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Q13137

- CACO2_HUMAN

UniProt

Q13137 - CACO2_HUMAN

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Protein

Calcium-binding and coiled-coil domain-containing protein 2

Gene

CALCOCO2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.1 Publication

GO - Molecular functioni

  1. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. response to interferon-gamma Source: BHF-UCL
  2. viral process Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding and coiled-coil domain-containing protein 2
Alternative name(s):
Antigen nuclear dot 52 kDa protein
Nuclear domain 10 protein NDP52
Short name:
Nuclear domain 10 protein 52
Nuclear dot protein 52
Gene namesi
Name:CALCOCO2
Synonyms:NDP52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29912. CALCOCO2.

Subcellular locationi

Cytoplasmperinuclear region. Golgi apparatus. Cytoplasmcytoskeleton
Note: According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytoskeleton Source: UniProtKB-KW
  3. Golgi apparatus Source: UniProtKB-KW
  4. intracellular membrane-bounded organelle Source: HPA
  5. membrane Source: UniProtKB
  6. nucleus Source: ProtInc
  7. perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi400 – 4001C → A: Loss of interaction with MYO6. 1 Publication
Mutagenesisi425 – 4251C → A: No effect on interaction with MYO6. 1 Publication

Organism-specific databases

PharmGKBiPA143485407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Calcium-binding and coiled-coil domain-containing protein 2PRO_0000312337Add
BLAST

Proteomic databases

MaxQBiQ13137.
PaxDbiQ13137.
PRIDEiQ13137.

PTM databases

PhosphoSiteiQ13137.

Expressioni

Tissue specificityi

Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.1 Publication

Gene expression databases

BgeeiQ13137.
CleanExiHS_CALCOCO2.
ExpressionAtlasiQ13137. baseline and differential.
GenevestigatoriQ13137.

Organism-specific databases

HPAiHPA022989.
HPA023019.
HPA023195.

Interactioni

Subunit structurei

Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX23EBI-739580,EBI-6863741From a different organism.
MAVSQ7Z4343EBI-739580,EBI-995373
MTPAPQ9NVV42EBI-739580,EBI-2556166
TBK1Q9UHD25EBI-739580,EBI-356402

Protein-protein interaction databases

BioGridi115535. 87 interactions.
DIPiDIP-57534N.
IntActiQ13137. 76 interactions.
MINTiMINT-270155.
STRINGi9606.ENSP00000258947.

Structurei

Secondary structure

1
446
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 276Combined sources
Beta strandi30 – 323Combined sources
Beta strandi38 – 447Combined sources
Beta strandi55 – 606Combined sources
Helixi66 – 683Combined sources
Beta strandi70 – 745Combined sources
Beta strandi89 – 935Combined sources
Helixi95 – 973Combined sources
Beta strandi105 – 1106Combined sources
Beta strandi116 – 1194Combined sources
Beta strandi123 – 1264Combined sources
Beta strandi133 – 1353Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VVVX-ray1.35A21-141[»]
3VVWX-ray2.50A21-141[»]
4GXLX-ray2.02B368-381[»]
4HANX-ray2.55C/D372-385[»]
ProteinModelPortaliQ13137.
SMRiQ13137. Positions 21-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni395 – 44652Interaction with MYO6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili137 – 349213Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG87904.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000050230.
HOVERGENiHBG104102.
InParanoidiQ13137.
OMAiYYTFMWV.
OrthoDBiEOG7RRF8H.
PhylomeDBiQ13137.
TreeFamiTF329501.

Family and domain databases

InterProiIPR012852. CoCoA.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13137-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYIPGGDVTC HYTFTQHFIP
60 70 80 90 100
RRKDWIGIFR VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK
110 120 130 140 150
DDEYYQFCYV DEDGVVRGAS IPFQFRPENE EDILVVTTQG EVEEIEQHNK
160 170 180 190 200
ELCKENQELK DSCISLQKQN SDMQAELQKK QEELETLQSI NKKLELKVKE
210 220 230 240 250
QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ EKEMEKLVQG
260 270 280 290 300
DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ
310 320 330 340 350
QELMDENFDL SKRLSENEII CNALQRQKER LEGENDLLKR ENSRLLSYMG
360 370 380 390 400
LDFNSLPYQV PTSDEGGARQ NPGLAYGNPY SGIQESSSPS PLSIKKCPIC
410 420 430 440
KADDICDHTL EQQQMQPLCF NCPICDKIFP ATEKQIFEDH VFCHSL
Length:446
Mass (Da):52,254
Last modified:November 1, 1996 - v1
Checksum:i609B121DA1A9DCB8
GO
Isoform 2 (identifier: Q13137-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-180: Missing.

Note: No experimental confirmation available.

Show »
Length:404
Mass (Da):47,340
Checksum:i096590EDA273DE3E
GO
Isoform 3 (identifier: Q13137-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RCSLNQTIQLLITPDTGSIWHQ

Note: No experimental confirmation available.

Show »
Length:467
Mass (Da):54,605
Checksum:iCF0B512C4C91DB91
GO
Isoform 4 (identifier: Q13137-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RAFKCFQDKLEQELLKWRSQGQKLQ

Note: No experimental confirmation available.

Show »
Length:470
Mass (Da):55,188
Checksum:iDC114D09C4737FEC
GO
Isoform 5 (identifier: Q13137-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.

Show »
Length:374
Mass (Da):43,669
Checksum:iF20EB9A4621F735A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021D → Y in BAG64382. (PubMed:14702039)Curated
Sequence conflicti313 – 3131R → G in BAG56685. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401G → E.1 Publication
Corresponds to variant rs550510 [ dbSNP | Ensembl ].
VAR_037489
Natural varianti227 – 2271G → R.
Corresponds to variant rs2303016 [ dbSNP | Ensembl ].
VAR_037490
Natural varianti248 – 2481V → A.2 Publications
Corresponds to variant rs2303015 [ dbSNP | Ensembl ].
VAR_037491
Natural varianti273 – 2731T → A.1 Publication
Corresponds to variant rs17849804 [ dbSNP | Ensembl ].
VAR_037492
Natural varianti389 – 3891P → A.3 Publications
Corresponds to variant rs10278 [ dbSNP | Ensembl ].
VAR_037493

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272Missing in isoform 5. 1 PublicationVSP_047414Add
BLAST
Alternative sequencei60 – 601R → RCSLNQTIQLLITPDTGSIW HQ in isoform 3. 1 PublicationVSP_046766
Alternative sequencei60 – 601R → RAFKCFQDKLEQELLKWRSQ GQKLQ in isoform 4. 1 PublicationVSP_046767
Alternative sequencei139 – 18042Missing in isoform 2. 1 PublicationVSP_044728Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22897 mRNA. Translation: AAA75297.1.
AK293137 mRNA. Translation: BAG56685.1.
AK293329 mRNA. Translation: BAG56845.1.
AK298177 mRNA. Translation: BAG60448.1.
AK303313 mRNA. Translation: BAG64382.1.
AK314796 mRNA. Translation: BAG37327.1.
CR456763 mRNA. Translation: CAG33044.1.
AK222666 mRNA. Translation: BAD96386.1.
AK223227 mRNA. Translation: BAD96947.1.
AC068531 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94707.1.
BC004130 mRNA. Translation: AAH04130.1.
BC015893 mRNA. Translation: AAH15893.1.
CCDSiCCDS11538.1. [Q13137-1]
CCDS58558.1. [Q13137-3]
CCDS58559.1. [Q13137-4]
CCDS58560.1. [Q13137-2]
CCDS58561.1. [Q13137-5]
PIRiA56733.
RefSeqiNP_001248319.1. NM_001261390.1. [Q13137-4]
NP_001248320.1. NM_001261391.1. [Q13137-3]
NP_001248322.1. NM_001261393.1. [Q13137-2]
NP_001248324.1. NM_001261395.1. [Q13137-5]
NP_005822.1. NM_005831.4. [Q13137-1]
UniGeneiHs.514920.

Genome annotation databases

EnsembliENST00000258947; ENSP00000258947; ENSG00000136436. [Q13137-1]
ENST00000416445; ENSP00000406974; ENSG00000136436. [Q13137-2]
ENST00000448105; ENSP00000398523; ENSG00000136436. [Q13137-4]
ENST00000508679; ENSP00000423437; ENSG00000136436. [Q13137-5]
ENST00000509507; ENSP00000424352; ENSG00000136436. [Q13137-3]
GeneIDi10241.
KEGGihsa:10241.
UCSCiuc002iof.4. human. [Q13137-1]
uc010wlp.3. human.
uc010wlr.3. human.

Polymorphism databases

DMDMi74735623.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22897 mRNA. Translation: AAA75297.1 .
AK293137 mRNA. Translation: BAG56685.1 .
AK293329 mRNA. Translation: BAG56845.1 .
AK298177 mRNA. Translation: BAG60448.1 .
AK303313 mRNA. Translation: BAG64382.1 .
AK314796 mRNA. Translation: BAG37327.1 .
CR456763 mRNA. Translation: CAG33044.1 .
AK222666 mRNA. Translation: BAD96386.1 .
AK223227 mRNA. Translation: BAD96947.1 .
AC068531 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94707.1 .
BC004130 mRNA. Translation: AAH04130.1 .
BC015893 mRNA. Translation: AAH15893.1 .
CCDSi CCDS11538.1. [Q13137-1 ]
CCDS58558.1. [Q13137-3 ]
CCDS58559.1. [Q13137-4 ]
CCDS58560.1. [Q13137-2 ]
CCDS58561.1. [Q13137-5 ]
PIRi A56733.
RefSeqi NP_001248319.1. NM_001261390.1. [Q13137-4 ]
NP_001248320.1. NM_001261391.1. [Q13137-3 ]
NP_001248322.1. NM_001261393.1. [Q13137-2 ]
NP_001248324.1. NM_001261395.1. [Q13137-5 ]
NP_005822.1. NM_005831.4. [Q13137-1 ]
UniGenei Hs.514920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VVV X-ray 1.35 A 21-141 [» ]
3VVW X-ray 2.50 A 21-141 [» ]
4GXL X-ray 2.02 B 368-381 [» ]
4HAN X-ray 2.55 C/D 372-385 [» ]
ProteinModelPortali Q13137.
SMRi Q13137. Positions 21-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115535. 87 interactions.
DIPi DIP-57534N.
IntActi Q13137. 76 interactions.
MINTi MINT-270155.
STRINGi 9606.ENSP00000258947.

PTM databases

PhosphoSitei Q13137.

Polymorphism databases

DMDMi 74735623.

Proteomic databases

MaxQBi Q13137.
PaxDbi Q13137.
PRIDEi Q13137.

Protocols and materials databases

DNASUi 10241.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258947 ; ENSP00000258947 ; ENSG00000136436 . [Q13137-1 ]
ENST00000416445 ; ENSP00000406974 ; ENSG00000136436 . [Q13137-2 ]
ENST00000448105 ; ENSP00000398523 ; ENSG00000136436 . [Q13137-4 ]
ENST00000508679 ; ENSP00000423437 ; ENSG00000136436 . [Q13137-5 ]
ENST00000509507 ; ENSP00000424352 ; ENSG00000136436 . [Q13137-3 ]
GeneIDi 10241.
KEGGi hsa:10241.
UCSCi uc002iof.4. human. [Q13137-1 ]
uc010wlp.3. human.
uc010wlr.3. human.

Organism-specific databases

CTDi 10241.
GeneCardsi GC17P046908.
H-InvDB HIX0013950.
HGNCi HGNC:29912. CALCOCO2.
HPAi HPA022989.
HPA023019.
HPA023195.
MIMi 604587. gene.
neXtProti NX_Q13137.
PharmGKBi PA143485407.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87904.
GeneTreei ENSGT00530000063216.
HOGENOMi HOG000050230.
HOVERGENi HBG104102.
InParanoidi Q13137.
OMAi YYTFMWV.
OrthoDBi EOG7RRF8H.
PhylomeDBi Q13137.
TreeFami TF329501.

Miscellaneous databases

ChiTaRSi CALCOCO2. human.
GeneWikii CALCOCO2.
GenomeRNAii 10241.
NextBioi 38796.
PROi Q13137.
SOURCEi Search...

Gene expression databases

Bgeei Q13137.
CleanExi HS_CALCOCO2.
ExpressionAtlasi Q13137. baseline and differential.
Genevestigatori Q13137.

Family and domain databases

InterProi IPR012852. CoCoA.
[Graphical view ]
Pfami PF07888. CALCOCO1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment."
    Korioth F., Gieffers C., Maul G.G., Frey J.
    J. Cell Biol. 130:1-13(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), VARIANTS GLU-140; ALA-248 AND ALA-389.
    Tissue: Mammary gland, Neuroblastoma, Teratocarcinoma and Thymus.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-248.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-389.
    Tissue: Brain and Gastric mucosa.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-389.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-273.
    Tissue: Kidney and Skin.
  8. "Cellular localization, expression, and structure of the nuclear dot protein 52."
    Sternsdorf T., Jensen K., Zuchner D., Will H.
    J. Cell Biol. 138:435-448(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins."
    Di Y., Li J., Zhang Y., He X., Lu H., Xu D., Ling J., Huo K., Wan D., Li Y.Y., Gu J.
    J. Biochem. 133:713-718(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GEMIN4, SUBCELLULAR LOCATION.
  10. "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion."
    Morriswood B., Ryzhakov G., Puri C., Arden S.D., Roberts R., Dendrou C., Kendrick-Jones J., Buss F.
    J. Cell Sci. 120:2574-2585(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TAX1BP1 AND MYO6, MUTAGENESIS OF CYS-400 AND CYS-425.

Entry informationi

Entry nameiCACO2_HUMAN
AccessioniPrimary (citable) accession number: Q13137
Secondary accession number(s): B2RBT0
, B4DDC4, B4DDT4, B4DP36, B4E0C0, E7ENK0, E7ETP5, E9PBE5, Q53FQ5, Q53HB5, Q6IBN9, Q9BTF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

According to PubMed:7540613, HSV-1 infection removes CALCOCO2 from the nucleus, however, it remains faintly in areas shown to be domains, containing splicing components. Treatment with IFNB1/IFN-beta and IFNG/IFN-gamma show an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm. According to PubMed:9230084, IFNG/IFN-gamma increases gene expression only slightly and IFNB does not increase expression.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3