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Q13133

- NR1H3_HUMAN

UniProt

Q13133 - NR1H3_HUMAN

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Protein
Oxysterols receptor LXR-alpha
Gene
NR1H3, LXRA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi95 – 17076Nuclear receptor
Add
BLAST
Zinc fingeri98 – 11821NR C4-type
Add
BLAST
Zinc fingeri134 – 15825NR C4-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. cholesterol binding Source: BHF-UCL
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
  4. protein binding Source: UniProtKB
  5. sequence-specific DNA binding Source: InterPro
  6. steroid hormone receptor activity Source: InterPro
  7. sterol response element binding Source: UniProtKB
  8. transcription coactivator activity Source: ProtInc
  9. transcription regulatory region DNA binding Source: BHF-UCL
  10. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic cell clearance Source: UniProtKB
  2. cellular lipid metabolic process Source: Ensembl
  3. cellular response to lipopolysaccharide Source: BHF-UCL
  4. cholesterol homeostasis Source: BHF-UCL
  5. gene expression Source: Reactome
  6. lipid homeostasis Source: BHF-UCL
  7. negative regulation of cholesterol storage Source: BHF-UCL
  8. negative regulation of inflammatory response Source: BHF-UCL
  9. negative regulation of interferon-gamma-mediated signaling pathway Source: BHF-UCL
  10. negative regulation of lipid transport Source: BHF-UCL
  11. negative regulation of macrophage activation Source: BHF-UCL
  12. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  13. negative regulation of pancreatic juice secretion Source: BHF-UCL
  14. negative regulation of pinocytosis Source: BHF-UCL
  15. negative regulation of proteolysis Source: Ensembl
  16. negative regulation of secretion of lysosomal enzymes Source: BHF-UCL
  17. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  18. positive regulation of cellular protein metabolic process Source: BHF-UCL
  19. positive regulation of cholesterol efflux Source: BHF-UCL
  20. positive regulation of cholesterol homeostasis Source: BHF-UCL
  21. positive regulation of cholesterol transport Source: BHF-UCL
  22. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
  23. positive regulation of lipoprotein lipase activity Source: BHF-UCL
  24. positive regulation of receptor biosynthetic process Source: BHF-UCL
  25. positive regulation of toll-like receptor 4 signaling pathway Source: BHF-UCL
  26. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  27. positive regulation of transcription, DNA-templated Source: UniProtKB
  28. positive regulation of triglyceride biosynthetic process Source: BHF-UCL
  29. regulation of cholesterol homeostasis Source: UniProtKB
  30. regulation of circadian rhythm Source: BHF-UCL
  31. response to progesterone Source: BHF-UCL
  32. sterol homeostasis Source: BHF-UCL
  33. transcription initiation from RNA polymerase II promoter Source: Reactome
  34. triglyceride homeostasis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiQ13133.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterols receptor LXR-alpha
Alternative name(s):
Liver X receptor alpha
Nuclear receptor subfamily 1 group H member 3
Gene namesi
Name:NR1H3
Synonyms:LXRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7966. NR1H3.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nuclear chromatin Source: BHF-UCL
  2. nucleoplasm Source: Reactome
  3. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31751.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Oxysterols receptor LXR-alpha
PRO_0000053535Add
BLAST

Proteomic databases

PaxDbiQ13133.
PRIDEiQ13133.

PTM databases

PhosphoSiteiQ13133.

Expressioni

Tissue specificityi

Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.

Inductioni

By 9-cis retinoic acid (9CRA).

Gene expression databases

ArrayExpressiQ13133.
BgeeiQ13133.
CleanExiHS_NR1H3.
GenevestigatoriQ13133.

Organism-specific databases

HPAiCAB037109.
HPA036443.

Interactioni

Subunit structurei

Heterodimer of LXRA and RXR.

Binary interactionsi

WithEntry#Exp.IntActNotes
EDF1O608694EBI-781356,EBI-781301
KDM1AO603412EBI-781356,EBI-710124
NCOA1Q1578814EBI-781356,EBI-455189
SUV39H1O434632EBI-781356,EBI-349968

Protein-protein interaction databases

BioGridi115373. 32 interactions.
IntActiQ13133. 9 interactions.
MINTiMINT-3027136.
STRINGi9606.ENSP00000342470.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi208 – 22114
Helixi229 – 2335
Helixi250 – 27425
Helixi278 – 2803
Helixi283 – 30422
Turni308 – 3114
Beta strandi312 – 3154
Turni316 – 3183
Beta strandi319 – 3213
Helixi323 – 3286
Helixi333 – 34917
Helixi353 – 36412
Beta strandi369 – 3713
Helixi375 – 39622
Helixi403 – 43028
Helixi437 – 4437

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UHLX-ray2.90B207-447[»]
3IPQX-ray2.00A182-447[»]
3IPSX-ray2.26A/B182-447[»]
3IPUX-ray2.40A/B182-447[»]
ProteinModelPortaliQ13133.
SMRiQ13133. Positions 85-445.

Miscellaneous databases

EvolutionaryTraceiQ13133.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 434220Ligand-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG285805.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
InParanoidiQ13133.
KOiK08536.
OMAiCILREEA.
PhylomeDBiQ13133.
TreeFamiTF352167.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13133-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA    50
GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV 100
CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC 150
QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP 200
QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM APDPHSREAR 250
QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL 300
ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ 350
LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD 400
RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE 447
Length:447
Mass (Da):50,396
Last modified:September 19, 2002 - v2
Checksum:i0D27B237440F8C9C
GO
Isoform 2 (identifier: Q13133-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-296: Missing.

Note: No experimental confirmation available.

Show »
Length:387
Mass (Da):43,555
Checksum:i9C96CF2BBE66403C
GO
Isoform 3 (identifier: Q13133-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Note: No experimental confirmation available.

Show »
Length:402
Mass (Da):45,692
Checksum:i78EAE53CFB2358E7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521G → V.
Corresponds to variant rs41481445 [ dbSNP | Ensembl ].
VAR_050580

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545Missing in isoform 3.
VSP_044960Add
BLAST
Alternative sequencei237 – 29660Missing in isoform 2.
VSP_003664Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961A → R in AAA85856. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22662 mRNA. Translation: AAA85856.1.
AK290614 mRNA. Translation: BAF83303.1.
AC018410 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67949.1.
CH471064 Genomic DNA. Translation: EAW67942.1.
CH471064 Genomic DNA. Translation: EAW67943.1.
CH471064 Genomic DNA. Translation: EAW67944.1.
CH471064 Genomic DNA. Translation: EAW67947.1.
CH471064 Genomic DNA. Translation: EAW67948.1.
BC008819 mRNA. Translation: AAH08819.1.
BC041172 mRNA. Translation: AAH41172.1.
CCDSiCCDS44584.1. [Q13133-2]
CCDS44585.1. [Q13133-3]
CCDS7929.1. [Q13133-1]
PIRiI38975.
RefSeqiNP_001123573.1. NM_001130101.2. [Q13133-2]
NP_001123574.1. NM_001130102.2. [Q13133-3]
NP_005684.2. NM_005693.3. [Q13133-1]
XP_005252762.1. XM_005252705.1. [Q13133-1]
XP_005252763.1. XM_005252706.1. [Q13133-1]
XP_005252764.1. XM_005252707.2. [Q13133-1]
XP_005252766.1. XM_005252709.1. [Q13133-3]
XP_005252767.1. XM_005252710.1. [Q13133-3]
XP_005252770.1. XM_005252713.1. [Q13133-2]
XP_006718175.1. XM_006718112.1. [Q13133-1]
XP_006718176.1. XM_006718113.1. [Q13133-1]
XP_006718177.1. XM_006718114.1. [Q13133-1]
XP_006718178.1. XM_006718115.1. [Q13133-3]
XP_006718179.1. XM_006718116.1. [Q13133-3]
UniGeneiHs.438863.

Genome annotation databases

EnsembliENST00000395397; ENSP00000378793; ENSG00000025434. [Q13133-3]
ENST00000405853; ENSP00000384745; ENSG00000025434. [Q13133-2]
ENST00000407404; ENSP00000385801; ENSG00000025434. [Q13133-2]
ENST00000441012; ENSP00000387946; ENSG00000025434. [Q13133-1]
ENST00000467728; ENSP00000420656; ENSG00000025434. [Q13133-1]
GeneIDi10062.
KEGGihsa:10062.
UCSCiuc001nek.3. human. [Q13133-1]
uc001nen.4. human. [Q13133-2]

Polymorphism databases

DMDMi23503089.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22662 mRNA. Translation: AAA85856.1 .
AK290614 mRNA. Translation: BAF83303.1 .
AC018410 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67949.1 .
CH471064 Genomic DNA. Translation: EAW67942.1 .
CH471064 Genomic DNA. Translation: EAW67943.1 .
CH471064 Genomic DNA. Translation: EAW67944.1 .
CH471064 Genomic DNA. Translation: EAW67947.1 .
CH471064 Genomic DNA. Translation: EAW67948.1 .
BC008819 mRNA. Translation: AAH08819.1 .
BC041172 mRNA. Translation: AAH41172.1 .
CCDSi CCDS44584.1. [Q13133-2 ]
CCDS44585.1. [Q13133-3 ]
CCDS7929.1. [Q13133-1 ]
PIRi I38975.
RefSeqi NP_001123573.1. NM_001130101.2. [Q13133-2 ]
NP_001123574.1. NM_001130102.2. [Q13133-3 ]
NP_005684.2. NM_005693.3. [Q13133-1 ]
XP_005252762.1. XM_005252705.1. [Q13133-1 ]
XP_005252763.1. XM_005252706.1. [Q13133-1 ]
XP_005252764.1. XM_005252707.2. [Q13133-1 ]
XP_005252766.1. XM_005252709.1. [Q13133-3 ]
XP_005252767.1. XM_005252710.1. [Q13133-3 ]
XP_005252770.1. XM_005252713.1. [Q13133-2 ]
XP_006718175.1. XM_006718112.1. [Q13133-1 ]
XP_006718176.1. XM_006718113.1. [Q13133-1 ]
XP_006718177.1. XM_006718114.1. [Q13133-1 ]
XP_006718178.1. XM_006718115.1. [Q13133-3 ]
XP_006718179.1. XM_006718116.1. [Q13133-3 ]
UniGenei Hs.438863.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UHL X-ray 2.90 B 207-447 [» ]
3IPQ X-ray 2.00 A 182-447 [» ]
3IPS X-ray 2.26 A/B 182-447 [» ]
3IPU X-ray 2.40 A/B 182-447 [» ]
ProteinModelPortali Q13133.
SMRi Q13133. Positions 85-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115373. 32 interactions.
IntActi Q13133. 9 interactions.
MINTi MINT-3027136.
STRINGi 9606.ENSP00000342470.

Chemistry

BindingDBi Q13133.
ChEMBLi CHEMBL2808.
GuidetoPHARMACOLOGYi 602.

PTM databases

PhosphoSitei Q13133.

Polymorphism databases

DMDMi 23503089.

Proteomic databases

PaxDbi Q13133.
PRIDEi Q13133.

Protocols and materials databases

DNASUi 10062.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395397 ; ENSP00000378793 ; ENSG00000025434 . [Q13133-3 ]
ENST00000405853 ; ENSP00000384745 ; ENSG00000025434 . [Q13133-2 ]
ENST00000407404 ; ENSP00000385801 ; ENSG00000025434 . [Q13133-2 ]
ENST00000441012 ; ENSP00000387946 ; ENSG00000025434 . [Q13133-1 ]
ENST00000467728 ; ENSP00000420656 ; ENSG00000025434 . [Q13133-1 ]
GeneIDi 10062.
KEGGi hsa:10062.
UCSCi uc001nek.3. human. [Q13133-1 ]
uc001nen.4. human. [Q13133-2 ]

Organism-specific databases

CTDi 10062.
GeneCardsi GC11P047269.
HGNCi HGNC:7966. NR1H3.
HPAi CAB037109.
HPA036443.
MIMi 602423. gene.
neXtProti NX_Q13133.
PharmGKBi PA31751.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285805.
HOGENOMi HOG000220845.
HOVERGENi HBG108655.
InParanoidi Q13133.
KOi K08536.
OMAi CILREEA.
PhylomeDBi Q13133.
TreeFami TF352167.

Enzyme and pathway databases

Reactomei REACT_15525. Nuclear Receptor transcription pathway.
SignaLinki Q13133.

Miscellaneous databases

EvolutionaryTracei Q13133.
GeneWikii Liver_X_receptor_alpha.
GenomeRNAii 10062.
NextBioi 38029.
PROi Q13133.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13133.
Bgeei Q13133.
CleanExi HS_NR1H3.
Genevestigatori Q13133.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LXR, a nuclear receptor that defines a distinct retinoid response pathway."
    Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., Mangelsdorf D.J.
    Genes Dev. 9:1033-1045(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiNR1H3_HUMAN
AccessioniPrimary (citable) accession number: Q13133
Secondary accession number(s): A8K3J9
, D3DQR1, Q8IW13, Q96H87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 19, 2002
Last modified: September 3, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi