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Protein

Calcium-binding and coiled-coil domain-containing protein 2

Gene

CALCOCO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  • response to interferon-gamma Source: BHF-UCL
  • viral process Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding and coiled-coil domain-containing protein 2
Alternative name(s):
Antigen nuclear dot 52 kDa protein
Nuclear domain 10 protein NDP52
Short name:
Nuclear domain 10 protein 52
Nuclear dot protein 52
Gene namesi
Name:CALCOCO2
Synonyms:NDP52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29912. CALCOCO2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytoskeleton Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleus Source: ProtInc
  • perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi400 – 4001C → A: Loss of interaction with MYO6. 1 Publication
Mutagenesisi425 – 4251C → A: No effect on interaction with MYO6. 1 Publication

Organism-specific databases

PharmGKBiPA143485407.

Polymorphism and mutation databases

BioMutaiCALCOCO2.
DMDMi74735623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Calcium-binding and coiled-coil domain-containing protein 2PRO_0000312337Add
BLAST

Proteomic databases

MaxQBiQ13137.
PaxDbiQ13137.
PRIDEiQ13137.

PTM databases

PhosphoSiteiQ13137.

Expressioni

Tissue specificityi

Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.1 Publication

Gene expression databases

BgeeiQ13137.
CleanExiHS_CALCOCO2.
ExpressionAtlasiQ13137. baseline and differential.
GenevisibleiQ13137. HS.

Organism-specific databases

HPAiHPA022989.
HPA023019.
HPA023195.

Interactioni

Subunit structurei

Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KAD63EBI-739580,EBI-10174974
B2R9Y13EBI-739580,EBI-10175746
Q8WU023EBI-739580,EBI-747182
Q9WMX23EBI-739580,EBI-6863741From a different organism.
AESQ081173EBI-739580,EBI-717810
AKAP17AQ02040-33EBI-739580,EBI-10222656
AMMECR1Q9Y4X03EBI-739580,EBI-8583355
ARD1AQ6P4J03EBI-739580,EBI-10252815
ARHGEF39Q8N4T43EBI-739580,EBI-745468
ARHGEF5Q127743EBI-739580,EBI-602199
BAHD1Q8TBE03EBI-739580,EBI-742750
BCL6BA8KA133EBI-739580,EBI-10174813
BEX2Q9BXY83EBI-739580,EBI-745073
C20orf195Q9BVV24EBI-739580,EBI-744935
CBX8Q9HC523EBI-739580,EBI-712912
CCNHP519463EBI-739580,EBI-741406
CEP57L1Q8IYX83EBI-739580,EBI-1104570
CHCHD3Q9NX633EBI-739580,EBI-743375
DAZAP2Q150384EBI-739580,EBI-724310
DCTN4Q9UJW03EBI-739580,EBI-2134033
DCXO436023EBI-739580,EBI-8646694
DDIT4LQ96D033EBI-739580,EBI-742054
DDX6P261963EBI-739580,EBI-351257
DOCK2Q926083EBI-739580,EBI-448771
DUSP12Q9UNI64EBI-739580,EBI-715161
DUSP26Q9BV473EBI-739580,EBI-2924519
EEF1E1O433243EBI-739580,EBI-1048486
EXOSC5Q9NQT43EBI-739580,EBI-371876
FAM161AQ3B8203EBI-739580,EBI-719941
FAM168AQ925673EBI-739580,EBI-7957930
FAM90A1Q86YD74EBI-739580,EBI-6658203
FARS2O953633EBI-739580,EBI-2513774
FBF1Q8TES7-63EBI-739580,EBI-10244131
FBXL18Q96D164EBI-739580,EBI-744419
FKBPLQ9UIM33EBI-739580,EBI-719882
GABARAPL1Q9H0R84EBI-739580,EBI-746969
GABARAPL2P605204EBI-739580,EBI-720116
GATAD2BQ8WXI93EBI-739580,EBI-923440
GLYCTKQ8IVS83EBI-739580,EBI-748515
HDAC7Q8WUI4-53EBI-739580,EBI-10276431
HOXB9P174823EBI-739580,EBI-745290
KANSL1I3L4J33EBI-739580,EBI-10178305
KLHL42Q9P2K63EBI-739580,EBI-739890
LENG1Q96BZ83EBI-739580,EBI-726510
LGALS8O002144EBI-739580,EBI-740058
LIMS2Q7Z4I7-53EBI-739580,EBI-10257651
LITAFQ997324EBI-739580,EBI-725647
LMF2Q9BU233EBI-739580,EBI-10298556
LMO2P257913EBI-739580,EBI-739696
LMO4P619683EBI-739580,EBI-2798728
LONRF1Q17RB83EBI-739580,EBI-2341787
LSM4Q9Y4Z04EBI-739580,EBI-372521
MAGOHBQ96A723EBI-739580,EBI-746778
MAVSQ7Z4343EBI-739580,EBI-995373
METTL17Q9H7H03EBI-739580,EBI-749353
MID2Q9UJV3-23EBI-739580,EBI-10172526
MOSP005403EBI-739580,EBI-1757866
MTPAPQ9NVV42EBI-739580,EBI-2556166
MXI1P505393EBI-739580,EBI-752241
MXI1P50539-33EBI-739580,EBI-10211940
NAA10P412273EBI-739580,EBI-747693
NFU1Q9UMS03EBI-739580,EBI-725252
PAPD4Q6PIY73EBI-739580,EBI-2802204
PEF1Q9UBV84EBI-739580,EBI-724639
PEG10Q86TG73EBI-739580,EBI-2858265
PFDN5Q994714EBI-739580,EBI-357275
PHF1O431893EBI-739580,EBI-530034
PPP1R18Q6NYC83EBI-739580,EBI-2557469
PRPF31F1T0A53EBI-739580,EBI-10177194
PSME4Q149973EBI-739580,EBI-1236916
RBM15Q96T373EBI-739580,EBI-2514922
RIN1Q136714EBI-739580,EBI-366017
RPL9P9P329693EBI-739580,EBI-358122
RPS27AP629793EBI-739580,EBI-357375
RTP5Q14D333EBI-739580,EBI-10217913
SDCBPO005603EBI-739580,EBI-727004
SLC15A3Q05CH43EBI-739580,EBI-10223741
SMCPP499013EBI-739580,EBI-750494
SNRPBP14678-23EBI-739580,EBI-372475
SPATA24Q86W543EBI-739580,EBI-3916986
SRIP306264EBI-739580,EBI-750459
STK16O757163EBI-739580,EBI-749295
TBC1D22BQ9NU193EBI-739580,EBI-8787464
TBK1Q9UHD25EBI-739580,EBI-356402
TBRG4Q969Z03EBI-739580,EBI-702328
TCL1AP562795EBI-739580,EBI-749995
TEKT3Q9BXF93EBI-739580,EBI-8644516
TP53RKQ96S444EBI-739580,EBI-739588
UBAC2Q8NBM43EBI-739580,EBI-724045
UBBQ5U5U63EBI-739580,EBI-1642104
UBCQ96C323EBI-739580,EBI-745483
VARSP266403EBI-739580,EBI-355765
ZNF337Q9Y3M93EBI-739580,EBI-714987
ZNF564Q8TBZ83EBI-739580,EBI-10273713
ZNF581Q9P0T43EBI-739580,EBI-745520

Protein-protein interaction databases

BioGridi115535. 163 interactions.
DIPiDIP-57534N.
IntActiQ13137. 150 interactions.
MINTiMINT-270155.
STRINGi9606.ENSP00000258947.

Structurei

Secondary structure

1
446
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 276Combined sources
Beta strandi30 – 323Combined sources
Beta strandi38 – 447Combined sources
Beta strandi55 – 606Combined sources
Helixi66 – 683Combined sources
Beta strandi70 – 745Combined sources
Beta strandi89 – 935Combined sources
Helixi95 – 973Combined sources
Beta strandi105 – 1106Combined sources
Beta strandi116 – 1194Combined sources
Beta strandi123 – 1264Combined sources
Beta strandi133 – 1353Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VVVX-ray1.35A21-141[»]
3VVWX-ray2.50A21-141[»]
4GXLX-ray2.02B368-381[»]
4HANX-ray2.55C/D372-385[»]
ProteinModelPortaliQ13137.
SMRiQ13137. Positions 21-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni395 – 44652Interaction with MYO6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili137 – 349213Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG87904.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000050230.
HOVERGENiHBG104102.
InParanoidiQ13137.
OMAiSIPFQFR.
OrthoDBiEOG7RRF8H.
PhylomeDBiQ13137.
TreeFamiTF329501.

Family and domain databases

InterProiIPR012852. CoCoA.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13137-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYIPGGDVTC HYTFTQHFIP
60 70 80 90 100
RRKDWIGIFR VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK
110 120 130 140 150
DDEYYQFCYV DEDGVVRGAS IPFQFRPENE EDILVVTTQG EVEEIEQHNK
160 170 180 190 200
ELCKENQELK DSCISLQKQN SDMQAELQKK QEELETLQSI NKKLELKVKE
210 220 230 240 250
QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ EKEMEKLVQG
260 270 280 290 300
DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ
310 320 330 340 350
QELMDENFDL SKRLSENEII CNALQRQKER LEGENDLLKR ENSRLLSYMG
360 370 380 390 400
LDFNSLPYQV PTSDEGGARQ NPGLAYGNPY SGIQESSSPS PLSIKKCPIC
410 420 430 440
KADDICDHTL EQQQMQPLCF NCPICDKIFP ATEKQIFEDH VFCHSL
Length:446
Mass (Da):52,254
Last modified:November 1, 1996 - v1
Checksum:i609B121DA1A9DCB8
GO
Isoform 2 (identifier: Q13137-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-180: Missing.

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):47,340
Checksum:i096590EDA273DE3E
GO
Isoform 3 (identifier: Q13137-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RCSLNQTIQLLITPDTGSIWHQ

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):54,605
Checksum:iCF0B512C4C91DB91
GO
Isoform 4 (identifier: Q13137-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RAFKCFQDKLEQELLKWRSQGQKLQ

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):55,188
Checksum:iDC114D09C4737FEC
GO
Isoform 5 (identifier: Q13137-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):43,669
Checksum:iF20EB9A4621F735A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021D → Y in BAG64382 (PubMed:14702039).Curated
Sequence conflicti313 – 3131R → G in BAG56685 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401G → E.1 Publication
Corresponds to variant rs550510 [ dbSNP | Ensembl ].
VAR_037489
Natural varianti227 – 2271G → R.
Corresponds to variant rs2303016 [ dbSNP | Ensembl ].
VAR_037490
Natural varianti248 – 2481V → A.2 Publications
Corresponds to variant rs2303015 [ dbSNP | Ensembl ].
VAR_037491
Natural varianti273 – 2731T → A.1 Publication
Corresponds to variant rs17849804 [ dbSNP | Ensembl ].
VAR_037492
Natural varianti389 – 3891P → A.3 Publications
Corresponds to variant rs10278 [ dbSNP | Ensembl ].
VAR_037493

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272Missing in isoform 5. 1 PublicationVSP_047414Add
BLAST
Alternative sequencei60 – 601R → RCSLNQTIQLLITPDTGSIW HQ in isoform 3. 1 PublicationVSP_046766
Alternative sequencei60 – 601R → RAFKCFQDKLEQELLKWRSQ GQKLQ in isoform 4. 1 PublicationVSP_046767
Alternative sequencei139 – 18042Missing in isoform 2. 1 PublicationVSP_044728Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22897 mRNA. Translation: AAA75297.1.
AK293137 mRNA. Translation: BAG56685.1.
AK293329 mRNA. Translation: BAG56845.1.
AK298177 mRNA. Translation: BAG60448.1.
AK303313 mRNA. Translation: BAG64382.1.
AK314796 mRNA. Translation: BAG37327.1.
CR456763 mRNA. Translation: CAG33044.1.
AK222666 mRNA. Translation: BAD96386.1.
AK223227 mRNA. Translation: BAD96947.1.
AC068531 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94707.1.
BC004130 mRNA. Translation: AAH04130.1.
BC015893 mRNA. Translation: AAH15893.1.
CCDSiCCDS11538.1. [Q13137-1]
CCDS58558.1. [Q13137-3]
CCDS58559.1. [Q13137-4]
CCDS58560.1. [Q13137-2]
CCDS58561.1. [Q13137-5]
PIRiA56733.
RefSeqiNP_001248319.1. NM_001261390.1. [Q13137-4]
NP_001248320.1. NM_001261391.1. [Q13137-3]
NP_001248322.1. NM_001261393.1. [Q13137-2]
NP_001248324.1. NM_001261395.1. [Q13137-5]
NP_005822.1. NM_005831.4. [Q13137-1]
UniGeneiHs.514920.

Genome annotation databases

EnsembliENST00000258947; ENSP00000258947; ENSG00000136436.
ENST00000416445; ENSP00000406974; ENSG00000136436. [Q13137-2]
ENST00000448105; ENSP00000398523; ENSG00000136436. [Q13137-4]
ENST00000508679; ENSP00000423437; ENSG00000136436. [Q13137-5]
ENST00000509507; ENSP00000424352; ENSG00000136436. [Q13137-3]
GeneIDi10241.
KEGGihsa:10241.
UCSCiuc002iof.4. human. [Q13137-1]
uc010wlp.3. human.
uc010wlr.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22897 mRNA. Translation: AAA75297.1.
AK293137 mRNA. Translation: BAG56685.1.
AK293329 mRNA. Translation: BAG56845.1.
AK298177 mRNA. Translation: BAG60448.1.
AK303313 mRNA. Translation: BAG64382.1.
AK314796 mRNA. Translation: BAG37327.1.
CR456763 mRNA. Translation: CAG33044.1.
AK222666 mRNA. Translation: BAD96386.1.
AK223227 mRNA. Translation: BAD96947.1.
AC068531 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94707.1.
BC004130 mRNA. Translation: AAH04130.1.
BC015893 mRNA. Translation: AAH15893.1.
CCDSiCCDS11538.1. [Q13137-1]
CCDS58558.1. [Q13137-3]
CCDS58559.1. [Q13137-4]
CCDS58560.1. [Q13137-2]
CCDS58561.1. [Q13137-5]
PIRiA56733.
RefSeqiNP_001248319.1. NM_001261390.1. [Q13137-4]
NP_001248320.1. NM_001261391.1. [Q13137-3]
NP_001248322.1. NM_001261393.1. [Q13137-2]
NP_001248324.1. NM_001261395.1. [Q13137-5]
NP_005822.1. NM_005831.4. [Q13137-1]
UniGeneiHs.514920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VVVX-ray1.35A21-141[»]
3VVWX-ray2.50A21-141[»]
4GXLX-ray2.02B368-381[»]
4HANX-ray2.55C/D372-385[»]
ProteinModelPortaliQ13137.
SMRiQ13137. Positions 21-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115535. 163 interactions.
DIPiDIP-57534N.
IntActiQ13137. 150 interactions.
MINTiMINT-270155.
STRINGi9606.ENSP00000258947.

PTM databases

PhosphoSiteiQ13137.

Polymorphism and mutation databases

BioMutaiCALCOCO2.
DMDMi74735623.

Proteomic databases

MaxQBiQ13137.
PaxDbiQ13137.
PRIDEiQ13137.

Protocols and materials databases

DNASUi10241.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258947; ENSP00000258947; ENSG00000136436.
ENST00000416445; ENSP00000406974; ENSG00000136436. [Q13137-2]
ENST00000448105; ENSP00000398523; ENSG00000136436. [Q13137-4]
ENST00000508679; ENSP00000423437; ENSG00000136436. [Q13137-5]
ENST00000509507; ENSP00000424352; ENSG00000136436. [Q13137-3]
GeneIDi10241.
KEGGihsa:10241.
UCSCiuc002iof.4. human. [Q13137-1]
uc010wlp.3. human.
uc010wlr.3. human.

Organism-specific databases

CTDi10241.
GeneCardsiGC17P046908.
H-InvDBHIX0013950.
HGNCiHGNC:29912. CALCOCO2.
HPAiHPA022989.
HPA023019.
HPA023195.
MIMi604587. gene.
neXtProtiNX_Q13137.
PharmGKBiPA143485407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87904.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000050230.
HOVERGENiHBG104102.
InParanoidiQ13137.
OMAiSIPFQFR.
OrthoDBiEOG7RRF8H.
PhylomeDBiQ13137.
TreeFamiTF329501.

Miscellaneous databases

ChiTaRSiCALCOCO2. human.
GeneWikiiCALCOCO2.
GenomeRNAii10241.
NextBioi38796.
PROiQ13137.
SOURCEiSearch...

Gene expression databases

BgeeiQ13137.
CleanExiHS_CALCOCO2.
ExpressionAtlasiQ13137. baseline and differential.
GenevisibleiQ13137. HS.

Family and domain databases

InterProiIPR012852. CoCoA.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment."
    Korioth F., Gieffers C., Maul G.G., Frey J.
    J. Cell Biol. 130:1-13(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), VARIANTS GLU-140; ALA-248 AND ALA-389.
    Tissue: Mammary gland, Neuroblastoma, Teratocarcinoma and Thymus.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-248.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-389.
    Tissue: Brain and Gastric mucosa.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-389.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-273.
    Tissue: Kidney and Skin.
  8. "Cellular localization, expression, and structure of the nuclear dot protein 52."
    Sternsdorf T., Jensen K., Zuchner D., Will H.
    J. Cell Biol. 138:435-448(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins."
    Di Y., Li J., Zhang Y., He X., Lu H., Xu D., Ling J., Huo K., Wan D., Li Y.Y., Gu J.
    J. Biochem. 133:713-718(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GEMIN4, SUBCELLULAR LOCATION.
  10. "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion."
    Morriswood B., Ryzhakov G., Puri C., Arden S.D., Roberts R., Dendrou C., Kendrick-Jones J., Buss F.
    J. Cell Sci. 120:2574-2585(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TAX1BP1 AND MYO6, MUTAGENESIS OF CYS-400 AND CYS-425.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCACO2_HUMAN
AccessioniPrimary (citable) accession number: Q13137
Secondary accession number(s): B2RBT0
, B4DDC4, B4DDT4, B4DP36, B4E0C0, E7ENK0, E7ETP5, E9PBE5, Q53FQ5, Q53HB5, Q6IBN9, Q9BTF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

According to PubMed:7540613, HSV-1 infection removes CALCOCO2 from the nucleus, however, it remains faintly in areas shown to be domains, containing splicing components. Treatment with IFNB1/IFN-beta and IFNG/IFN-gamma show an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm. According to PubMed:9230084, IFNG/IFN-gamma increases gene expression only slightly and IFNB does not increase expression.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.