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Q13118

- KLF10_HUMAN

UniProt

Q13118 - KLF10_HUMAN

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Protein

Krueppel-like factor 10

Gene

KLF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri369 – 39325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cell-cell signaling Source: ProtInc
  3. cell proliferation Source: ProtInc
  4. cellular response to peptide Source: Ensembl
  5. cellular response to starvation Source: UniProtKB
  6. negative regulation of cell proliferation Source: ProtInc
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  9. positive regulation of osteoclast differentiation Source: Ensembl
  10. regulation of circadian rhythm Source: UniProtKB
  11. skeletal system development Source: ProtInc
  12. somatic stem cell maintenance Source: Ensembl
  13. transcription, DNA-templated Source: UniProtKB-KW
  14. transforming growth factor beta receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
EGR-alpha
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
Gene namesi
Name:KLF10
Synonyms:TIEG, TIEG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:11810. KLF10.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Krueppel-like factor 10PRO_0000047177Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ13118.
PaxDbiQ13118.
PRIDEiQ13118.

PTM databases

PhosphoSiteiQ13118.

Expressioni

Inductioni

By TGFB1 and BMP2.1 Publication

Gene expression databases

BgeeiQ13118.
CleanExiHS_KLF10.
GenevestigatoriQ13118.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SP1P080472EBI-1389509,EBI-298336

Protein-protein interaction databases

BioGridi112927. 17 interactions.
IntActiQ13118. 15 interactions.
MINTiMINT-144333.
STRINGi9606.ENSP00000285407.

Structurei

Secondary structure

1
480
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni374 – 3763
Beta strandi379 – 3824
Helixi383 – 39311
Beta strandi394 – 3963
Beta strandi398 – 4003
Beta strandi409 – 4124
Helixi413 – 4197
Turni420 – 4223

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EPANMR-A359-423[»]
ProteinModelPortaliQ13118.
SMRiQ13118. Positions 353-452.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13118.

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri369 – 39325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiQ13118.
KOiK09209.
OMAiVQNPKPP.
OrthoDBiEOG7FJH0Q.
PhylomeDBiQ13118.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13118-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC
60 70 80 90 100
SWKSDFKKYV ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD
110 120 130 140 150
FEPSQVSNLM APAPSTVHFK SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA
160 170 180 190 200
QATSVIRHTA DAQLCNHQTC PMKAASILNY QNNSFRRRTH LNVEAARKNI
210 220 230 240 250
PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI CRSQPAPVSP
260 270 280 290 300
QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA
310 320 330 340 350
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF
360 370 380 390 400
SPSAAKVTPQ IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS
410 420 430 440 450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
460 470 480
HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ
Length:480
Mass (Da):52,555
Last modified:November 1, 1996 - v1
Checksum:i78B1EBB0DB97579D
GO
Isoform 2 (identifier: Q13118-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M

Note: No experimental confirmation available.

Show »
Length:469
Mass (Da):51,424
Checksum:iE825F2BA7D5F74BD
GO
Isoform 3 (identifier: Q13118-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-102: CLTPPYSPSDFE → QQKSLLRLIHQG
     103-480: Missing.

Show »
Length:91
Mass (Da):10,600
Checksum:i333972E3AEDCCBCD
GO
Isoform 4 (identifier: Q13118-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-134: CLTPPYSPSD...TAKPHIAAPF → EKSLSAVAGK...LRAPCVTGGS
     135-480: Missing.

Show »
Length:123
Mass (Da):13,702
Checksum:i23B95EC936A769C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491S → F.
Corresponds to variant rs4734653 [ dbSNP | Ensembl ].
VAR_052716

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212MLNFG…LQQTA → M in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_042653Add
BLAST
Alternative sequencei91 – 13444CLTPP…IAAPF → EKSLSAVAGKVVKGGLPVLM NCPDTGEPTRVRRNLRAPCV TGGS in isoform 4. 1 PublicationVSP_047482Add
BLAST
Alternative sequencei91 – 10212CLTPP…PSDFE → QQKSLLRLIHQG in isoform 3. 1 PublicationVSP_047483Add
BLAST
Alternative sequencei103 – 480378Missing in isoform 3. 1 PublicationVSP_047484Add
BLAST
Alternative sequencei135 – 480346Missing in isoform 4. 1 PublicationVSP_047485Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S81439 mRNA. Translation: AAB36088.1.
U21847 mRNA. Translation: AAC50340.1.
AF050110 Genomic DNA. Translation: AAC34293.1.
AF050110 Genomic DNA. Translation: AAC34294.1.
HF546210 mRNA. Translation: CCO02796.1.
HF546211 mRNA. Translation: CCO02797.1.
BT006634 mRNA. Translation: AAP35280.1.
AK312894 mRNA. Translation: BAG35741.1.
AP002851 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91850.1.
BC011538 mRNA. Translation: AAH11538.1.
BC095399 mRNA. Translation: AAH95399.1.
CCDSiCCDS47905.1. [Q13118-2]
CCDS6294.1. [Q13118-1]
RefSeqiNP_001027453.1. NM_001032282.3. [Q13118-2]
NP_005646.1. NM_005655.3. [Q13118-1]
UniGeneiHs.435001.

Genome annotation databases

EnsembliENST00000285407; ENSP00000285407; ENSG00000155090. [Q13118-1]
ENST00000395884; ENSP00000379222; ENSG00000155090. [Q13118-2]
GeneIDi7071.
KEGGihsa:7071.
UCSCiuc011lhj.1. human. [Q13118-2]
uc011lhk.1. human. [Q13118-1]

Polymorphism databases

DMDMi11387050.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S81439 mRNA. Translation: AAB36088.1 .
U21847 mRNA. Translation: AAC50340.1 .
AF050110 Genomic DNA. Translation: AAC34293.1 .
AF050110 Genomic DNA. Translation: AAC34294.1 .
HF546210 mRNA. Translation: CCO02796.1 .
HF546211 mRNA. Translation: CCO02797.1 .
BT006634 mRNA. Translation: AAP35280.1 .
AK312894 mRNA. Translation: BAG35741.1 .
AP002851 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91850.1 .
BC011538 mRNA. Translation: AAH11538.1 .
BC095399 mRNA. Translation: AAH95399.1 .
CCDSi CCDS47905.1. [Q13118-2 ]
CCDS6294.1. [Q13118-1 ]
RefSeqi NP_001027453.1. NM_001032282.3. [Q13118-2 ]
NP_005646.1. NM_005655.3. [Q13118-1 ]
UniGenei Hs.435001.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EPA NMR - A 359-423 [» ]
ProteinModelPortali Q13118.
SMRi Q13118. Positions 353-452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112927. 17 interactions.
IntActi Q13118. 15 interactions.
MINTi MINT-144333.
STRINGi 9606.ENSP00000285407.

PTM databases

PhosphoSitei Q13118.

Polymorphism databases

DMDMi 11387050.

Proteomic databases

MaxQBi Q13118.
PaxDbi Q13118.
PRIDEi Q13118.

Protocols and materials databases

DNASUi 7071.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285407 ; ENSP00000285407 ; ENSG00000155090 . [Q13118-1 ]
ENST00000395884 ; ENSP00000379222 ; ENSG00000155090 . [Q13118-2 ]
GeneIDi 7071.
KEGGi hsa:7071.
UCSCi uc011lhj.1. human. [Q13118-2 ]
uc011lhk.1. human. [Q13118-1 ]

Organism-specific databases

CTDi 7071.
GeneCardsi GC08M103661.
HGNCi HGNC:11810. KLF10.
MIMi 601878. gene.
neXtProti NX_Q13118.
PharmGKBi PA36517.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118984.
HOGENOMi HOG000059558.
HOVERGENi HBG052264.
InParanoidi Q13118.
KOi K09209.
OMAi VQNPKPP.
OrthoDBi EOG7FJH0Q.
PhylomeDBi Q13118.
TreeFami TF315506.

Miscellaneous databases

EvolutionaryTracei Q13118.
GeneWikii KLF10.
GenomeRNAii 7071.
NextBioi 27649.
PROi Q13118.
SOURCEi Search...

Gene expression databases

Bgeei Q13118.
CleanExi HS_KLF10.
Genevestigatori Q13118.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation."
    Blok L.J., Grossmann M.E., Perry J.E., Tindall D.J.
    Mol. Endocrinol. 9:1610-1620(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
  2. "Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts."
    Subramaniam M., Harris S.A., Oursler M.J., Rasmussen K., Riggs B.L., Spelsberg T.C.
    Nucleic Acids Res. 23:4907-4912(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
  3. "TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters."
    Fautsch M.P., Vrabel A., Subramaniam M., Hefferen T.E., Spelsberg T.C., Wieben E.D.
    Genomics 51:408-416(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
    Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
    FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), ALTERNATIVE SPLICING.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  7. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Placenta.
  10. "Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue."
    Johnsen S.A., Subramaniam M., Monroe D.G., Janknecht R., Spelsberg T.C.
    J. Biol. Chem. 277:30754-30759(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIAH1, UBIQUITINATION, PROTEASOMAL DEGRADATION.
  11. "Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha."
    Chrisman H.R., Tindall D.J.
    DNA Cell Biol. 22:187-199(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Solution structure of the first and second ZF-C2H2 domains from human krueppel-like factor 10."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 353-423.

Entry informationi

Entry nameiKLF10_HUMAN
AccessioniPrimary (citable) accession number: Q13118
Secondary accession number(s): A8MVH0
, B2R794, L0R4P6, L0R679, O75411, Q503B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3