimary (citable) accession number: Q13137
    Secondary accession number(s): B2RBT0
    , B4DDC4, B4DDT4, B4DP36, B4E0C0, E7ENK0, E7ETP5, E9PBE5, Q53FQ5, Q53HB5, Q6IBN9, Q9BTF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    According to PubMed:7540613, HSV-1 infection removes CALCOCO2 from the nucleus, however, it remains faintly in areas shown to be domains, containing splicing components. Treatment with IFNB1/IFN-beta and IFNG/IFN-gamma show an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm. According to PubMed:9230084, IFNG/IFN-gamma increases gene expression only slightly and IFNB does not increase expression.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3