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Protein

Secreted phosphoprotein 24

Gene

SPP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could coordinate an aspect of bone turnover.By similarity

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

  • bone remodeling Source: InterPro
  • platelet degranulation Source: Reactome
  • skeletal system development Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072080-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted phosphoprotein 24
Short name:
Spp-24
Alternative name(s):
Secreted phosphoprotein 2
Gene namesi
Name:SPP2
Synonyms:SPP24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11256. SPP2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • platelet dense granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6694.
OpenTargetsiENSG00000072080.
PharmGKBiPA36086.

Polymorphism and mutation databases

BioMutaiSPP2.
DMDMi2498939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002240330 – 211Secreted phosphoprotein 24Add BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi92 ↔ 103By similarity
Modified residuei96PhosphoserineCombined sources1
Disulfide bondi116 ↔ 134By similarity
Modified residuei145PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ13103.
PeptideAtlasiQ13103.
PRIDEiQ13103.

PTM databases

iPTMnetiQ13103.
PhosphoSitePlusiQ13103.

Expressioni

Tissue specificityi

Detected in liver and plasma.1 Publication

Developmental stagei

Found in fetal liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000072080.
CleanExiHS_SPP2.
ExpressionAtlasiQ13103. baseline and differential.
GenevisibleiQ13103. HS.

Organism-specific databases

HPAiCAB046011.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000168148.

Structurei

3D structure databases

ProteinModelPortaliQ13103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWPI. Eukaryota.
ENOG410Z1VS. LUCA.
GeneTreeiENSGT00390000009001.
HOGENOMiHOG000264228.
HOVERGENiHBG065800.
InParanoidiQ13103.
OMAiCAGFPVY.
OrthoDBiEOG091G0MTC.
PhylomeDBiQ13103.
TreeFamiTF335972.

Family and domain databases

InterProiIPR010892. Spp-24.
[Graphical view]
PfamiPF07448. Spp-24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRMEKMTM MMKILIMFAL GMNYWSCSGF PVYDYDPSSL RDALSASVVK
60 70 80 90 100
VNSQSLSPYL FRAFRSSLKR VEVLDENNLV MNLEFSIRET TCRKDSGEDP
110 120 130 140 150
ATCAFQRDYY VSTAVCRSTV KVSAQQVQGV HARCSWSSST SESYSSEEMI
160 170 180 190 200
FGDMLGSHKW RNNYLFGLIS DESISEQFYD RSLGIMRRVL PPGNRRYPNH
210
RHRARINTDF E
Length:211
Mass (Da):24,338
Last modified:November 1, 1997 - v1
Checksum:iAED049E63464E38D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → V in AAI06706 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02569838S → F.1 PublicationCorresponds to variant rs34347825dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20530 mRNA. Translation: AAA87905.1.
AJ272265 Genomic DNA. Translation: CAB75571.1.
AJ308099 mRNA. Translation: CAC87050.1.
AC006037 Genomic DNA. Translation: AAX93090.1.
CH471063 Genomic DNA. Translation: EAW71070.1.
BC069401 mRNA. Translation: AAH69401.1.
BC106705 mRNA. Translation: AAI06706.1.
BC112438 mRNA. Translation: AAI12439.1.
CCDSiCCDS2511.1.
PIRiG01654.
RefSeqiNP_008875.1. NM_006944.2.
XP_005246159.1. XM_005246102.3.
XP_011510000.1. XM_011511698.2.
XP_011510001.1. XM_011511699.2.
XP_011510002.1. XM_011511700.2.
UniGeneiHs.444488.

Genome annotation databases

EnsembliENST00000168148; ENSP00000168148; ENSG00000072080.
ENST00000373368; ENSP00000362466; ENSG00000072080.
GeneIDi6694.
KEGGihsa:6694.
UCSCiuc002vvk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20530 mRNA. Translation: AAA87905.1.
AJ272265 Genomic DNA. Translation: CAB75571.1.
AJ308099 mRNA. Translation: CAC87050.1.
AC006037 Genomic DNA. Translation: AAX93090.1.
CH471063 Genomic DNA. Translation: EAW71070.1.
BC069401 mRNA. Translation: AAH69401.1.
BC106705 mRNA. Translation: AAI06706.1.
BC112438 mRNA. Translation: AAI12439.1.
CCDSiCCDS2511.1.
PIRiG01654.
RefSeqiNP_008875.1. NM_006944.2.
XP_005246159.1. XM_005246102.3.
XP_011510000.1. XM_011511698.2.
XP_011510001.1. XM_011511699.2.
XP_011510002.1. XM_011511700.2.
UniGeneiHs.444488.

3D structure databases

ProteinModelPortaliQ13103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000168148.

PTM databases

iPTMnetiQ13103.
PhosphoSitePlusiQ13103.

Polymorphism and mutation databases

BioMutaiSPP2.
DMDMi2498939.

Proteomic databases

PaxDbiQ13103.
PeptideAtlasiQ13103.
PRIDEiQ13103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000168148; ENSP00000168148; ENSG00000072080.
ENST00000373368; ENSP00000362466; ENSG00000072080.
GeneIDi6694.
KEGGihsa:6694.
UCSCiuc002vvk.2. human.

Organism-specific databases

CTDi6694.
DisGeNETi6694.
GeneCardsiSPP2.
HGNCiHGNC:11256. SPP2.
HPAiCAB046011.
MIMi602637. gene.
neXtProtiNX_Q13103.
OpenTargetsiENSG00000072080.
PharmGKBiPA36086.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWPI. Eukaryota.
ENOG410Z1VS. LUCA.
GeneTreeiENSGT00390000009001.
HOGENOMiHOG000264228.
HOVERGENiHBG065800.
InParanoidiQ13103.
OMAiCAGFPVY.
OrthoDBiEOG091G0MTC.
PhylomeDBiQ13103.
TreeFamiTF335972.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072080-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiSPP2. human.
GenomeRNAii6694.
PROiQ13103.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072080.
CleanExiHS_SPP2.
ExpressionAtlasiQ13103. baseline and differential.
GenevisibleiQ13103. HS.

Family and domain databases

InterProiIPR010892. Spp-24.
[Graphical view]
PfamiPF07448. Spp-24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPP24_HUMAN
AccessioniPrimary (citable) accession number: Q13103
Secondary accession number(s): A4QMV3, Q3B892, Q546M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.