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Q13129 (RLF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein Rlf
Alternative name(s):
Rearranged L-myc fusion gene protein
Zn-15-related protein
Gene names
Name:RLF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1914 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subunit structure

Interacts with RIT1 and RIT2 By similarity.

Subcellular location

Nucleus Probable.

Tissue specificity

Widely expressed in fetal and adult tissues.

Miscellaneous

In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 14 C2H2-type zinc fingers.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q99IB82EBI-958266,EBI-6927928From a different organism.
RIT1Q929633EBI-958266,EBI-365845
Rit2P704252EBI-958266,EBI-2649620From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19141914Zinc finger protein Rlf
PRO_0000047325

Regions

Zinc finger582 – 60423C2H2-type 1
Zinc finger671 – 69626C2H2-type 2
Zinc finger714 – 73623C2H2-type 3
Zinc finger742 – 76625C2H2-type 4
Zinc finger771 – 79525C2H2-type 5
Zinc finger801 – 82525C2H2-type 6
Zinc finger954 – 97926C2H2-type 7
Zinc finger1127 – 115226C2H2-type 8
Zinc finger1172 – 119524C2H2-type 9
Zinc finger1310 – 133526C2H2-type 10
Zinc finger1362 – 138726C2H2-type 11
Zinc finger1407 – 143226C2H2-type 12
Zinc finger1444 – 146926C2H2-type 13
Zinc finger1549 – 157426C2H2-type 14

Amino acid modifications

Modified residue411Phosphoserine Ref.5
Modified residue6321Phosphoserine Ref.6

Natural variations

Natural variant6681R → K.
Corresponds to variant rs35189918 [ dbSNP | Ensembl ].
VAR_052739
Natural variant9321V → A.
Corresponds to variant rs35563960 [ dbSNP | Ensembl ].
VAR_052740
Natural variant9571G → D.
Corresponds to variant rs35042446 [ dbSNP | Ensembl ].
VAR_052741
Natural variant16291P → L.
Corresponds to variant rs34123123 [ dbSNP | Ensembl ].
VAR_061929
Natural variant16851Q → E.
Corresponds to variant rs34141181 [ dbSNP | Ensembl ].
VAR_061930
Natural variant17841E → D.
Corresponds to variant rs10889205 [ dbSNP | Ensembl ].
VAR_052742

Experimental info

Sequence conflict1546 – 15483HTQ → LSL in AAC50396. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q13129 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: 105C85C645563999

FASTA1,914217,953
        10         20         30         40         50         60 
MADGKGDAAA VAGAGAEAPA VAGAGDGVET ESMVRGHRPV SPAPGASGLR PCLWQLETEL 

        70         80         90        100        110        120 
REQEVSEVSS LNYCRSFCQT LLQYASNKNA SEHIVYLLEV YRLAIQSFAS ARPYLTTECE 

       130        140        150        160        170        180 
DVLLVLGRLV LSCFELLLSV SESELPCEVW LPFLQSLQES HDALLEFGNN NLQILVHVTK 

       190        200        210        220        230        240 
EGVWKNPVLL KILSQQPVET EEVNKLIAQE GPSFLQMRIK HLLKSNCIPQ ATALSKLCAE 

       250        260        270        280        290        300 
SKEISNVSSF QQAYITCLCS MLPNEDAIKE IAKVDCKEVL DIICNLESEG QDNTAFVLCT 

       310        320        330        340        350        360 
TYLTQQLQTA SVYCSWELTL FWSKLQRRID PSLDTFLERC RQFGVIAKTQ QHLFCLIRVI 

       370        380        390        400        410        420 
QTEAQDAGLG VSILLCVRAL QLRSSEDEEM KASVCKTIAC LLPEDLEVRR ACQLTEFLIE 

       430        440        450        460        470        480 
PSLDGFNMLE ELYLQPDQKF DEENAPVPNS LRCELLLALK AHWPFDPEFW DWKTLKRHCH 

       490        500        510        520        530        540 
QLLGQEASDS DDDLSGYEMS INDTDVLESF LSDYDEGKED KQYRRRDLTD QHKEKRDKKP 

       550        560        570        580        590        600 
IGSSERYQRW LQYKFFCLLC KRECIEARIL HHSKMHMEDG IYTCPVCIKK FKRKEMFVPH 

       610        620        630        640        650        660 
VMEHVKMPPS RRDRSKKKLL LKGSQKGICP KSPSAIPEQN HSLNDQAKGE SHEYVTFSKL 

       670        680        690        700        710        720 
EDCHLQDRDL YPCPGTDCSR VFKQFKYLSV HLKAEHQNND ENAKHYLDMK NRREKCTYCR 

       730        740        750        760        770        780 
RHFMSAFHLR EHEQVHCGPQ PYMCVSIDCY ARFGSVNELL NHKQKHDDLR YKCELNGCNI 

       790        800        810        820        830        840 
VFSDLGQLYH HEAQHFRDAS YTCNFLGCKK FYYSKIEYQN HLSMHNVENS NGDIKKSVKL 

       850        860        870        880        890        900 
EESATGEKQD CINQPHLLNQ TDKSHLPEDL FCAESANSQI DTETAENLKE NSDSNSSDQL 

       910        920        930        940        950        960 
SHSSSASMNE ELIDTLDHSE TMQDVLLSNE KVFGPSSLKE KCSSMAVCFD GTKFTCGFDG 

       970        980        990       1000       1010       1020 
CGSTYKNARG MQKHLRKVHP YHFKPKKIKT KDLFPSLGNE HNQTTEKLDA EPKPCSDTNS 

      1030       1040       1050       1060       1070       1080 
DSPDEGLDHN IHIKCKREHQ GYSSESSICA SKRPCTEDTM LELLLRLKHL SLKNSITHGS 

      1090       1100       1110       1120       1130       1140 
FSGSLQGYPS SGAKSLQSVS SISDLNFQNQ DENMPSQYLA QLAAKPFFCE LQGCKYEFVT 

      1150       1160       1170       1180       1190       1200 
REALLMHYLK KHNYSKEKVL QLTMFQHRYS PFQCHICQRS FTRKTHLRIH YKNKHQIGSD 

      1210       1220       1230       1240       1250       1260 
RATHKLLDNE KCDHEGPCSV DRLKGDCSAE LGGDPSSNSE KPHCHPKKDE CSSETDLESS 

      1270       1280       1290       1300       1310       1320 
CEETESKTSD ISSPIGSHRE EQEGREGRGS RRTVAKGNLC YILNKYHKPF HCIHKTCNSS 

      1330       1340       1350       1360       1370       1380 
FTNLKGLIRH YRTVHQYNKE QLCLEKDKAR TKRELVKCKK IFACKYKECN KRFLCSKALA 

      1390       1400       1410       1420       1430       1440 
KHCSDSHNLD HIEEPKVLSE AGSAARFSCN QPQCPAVFYT FNKLKHHLME QHNIEGEIHS 

      1450       1460       1470       1480       1490       1500 
DYEIHCDLNG CGQIFTHRSN YSQHVYYRHK DYYDDLFRSQ KVANERLLRS EKVCQTADTQ 

      1510       1520       1530       1540       1550       1560 
GHEHQTTRRS FNAKSKKCGL IKEKKAPISF KTRAEALHMC VEHSEHTQYP CMVQGCLSVV 

      1570       1580       1590       1600       1610       1620 
KLESSIVRHY KRTHQMSSAY LEQQMENLVV CVKYGTKIKE EPPSEADPCI KKEENRSCES 

      1630       1640       1650       1660       1670       1680 
ERTEHSHSPG DSSAPIQNTD CCHSSERDGG QKGCIESSSV FDADTLLYRG TLKCNHSSKT 

      1690       1700       1710       1720       1730       1740 
TSLEQCNIVQ PPPPCKIENS IPNPNGTESG TYFTSFQLPL PRIKESETRQ HSSGQENTVK 

      1750       1760       1770       1780       1790       1800 
NPTHVPKENF RKHSQPRSFD LKTYKPMGFE SSFLKFIQES EEKEDDFDDW EPSEHLTLSN 

      1810       1820       1830       1840       1850       1860 
SSQSSNDLTG NVVANNMVND SEPEVDIPHS SSDSTIHENL TAIPPLIVAE TTTVPSLENL 

      1870       1880       1890       1900       1910 
RVVLDKALTD CGELALKQLH YLRPVVVLER SKFSTPILDL FPTKKTDELC VGSS 

« Hide

References

« Hide 'large scale' references
[1]"The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein."
Makela T.P., Hellsten E., Vesa J., Hirvonen H., Palotie A., Peltonen L., Alitalo K.
Oncogene 11:2699-2704(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22377 mRNA. Translation: AAC50396.1.
AL050341 Genomic DNA. Translation: CAB81608.2.
AL929567 expand/collapse EMBL AC list , AL050341, AL356424, AL512599 Genomic DNA. Translation: CAH71081.1.
AL512599 expand/collapse EMBL AC list , AL050341, AL356424, AL929567 Genomic DNA. Translation: CAI11028.1.
AL356424 expand/collapse EMBL AC list , AL050341, AL512599, AL929567 Genomic DNA. Translation: CAI21999.1.
BC113666 mRNA. Translation: AAI13667.1.
PIRS21662.
RefSeqNP_036553.2. NM_012421.3.
UniGeneHs.205627.

3D structure databases

ProteinModelPortalQ13129.
SMRQ13129. Positions 560-609, 672-871, 1097-1192, 1261-1469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111950. 8 interactions.
IntActQ13129. 9 interactions.
MINTMINT-1192845.
STRING9606.ENSP00000361857.

PTM databases

PhosphoSiteQ13129.

Polymorphism databases

DMDM62296764.

Proteomic databases

PaxDbQ13129.
PRIDEQ13129.

Protocols and materials databases

DNASU6018.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372771; ENSP00000361857; ENSG00000117000.
GeneID6018.
KEGGhsa:6018.
UCSCuc001cfc.4. human.

Organism-specific databases

CTD6018.
GeneCardsGC01P040627.
HGNCHGNC:10025. RLF.
HPAHPA057300.
MIM180610. gene.
neXtProtNX_Q13129.
PharmGKBPA34398.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG330998.
HOGENOMHOG000231080.
HOVERGENHBG057472.
InParanoidQ13129.
OMAGQLYHHE.
OrthoDBEOG7966FN.
PhylomeDBQ13129.
TreeFamTF350813.

Gene expression databases

BgeeQ13129.
CleanExHS_RLF.
GenevestigatorQ13129.

Family and domain databases

Gene3D3.30.160.60. 1 hit.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRLF. human.
GeneWikiRLF_(gene).
GenomeRNAi6018.
NextBio23479.
PROQ13129.
SOURCESearch...

Entry information

Entry nameRLF_HUMAN
AccessionPrimary (citable) accession number: Q13129
Secondary accession number(s): Q14CQ1, Q9NU60
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 29, 2005
Last modified: April 16, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM