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Protein

Zinc finger protein 154

Gene

ZNF154

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 111C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri133 – 155C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri161 – 183C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179909-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 154
Gene namesi
Name:ZNF154
Synonyms:KIAA2003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12939. ZNF154.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7710.
OpenTargetsiENSG00000179909.
PharmGKBiPA37523.

Polymorphism and mutation databases

BioMutaiZNF154.
DMDMi143811477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474301 – 437Zinc finger protein 154Add BLAST437

Proteomic databases

EPDiQ13106.
MaxQBiQ13106.
PaxDbiQ13106.
PeptideAtlasiQ13106.
PRIDEiQ13106.

PTM databases

iPTMnetiQ13106.
PhosphoSitePlusiQ13106.

Expressioni

Gene expression databases

BgeeiENSG00000179909.
CleanExiHS_ZNF154.
ExpressionAtlasiQ13106. baseline and differential.
GenevisibleiQ13106. HS.

Interactioni

Protein-protein interaction databases

IntActiQ13106. 1 interactor.
STRINGi9606.ENSP00000421258.

Structurei

3D structure databases

ProteinModelPortaliQ13106.
SMRiQ13106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 88KRABPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 111C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri133 – 155C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri161 – 183C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ13106.
KOiK09228.
OMAiTHYNCGE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ13106.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATLRTPT QGTVTFEDVA VHFSWEEWGL LDEAQRCLYR DVMLENLALL
60 70 80 90 100
TSLDVHHQKQ HLGEKHFRSN VGRALFVKTC TFHVSGEPST CREVGKDFLA
110 120 130 140 150
KLGFLHQQAA HTGEQSNSKS DGGAISHRGK THYNCGEHTK AFSGKHTLVQ
160 170 180 190 200
QQRTLTTERC YICSECGKSF SKSYSLNDHW RLHTGEKPYE CRECGKSFRQ
210 220 230 240 250
SSSLIQHRRV HTAVRPHECD ECGKLFSNKS NLIKHRRVHT GERPYECSEC
260 270 280 290 300
GKSFSQRSAL LQHRGVHTGE RPYECSECGK FFTYHSSLIK HQKVHSGSRP
310 320 330 340 350
YECSECGKSF SQNSSLIEHH RVHTGERPYK CSECGKSFSQ RSALLQHRGV
360 370 380 390 400
HTGERPYECS ECGKFFPYSS SLRKHQRVHT GSRPYECSEC GKSFTQNSGL
410 420 430
IKHRRVHTGE KPYECTECGK SFSHNSSLIK HQRIHSR
Length:437
Mass (Da):49,865
Last modified:April 3, 2007 - v3
Checksum:i37469112DC85BFEB
GO

Sequence cautioni

The sequence BAC23100 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → V in BAC03839 (PubMed:14702039).Curated1
Sequence conflicti296S → I in BAC03839 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06067857H → R.2 PublicationsCorresponds to variant rs34282745dbSNPEnsembl.1
Natural variantiVAR_052779122G → V.Corresponds to variant rs2074078dbSNPEnsembl.1
Natural variantiVAR_052780182L → V.Corresponds to variant rs2188736dbSNPEnsembl.1
Natural variantiVAR_052781384P → L.Corresponds to variant rs34746514dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092261 mRNA. Translation: BAC03839.1.
AB095924 mRNA. Translation: BAC23100.1. Different initiation.
BC152404 mRNA. Translation: AAI52405.1.
BC152426 mRNA. Translation: AAI52427.1.
BC152561 mRNA. Translation: AAI52562.1.
U20648 mRNA. Translation: AAC50257.1.
CCDSiCCDS42639.1.
PIRiI38941.
RefSeqiNP_001078853.1. NM_001085384.2.
UniGeneiHs.646378.

Genome annotation databases

EnsembliENST00000451275; ENSP00000469633; ENSG00000179909.
ENST00000512439; ENSP00000421258; ENSG00000179909.
GeneIDi7710.
KEGGihsa:7710.
UCSCiuc061dmm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092261 mRNA. Translation: BAC03839.1.
AB095924 mRNA. Translation: BAC23100.1. Different initiation.
BC152404 mRNA. Translation: AAI52405.1.
BC152426 mRNA. Translation: AAI52427.1.
BC152561 mRNA. Translation: AAI52562.1.
U20648 mRNA. Translation: AAC50257.1.
CCDSiCCDS42639.1.
PIRiI38941.
RefSeqiNP_001078853.1. NM_001085384.2.
UniGeneiHs.646378.

3D structure databases

ProteinModelPortaliQ13106.
SMRiQ13106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ13106. 1 interactor.
STRINGi9606.ENSP00000421258.

PTM databases

iPTMnetiQ13106.
PhosphoSitePlusiQ13106.

Polymorphism and mutation databases

BioMutaiZNF154.
DMDMi143811477.

Proteomic databases

EPDiQ13106.
MaxQBiQ13106.
PaxDbiQ13106.
PeptideAtlasiQ13106.
PRIDEiQ13106.

Protocols and materials databases

DNASUi7710.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000451275; ENSP00000469633; ENSG00000179909.
ENST00000512439; ENSP00000421258; ENSG00000179909.
GeneIDi7710.
KEGGihsa:7710.
UCSCiuc061dmm.1. human.

Organism-specific databases

CTDi7710.
DisGeNETi7710.
GeneCardsiZNF154.
HGNCiHGNC:12939. ZNF154.
MIMi604085. gene.
neXtProtiNX_Q13106.
OpenTargetsiENSG00000179909.
PharmGKBiPA37523.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ13106.
KOiK09228.
OMAiTHYNCGE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ13106.
TreeFamiTF339848.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179909-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7710.
PROiQ13106.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179909.
CleanExiHS_ZNF154.
ExpressionAtlasiQ13106. baseline and differential.
GenevisibleiQ13106. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN154_HUMAN
AccessioniPrimary (citable) accession number: Q13106
Secondary accession number(s): A7MCY3, Q8IVG7, Q8NAR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.