Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PDZK1-interacting protein 1

Gene

PDZK1IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in tumor biology.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PDZK1-interacting protein 1
Alternative name(s):
17 kDa membrane-associated protein
Protein DD96
Gene namesi
Name:PDZK1IP1
Synonyms:MAP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16887. PDZK1IP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10158.
OpenTargetsiENSG00000162366.
PharmGKBiPA142671188.

Polymorphism and mutation databases

BioMutaiPDZK1IP1.
DMDMi6225642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582821 – 114PDZK1-interacting protein 1Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ13113.
PeptideAtlasiQ13113.
PRIDEiQ13113.

PTM databases

iPTMnetiQ13113.
PhosphoSitePlusiQ13113.
SwissPalmiQ13113.

Expressioni

Tissue specificityi

Expressed at significant levels only in a single epithelial cell population, the proximal tubular epithelial cells of the kidney. Diffusely expressed in various carcinomas originating from kidney, colon, lung and breast.

Gene expression databases

BgeeiENSG00000162366.
CleanExiHS_PDZK1IP1.
GenevisibleiQ13113. HS.

Organism-specific databases

HPAiHPA014907.

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

Protein-protein interaction databases

BioGridi115460. 4 interactors.
IntActiQ13113. 3 interactors.
MINTiMINT-1386526.
STRINGi9606.ENSP00000294338.

Structurei

3D structure databases

ProteinModelPortaliQ13113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J305. Eukaryota.
ENOG41116TZ. LUCA.
GeneTreeiENSGT00390000014478.
HOGENOMiHOG000231172.
HOVERGENiHBG080155.
InParanoidiQ13113.
OMAiVNRFWCK.
OrthoDBiEOG091G13G3.
PhylomeDBiQ13113.
TreeFamiTF328829.

Family and domain databases

InterProiIPR026628. PDZK-int_prot1.
IPR031627. PDZK1IP1/SMIM24.
[Graphical view]
PANTHERiPTHR15296:SF0. PTHR15296:SF0. 1 hit.
PfamiPF15807. MAP17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALSLLILG LLTAVPPASC QQGLGNLQPW MQGLIAVAVF LVLVAIAFAV
60 70 80 90 100
NHFWCQEEPE PAHMILTVGN KADGVLVGTD GRYSSMAASF RSSEHENAYE
110
NVPEEEGKVR STPM
Length:114
Mass (Da):12,227
Last modified:November 1, 1996 - v1
Checksum:i7DEB64C3AF78CB18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13T → M in AAH12303 (PubMed:15489334).Curated1
Sequence conflicti51N → K in AAH12303 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21049 mRNA. Translation: AAA92690.1.
CR450304 mRNA. Translation: CAG29300.1.
AL135960 Genomic DNA. Translation: CAB72104.1.
CH471059 Genomic DNA. Translation: EAX06878.1.
BC012303 mRNA. Translation: AAH12303.1.
CCDSiCCDS546.1.
RefSeqiNP_005755.1. NM_005764.3.
UniGeneiHs.431099.

Genome annotation databases

EnsembliENST00000294338; ENSP00000294338; ENSG00000162366.
ENST00000371885; ENSP00000360952; ENSG00000162366.
GeneIDi10158.
KEGGihsa:10158.
UCSCiuc001cqw.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21049 mRNA. Translation: AAA92690.1.
CR450304 mRNA. Translation: CAG29300.1.
AL135960 Genomic DNA. Translation: CAB72104.1.
CH471059 Genomic DNA. Translation: EAX06878.1.
BC012303 mRNA. Translation: AAH12303.1.
CCDSiCCDS546.1.
RefSeqiNP_005755.1. NM_005764.3.
UniGeneiHs.431099.

3D structure databases

ProteinModelPortaliQ13113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115460. 4 interactors.
IntActiQ13113. 3 interactors.
MINTiMINT-1386526.
STRINGi9606.ENSP00000294338.

PTM databases

iPTMnetiQ13113.
PhosphoSitePlusiQ13113.
SwissPalmiQ13113.

Polymorphism and mutation databases

BioMutaiPDZK1IP1.
DMDMi6225642.

Proteomic databases

PaxDbiQ13113.
PeptideAtlasiQ13113.
PRIDEiQ13113.

Protocols and materials databases

DNASUi10158.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294338; ENSP00000294338; ENSG00000162366.
ENST00000371885; ENSP00000360952; ENSG00000162366.
GeneIDi10158.
KEGGihsa:10158.
UCSCiuc001cqw.4. human.

Organism-specific databases

CTDi10158.
DisGeNETi10158.
GeneCardsiPDZK1IP1.
HGNCiHGNC:16887. PDZK1IP1.
HPAiHPA014907.
MIMi607178. gene.
neXtProtiNX_Q13113.
OpenTargetsiENSG00000162366.
PharmGKBiPA142671188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J305. Eukaryota.
ENOG41116TZ. LUCA.
GeneTreeiENSGT00390000014478.
HOGENOMiHOG000231172.
HOVERGENiHBG080155.
InParanoidiQ13113.
OMAiVNRFWCK.
OrthoDBiEOG091G13G3.
PhylomeDBiQ13113.
TreeFamiTF328829.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162366-MONOMER.

Miscellaneous databases

ChiTaRSiPDZK1IP1. human.
GeneWikiiPDZK1IP1.
GenomeRNAii10158.
PROiQ13113.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162366.
CleanExiHS_PDZK1IP1.
GenevisibleiQ13113. HS.

Family and domain databases

InterProiIPR026628. PDZK-int_prot1.
IPR031627. PDZK1IP1/SMIM24.
[Graphical view]
PANTHERiPTHR15296:SF0. PTHR15296:SF0. 1 hit.
PfamiPF15807. MAP17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDZ1I_HUMAN
AccessioniPrimary (citable) accession number: Q13113
Secondary accession number(s): Q6ICT9, Q96EI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.