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Protein

Protein Red

Gene

IK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind to chromatin.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • mitotic cell cycle Source: UniProtKB
  • mitotic spindle assembly checkpoint Source: UniProtKB
  • protein localization to kinetochore Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Red
Alternative name(s):
Cytokine IK
IK factor
Protein RER
Gene namesi
Name:IK
Synonyms:RED, RER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113141.15.
HGNCiHGNC:5958. IK.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3550.
OpenTargetsiENSG00000113141.
PharmGKBiPA29774.

Chemistry databases

ChEMBLiCHEMBL2321616.

Polymorphism and mutation databases

BioMutaiIK.
DMDMi296452987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000972351 – 557Protein RedAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-acetyllysineCombined sources1
Modified residuei137N6-acetyllysineBy similarity1
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei287PhosphoserineCombined sources1
Cross-linki310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki408Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei417PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei485PhosphothreonineCombined sources1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki501Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei536PhosphoserineCombined sources1
Cross-linki541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki544Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13123.
MaxQBiQ13123.
PaxDbiQ13123.
PeptideAtlasiQ13123.
PRIDEiQ13123.

PTM databases

iPTMnetiQ13123.
PhosphoSitePlusiQ13123.

Miscellaneous databases

PMAP-CutDBiQ13123.

Expressioni

Tissue specificityi

Ubiquitous.

Developmental stagei

Expressed at similar levels in fetal and adult tissues.

Gene expression databases

BgeeiENSG00000113141.
CleanExiHS_IK.
ExpressionAtlasiQ13123. baseline and differential.
GenevisibleiQ13123. HS.

Organism-specific databases

HPAiHPA048798.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi109766. 86 interactors.
CORUMiQ13123.
IntActiQ13123. 40 interactors.
MINTiMINT-1371308.
STRINGi9606.ENSP00000396301.

Chemistry databases

BindingDBiQ13123.

Structurei

3D structure databases

ProteinModelPortaliQ13123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati342 – 34312
Repeati344 – 34522
Repeati346 – 34732
Repeati348 – 34942
Repeati350 – 35152
Repeati352 – 35362
Repeati354 – 35572
Repeati356 – 35782
Repeati358 – 35992
Repeati360 – 361102
Repeati362 – 363112
Repeati364 – 365122
Repeati366 – 367132
Repeati368 – 369142
Repeati370 – 371152
Repeati372 – 373162
Repeati374 – 375172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni342 – 37517 X 2 AA tandem repeats of R-[ED]Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 187Poly-Glu4

Sequence similaritiesi

Belongs to the RED family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2498. Eukaryota.
ENOG410YR3Z. LUCA.
GeneTreeiENSGT00630000089902.
HOGENOMiHOG000007717.
HOVERGENiHBG017223.
InParanoidiQ13123.
KOiK13109.
OMAiLEEMNDA.
OrthoDBiEOG091G0BYA.
PhylomeDBiQ13123.
TreeFamiTF321907.

Family and domain databases

InterProiView protein in InterPro
IPR012492. RED_C.
IPR012916. RED_N.
PfamiView protein in Pfam
PF07807. RED_C. 1 hit.
PF07808. RED_N. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD311621. RED_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA
60 70 80 90 100
PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR
110 120 130 140 150
DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES
160 170 180 190 200
KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS KEKEEEELME KPQKETKKDE
210 220 230 240 250
DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT
260 270 280 290 300
DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK
310 320 330 340 350
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER
360 370 380 390 400
DRDRDRERER ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP
410 420 430 440 450
GSTKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP
460 470 480 490 500
ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP
510 520 530 540 550
KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV

EVKRPKY
Length:557
Mass (Da):65,602
Last modified:May 18, 2010 - v3
Checksum:iBE7B332985D5F4CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176A → L in CAA06607 (PubMed:10216252).Curated1
Sequence conflicti182E → D in CAA06607 (PubMed:10216252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005579 mRNA. Translation: CAA06607.1.
AC116353 Genomic DNA. No translation available.
BC071964 mRNA. Translation: AAH71964.1.
S74221 mRNA. Translation: AAB32531.1.
CCDSiCCDS47280.1.
PIRiI58408.
RefSeqiNP_006074.2. NM_006083.3.
UniGeneiHs.421245.

Genome annotation databases

EnsembliENST00000417647; ENSP00000396301; ENSG00000113141.
GeneIDi3550.
KEGGihsa:3550.
UCSCiuc003lgq.4. human.

Similar proteinsi

Entry informationi

Entry nameiRED_HUMAN
AccessioniPrimary (citable) accession number: Q13123
Secondary accession number(s): Q6IPD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families