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Protein

Zinc finger and BTB domain-containing protein 17

Gene

ZBTB17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 328C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 637C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri717 – 739C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • ectoderm development Source: Ensembl
  • gastrulation with mouth forming second Source: Ensembl
  • IRE1-mediated unfolded protein response Source: Reactome
  • negative regulation of cell cycle Source: UniProtKB
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • regulation of mitophagy Source: ParkinsonsUK-UCL
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116809-MONOMER.
ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.
SIGNORiQ13105.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 17
Alternative name(s):
Myc-interacting zinc finger protein 1
Short name:
Miz-1
Zinc finger protein 151
Zinc finger protein 60
Gene namesi
Name:ZBTB17
Synonyms:MIZ1, ZNF151, ZNF60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12936. ZBTB17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7709.
OpenTargetsiENSG00000116809.
PharmGKBiPA37522.

Polymorphism and mutation databases

BioMutaiZBTB17.
DMDMi62906906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477301 – 803Zinc finger and BTB domain-containing protein 17Add BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineCombined sources1
Cross-linki397Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13105.
MaxQBiQ13105.
PaxDbiQ13105.
PeptideAtlasiQ13105.
PRIDEiQ13105.

PTM databases

iPTMnetiQ13105.
PhosphoSitePlusiQ13105.

Expressioni

Tissue specificityi

Expressed in germinal center B-cells.1 Publication

Gene expression databases

BgeeiENSG00000116809.
CleanExiHS_ZBTB17.
ExpressionAtlasiQ13105. baseline and differential.
GenevisibleiQ13105. HS.

Organism-specific databases

HPAiHPA005789.

Interactioni

Subunit structurei

Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1 (PubMed:25245946).8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HCFC1P516109EBI-372156,EBI-396176
MAGEA4P433585EBI-372156,EBI-743122
MYCP011069EBI-372156,EBI-447544
MYCNP041983EBI-372156,EBI-878369
TOPBP1Q925472EBI-372156,EBI-308302

Protein-protein interaction databases

BioGridi113503. 28 interactors.
DIPiDIP-5968N.
IntActiQ13105. 20 interactors.
MINTiMINT-1527698.
STRINGi9606.ENSP00000364895.

Structurei

Secondary structure

1803
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 20Combined sources18
Turni21 – 23Combined sources3
Beta strandi26 – 30Combined sources5
Beta strandi33 – 37Combined sources5
Helixi39 – 45Combined sources7
Helixi47 – 55Combined sources9
Helixi56 – 58Combined sources3
Helixi59 – 64Combined sources6
Helixi67 – 79Combined sources13
Beta strandi80 – 84Combined sources5
Turni86 – 88Combined sources3
Helixi89 – 98Combined sources10
Helixi102 – 112Combined sources11
Turni337 – 339Combined sources3
Beta strandi342 – 344Combined sources3
Helixi348 – 356Combined sources9
Turni365 – 367Combined sources3
Beta strandi370 – 373Combined sources4
Helixi374 – 384Combined sources11
Turni393 – 395Combined sources3
Beta strandi398 – 401Combined sources4
Helixi402 – 409Combined sources8
Turni421 – 423Combined sources3
Beta strandi426 – 428Combined sources3
Helixi430 – 438Combined sources9
Turni457 – 459Combined sources3
Helixi460 – 469Combined sources10
Turni477 – 479Combined sources3
Beta strandi482 – 484Combined sources3
Helixi486 – 497Combined sources12
Turni505 – 507Combined sources3
Beta strandi510 – 512Combined sources3
Helixi514 – 525Combined sources12
Turni533 – 535Combined sources3
Beta strandi538 – 541Combined sources4
Helixi542 – 553Combined sources12
Turni561 – 563Combined sources3
Helixi570 – 578Combined sources9
Beta strandi717 – 719Combined sources3
Turni720 – 723Combined sources4
Beta strandi724 – 727Combined sources4
Helixi729 – 740Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LVRNMR-A500-581[»]
2LVTNMR-A500-581[»]
2LVUNMR-A500-581[»]
2M0DNMR-A416-526[»]
2M0ENMR-A416-526[»]
2M0FNMR-A416-526[»]
2N25NMR-A304-414[»]
2N26NMR-A304-414[»]
2Q81X-ray2.10A/B/C/D2-115[»]
3M52X-ray2.59A/B1-115[»]
4U2MX-ray2.23A/B/C/D2-115[»]
4U2NX-ray2.30A/B2-115[»]
5IONNMR-A714-742[»]
ProteinModelPortaliQ13105.
SMRiQ13105.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 104BTBPROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni269 – 308Interaction with MYCAdd BLAST40
Regioni637 – 803Interaction with HCFC11 PublicationAdd BLAST167
Regioni637 – 718Interaction with MYCAdd BLAST82

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 328C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 637C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri717 – 739C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133719.
HOGENOMiHOG000231298.
HOVERGENiHBG054919.
InParanoidiQ13105.
KOiK10500.
OMAiPGENMEA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ13105.
TreeFamiTF332047.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13105-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFPQHSQHV LEQLNQQRQL GLLCDCTFVV DGVHFKAHKA VLAACSEYFK
60 70 80 90 100
MLFVDQKDVV HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVATFLQ
110 120 130 140 150
MQDIITACHA LKSLAEPATS PGGNAEALAT EGGDKRAKEE KVATSTLSRL
160 170 180 190 200
EQAGRSTPIG PSRDLKEERG GQAQSAASGA EQTEKADAPR EPPPVELKPD
210 220 230 240 250
PTSGMAAAEA EAALSESSEQ EMEVEPARKG EEEQKEQEEQ EEEGAGPAEV
260 270 280 290 300
KEEGSQLENG EAPEENENEE SAGTDSGQEL GSEARGLRSG TYGDRTESKA
310 320 330 340 350
YGSVIHKCED CGKEFTHTGN FKRHIRIHTG EKPFSCRECS KAFSDPAACK
360 370 380 390 400
AHEKTHSPLK PYGCEECGKS YRLISLLNLH KKRHSGEARY RCEDCGKLFT
410 420 430 440 450
TSGNLKRHQL VHSGEKPYQC DYCGRSFSDP TSKMRHLETH DTDKEHKCPH
460 470 480 490 500
CDKKFNQVGN LKAHLKIHIA DGPLKCRECG KQFTTSGNLK RHLRIHSGEK
510 520 530 540 550
PYVCIHCQRQ FADPGALQRH VRIHTGEKPC QCVMCGKAFT QASSLIAHVR
560 570 580 590 600
QHTGEKPYVC ERCGKRFVQS SQLANHIRHH DNIRPHKCSV CSKAFVNVGD
610 620 630 640 650
LSKHIIIHTG EKPYLCDKCG RGFNRVDNLR SHVKTVHQGK AGIKILEPEE
660 670 680 690 700
GSEVSVVTVD DMVTLATEAL AATAVTQLTV VPVGAAVTAD ETEVLKAEIS
710 720 730 740 750
KAVKQVQEED PNTHILYACD SCGDKFLDAN SLAQHVRIHT AQALVMFQTD
760 770 780 790 800
ADFYQQYGPG GTWPAGQVLQ AGELVFRPRD GAEGQPALAE TSPTAPECPP

PAE
Length:803
Mass (Da):87,928
Last modified:April 26, 2005 - v3
Checksum:iC159D177C8A2D4A3
GO
Isoform 2 (identifier: Q13105-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     679-679: T → TGPATLPA

Note: No experimental confirmation available.
Show »
Length:810
Mass (Da):88,535
Checksum:iE59D5EBF4A77C210
GO
Isoform 3 (identifier: Q13105-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: MDFPQHSQHV...GGNAEALATE → MMCWPWPLSS...PQKVCPVPSP

Note: No experimental confirmation available.
Show »
Length:721
Mass (Da):79,228
Checksum:i7C8788248C093F0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73V → M in CAA70889 (PubMed:9312026).Curated1
Sequence conflicti334F → S in BAG63326 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445641 – 131MDFPQ…ALATE → MMCWPWPLSSKCRTSSRPAM PSSHLLSRLPALGEMRRPWP QKVCPVPSP in isoform 3. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_013424679T → TGPATLPA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09723 mRNA. Translation: CAA70889.1.
AK301896 mRNA. Translation: BAG63326.1.
AL034555 Genomic DNA. Translation: CAB85445.1.
AL034555 Genomic DNA. Translation: CAI19524.1.
AL355994 Genomic DNA. No translation available.
BC126163 mRNA. Translation: AAI26164.1.
BC143965 mRNA. Translation: AAI43966.1.
M88369 Genomic DNA. Translation: AAA61327.1.
U20647 mRNA. Translation: AAC50256.1.
CCDSiCCDS165.1. [Q13105-1]
CCDS55576.1. [Q13105-3]
CCDS72712.1. [Q13105-2]
PIRiD45193.
I38940.
RefSeqiNP_001229813.1. NM_001242884.1. [Q13105-3]
NP_001274532.1. NM_001287603.1. [Q13105-2]
NP_003434.2. NM_003443.2. [Q13105-1]
XP_011540390.1. XM_011542088.1. [Q13105-3]
UniGeneiHs.433764.

Genome annotation databases

EnsembliENST00000375733; ENSP00000364885; ENSG00000116809. [Q13105-2]
ENST00000375743; ENSP00000364895; ENSG00000116809. [Q13105-1]
ENST00000537142; ENSP00000438529; ENSG00000116809. [Q13105-3]
GeneIDi7709.
KEGGihsa:7709.
UCSCiuc001axl.5. human. [Q13105-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09723 mRNA. Translation: CAA70889.1.
AK301896 mRNA. Translation: BAG63326.1.
AL034555 Genomic DNA. Translation: CAB85445.1.
AL034555 Genomic DNA. Translation: CAI19524.1.
AL355994 Genomic DNA. No translation available.
BC126163 mRNA. Translation: AAI26164.1.
BC143965 mRNA. Translation: AAI43966.1.
M88369 Genomic DNA. Translation: AAA61327.1.
U20647 mRNA. Translation: AAC50256.1.
CCDSiCCDS165.1. [Q13105-1]
CCDS55576.1. [Q13105-3]
CCDS72712.1. [Q13105-2]
PIRiD45193.
I38940.
RefSeqiNP_001229813.1. NM_001242884.1. [Q13105-3]
NP_001274532.1. NM_001287603.1. [Q13105-2]
NP_003434.2. NM_003443.2. [Q13105-1]
XP_011540390.1. XM_011542088.1. [Q13105-3]
UniGeneiHs.433764.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LVRNMR-A500-581[»]
2LVTNMR-A500-581[»]
2LVUNMR-A500-581[»]
2M0DNMR-A416-526[»]
2M0ENMR-A416-526[»]
2M0FNMR-A416-526[»]
2N25NMR-A304-414[»]
2N26NMR-A304-414[»]
2Q81X-ray2.10A/B/C/D2-115[»]
3M52X-ray2.59A/B1-115[»]
4U2MX-ray2.23A/B/C/D2-115[»]
4U2NX-ray2.30A/B2-115[»]
5IONNMR-A714-742[»]
ProteinModelPortaliQ13105.
SMRiQ13105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113503. 28 interactors.
DIPiDIP-5968N.
IntActiQ13105. 20 interactors.
MINTiMINT-1527698.
STRINGi9606.ENSP00000364895.

PTM databases

iPTMnetiQ13105.
PhosphoSitePlusiQ13105.

Polymorphism and mutation databases

BioMutaiZBTB17.
DMDMi62906906.

Proteomic databases

EPDiQ13105.
MaxQBiQ13105.
PaxDbiQ13105.
PeptideAtlasiQ13105.
PRIDEiQ13105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375733; ENSP00000364885; ENSG00000116809. [Q13105-2]
ENST00000375743; ENSP00000364895; ENSG00000116809. [Q13105-1]
ENST00000537142; ENSP00000438529; ENSG00000116809. [Q13105-3]
GeneIDi7709.
KEGGihsa:7709.
UCSCiuc001axl.5. human. [Q13105-1]

Organism-specific databases

CTDi7709.
DisGeNETi7709.
GeneCardsiZBTB17.
HGNCiHGNC:12936. ZBTB17.
HPAiHPA005789.
MIMi604084. gene.
neXtProtiNX_Q13105.
OpenTargetsiENSG00000116809.
PharmGKBiPA37522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133719.
HOGENOMiHOG000231298.
HOVERGENiHBG054919.
InParanoidiQ13105.
KOiK10500.
OMAiPGENMEA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ13105.
TreeFamiTF332047.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116809-MONOMER.
ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.
SIGNORiQ13105.

Miscellaneous databases

ChiTaRSiZBTB17. human.
EvolutionaryTraceiQ13105.
GeneWikiiZBTB17.
GenomeRNAii7709.
PROiQ13105.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116809.
CleanExiHS_ZBTB17.
ExpressionAtlasiQ13105. baseline and differential.
GenevisibleiQ13105. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT17_HUMAN
AccessioniPrimary (citable) accession number: Q13105
Secondary accession number(s): A0AV07
, B4DXB4, B7ZLQ9, F5H411, Q15932, Q5JYB2, Q9NUC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 177 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.