Reviewed,
UniProtKB/Swiss-Prot Q13105 (ZBT17_HUMAN)
Last modified
January 19, 2010.
Version 106.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Zinc finger and BTB domain-containing protein 17 Alternative name(s): Zinc finger protein 60 Zinc finger protein 151 Myc-interacting zinc finger protein Miz-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 803 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May function as a housekeeping DNA-binding protein that regulates the expression of specific genes. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Also has potent growth arrest activity, probably through inhibition of cell cycle progression. Required for early embryonic development during gastrulation. Ref.1 Ref.6 |
| Subunit structure | Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Ref.1 Ref.7 Ref.8 Ref.9 Ref.10 |
| Subcellular location | |
| Sequence similarities | Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 1 BTB (POZ) domain. Contains 13 C2H2-type zinc fingers. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| DIS3 | Q9Y2L1 | 1 | EBI-372156,EBI-373539 | |
| EP300 | Q09472 | 1 | EBI-372156,EBI-447295 | |
| HCFC1 | P51610 | 5 | EBI-372156,EBI-396176 | |
| MAGEA4 | P43358 | 2 | EBI-372156,EBI-743122 | |
| MYC | P01106 | 1 | EBI-372156,EBI-447544 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q13105-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q13105-2) The sequence of this isoform differs from the canonical sequence as follows: 679-679: T → TGPATLPA | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 803 | 803 | Zinc finger and BTB domain-containing protein 17 | PRO_0000047730 | ||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||
| Domain | 1 – 104 | 104 | BTB | |||||||||||||||||||||||||
| Zinc finger | 306 – 328 | 23 | C2H2-type 1 | |||||||||||||||||||||||||
| Zinc finger | 334 – 356 | 23 | C2H2-type 2 | |||||||||||||||||||||||||
| Zinc finger | 362 – 384 | 23 | C2H2-type 3 | |||||||||||||||||||||||||
| Zinc finger | 390 – 412 | 23 | C2H2-type 4 | |||||||||||||||||||||||||
| Zinc finger | 418 – 440 | 23 | C2H2-type 5 | |||||||||||||||||||||||||
| Zinc finger | 446 – 468 | 23 | C2H2-type 6 | |||||||||||||||||||||||||
| Zinc finger | 474 – 496 | 23 | C2H2-type 7 | |||||||||||||||||||||||||
| Zinc finger | 502 – 524 | 23 | C2H2-type 8 | |||||||||||||||||||||||||
| Zinc finger | 530 – 552 | 23 | C2H2-type 9 | |||||||||||||||||||||||||
| Zinc finger | 558 – 580 | 23 | C2H2-type 10 | |||||||||||||||||||||||||
| Zinc finger | 586 – 608 | 23 | C2H2-type 11 | |||||||||||||||||||||||||
| Zinc finger | 614 – 637 | 24 | C2H2-type 12 | |||||||||||||||||||||||||
| Zinc finger | 717 – 739 | 23 | C2H2-type 13 | |||||||||||||||||||||||||
| Region | 269 – 308 | 40 | Interaction with MYC | |||||||||||||||||||||||||
| Region | 637 – 803 | 167 | Interaction with HCFC1 | |||||||||||||||||||||||||
| Region | 637 – 718 | 82 | Interaction with MYC | |||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||
| Alternative sequence | 679 | 1 | T → TGPATLPA in isoform 2. | VSP_013424 | ||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||
| Sequence conflict | 73 | 1 | V → M in CAA70889. Ref.1 | |||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||
| Helix | 3 – 20 | 18 | ||||||||||||||||||||||||||
| Beta strand | 26 – 30 | 5 | ||||||||||||||||||||||||||
| Beta strand | 33 – 37 | 5 | ||||||||||||||||||||||||||
| Helix | 39 – 45 | 7 | ||||||||||||||||||||||||||
| Helix | 47 – 55 | 9 | ||||||||||||||||||||||||||
| Helix | 59 – 64 | 6 | ||||||||||||||||||||||||||
| Helix | 67 – 79 | 13 | ||||||||||||||||||||||||||
| Turn | 86 – 88 | 3 | ||||||||||||||||||||||||||
| Helix | 89 – 98 | 10 | ||||||||||||||||||||||||||
| Helix | 102 – 112 | 11 | ||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "An alternative pathway for gene regulation by Myc." Peukert K., Staller P., Schneider A., Carmichael G., Haenel F., Eilers M. EMBO J. 16:5672-5686(1997) [PubMed: 9312026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MYC. |
| [2] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain. |
| [4] | "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes." Lichter P., Bray P., Ried T., Dawid I.B., Ward D.C. Genomics 13:999-1007(1992) [PubMed: 1505991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 327-342. Tissue: Placenta. |
| [5] | "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders." Tommerup N., Vissing H. Genomics 27:259-264(1995) [PubMed: 7557990] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 580-803 (ISOFORM 1). Tissue: Insulinoma. |
| [6] | "Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc." Schneider A., Peukert K., Eilers M., Haenel F. Curr. Top. Microbiol. Immunol. 224:137-146(1997) [PubMed: 9308237] [Abstract] Cited for: FUNCTION. Tissue: Cervix carcinoma. |
| [7] | "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1." Piluso D., Bilan P., Capone J.P. J. Biol. Chem. 277:46799-46808(2002) [PubMed: 12244100] [Abstract] Cited for: INTERACTION WITH HCFC1. |
| [8] | "Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter." Wu S., Cetinkaya C., Munoz-Alonso M.J., von der Lehr N., Bahram F., Beuger V., Eilers M., Leon J., Larsson L.-G. Oncogene 22:351-360(2003) [PubMed: 12545156] [Abstract] Cited for: INTERACTION WITH MYC. |
| [9] | "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells." Sakurai T., Itoh K., Higashitsuji H., Nagao T., Nonoguchi K., Chiba T., Fujita J. J. Biol. Chem. 279:15505-15514(2004) [PubMed: 14739298] [Abstract] Cited for: INTERACTION WITH MAGEA4, SUBCELLULAR LOCATION. |
| [10] | "Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1." Zhao N., Wang J., Cui Y., Guo L., Lu S.-H. J. Cell. Biochem. 92:65-76(2004) [PubMed: 15095404] [Abstract] Cited for: INTERACTION WITH TMPRSS11A. |
| [11] | "A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain." Stead M.A., Trinh C.H., Garnett J.A., Carr S.B., Baron A.J., Edwards T.A., Wright S.C. J. Mol. Biol. 373:820-826(2007) [PubMed: 17880999] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2-115. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | Y09723 mRNA. Translation: CAA70889.1. AL034555 Genomic DNA. Translation: CAB85445.1. AL034555 Genomic DNA. Translation: CAI19524.1. BC126163 mRNA. Translation: AAI26164.1. BC143965 mRNA. Translation: AAI43966.1. M88369 Genomic DNA. Translation: AAA61327.1. U20647 mRNA. Translation: AAC50256.1. | ||||||||||||
| IPI | IPI00011834. IPI00556634. | ||||||||||||
| PIR | D45193. I38940. | ||||||||||||
| RefSeq | NP_003434.2. | ||||||||||||
| UniGene | Hs.433764 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| SMR | Q13105. Positions 387-579, 472-637. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP-5968N. | ||||||||||||
| IntAct | Q13105. 6 interactions. | ||||||||||||
| STRING | Q13105. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q13105. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q13105. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000375733; ENSP00000364885; ENSG00000116809; Homo sapiens. [Genome view] ENST00000375743; ENSP00000364895; ENSG00000116809; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 7709. | ||||||||||||
| KEGG | hsa:7709. | ||||||||||||
| UCSC | uc001axl.2. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 7709. | ||||||||||||
| GeneCards | GC01M016140. | ||||||||||||
| HGNC | HGNC:12936. ZBTB17. | ||||||||||||
| HPA | HPA005789. | ||||||||||||
| MIM | 604084. gene. | ||||||||||||
| PharmGKB | PA37522. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG13248. | ||||||||||||
| HOVERGEN | Q13105. | ||||||||||||
| OMA | TAPECPP. | ||||||||||||
| PhylomeDB | Q13105. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | smad2_3nuclearpathway. Regulation of nuclear SMAD2/3 signaling. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q13105. | ||||||||||||
| Bgee | Q13105. | ||||||||||||
| CleanEx | HS_ZBTB17. | ||||||||||||
| Genevestigator | Q13105. | ||||||||||||
| GermOnline | ENSG00000116809. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 9 hits. | ||||||||||||
| Pfam | PF00651. BTB. 1 hit. PF00096. zf-C2H2. 5 hits. [Graphical view] | ||||||||||||
| SMART | SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view] | ||||||||||||
| PROSITE | PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 29884. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | ZBT17_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13105 Secondary accession number(s): A0AV07 Q9NUC9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


