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Q13123

- RED_HUMAN

UniProt

Q13123 - RED_HUMAN

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Protein

Protein Red

Gene
IK, RED, RER
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May bind to chromatin.

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. protein binding Source: IntAct

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. immune response Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Red
Alternative name(s):
Cytokine IK
IK factor
Protein RER
Gene namesi
Name:IK
Synonyms:RED, RER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5958. IK.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Protein RedPRO_0000097235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981N6-acetyllysine1 Publication
Modified residuei137 – 1371N6-acetyllysine By similarity
Modified residuei460 – 4601Phosphoserine1 Publication
Modified residuei485 – 4851Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ13123.
PaxDbiQ13123.
PeptideAtlasiQ13123.
PRIDEiQ13123.

PTM databases

PhosphoSiteiQ13123.

Miscellaneous databases

PMAP-CutDBQ13123.

Expressioni

Tissue specificityi

Ubiquitous.

Developmental stagei

Expressed at similar levels in fetal and adult tissues.

Gene expression databases

ArrayExpressiQ13123.
BgeeiQ13123.
CleanExiHS_IK.
GenevestigatoriQ13123.

Organism-specific databases

HPAiHPA019754.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-713456,EBI-713456
EFTUD2Q150292EBI-713456,EBI-357897
FRA10AC1Q70Z532EBI-713456,EBI-710176
MFAP1P550812EBI-713456,EBI-1048159
PRPF6O949062EBI-713456,EBI-536755
RBM10P981752EBI-713456,EBI-721525
revP046183EBI-713456,EBI-6164309From a different organism.
RNF113AO155412EBI-713456,EBI-2130294
SMU1Q2TAY72EBI-713456,EBI-298027
SNIP1Q8TAD82EBI-713456,EBI-749336
XAB2Q9HCS72EBI-713456,EBI-295232
ZNF830Q96NB32EBI-713456,EBI-3920997

Protein-protein interaction databases

BioGridi109766. 67 interactions.
IntActiQ13123. 30 interactions.
MINTiMINT-1371308.
STRINGi9606.ENSP00000396301.

Structurei

3D structure databases

ProteinModelPortaliQ13123.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati342 – 34321
Repeati344 – 34522
Repeati346 – 34723
Repeati348 – 34924
Repeati350 – 35125
Repeati352 – 35326
Repeati354 – 35527
Repeati356 – 35728
Repeati358 – 35929
Repeati360 – 361210
Repeati362 – 363211
Repeati364 – 365212
Repeati366 – 367213
Repeati368 – 369214
Repeati370 – 371215
Repeati372 – 373216
Repeati374 – 375217

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni342 – 3753417 X 2 AA tandem repeats of R-[ED]Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi184 – 1874Poly-Glu

Sequence similaritiesi

Belongs to the RED family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG85622.
HOGENOMiHOG000007717.
HOVERGENiHBG017223.
InParanoidiQ13123.
KOiK13109.
OMAiDIDKGPG.
OrthoDBiEOG7RNK0J.
PhylomeDBiQ13123.
TreeFamiTF321907.

Family and domain databases

InterProiIPR012492. RED_C.
IPR012916. RED_N.
[Graphical view]
PfamiPF07807. RED_C. 1 hit.
PF07808. RED_N. 1 hit.
[Graphical view]
ProDomiPD311621. RED_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q13123-1 [UniParc]FASTAAdd to Basket

« Hide

MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA    50
PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR 100
DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES 150
KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS KEKEEEELME KPQKETKKDE 200
DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT 250
DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK 300
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER 350
DRDRDRERER ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP 400
GSTKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP 450
ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP 500
KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV 550
EVKRPKY 557
Length:557
Mass (Da):65,602
Last modified:May 18, 2010 - v3
Checksum:iBE7B332985D5F4CA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761A → L in CAA06607. 1 Publication
Sequence conflicti182 – 1821E → D in CAA06607. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005579 mRNA. Translation: CAA06607.1.
AC116353 Genomic DNA. No translation available.
BC071964 mRNA. Translation: AAH71964.1.
S74221 mRNA. Translation: AAB32531.1.
CCDSiCCDS47280.1.
PIRiI58408.
RefSeqiNP_006074.2. NM_006083.3.
UniGeneiHs.421245.

Genome annotation databases

EnsembliENST00000417647; ENSP00000396301; ENSG00000113141.
GeneIDi3550.
KEGGihsa:3550.
UCSCiuc003lgq.3. human.

Polymorphism databases

DMDMi296452987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005579 mRNA. Translation: CAA06607.1 .
AC116353 Genomic DNA. No translation available.
BC071964 mRNA. Translation: AAH71964.1 .
S74221 mRNA. Translation: AAB32531.1 .
CCDSi CCDS47280.1.
PIRi I58408.
RefSeqi NP_006074.2. NM_006083.3.
UniGenei Hs.421245.

3D structure databases

ProteinModelPortali Q13123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109766. 67 interactions.
IntActi Q13123. 30 interactions.
MINTi MINT-1371308.
STRINGi 9606.ENSP00000396301.

Chemistry

ChEMBLi CHEMBL2321616.

PTM databases

PhosphoSitei Q13123.

Polymorphism databases

DMDMi 296452987.

Proteomic databases

MaxQBi Q13123.
PaxDbi Q13123.
PeptideAtlasi Q13123.
PRIDEi Q13123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000417647 ; ENSP00000396301 ; ENSG00000113141 .
GeneIDi 3550.
KEGGi hsa:3550.
UCSCi uc003lgq.3. human.

Organism-specific databases

CTDi 3550.
GeneCardsi GC05P140028.
HGNCi HGNC:5958. IK.
HPAi HPA019754.
MIMi 600549. gene.
neXtProti NX_Q13123.
PharmGKBi PA29774.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85622.
HOGENOMi HOG000007717.
HOVERGENi HBG017223.
InParanoidi Q13123.
KOi K13109.
OMAi DIDKGPG.
OrthoDBi EOG7RNK0J.
PhylomeDBi Q13123.
TreeFami TF321907.

Miscellaneous databases

ChiTaRSi IK. human.
GeneWikii IK_(gene).
GenomeRNAii 3550.
NextBioi 13860.
PMAP-CutDB Q13123.
PROi Q13123.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13123.
Bgeei Q13123.
CleanExi HS_IK.
Genevestigatori Q13123.

Family and domain databases

InterProi IPR012492. RED_C.
IPR012916. RED_N.
[Graphical view ]
Pfami PF07807. RED_C. 1 hit.
PF07808. RED_N. 1 hit.
[Graphical view ]
ProDomi PD311621. RED_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat."
    Assier E., Bouzinba-Segard H., Stolzenberg M.-C., Stephens R., Bardos J., Freemont P., Charron D., Trowsdale J., Rich T.
    Gene 230:145-154(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leukemia.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization."
    Krief P., Augery-Bourget Y., Plaisance S., Merck M.F., Assier E., Tanchou V., Billard M., Boucheix C., Jasmin C., Azzarone B.
    Oncogene 9:3449-3456(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 316-477.
    Tissue: Leukemia.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRED_HUMAN
AccessioniPrimary (citable) accession number: Q13123
Secondary accession number(s): Q6IPD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (1 Publication) thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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