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Q13129

- RLF_HUMAN

UniProt

Q13129 - RLF_HUMAN

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Protein
Zinc finger protein Rlf
Gene
RLF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri582 – 60423C2H2-type 1
Add
BLAST
Zinc fingeri671 – 69626C2H2-type 2
Add
BLAST
Zinc fingeri714 – 73623C2H2-type 3
Add
BLAST
Zinc fingeri742 – 76625C2H2-type 4
Add
BLAST
Zinc fingeri771 – 79525C2H2-type 5
Add
BLAST
Zinc fingeri801 – 82525C2H2-type 6
Add
BLAST
Zinc fingeri954 – 97926C2H2-type 7
Add
BLAST
Zinc fingeri1127 – 115226C2H2-type 8
Add
BLAST
Zinc fingeri1172 – 119524C2H2-type 9
Add
BLAST
Zinc fingeri1310 – 133526C2H2-type 10
Add
BLAST
Zinc fingeri1362 – 138726C2H2-type 11
Add
BLAST
Zinc fingeri1407 – 143226C2H2-type 12
Add
BLAST
Zinc fingeri1444 – 146926C2H2-type 13
Add
BLAST
Zinc fingeri1549 – 157426C2H2-type 14
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. zinc ion binding Source: ProtInc

GO - Biological processi

  1. DNA integration Source: UniProtKB
  2. DNA mediated transformation Source: UniProtKB
  3. chromosome organization Source: UniProtKB
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. regulation of transcription, DNA-templated Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Rlf
Alternative name(s):
Rearranged L-myc fusion gene protein
Zn-15-related protein
Gene namesi
Name:RLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10025. RLF.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19141914Zinc finger protein Rlf
PRO_0000047325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Phosphoserine1 Publication
Modified residuei632 – 6321Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13129.
PaxDbiQ13129.
PRIDEiQ13129.

PTM databases

PhosphoSiteiQ13129.

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues.

Gene expression databases

BgeeiQ13129.
CleanExiHS_RLF.
GenevestigatoriQ13129.

Organism-specific databases

HPAiHPA057300.

Interactioni

Subunit structurei

Interacts with RIT1 and RIT2 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB82EBI-958266,EBI-6927928From a different organism.
RIT1Q929633EBI-958266,EBI-365845
Rit2P704252EBI-958266,EBI-2649620From a different organism.

Protein-protein interaction databases

BioGridi111950. 8 interactions.
IntActiQ13129. 9 interactions.
MINTiMINT-1192845.
STRINGi9606.ENSP00000361857.

Structurei

3D structure databases

ProteinModelPortaliQ13129.
SMRiQ13129. Positions 572-612, 674-825, 1116-1178, 1308-1343.

Family & Domainsi

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG330998.
HOGENOMiHOG000231080.
HOVERGENiHBG057472.
InParanoidiQ13129.
OMAiGQLYHHE.
OrthoDBiEOG7966FN.
PhylomeDBiQ13129.
TreeFamiTF350813.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13129-1 [UniParc]FASTAAdd to Basket

« Hide

MADGKGDAAA VAGAGAEAPA VAGAGDGVET ESMVRGHRPV SPAPGASGLR     50
PCLWQLETEL REQEVSEVSS LNYCRSFCQT LLQYASNKNA SEHIVYLLEV 100
YRLAIQSFAS ARPYLTTECE DVLLVLGRLV LSCFELLLSV SESELPCEVW 150
LPFLQSLQES HDALLEFGNN NLQILVHVTK EGVWKNPVLL KILSQQPVET 200
EEVNKLIAQE GPSFLQMRIK HLLKSNCIPQ ATALSKLCAE SKEISNVSSF 250
QQAYITCLCS MLPNEDAIKE IAKVDCKEVL DIICNLESEG QDNTAFVLCT 300
TYLTQQLQTA SVYCSWELTL FWSKLQRRID PSLDTFLERC RQFGVIAKTQ 350
QHLFCLIRVI QTEAQDAGLG VSILLCVRAL QLRSSEDEEM KASVCKTIAC 400
LLPEDLEVRR ACQLTEFLIE PSLDGFNMLE ELYLQPDQKF DEENAPVPNS 450
LRCELLLALK AHWPFDPEFW DWKTLKRHCH QLLGQEASDS DDDLSGYEMS 500
INDTDVLESF LSDYDEGKED KQYRRRDLTD QHKEKRDKKP IGSSERYQRW 550
LQYKFFCLLC KRECIEARIL HHSKMHMEDG IYTCPVCIKK FKRKEMFVPH 600
VMEHVKMPPS RRDRSKKKLL LKGSQKGICP KSPSAIPEQN HSLNDQAKGE 650
SHEYVTFSKL EDCHLQDRDL YPCPGTDCSR VFKQFKYLSV HLKAEHQNND 700
ENAKHYLDMK NRREKCTYCR RHFMSAFHLR EHEQVHCGPQ PYMCVSIDCY 750
ARFGSVNELL NHKQKHDDLR YKCELNGCNI VFSDLGQLYH HEAQHFRDAS 800
YTCNFLGCKK FYYSKIEYQN HLSMHNVENS NGDIKKSVKL EESATGEKQD 850
CINQPHLLNQ TDKSHLPEDL FCAESANSQI DTETAENLKE NSDSNSSDQL 900
SHSSSASMNE ELIDTLDHSE TMQDVLLSNE KVFGPSSLKE KCSSMAVCFD 950
GTKFTCGFDG CGSTYKNARG MQKHLRKVHP YHFKPKKIKT KDLFPSLGNE 1000
HNQTTEKLDA EPKPCSDTNS DSPDEGLDHN IHIKCKREHQ GYSSESSICA 1050
SKRPCTEDTM LELLLRLKHL SLKNSITHGS FSGSLQGYPS SGAKSLQSVS 1100
SISDLNFQNQ DENMPSQYLA QLAAKPFFCE LQGCKYEFVT REALLMHYLK 1150
KHNYSKEKVL QLTMFQHRYS PFQCHICQRS FTRKTHLRIH YKNKHQIGSD 1200
RATHKLLDNE KCDHEGPCSV DRLKGDCSAE LGGDPSSNSE KPHCHPKKDE 1250
CSSETDLESS CEETESKTSD ISSPIGSHRE EQEGREGRGS RRTVAKGNLC 1300
YILNKYHKPF HCIHKTCNSS FTNLKGLIRH YRTVHQYNKE QLCLEKDKAR 1350
TKRELVKCKK IFACKYKECN KRFLCSKALA KHCSDSHNLD HIEEPKVLSE 1400
AGSAARFSCN QPQCPAVFYT FNKLKHHLME QHNIEGEIHS DYEIHCDLNG 1450
CGQIFTHRSN YSQHVYYRHK DYYDDLFRSQ KVANERLLRS EKVCQTADTQ 1500
GHEHQTTRRS FNAKSKKCGL IKEKKAPISF KTRAEALHMC VEHSEHTQYP 1550
CMVQGCLSVV KLESSIVRHY KRTHQMSSAY LEQQMENLVV CVKYGTKIKE 1600
EPPSEADPCI KKEENRSCES ERTEHSHSPG DSSAPIQNTD CCHSSERDGG 1650
QKGCIESSSV FDADTLLYRG TLKCNHSSKT TSLEQCNIVQ PPPPCKIENS 1700
IPNPNGTESG TYFTSFQLPL PRIKESETRQ HSSGQENTVK NPTHVPKENF 1750
RKHSQPRSFD LKTYKPMGFE SSFLKFIQES EEKEDDFDDW EPSEHLTLSN 1800
SSQSSNDLTG NVVANNMVND SEPEVDIPHS SSDSTIHENL TAIPPLIVAE 1850
TTTVPSLENL RVVLDKALTD CGELALKQLH YLRPVVVLER SKFSTPILDL 1900
FPTKKTDELC VGSS 1914
Length:1,914
Mass (Da):217,953
Last modified:March 29, 2005 - v2
Checksum:i105C85C645563999
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti668 – 6681R → K.
Corresponds to variant rs35189918 [ dbSNP | Ensembl ].
VAR_052739
Natural varianti932 – 9321V → A.
Corresponds to variant rs35563960 [ dbSNP | Ensembl ].
VAR_052740
Natural varianti957 – 9571G → D.
Corresponds to variant rs35042446 [ dbSNP | Ensembl ].
VAR_052741
Natural varianti1629 – 16291P → L.
Corresponds to variant rs34123123 [ dbSNP | Ensembl ].
VAR_061929
Natural varianti1685 – 16851Q → E.
Corresponds to variant rs34141181 [ dbSNP | Ensembl ].
VAR_061930
Natural varianti1784 – 17841E → D.
Corresponds to variant rs10889205 [ dbSNP | Ensembl ].
VAR_052742

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1546 – 15483HTQ → LSL in AAC50396. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22377 mRNA. Translation: AAC50396.1.
AL050341 Genomic DNA. Translation: CAB81608.2.
AL929567
, AL050341, AL356424, AL512599 Genomic DNA. Translation: CAH71081.1.
AL512599
, AL050341, AL356424, AL929567 Genomic DNA. Translation: CAI11028.1.
AL356424
, AL050341, AL512599, AL929567 Genomic DNA. Translation: CAI21999.1.
BC113666 mRNA. Translation: AAI13667.1.
CCDSiCCDS448.1.
PIRiS21662.
RefSeqiNP_036553.2. NM_012421.3.
UniGeneiHs.205627.

Genome annotation databases

EnsembliENST00000372771; ENSP00000361857; ENSG00000117000.
GeneIDi6018.
KEGGihsa:6018.
UCSCiuc001cfc.4. human.

Polymorphism databases

DMDMi62296764.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22377 mRNA. Translation: AAC50396.1 .
AL050341 Genomic DNA. Translation: CAB81608.2 .
AL929567
, AL050341 , AL356424 , AL512599 Genomic DNA. Translation: CAH71081.1 .
AL512599
, AL050341 , AL356424 , AL929567 Genomic DNA. Translation: CAI11028.1 .
AL356424
, AL050341 , AL512599 , AL929567 Genomic DNA. Translation: CAI21999.1 .
BC113666 mRNA. Translation: AAI13667.1 .
CCDSi CCDS448.1.
PIRi S21662.
RefSeqi NP_036553.2. NM_012421.3.
UniGenei Hs.205627.

3D structure databases

ProteinModelPortali Q13129.
SMRi Q13129. Positions 572-612, 674-825, 1116-1178, 1308-1343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111950. 8 interactions.
IntActi Q13129. 9 interactions.
MINTi MINT-1192845.
STRINGi 9606.ENSP00000361857.

PTM databases

PhosphoSitei Q13129.

Polymorphism databases

DMDMi 62296764.

Proteomic databases

MaxQBi Q13129.
PaxDbi Q13129.
PRIDEi Q13129.

Protocols and materials databases

DNASUi 6018.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372771 ; ENSP00000361857 ; ENSG00000117000 .
GeneIDi 6018.
KEGGi hsa:6018.
UCSCi uc001cfc.4. human.

Organism-specific databases

CTDi 6018.
GeneCardsi GC01P040627.
HGNCi HGNC:10025. RLF.
HPAi HPA057300.
MIMi 180610. gene.
neXtProti NX_Q13129.
PharmGKBi PA34398.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330998.
HOGENOMi HOG000231080.
HOVERGENi HBG057472.
InParanoidi Q13129.
OMAi GQLYHHE.
OrthoDBi EOG7966FN.
PhylomeDBi Q13129.
TreeFami TF350813.

Miscellaneous databases

ChiTaRSi RLF. human.
GeneWikii RLF_(gene).
GenomeRNAii 6018.
NextBioi 23479.
PROi Q13129.
SOURCEi Search...

Gene expression databases

Bgeei Q13129.
CleanExi HS_RLF.
Genevestigatori Q13129.

Family and domain databases

Gene3Di 3.30.160.60. 1 hit.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 15 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein."
    Makela T.P., Hellsten E., Vesa J., Hirvonen H., Palotie A., Peltonen L., Alitalo K.
    Oncogene 11:2699-2704(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRLF_HUMAN
AccessioniPrimary (citable) accession number: Q13129
Secondary accession number(s): Q14CQ1, Q9NU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 29, 2005
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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