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Q13123 (RED_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Red
Alternative name(s):
Cytokine IK
IK factor
Protein RER
Gene names
Name:IK
Synonyms:RED, RER
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind to chromatin.

Subcellular location

Nucleus.

Tissue specificity

Ubiquitous.

Developmental stage

Expressed at similar levels in fetal and adult tissues.

Sequence similarities

Belongs to the RED family.

Caution

Was originally (Ref.4) thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell-cell signaling

Traceable author statement Ref.4. Source: ProtInc

immune response

Traceable author statement Ref.4. Source: ProtInc

   Cellular_componentextracellular space

Traceable author statement Ref.4. Source: ProtInc

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionidentical protein binding

Inferred from physical interaction PubMed 22365833. Source: IntAct

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Protein Red
PRO_0000097235

Regions

Repeat342 – 34321
Repeat344 – 34522
Repeat346 – 34723
Repeat348 – 34924
Repeat350 – 35125
Repeat352 – 35326
Repeat354 – 35527
Repeat356 – 35728
Repeat358 – 35929
Repeat360 – 361210
Repeat362 – 363211
Repeat364 – 365212
Repeat366 – 367213
Repeat368 – 369214
Repeat370 – 371215
Repeat372 – 373216
Repeat374 – 375217
Region342 – 3753417 X 2 AA tandem repeats of R-[ED]
Compositional bias184 – 1874Poly-Glu

Amino acid modifications

Modified residue981N6-acetyllysine Ref.8
Modified residue1371N6-acetyllysine By similarity
Modified residue4601Phosphoserine Ref.6
Modified residue4851Phosphothreonine Ref.5

Experimental info

Sequence conflict1761A → L in CAA06607. Ref.1
Sequence conflict1821E → D in CAA06607. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q13123 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: BE7B332985D5F4CA

FASTA55765,602
        10         20         30         40         50         60 
MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM 

        70         80         90        100        110        120 
PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI 

       130        140        150        160        170        180 
STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS 

       190        200        210        220        230        240 
KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV 

       250        260        270        280        290        300 
VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK 

       310        320        330        340        350        360 
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER 

       370        380        390        400        410        420 
ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW 

       430        440        450        460        470        480 
EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR 

       490        500        510        520        530        540 
WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE 

       550 
KRKKMEADGV EVKRPKY 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat."
Assier E., Bouzinba-Segard H., Stolzenberg M.-C., Stephens R., Bardos J., Freemont P., Charron D., Trowsdale J., Rich T.
Gene 230:145-154(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leukemia.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization."
Krief P., Augery-Bourget Y., Plaisance S., Merck M.F., Assier E., Tanchou V., Billard M., Boucheix C., Jasmin C., Azzarone B.
Oncogene 9:3449-3456(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 316-477.
Tissue: Leukemia.
[5]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ005579 mRNA. Translation: CAA06607.1.
AC116353 Genomic DNA. No translation available.
BC071964 mRNA. Translation: AAH71964.1.
S74221 mRNA. Translation: AAB32531.1.
PIRI58408.
RefSeqNP_006074.2. NM_006083.3.
UniGeneHs.421245.

3D structure databases

ProteinModelPortalQ13123.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109766. 64 interactions.
IntActQ13123. 30 interactions.
MINTMINT-1371308.
STRING9606.ENSP00000396301.

Chemistry

ChEMBLCHEMBL2321616.

PTM databases

PhosphoSiteQ13123.

Polymorphism databases

DMDM296452987.

Proteomic databases

PaxDbQ13123.
PeptideAtlasQ13123.
PRIDEQ13123.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000417647; ENSP00000396301; ENSG00000113141.
GeneID3550.
KEGGhsa:3550.
UCSCuc003lgq.3. human.

Organism-specific databases

CTD3550.
GeneCardsGC05P140028.
HGNCHGNC:5958. IK.
HPAHPA019754.
MIM600549. gene.
neXtProtNX_Q13123.
PharmGKBPA29774.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85622.
HOGENOMHOG000007717.
HOVERGENHBG017223.
InParanoidQ13123.
KOK13109.
OMADIDKGPG.
OrthoDBEOG7RNK0J.
PhylomeDBQ13123.
TreeFamTF321907.

Gene expression databases

ArrayExpressQ13123.
BgeeQ13123.
CleanExHS_IK.
GenevestigatorQ13123.

Family and domain databases

InterProIPR012492. RED_C.
IPR012916. RED_N.
[Graphical view]
PfamPF07807. RED_C. 1 hit.
PF07808. RED_N. 1 hit.
[Graphical view]
ProDomPD311621. RED_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

ChiTaRSIK. human.
GeneWikiIK_(gene).
GenomeRNAi3550.
NextBio13860.
PMAP-CutDBQ13123.
PROQ13123.
SOURCESearch...

Entry information

Entry nameRED_HUMAN
AccessionPrimary (citable) accession number: Q13123
Secondary accession number(s): Q6IPD8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM