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Protein

Calcium-binding and coiled-coil domain-containing protein 2

Gene

CALCOCO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).5 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  • positive regulation of autophagosome maturation Source: GO_Central
  • response to interferon-gamma Source: BHF-UCL
  • viral process Source: ProtInc
  • xenophagy Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136436-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding and coiled-coil domain-containing protein 2
Alternative name(s):
Antigen nuclear dot 52 kDa protein
Nuclear domain 10 protein NDP52Curated
Short name:
Nuclear domain 10 protein 521 Publication
Nuclear dot protein 521 Publication
Gene namesi
Name:CALCOCO2
Synonyms:NDP521 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29912. CALCOCO2.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: GO_Central
  • autophagosome membrane Source: UniProtKB-SubCell
  • cytoplasm Source: BHF-UCL
  • cytoplasmic vesicle Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleus Source: ProtInc
  • perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi136V → S: Abrogates the interaction with MAP1LC3C. 1 Publication1
Mutagenesisi203 – 206DYWE → AAAA: Abrogates interaction with MAPLC3A, MAPLC3B and GABARAPL2. 1 Publication4
Mutagenesisi374L → A: Severely reduces affinity for LGALS8. 2 Publications1
Mutagenesisi376Y → A: Severely reduces affinity for LGALS8. 1 Publication1
Mutagenesisi378N → A: Prevents interaction with LGALS8. 1 Publication1
Mutagenesisi380Y → A or F: Severely reduced affinity for LGALS8. 2 Publications1
Mutagenesisi400C → A: Does not affect interaction with MYO6. 1 Publication1
Mutagenesisi425C → A: Fails interact with MYO6 and to promote maturation of autophagosomes. 2 Publications1

Organism-specific databases

DisGeNETi10241.
OpenTargetsiENSG00000136436.
PharmGKBiPA143485407.

Polymorphism and mutation databases

BioMutaiCALCOCO2.
DMDMi74735623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123371 – 446Calcium-binding and coiled-coil domain-containing protein 2Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13137.
MaxQBiQ13137.
PaxDbiQ13137.
PeptideAtlasiQ13137.
PRIDEiQ13137.

PTM databases

iPTMnetiQ13137.
PhosphoSitePlusiQ13137.

Expressioni

Tissue specificityi

Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.1 Publication

Inductioni

Treatment with IFNB1/IFN-beta and IFNG/IFN-gamma show an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm (PubMed:7540613). IFNG/IFN-gamma increases gene expression only slightly and IFNB does not increase expression (PubMed:9230084).2 Publications

Gene expression databases

BgeeiENSG00000136436.
CleanExiHS_CALCOCO2.
ExpressionAtlasiQ13137. baseline and differential.
GenevisibleiQ13137. HS.

Organism-specific databases

HPAiHPA022989.
HPA023019.
HPA023195.

Interactioni

Subunit structurei

Dimer (PubMed:23511477). Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6 (PubMed:17635994). Interacts with GEMIN4 (PubMed:12869526). Interacts with ATG8 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2 (PubMed:25771791). Interacts with ATG8 family member MAP1LC3C (PubMed:23022382). Interacts with LGALS8 (PubMed:22246324, PubMed:25771791, PubMed:23511477, PubMed:23386746).7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KAD63EBI-739580,EBI-10174974
B2R9Y13EBI-739580,EBI-10175746
Q8WU023EBI-739580,EBI-747182
Q9WMX23EBI-739580,EBI-6863741From a different organism.
AESQ081173EBI-739580,EBI-717810
AKAP17AQ02040-33EBI-739580,EBI-10222656
AMMECR1Q9Y4X03EBI-739580,EBI-8583355
ARD1AQ6P4J03EBI-739580,EBI-10252815
ARHGEF39Q8N4T43EBI-739580,EBI-745468
ARHGEF5Q127743EBI-739580,EBI-602199
BAHD1Q8TBE03EBI-739580,EBI-742750
BCL6BA8KA133EBI-739580,EBI-10174813
BEX2Q9BXY83EBI-739580,EBI-745073
C20orf195Q9BVV24EBI-739580,EBI-744935
CBX8Q9HC525EBI-739580,EBI-712912
CCNHP519463EBI-739580,EBI-741406
CEP57L1Q8IYX83EBI-739580,EBI-1104570
CHCHD3Q9NX633EBI-739580,EBI-743375
DAZAP2Q150384EBI-739580,EBI-724310
DCTN4Q9UJW03EBI-739580,EBI-2134033
DCXO436023EBI-739580,EBI-8646694
DDIT4LQ96D033EBI-739580,EBI-742054
DDX6P261965EBI-739580,EBI-351257
DOCK2Q926083EBI-739580,EBI-448771
DUSP12Q9UNI64EBI-739580,EBI-715161
DUSP26Q9BV473EBI-739580,EBI-2924519
EEF1E1O433243EBI-739580,EBI-1048486
ENKD1Q9H0I23EBI-739580,EBI-744099
EXOSC5Q9NQT43EBI-739580,EBI-371876
FAM161AQ3B8205EBI-739580,EBI-719941
FAM168AQ925673EBI-739580,EBI-7957930
FAM90A1Q86YD76EBI-739580,EBI-6658203
FARS2O953635EBI-739580,EBI-2513774
FBF1Q8TES7-63EBI-739580,EBI-10244131
FBXL18Q96D164EBI-739580,EBI-744419
FKBPLQ9UIM33EBI-739580,EBI-719882
GABARAPL1Q9H0R86EBI-739580,EBI-746969
GABARAPL2P605206EBI-739580,EBI-720116
GATAD2BQ8WXI93EBI-739580,EBI-923440
GLYCTKQ8IVS83EBI-739580,EBI-748515
HDAC7Q8WUI4-53EBI-739580,EBI-10276431
HOXB9P174823EBI-739580,EBI-745290
KANSL1I3L4J33EBI-739580,EBI-10178305
KLHL42Q9P2K63EBI-739580,EBI-739890
LENG1Q96BZ83EBI-739580,EBI-726510
LGALS8O002144EBI-739580,EBI-740058
LIMS2Q7Z4I7-53EBI-739580,EBI-10257651
LITAFQ997324EBI-739580,EBI-725647
LMF2Q9BU233EBI-739580,EBI-10298556
LMO2P257913EBI-739580,EBI-739696
LMO4P619683EBI-739580,EBI-2798728
LONRF1Q17RB83EBI-739580,EBI-2341787
LSM4Q9Y4Z06EBI-739580,EBI-372521
MAGOHBQ96A725EBI-739580,EBI-746778
MAVSQ7Z4343EBI-739580,EBI-995373
METTL17Q9H7H03EBI-739580,EBI-749353
MID2Q9UJV3-23EBI-739580,EBI-10172526
MOSP005405EBI-739580,EBI-1757866
MTPAPQ9NVV42EBI-739580,EBI-2556166
MXI1P505393EBI-739580,EBI-752241
MXI1P50539-35EBI-739580,EBI-10211940
NAA10P412275EBI-739580,EBI-747693
NFU1Q9UMS03EBI-739580,EBI-725252
PAPD4Q6PIY73EBI-739580,EBI-2802204
PEF1Q9UBV84EBI-739580,EBI-724639
PEG10Q86TG73EBI-739580,EBI-2858265
PFDN5Q994714EBI-739580,EBI-357275
PHF1O431893EBI-739580,EBI-530034
PPP1R18Q6NYC83EBI-739580,EBI-2557469
PRPF31F1T0A53EBI-739580,EBI-10177194
PSMA1P257863EBI-739580,EBI-359352
PSME4Q149973EBI-739580,EBI-1236916
RBM15Q96T373EBI-739580,EBI-2514922
RIN1Q136714EBI-739580,EBI-366017
RPL9P9P329693EBI-739580,EBI-358122
RPS27AP629793EBI-739580,EBI-357375
RTP5Q14D335EBI-739580,EBI-10217913
SDCBPO005603EBI-739580,EBI-727004
SLC15A3Q05CH43EBI-739580,EBI-10223741
SMCPP499013EBI-739580,EBI-750494
SNRPBP14678-23EBI-739580,EBI-372475
SPATA24Q86W543EBI-739580,EBI-3916986
SRIP306264EBI-739580,EBI-750459
STK16O757163EBI-739580,EBI-749295
TBC1D22BQ9NU193EBI-739580,EBI-8787464
TBK1Q9UHD25EBI-739580,EBI-356402
TBRG4Q969Z03EBI-739580,EBI-702328
TCL1AP562797EBI-739580,EBI-749995
TEKT3Q9BXF93EBI-739580,EBI-8644516
TP53RKQ96S444EBI-739580,EBI-739588
UBAC2Q8NBM43EBI-739580,EBI-724045
UBBQ5U5U63EBI-739580,EBI-1642104
UBCQ96C323EBI-739580,EBI-745483
VARSP266403EBI-739580,EBI-355765
ZNF337Q9Y3M93EBI-739580,EBI-714987
ZNF408Q9H9D43EBI-739580,EBI-347633
ZNF564Q8TBZ83EBI-739580,EBI-10273713
ZNF581Q9P0T43EBI-739580,EBI-745520

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi115535. 173 interactors.
DIPiDIP-57534N.
IntActiQ13137. 181 interactors.
MINTiMINT-270155.
STRINGi9606.ENSP00000258947.

Structurei

Secondary structure

1446
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 27Combined sources6
Beta strandi30 – 32Combined sources3
Beta strandi38 – 44Combined sources7
Beta strandi55 – 60Combined sources6
Helixi66 – 68Combined sources3
Beta strandi70 – 74Combined sources5
Beta strandi89 – 93Combined sources5
Helixi95 – 97Combined sources3
Beta strandi105 – 110Combined sources6
Beta strandi116 – 119Combined sources4
Beta strandi123 – 126Combined sources4
Beta strandi133 – 135Combined sources3
Turni401 – 403Combined sources3
Beta strandi404 – 406Combined sources3
Helixi410 – 413Combined sources4
Beta strandi419 – 421Combined sources3
Turni423 – 425Combined sources3
Beta strandi428 – 430Combined sources3
Helixi431 – 433Combined sources3
Helixi434 – 443Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MXPNMR-A414-446[»]
3VVVX-ray1.35A21-141[»]
3VVWX-ray2.50A21-141[»]
4GXLX-ray2.02B368-381[»]
4HANX-ray2.55C/D372-385[»]
4XKLX-ray2.10B/D414-446[»]
5AAQNMR-A388-446[»]
ProteinModelPortaliQ13137.
SMRiQ13137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni371 – 381Interaction with LGALS82 PublicationsAdd BLAST11
Regioni395 – 446Interaction with MYO61 PublicationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili137 – 349Sequence analysisAdd BLAST213

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 136CLIR2 Publications4
Motifi203 – 206LIR-like1 Publication4

Domaini

The MYO6-binding domain is required for autophagy-mediated degradation of infecting bacteria such as Salmonella typhimurium, but not for bacteria targeting to autophagosomes.1 Publication
The CLIR (LC3C-interacting region) motif is required for interaction with MAP1LC3C, but dispensable for CALCOCO2-mediated autophagosome maturation.2 Publications
The LIR-like motif is required for interaction with MAP1LC3A, MAP1LC3B and GABARAPL2, as well as for CALCOCO2-mediated autophagosome maturation.1 Publication
The LGALS8-binding domain is essential for the recruitment to cytosol-exposed infecting bacteria.1 Publication

Sequence similaritiesi

Belongs to the CALCOCO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKI3. Eukaryota.
ENOG4112B0R. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000050230.
HOVERGENiHBG104102.
InParanoidiQ13137.
OMAiSIPFQFR.
OrthoDBiEOG091G01W2.
PhylomeDBiQ13137.
TreeFamiTF329501.

Family and domain databases

InterProiIPR012852. CALCOCO1-like.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13137-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYIPGGDVTC HYTFTQHFIP
60 70 80 90 100
RRKDWIGIFR VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK
110 120 130 140 150
DDEYYQFCYV DEDGVVRGAS IPFQFRPENE EDILVVTTQG EVEEIEQHNK
160 170 180 190 200
ELCKENQELK DSCISLQKQN SDMQAELQKK QEELETLQSI NKKLELKVKE
210 220 230 240 250
QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ EKEMEKLVQG
260 270 280 290 300
DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ
310 320 330 340 350
QELMDENFDL SKRLSENEII CNALQRQKER LEGENDLLKR ENSRLLSYMG
360 370 380 390 400
LDFNSLPYQV PTSDEGGARQ NPGLAYGNPY SGIQESSSPS PLSIKKCPIC
410 420 430 440
KADDICDHTL EQQQMQPLCF NCPICDKIFP ATEKQIFEDH VFCHSL
Length:446
Mass (Da):52,254
Last modified:November 1, 1996 - v1
Checksum:i609B121DA1A9DCB8
GO
Isoform 2 (identifier: Q13137-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-180: Missing.

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):47,340
Checksum:i096590EDA273DE3E
GO
Isoform 3 (identifier: Q13137-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RCSLNQTIQLLITPDTGSIWHQ

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):54,605
Checksum:iCF0B512C4C91DB91
GO
Isoform 4 (identifier: Q13137-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RAFKCFQDKLEQELLKWRSQGQKLQ

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):55,188
Checksum:iDC114D09C4737FEC
GO
Isoform 5 (identifier: Q13137-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):43,669
Checksum:iF20EB9A4621F735A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102D → Y in BAG64382 (PubMed:14702039).Curated1
Sequence conflicti313R → G in BAG56685 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037489140G → E.1 PublicationCorresponds to variant rs550510dbSNPEnsembl.1
Natural variantiVAR_037490227G → R.Corresponds to variant rs2303016dbSNPEnsembl.1
Natural variantiVAR_037491248V → A.2 PublicationsCorresponds to variant rs2303015dbSNPEnsembl.1
Natural variantiVAR_037492273T → A.1 PublicationCorresponds to variant rs17849804dbSNPEnsembl.1
Natural variantiVAR_037493389P → A.3 PublicationsCorresponds to variant rs10278dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474141 – 72Missing in isoform 5. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_04676660R → RCSLNQTIQLLITPDTGSIW HQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_04676760R → RAFKCFQDKLEQELLKWRSQ GQKLQ in isoform 4. 1 Publication1
Alternative sequenceiVSP_044728139 – 180Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22897 mRNA. Translation: AAA75297.1.
AK293137 mRNA. Translation: BAG56685.1.
AK293329 mRNA. Translation: BAG56845.1.
AK298177 mRNA. Translation: BAG60448.1.
AK303313 mRNA. Translation: BAG64382.1.
AK314796 mRNA. Translation: BAG37327.1.
CR456763 mRNA. Translation: CAG33044.1.
AK222666 mRNA. Translation: BAD96386.1.
AK223227 mRNA. Translation: BAD96947.1.
AC068531 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94707.1.
BC004130 mRNA. Translation: AAH04130.1.
BC015893 mRNA. Translation: AAH15893.1.
CCDSiCCDS11538.1. [Q13137-1]
CCDS58558.1. [Q13137-3]
CCDS58559.1. [Q13137-4]
CCDS58560.1. [Q13137-2]
CCDS58561.1. [Q13137-5]
PIRiA56733.
RefSeqiNP_001248319.1. NM_001261390.1. [Q13137-4]
NP_001248320.1. NM_001261391.1. [Q13137-3]
NP_001248322.1. NM_001261393.1. [Q13137-2]
NP_001248324.1. NM_001261395.1. [Q13137-5]
NP_005822.1. NM_005831.4. [Q13137-1]
UniGeneiHs.514920.

Genome annotation databases

EnsembliENST00000258947; ENSP00000258947; ENSG00000136436. [Q13137-1]
ENST00000416445; ENSP00000406974; ENSG00000136436. [Q13137-2]
ENST00000448105; ENSP00000398523; ENSG00000136436. [Q13137-4]
ENST00000508679; ENSP00000423437; ENSG00000136436. [Q13137-5]
ENST00000509507; ENSP00000424352; ENSG00000136436. [Q13137-3]
GeneIDi10241.
KEGGihsa:10241.
UCSCiuc002iof.4. human. [Q13137-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22897 mRNA. Translation: AAA75297.1.
AK293137 mRNA. Translation: BAG56685.1.
AK293329 mRNA. Translation: BAG56845.1.
AK298177 mRNA. Translation: BAG60448.1.
AK303313 mRNA. Translation: BAG64382.1.
AK314796 mRNA. Translation: BAG37327.1.
CR456763 mRNA. Translation: CAG33044.1.
AK222666 mRNA. Translation: BAD96386.1.
AK223227 mRNA. Translation: BAD96947.1.
AC068531 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94707.1.
BC004130 mRNA. Translation: AAH04130.1.
BC015893 mRNA. Translation: AAH15893.1.
CCDSiCCDS11538.1. [Q13137-1]
CCDS58558.1. [Q13137-3]
CCDS58559.1. [Q13137-4]
CCDS58560.1. [Q13137-2]
CCDS58561.1. [Q13137-5]
PIRiA56733.
RefSeqiNP_001248319.1. NM_001261390.1. [Q13137-4]
NP_001248320.1. NM_001261391.1. [Q13137-3]
NP_001248322.1. NM_001261393.1. [Q13137-2]
NP_001248324.1. NM_001261395.1. [Q13137-5]
NP_005822.1. NM_005831.4. [Q13137-1]
UniGeneiHs.514920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MXPNMR-A414-446[»]
3VVVX-ray1.35A21-141[»]
3VVWX-ray2.50A21-141[»]
4GXLX-ray2.02B368-381[»]
4HANX-ray2.55C/D372-385[»]
4XKLX-ray2.10B/D414-446[»]
5AAQNMR-A388-446[»]
ProteinModelPortaliQ13137.
SMRiQ13137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115535. 173 interactors.
DIPiDIP-57534N.
IntActiQ13137. 181 interactors.
MINTiMINT-270155.
STRINGi9606.ENSP00000258947.

PTM databases

iPTMnetiQ13137.
PhosphoSitePlusiQ13137.

Polymorphism and mutation databases

BioMutaiCALCOCO2.
DMDMi74735623.

Proteomic databases

EPDiQ13137.
MaxQBiQ13137.
PaxDbiQ13137.
PeptideAtlasiQ13137.
PRIDEiQ13137.

Protocols and materials databases

DNASUi10241.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258947; ENSP00000258947; ENSG00000136436. [Q13137-1]
ENST00000416445; ENSP00000406974; ENSG00000136436. [Q13137-2]
ENST00000448105; ENSP00000398523; ENSG00000136436. [Q13137-4]
ENST00000508679; ENSP00000423437; ENSG00000136436. [Q13137-5]
ENST00000509507; ENSP00000424352; ENSG00000136436. [Q13137-3]
GeneIDi10241.
KEGGihsa:10241.
UCSCiuc002iof.4. human. [Q13137-1]

Organism-specific databases

CTDi10241.
DisGeNETi10241.
GeneCardsiCALCOCO2.
H-InvDBHIX0013950.
HGNCiHGNC:29912. CALCOCO2.
HPAiHPA022989.
HPA023019.
HPA023195.
MIMi604587. gene.
neXtProtiNX_Q13137.
OpenTargetsiENSG00000136436.
PharmGKBiPA143485407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKI3. Eukaryota.
ENOG4112B0R. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000050230.
HOVERGENiHBG104102.
InParanoidiQ13137.
OMAiSIPFQFR.
OrthoDBiEOG091G01W2.
PhylomeDBiQ13137.
TreeFamiTF329501.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136436-MONOMER.

Miscellaneous databases

ChiTaRSiCALCOCO2. human.
GeneWikiiCALCOCO2.
GenomeRNAii10241.
PROiQ13137.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136436.
CleanExiHS_CALCOCO2.
ExpressionAtlasiQ13137. baseline and differential.
GenevisibleiQ13137. HS.

Family and domain databases

InterProiIPR012852. CALCOCO1-like.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCACO2_HUMAN
AccessioniPrimary (citable) accession number: Q13137
Secondary accession number(s): B2RBT0
, B4DDC4, B4DDT4, B4DP36, B4E0C0, E7ENK0, E7ETP5, E9PBE5, Q53FQ5, Q53HB5, Q6IBN9, Q9BTF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.