Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13133

- NR1H3_HUMAN

UniProt

Q13133 - NR1H3_HUMAN

Protein

Oxysterols receptor LXR-alpha

Gene

NR1H3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi95 – 17076Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri98 – 11821NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri134 – 15825NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. cholesterol binding Source: BHF-UCL
    2. DNA binding Source: ProtInc
    3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
    4. protein binding Source: UniProtKB
    5. sequence-specific DNA binding Source: InterPro
    6. steroid hormone receptor activity Source: InterPro
    7. sterol response element binding Source: UniProtKB
    8. transcription coactivator activity Source: ProtInc
    9. transcription regulatory region DNA binding Source: BHF-UCL
    10. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic cell clearance Source: UniProtKB
    2. cellular lipid metabolic process Source: Ensembl
    3. cellular response to lipopolysaccharide Source: BHF-UCL
    4. cholesterol homeostasis Source: BHF-UCL
    5. gene expression Source: Reactome
    6. lipid homeostasis Source: BHF-UCL
    7. negative regulation of cholesterol storage Source: BHF-UCL
    8. negative regulation of inflammatory response Source: BHF-UCL
    9. negative regulation of interferon-gamma-mediated signaling pathway Source: BHF-UCL
    10. negative regulation of lipid transport Source: BHF-UCL
    11. negative regulation of macrophage activation Source: BHF-UCL
    12. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    13. negative regulation of pancreatic juice secretion Source: BHF-UCL
    14. negative regulation of pinocytosis Source: BHF-UCL
    15. negative regulation of proteolysis Source: Ensembl
    16. negative regulation of secretion of lysosomal enzymes Source: BHF-UCL
    17. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    18. positive regulation of cellular protein metabolic process Source: BHF-UCL
    19. positive regulation of cholesterol efflux Source: BHF-UCL
    20. positive regulation of cholesterol homeostasis Source: BHF-UCL
    21. positive regulation of cholesterol transport Source: BHF-UCL
    22. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
    23. positive regulation of lipoprotein lipase activity Source: BHF-UCL
    24. positive regulation of receptor biosynthetic process Source: BHF-UCL
    25. positive regulation of toll-like receptor 4 signaling pathway Source: BHF-UCL
    26. positive regulation of transcription, DNA-templated Source: UniProtKB
    27. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    28. positive regulation of triglyceride biosynthetic process Source: BHF-UCL
    29. regulation of cholesterol homeostasis Source: UniProtKB
    30. regulation of circadian rhythm Source: BHF-UCL
    31. response to progesterone Source: BHF-UCL
    32. sterol homeostasis Source: BHF-UCL
    33. transcription initiation from RNA polymerase II promoter Source: Reactome
    34. triglyceride homeostasis Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
    SignaLinkiQ13133.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxysterols receptor LXR-alpha
    Alternative name(s):
    Liver X receptor alpha
    Nuclear receptor subfamily 1 group H member 3
    Gene namesi
    Name:NR1H3
    Synonyms:LXRA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7966. NR1H3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nuclear chromatin Source: BHF-UCL
    2. nucleoplasm Source: Reactome
    3. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31751.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Oxysterols receptor LXR-alphaPRO_0000053535Add
    BLAST

    Proteomic databases

    PaxDbiQ13133.
    PRIDEiQ13133.

    PTM databases

    PhosphoSiteiQ13133.

    Expressioni

    Tissue specificityi

    Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.

    Inductioni

    By 9-cis retinoic acid (9CRA).

    Gene expression databases

    ArrayExpressiQ13133.
    BgeeiQ13133.
    CleanExiHS_NR1H3.
    GenevestigatoriQ13133.

    Organism-specific databases

    HPAiCAB037109.
    HPA036443.

    Interactioni

    Subunit structurei

    Heterodimer of LXRA and RXR.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EDF1O608694EBI-781356,EBI-781301
    KDM1AO603412EBI-781356,EBI-710124
    NCOA1Q1578814EBI-781356,EBI-455189
    SUV39H1O434632EBI-781356,EBI-349968

    Protein-protein interaction databases

    BioGridi115373. 32 interactions.
    IntActiQ13133. 15 interactions.
    MINTiMINT-3027136.
    STRINGi9606.ENSP00000342470.

    Structurei

    Secondary structure

    1
    447
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi208 – 22114
    Helixi229 – 2335
    Helixi250 – 27425
    Helixi278 – 2803
    Helixi283 – 30422
    Turni308 – 3114
    Beta strandi312 – 3154
    Turni316 – 3183
    Beta strandi319 – 3213
    Helixi323 – 3286
    Helixi333 – 34917
    Helixi353 – 36412
    Beta strandi369 – 3713
    Helixi375 – 39622
    Helixi403 – 43028
    Helixi437 – 4437

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UHLX-ray2.90B207-447[»]
    3IPQX-ray2.00A182-447[»]
    3IPSX-ray2.26A/B182-447[»]
    3IPUX-ray2.40A/B182-447[»]
    ProteinModelPortaliQ13133.
    SMRiQ13133. Positions 85-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13133.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni215 – 434220Ligand-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri98 – 11821NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri134 – 15825NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG285805.
    HOGENOMiHOG000220845.
    HOVERGENiHBG108655.
    InParanoidiQ13133.
    KOiK08536.
    OMAiCILREEA.
    PhylomeDBiQ13133.
    TreeFamiTF352167.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13133-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA    50
    GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV 100
    CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC 150
    QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP 200
    QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM APDPHSREAR 250
    QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL 300
    ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ 350
    LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD 400
    RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE 447
    Length:447
    Mass (Da):50,396
    Last modified:September 19, 2002 - v2
    Checksum:i0D27B237440F8C9C
    GO
    Isoform 2 (identifier: Q13133-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-296: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:387
    Mass (Da):43,555
    Checksum:i9C96CF2BBE66403C
    GO
    Isoform 3 (identifier: Q13133-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-45: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:402
    Mass (Da):45,692
    Checksum:i78EAE53CFB2358E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961A → R in AAA85856. (PubMed:7744246)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti52 – 521G → V.
    Corresponds to variant rs41481445 [ dbSNP | Ensembl ].
    VAR_050580

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4545Missing in isoform 3. 1 PublicationVSP_044960Add
    BLAST
    Alternative sequencei237 – 29660Missing in isoform 2. 1 PublicationVSP_003664Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22662 mRNA. Translation: AAA85856.1.
    AK290614 mRNA. Translation: BAF83303.1.
    AC018410 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67949.1.
    CH471064 Genomic DNA. Translation: EAW67942.1.
    CH471064 Genomic DNA. Translation: EAW67943.1.
    CH471064 Genomic DNA. Translation: EAW67944.1.
    CH471064 Genomic DNA. Translation: EAW67947.1.
    CH471064 Genomic DNA. Translation: EAW67948.1.
    BC008819 mRNA. Translation: AAH08819.1.
    BC041172 mRNA. Translation: AAH41172.1.
    CCDSiCCDS44584.1. [Q13133-2]
    CCDS44585.1. [Q13133-3]
    CCDS7929.1. [Q13133-1]
    PIRiI38975.
    RefSeqiNP_001123573.1. NM_001130101.2. [Q13133-2]
    NP_001123574.1. NM_001130102.2. [Q13133-3]
    NP_005684.2. NM_005693.3. [Q13133-1]
    XP_005252762.1. XM_005252705.1. [Q13133-1]
    XP_005252763.1. XM_005252706.1. [Q13133-1]
    XP_005252764.1. XM_005252707.2. [Q13133-1]
    XP_005252766.1. XM_005252709.1. [Q13133-3]
    XP_005252767.1. XM_005252710.1. [Q13133-3]
    XP_005252770.1. XM_005252713.1. [Q13133-2]
    XP_006718175.1. XM_006718112.1. [Q13133-1]
    XP_006718176.1. XM_006718113.1. [Q13133-1]
    XP_006718177.1. XM_006718114.1. [Q13133-1]
    XP_006718178.1. XM_006718115.1. [Q13133-3]
    XP_006718179.1. XM_006718116.1. [Q13133-3]
    UniGeneiHs.438863.

    Genome annotation databases

    EnsembliENST00000395397; ENSP00000378793; ENSG00000025434. [Q13133-3]
    ENST00000405853; ENSP00000384745; ENSG00000025434. [Q13133-2]
    ENST00000407404; ENSP00000385801; ENSG00000025434. [Q13133-2]
    ENST00000441012; ENSP00000387946; ENSG00000025434. [Q13133-1]
    ENST00000467728; ENSP00000420656; ENSG00000025434. [Q13133-1]
    GeneIDi10062.
    KEGGihsa:10062.
    UCSCiuc001nek.3. human. [Q13133-1]
    uc001nen.4. human. [Q13133-2]

    Polymorphism databases

    DMDMi23503089.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22662 mRNA. Translation: AAA85856.1 .
    AK290614 mRNA. Translation: BAF83303.1 .
    AC018410 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67949.1 .
    CH471064 Genomic DNA. Translation: EAW67942.1 .
    CH471064 Genomic DNA. Translation: EAW67943.1 .
    CH471064 Genomic DNA. Translation: EAW67944.1 .
    CH471064 Genomic DNA. Translation: EAW67947.1 .
    CH471064 Genomic DNA. Translation: EAW67948.1 .
    BC008819 mRNA. Translation: AAH08819.1 .
    BC041172 mRNA. Translation: AAH41172.1 .
    CCDSi CCDS44584.1. [Q13133-2 ]
    CCDS44585.1. [Q13133-3 ]
    CCDS7929.1. [Q13133-1 ]
    PIRi I38975.
    RefSeqi NP_001123573.1. NM_001130101.2. [Q13133-2 ]
    NP_001123574.1. NM_001130102.2. [Q13133-3 ]
    NP_005684.2. NM_005693.3. [Q13133-1 ]
    XP_005252762.1. XM_005252705.1. [Q13133-1 ]
    XP_005252763.1. XM_005252706.1. [Q13133-1 ]
    XP_005252764.1. XM_005252707.2. [Q13133-1 ]
    XP_005252766.1. XM_005252709.1. [Q13133-3 ]
    XP_005252767.1. XM_005252710.1. [Q13133-3 ]
    XP_005252770.1. XM_005252713.1. [Q13133-2 ]
    XP_006718175.1. XM_006718112.1. [Q13133-1 ]
    XP_006718176.1. XM_006718113.1. [Q13133-1 ]
    XP_006718177.1. XM_006718114.1. [Q13133-1 ]
    XP_006718178.1. XM_006718115.1. [Q13133-3 ]
    XP_006718179.1. XM_006718116.1. [Q13133-3 ]
    UniGenei Hs.438863.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UHL X-ray 2.90 B 207-447 [» ]
    3IPQ X-ray 2.00 A 182-447 [» ]
    3IPS X-ray 2.26 A/B 182-447 [» ]
    3IPU X-ray 2.40 A/B 182-447 [» ]
    ProteinModelPortali Q13133.
    SMRi Q13133. Positions 85-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115373. 32 interactions.
    IntActi Q13133. 15 interactions.
    MINTi MINT-3027136.
    STRINGi 9606.ENSP00000342470.

    Chemistry

    BindingDBi Q13133.
    ChEMBLi CHEMBL2808.
    GuidetoPHARMACOLOGYi 602.

    PTM databases

    PhosphoSitei Q13133.

    Polymorphism databases

    DMDMi 23503089.

    Proteomic databases

    PaxDbi Q13133.
    PRIDEi Q13133.

    Protocols and materials databases

    DNASUi 10062.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395397 ; ENSP00000378793 ; ENSG00000025434 . [Q13133-3 ]
    ENST00000405853 ; ENSP00000384745 ; ENSG00000025434 . [Q13133-2 ]
    ENST00000407404 ; ENSP00000385801 ; ENSG00000025434 . [Q13133-2 ]
    ENST00000441012 ; ENSP00000387946 ; ENSG00000025434 . [Q13133-1 ]
    ENST00000467728 ; ENSP00000420656 ; ENSG00000025434 . [Q13133-1 ]
    GeneIDi 10062.
    KEGGi hsa:10062.
    UCSCi uc001nek.3. human. [Q13133-1 ]
    uc001nen.4. human. [Q13133-2 ]

    Organism-specific databases

    CTDi 10062.
    GeneCardsi GC11P047269.
    HGNCi HGNC:7966. NR1H3.
    HPAi CAB037109.
    HPA036443.
    MIMi 602423. gene.
    neXtProti NX_Q13133.
    PharmGKBi PA31751.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285805.
    HOGENOMi HOG000220845.
    HOVERGENi HBG108655.
    InParanoidi Q13133.
    KOi K08536.
    OMAi CILREEA.
    PhylomeDBi Q13133.
    TreeFami TF352167.

    Enzyme and pathway databases

    Reactomei REACT_15525. Nuclear Receptor transcription pathway.
    SignaLinki Q13133.

    Miscellaneous databases

    EvolutionaryTracei Q13133.
    GeneWikii Liver_X_receptor_alpha.
    GenomeRNAii 10062.
    NextBioi 38029.
    PROi Q13133.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13133.
    Bgeei Q13133.
    CleanExi HS_NR1H3.
    Genevestigatori Q13133.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LXR, a nuclear receptor that defines a distinct retinoid response pathway."
      Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., Mangelsdorf D.J.
      Genes Dev. 9:1033-1045(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain and Placenta.

    Entry informationi

    Entry nameiNR1H3_HUMAN
    AccessioniPrimary (citable) accession number: Q13133
    Secondary accession number(s): A8K3J9
    , D3DQR1, Q8IW13, Q96H87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 155 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3