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Q13123

- RED_HUMAN

UniProt

Q13123 - RED_HUMAN

Protein

Protein Red

Gene

IK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May bind to chromatin.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. immune response Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Red
    Alternative name(s):
    Cytokine IK
    IK factor
    Protein RER
    Gene namesi
    Name:IK
    Synonyms:RED, RER
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:5958. IK.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29774.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Protein RedPRO_0000097235Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei98 – 981N6-acetyllysine1 Publication
    Modified residuei137 – 1371N6-acetyllysineBy similarity
    Modified residuei460 – 4601Phosphoserine1 Publication
    Modified residuei485 – 4851Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13123.
    PaxDbiQ13123.
    PeptideAtlasiQ13123.
    PRIDEiQ13123.

    PTM databases

    PhosphoSiteiQ13123.

    Miscellaneous databases

    PMAP-CutDBQ13123.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Developmental stagei

    Expressed at similar levels in fetal and adult tissues.

    Gene expression databases

    ArrayExpressiQ13123.
    BgeeiQ13123.
    CleanExiHS_IK.
    GenevestigatoriQ13123.

    Organism-specific databases

    HPAiHPA019754.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-713456,EBI-713456
    AURKAO149653EBI-713456,EBI-448680
    EFTUD2Q150292EBI-713456,EBI-357897
    FRA10AC1Q70Z532EBI-713456,EBI-710176
    MFAP1P550812EBI-713456,EBI-1048159
    PRPF6O949062EBI-713456,EBI-536755
    RBM10P981752EBI-713456,EBI-721525
    revP046183EBI-713456,EBI-6164309From a different organism.
    RNF113AO155412EBI-713456,EBI-2130294
    SMU1Q2TAY72EBI-713456,EBI-298027
    SNIP1Q8TAD82EBI-713456,EBI-749336
    XAB2Q9HCS72EBI-713456,EBI-295232
    ZNF830Q96NB32EBI-713456,EBI-3920997

    Protein-protein interaction databases

    BioGridi109766. 67 interactions.
    IntActiQ13123. 32 interactions.
    MINTiMINT-1371308.
    STRINGi9606.ENSP00000396301.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati342 – 34321
    Repeati344 – 34522
    Repeati346 – 34723
    Repeati348 – 34924
    Repeati350 – 35125
    Repeati352 – 35326
    Repeati354 – 35527
    Repeati356 – 35728
    Repeati358 – 35929
    Repeati360 – 361210
    Repeati362 – 363211
    Repeati364 – 365212
    Repeati366 – 367213
    Repeati368 – 369214
    Repeati370 – 371215
    Repeati372 – 373216
    Repeati374 – 375217

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni342 – 3753417 X 2 AA tandem repeats of R-[ED]Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi184 – 1874Poly-Glu

    Sequence similaritiesi

    Belongs to the RED family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG85622.
    HOGENOMiHOG000007717.
    HOVERGENiHBG017223.
    InParanoidiQ13123.
    KOiK13109.
    OMAiDIDKGPG.
    OrthoDBiEOG7RNK0J.
    PhylomeDBiQ13123.
    TreeFamiTF321907.

    Family and domain databases

    InterProiIPR012492. RED_C.
    IPR012916. RED_N.
    [Graphical view]
    PfamiPF07807. RED_C. 1 hit.
    PF07808. RED_N. 1 hit.
    [Graphical view]
    ProDomiPD311621. RED_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q13123-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA    50
    PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR 100
    DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES 150
    KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS KEKEEEELME KPQKETKKDE 200
    DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT 250
    DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK 300
    KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER 350
    DRDRDRERER ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP 400
    GSTKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP 450
    ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP 500
    KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV 550
    EVKRPKY 557
    Length:557
    Mass (Da):65,602
    Last modified:May 18, 2010 - v3
    Checksum:iBE7B332985D5F4CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761A → L in CAA06607. (PubMed:10216252)Curated
    Sequence conflicti182 – 1821E → D in CAA06607. (PubMed:10216252)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005579 mRNA. Translation: CAA06607.1.
    AC116353 Genomic DNA. No translation available.
    BC071964 mRNA. Translation: AAH71964.1.
    S74221 mRNA. Translation: AAB32531.1.
    CCDSiCCDS47280.1.
    PIRiI58408.
    RefSeqiNP_006074.2. NM_006083.3.
    UniGeneiHs.421245.

    Genome annotation databases

    EnsembliENST00000417647; ENSP00000396301; ENSG00000113141.
    GeneIDi3550.
    KEGGihsa:3550.
    UCSCiuc003lgq.3. human.

    Polymorphism databases

    DMDMi296452987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005579 mRNA. Translation: CAA06607.1 .
    AC116353 Genomic DNA. No translation available.
    BC071964 mRNA. Translation: AAH71964.1 .
    S74221 mRNA. Translation: AAB32531.1 .
    CCDSi CCDS47280.1.
    PIRi I58408.
    RefSeqi NP_006074.2. NM_006083.3.
    UniGenei Hs.421245.

    3D structure databases

    ProteinModelPortali Q13123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109766. 67 interactions.
    IntActi Q13123. 32 interactions.
    MINTi MINT-1371308.
    STRINGi 9606.ENSP00000396301.

    Chemistry

    ChEMBLi CHEMBL2321616.

    PTM databases

    PhosphoSitei Q13123.

    Polymorphism databases

    DMDMi 296452987.

    Proteomic databases

    MaxQBi Q13123.
    PaxDbi Q13123.
    PeptideAtlasi Q13123.
    PRIDEi Q13123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000417647 ; ENSP00000396301 ; ENSG00000113141 .
    GeneIDi 3550.
    KEGGi hsa:3550.
    UCSCi uc003lgq.3. human.

    Organism-specific databases

    CTDi 3550.
    GeneCardsi GC05P140028.
    HGNCi HGNC:5958. IK.
    HPAi HPA019754.
    MIMi 600549. gene.
    neXtProti NX_Q13123.
    PharmGKBi PA29774.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85622.
    HOGENOMi HOG000007717.
    HOVERGENi HBG017223.
    InParanoidi Q13123.
    KOi K13109.
    OMAi DIDKGPG.
    OrthoDBi EOG7RNK0J.
    PhylomeDBi Q13123.
    TreeFami TF321907.

    Miscellaneous databases

    ChiTaRSi IK. human.
    GeneWikii IK_(gene).
    GenomeRNAii 3550.
    NextBioi 13860.
    PMAP-CutDB Q13123.
    PROi Q13123.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13123.
    Bgeei Q13123.
    CleanExi HS_IK.
    Genevestigatori Q13123.

    Family and domain databases

    InterProi IPR012492. RED_C.
    IPR012916. RED_N.
    [Graphical view ]
    Pfami PF07807. RED_C. 1 hit.
    PF07808. RED_N. 1 hit.
    [Graphical view ]
    ProDomi PD311621. RED_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat."
      Assier E., Bouzinba-Segard H., Stolzenberg M.-C., Stephens R., Bardos J., Freemont P., Charron D., Trowsdale J., Rich T.
      Gene 230:145-154(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Leukemia.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization."
      Krief P., Augery-Bourget Y., Plaisance S., Merck M.F., Assier E., Tanchou V., Billard M., Boucheix C., Jasmin C., Azzarone B.
      Oncogene 9:3449-3456(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 316-477.
      Tissue: Leukemia.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRED_HUMAN
    AccessioniPrimary (citable) accession number: Q13123
    Secondary accession number(s): Q6IPD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3