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Protein

TNF receptor-associated factor 3

Gene

TRAF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 7710RING-typePROSITE-ProRule annotation
Zinc fingeri135 – 19056TRAF-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri191 – 24959TRAF-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • protein phosphatase binding Source: UniProtKB
  • signal transducer activity Source: ProtInc
  • thioesterase binding Source: UniProtKB
  • tumor necrosis factor receptor binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB
  • ubiquitin-protein transferase activity Source: Reactome
  • zinc ion binding Source: InterPro

GO - Biological processi

  • apoptotic process Source: ProtInc
  • innate immune response Source: InterPro
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of type I interferon production Source: Reactome
  • regulation of apoptotic process Source: InterPro
  • regulation of cytokine production Source: UniProtKB
  • regulation of defense response to virus Source: UniProtKB
  • regulation of interferon-beta production Source: UniProtKB
  • regulation of proteolysis Source: UniProtKB
  • signal transduction Source: ProtInc
  • toll-like receptor signaling pathway Source: UniProtKB
  • Toll signaling pathway Source: InterPro
  • TRIF-dependent toll-like receptor signaling pathway Source: Reactome
  • tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Immunity, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5602571. TRAF3 deficiency - HSE.
R-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
R-HSA-918233. TRAF3-dependent IRF activation pathway.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.
R-HSA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
SignaLinkiQ13114.
SIGNORiQ13114.

Names & Taxonomyi

Protein namesi
Recommended name:
TNF receptor-associated factor 3 (EC:6.3.2.-)
Alternative name(s):
CAP-1
CD40 receptor-associated factor 1
Short name:
CRAF1
CD40-binding protein
Short name:
CD40BP
LMP1-associated protein 1
Short name:
LAP1
Gene namesi
Name:TRAF3
Synonyms:CAP1, CRAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:12033. TRAF3.

Subcellular locationi

  • Cytoplasm Curated
  • Endosome By similarity
  • Mitochondrion

  • Note: Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Herpes simplex encephalitis 3 (HSE3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
See also OMIM:614849
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181R → W in HSE3. 1 Publication
Corresponds to variant rs143813189 [ dbSNP | Ensembl ].
VAR_069081

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi441 – 4411Y → A: Abolishes interaction with RNF216; when associated with A-443. 1 Publication
Mutagenesisi443 – 4431Q → A: Abolishes interaction with RNF216; when associated with A-441. 1 Publication
Mutagenesisi459 – 4591Y → A: Abolishes interaction with LTBR, CD40 and TANK. 1 Publication
Mutagenesisi512 – 5121F → E: Abolishes interaction with LTBR, CD40 and TANK. 1 Publication
Mutagenesisi521 – 5211F → A: Abolishes interaction with LTBR, CD40 and TANK. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiTRAF3.
MIMi614849. phenotype.
Orphaneti1930. Herpetic encephalitis.
PharmGKBiPA36710.

Polymorphism and mutation databases

BioMutaiTRAF3.
DMDMi116242824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568TNF receptor-associated factor 3PRO_0000056401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineCombined sources

Post-translational modificationi

Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by OTUB1, OTUB2 and OTUD5.5 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13114.
MaxQBiQ13114.
PaxDbiQ13114.
PeptideAtlasiQ13114.
PRIDEiQ13114.

PTM databases

iPTMnetiQ13114.
PhosphoSiteiQ13114.

Miscellaneous databases

PMAP-CutDBQ13114.

Expressioni

Gene expression databases

BgeeiENSG00000131323.
CleanExiHS_CAP1.
HS_TRAF3.
ExpressionAtlasiQ13114. baseline and differential.
GenevisibleiQ13114. HS.

Organism-specific databases

HPAiHPA002933.

Interactioni

Subunit structurei

Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N (By similarity). Interacts with Epstein-Barr virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Interacts with CARD14. Interacts (via MATH domain) with PTPN22; the interaction promotes TRAF3 polyubiquitination (PubMed:23871208).By similarity36 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Azi2Q9QYP62EBI-357631,EBI-6115874From a different organism.
BRAFP150562EBI-357631,EBI-365980
CD40P259423EBI-357631,EBI-525714
Irf1P153142EBI-357631,EBI-6115486From a different organism.
PTPN22Q9Y2R22EBI-357631,EBI-1211241
RIPK2O433535EBI-357631,EBI-358522
TANKQ928444EBI-357631,EBI-356349
TRAF3IP1Q8TDR08EBI-357631,EBI-928811
Zbp1A2APF72EBI-357631,EBI-6115394From a different organism.
ZMYND11Q153262EBI-357631,EBI-2623509

GO - Molecular functioni

  • protein phosphatase binding Source: UniProtKB
  • thioesterase binding Source: UniProtKB
  • tumor necrosis factor receptor binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113039. 104 interactions.
DIPiDIP-6222N.
IntActiQ13114. 33 interactions.
MINTiMINT-1144408.
STRINGi9606.ENSP00000376500.

Structurei

Secondary structure

1
568
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni54 – 563Combined sources
Beta strandi59 – 624Combined sources
Beta strandi67 – 693Combined sources
Helixi74 – 818Combined sources
Turni89 – 913Combined sources
Turni97 – 993Combined sources
Turni365 – 3739Combined sources
Turni375 – 3773Combined sources
Helixi378 – 41033Combined sources
Beta strandi415 – 4239Combined sources
Helixi425 – 4339Combined sources
Beta strandi438 – 4414Combined sources
Beta strandi445 – 4484Combined sources
Beta strandi453 – 4597Combined sources
Helixi464 – 4663Combined sources
Turni467 – 4693Combined sources
Beta strandi470 – 4789Combined sources
Helixi483 – 4853Combined sources
Beta strandi494 – 4985Combined sources
Beta strandi502 – 5043Combined sources
Beta strandi508 – 5125Combined sources
Beta strandi521 – 5233Combined sources
Beta strandi525 – 5284Combined sources
Beta strandi532 – 5398Combined sources
Helixi540 – 5456Combined sources
Beta strandi553 – 5608Combined sources
Beta strandi563 – 5653Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FLKX-ray2.80A/B341-568[»]
1FLLX-ray3.50A/B341-568[»]
1KZZX-ray3.50A377-568[»]
1L0AX-ray2.90A377-568[»]
1RF3X-ray3.50A377-568[»]
1ZMSX-ray2.80A377-568[»]
2ECYNMR-A43-101[»]
2GKWX-ray2.70A377-568[»]
ProteinModelPortaliQ13114.
SMRiQ13114. Positions 38-198, 364-568.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13114.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini415 – 560146MATHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili267 – 33872Sequence analysisAdd
BLAST

Domaini

The MATH/TRAF domain binds to receptor cytoplasmic domains.
The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing.By similarity

Sequence similaritiesi

Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 2 TRAF-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 7710RING-typePROSITE-ProRule annotation
Zinc fingeri135 – 19056TRAF-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri191 – 24959TRAF-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ISDV. Eukaryota.
ENOG410YQ97. LUCA.
GeneTreeiENSGT00550000074359.
HOVERGENiHBG058222.
InParanoidiQ13114.
KOiK03174.
OMAiFCETCMA.
OrthoDBiEOG091G0GHD.
PhylomeDBiQ13114.
TreeFamiTF321154.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027128. TRAF3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF76. PTHR10131:SF76. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13114-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK
60 70 80 90 100
YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV
110 120 130 140 150
FKDNCCKREI LALQIYCRNE SRGCAEQLML GHLLVHLKND CHFEELPCVR
160 170 180 190 200
PDCKEKVLRK DLRDHVEKAC KYREATCSHC KSQVPMIALQ KHEDTDCPCV
210 220 230 240 250
VVSCPHKCSV QTLLRSELSA HLSECVNAPS TCSFKRYGCV FQGTNQQIKA
260 270 280 290 300
HEASSAVQHV NLLKEWSNSL EKKVSLLQNE SVEKNKSIQS LHNQICSFEI
310 320 330 340 350
EIERQKEMLR NNESKILHLQ RVIDSQAEKL KELDKEIRPF RQNWEEADSM
360 370 380 390 400
KSSVESLQNR VTELESVDKS AGQVARNTGL LESQLSRHDQ MLSVHDIRLA
410 420 430 440 450
DMDLRFQVLE TASYNGVLIW KIRDYKRRKQ EAVMGKTLSL YSQPFYTGYF
460 470 480 490 500
GYKMCARVYL NGDGMGKGTH LSLFFVIMRG EYDALLPWPF KQKVTLMLMD
510 520 530 540 550
QGSSRRHLGD AFKPDPNSSS FKKPTGEMNI ASGCPVFVAQ TVLENGTYIK
560
DDTIFIKVIV DTSDLPDP
Length:568
Mass (Da):64,490
Last modified:October 17, 2006 - v2
Checksum:i9456E440C0A90FBF
GO
Isoform 2 (identifier: Q13114-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-273: Missing.

Show »
Length:485
Mass (Da):55,306
Checksum:i1280A3E1B054768D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341Missing in AAA56753 (PubMed:7533327).Curated
Sequence conflicti158 – 1581L → F in BAH13910 (PubMed:14702039).Curated
Sequence conflicti218 – 24225Missing in AAA68195 (PubMed:7530216).CuratedAdd
BLAST
Sequence conflicti339 – 3391P → S in AAA68195 (PubMed:7530216).Curated
Sequence conflicti405 – 4051R → G in AAA56753 (PubMed:7533327).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181R → W in HSE3. 1 Publication
Corresponds to variant rs143813189 [ dbSNP | Ensembl ].
VAR_069081
Natural varianti129 – 1291M → T.2 Publications
Corresponds to variant rs1131877 [ dbSNP | Ensembl ].
VAR_052149

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei191 – 27383Missing in isoform 2. 1 PublicationVSP_040040Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15637 mRNA. Translation: AAA56753.1.
U19260 mRNA. Translation: AAA65732.1.
L38509 mRNA. Translation: AAA68195.1.
U21092 mRNA. Translation: AAC50112.1.
BX247977 mRNA. Translation: CAD62311.1.
AK303172 mRNA. Translation: BAH13910.1.
AL117209 Genomic DNA. No translation available.
BC075087 mRNA. Translation: AAH75087.1.
BC075086 mRNA. Translation: AAH75086.1.
AF110908 mRNA. Translation: AAD29276.1.
CCDSiCCDS55946.1. [Q13114-2]
CCDS9975.1. [Q13114-1]
PIRiA55960.
S68467.
RefSeqiNP_001186356.1. NM_001199427.1. [Q13114-2]
NP_003291.2. NM_003300.3. [Q13114-1]
NP_663777.1. NM_145725.2. [Q13114-1]
NP_663778.1. NM_145726.2.
XP_011535420.1. XM_011537118.2. [Q13114-2]
UniGeneiHs.510528.

Genome annotation databases

EnsembliENST00000392745; ENSP00000376500; ENSG00000131323. [Q13114-1]
ENST00000539721; ENSP00000445998; ENSG00000131323. [Q13114-2]
ENST00000560371; ENSP00000454207; ENSG00000131323. [Q13114-1]
GeneIDi7187.
KEGGihsa:7187.
UCSCiuc001ymc.3. human. [Q13114-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15637 mRNA. Translation: AAA56753.1.
U19260 mRNA. Translation: AAA65732.1.
L38509 mRNA. Translation: AAA68195.1.
U21092 mRNA. Translation: AAC50112.1.
BX247977 mRNA. Translation: CAD62311.1.
AK303172 mRNA. Translation: BAH13910.1.
AL117209 Genomic DNA. No translation available.
BC075087 mRNA. Translation: AAH75087.1.
BC075086 mRNA. Translation: AAH75086.1.
AF110908 mRNA. Translation: AAD29276.1.
CCDSiCCDS55946.1. [Q13114-2]
CCDS9975.1. [Q13114-1]
PIRiA55960.
S68467.
RefSeqiNP_001186356.1. NM_001199427.1. [Q13114-2]
NP_003291.2. NM_003300.3. [Q13114-1]
NP_663777.1. NM_145725.2. [Q13114-1]
NP_663778.1. NM_145726.2.
XP_011535420.1. XM_011537118.2. [Q13114-2]
UniGeneiHs.510528.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FLKX-ray2.80A/B341-568[»]
1FLLX-ray3.50A/B341-568[»]
1KZZX-ray3.50A377-568[»]
1L0AX-ray2.90A377-568[»]
1RF3X-ray3.50A377-568[»]
1ZMSX-ray2.80A377-568[»]
2ECYNMR-A43-101[»]
2GKWX-ray2.70A377-568[»]
ProteinModelPortaliQ13114.
SMRiQ13114. Positions 38-198, 364-568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113039. 104 interactions.
DIPiDIP-6222N.
IntActiQ13114. 33 interactions.
MINTiMINT-1144408.
STRINGi9606.ENSP00000376500.

PTM databases

iPTMnetiQ13114.
PhosphoSiteiQ13114.

Polymorphism and mutation databases

BioMutaiTRAF3.
DMDMi116242824.

Proteomic databases

EPDiQ13114.
MaxQBiQ13114.
PaxDbiQ13114.
PeptideAtlasiQ13114.
PRIDEiQ13114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392745; ENSP00000376500; ENSG00000131323. [Q13114-1]
ENST00000539721; ENSP00000445998; ENSG00000131323. [Q13114-2]
ENST00000560371; ENSP00000454207; ENSG00000131323. [Q13114-1]
GeneIDi7187.
KEGGihsa:7187.
UCSCiuc001ymc.3. human. [Q13114-1]

Organism-specific databases

CTDi7187.
GeneCardsiTRAF3.
HGNCiHGNC:12033. TRAF3.
HPAiHPA002933.
MalaCardsiTRAF3.
MIMi601896. gene.
614849. phenotype.
neXtProtiNX_Q13114.
Orphaneti1930. Herpetic encephalitis.
PharmGKBiPA36710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISDV. Eukaryota.
ENOG410YQ97. LUCA.
GeneTreeiENSGT00550000074359.
HOVERGENiHBG058222.
InParanoidiQ13114.
KOiK03174.
OMAiFCETCMA.
OrthoDBiEOG091G0GHD.
PhylomeDBiQ13114.
TreeFamiTF321154.

Enzyme and pathway databases

ReactomeiR-HSA-5602571. TRAF3 deficiency - HSE.
R-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
R-HSA-918233. TRAF3-dependent IRF activation pathway.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.
R-HSA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
SignaLinkiQ13114.
SIGNORiQ13114.

Miscellaneous databases

ChiTaRSiTRAF3. human.
EvolutionaryTraceiQ13114.
GeneWikiiTRAF3.
GenomeRNAii7187.
PMAP-CutDBQ13114.
PROiQ13114.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131323.
CleanExiHS_CAP1.
HS_TRAF3.
ExpressionAtlasiQ13114. baseline and differential.
GenevisibleiQ13114. HS.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027128. TRAF3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF76. PTHR10131:SF76. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRAF3_HUMAN
AccessioniPrimary (citable) accession number: Q13114
Secondary accession number(s): B7Z8C4
, Q12990, Q13076, Q13947, Q6AZX1, Q9UNL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 189 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.