Reviewed, UniProtKB/Swiss-Prot Q13084 (RM28_HUMAN)

Names and origin

Protein names

Recommended name:
    39S ribosomal protein L28, mitochondrial
      Short name=L28mt
Alternative name(s):
    MRP-L28
    Melanoma antigen p15
    Melanoma-associated antigen recognized by T lymphocytes

Gene names

Name:	MRPL28
Synonyms:	MAAT1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Mitochondrion.
Tissue specificity	Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.
Miscellaneous	Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.
Sequence similarities	Belongs to the ribosomal protein L28P family.
Sequence caution	The sequence AAK61226.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: InterPro translation Non-traceable author statement. Source: UniProtKB
Cellular component	mitochondrial ribosome Non-traceable author statement. Source: UniProtKB nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	structural constituent of ribosome Non-traceable author statement. Source: UniProtKB transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 256		39S ribosomal protein L28, mitochondrial		PRO_0000030506
Experimental info
	Sequence conflict	27	1	H → Y in AAH00990. Ref.3
	Sequence conflict	147	1	K → KASG in AAK61226. Ref.1
	Sequence conflict	148 – 150	3	TPK → ASG Ref.2
	Sequence conflict	160	1	D → E in AAC50181. Ref.4
	Sequence conflict	252	1	R → T in AAC50181. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q13084-1 [UniParc]. Last modified January 24, 2006. Version 4. Checksum: 6578FD1E98FC5A6E	FASTA	256	30,157
	10 20 30 40 50 60 MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF KINPKNGQRE 70 80 90 100 110 120 RVEDVPIPIY FPPESQRGLW GGEGWILGQI YANNDKLSKR LKKVWKPQLF EREFYSEILD 130 140 150 160 170 180 KKFTVTVTMR TLDLIDEAYG LDFYILKTPK EDLCSKFGMD LKRGMLLRLA RQDPQLHPED 190 200 210 220 230 240 PERRAAIYDK YKEFAIPEEE AEWVGLTLEE AIEKQRLLEE KDPVPLFKIY VAELIQQLQQ 250 QALSEPAVVQ KRASGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Placenta.
[4]	"Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes." Robbins P.F., El-Gamil M., Li Y.F., Topalian S.L., Rivoltini L., Sakaguchi K., Appella E., Kawakami Y., Rosenberg S.A. J. Immunol. 154:5944-5950(1995) [PubMed: 7751637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-256, SYNTHESIS OF 137-146. Tissue: Melanoma.
[5]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-256.
[6]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed: 11551941] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006463 Genomic DNA. Translation: AAK61226.1. Sequence problems. Z97634 Genomic DNA. Translation: CAI95594.1. BC000507 mRNA. Translation: AAH00507.2. BC000990 mRNA. Translation: AAH00990.2. U19796 mRNA. Translation: AAC50181.1. Different initiation. BT009857 mRNA. Translation: AAP88859.1.
RefSeq	NP_006419.2.
UniGene	Hs.513230
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13084.
PTM databases
PhosphoSite	Q13084.
Genome annotation databases
Ensembl	ENSG00000086504. Homo sapiens. [Contig view]
GeneID	10573.
KEGG	hsa:10573.
Organism-specific databases
HGNC	HGNC:14484. MRPL28.
MIM	604853. gene.
PharmGKB	PA30515.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q13084.
Gene expression databases
ArrayExpress	Q13084.
CleanEx	HS_MRPL28.
GermOnline	ENSG00000086504. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	40127.
SOURCE	Search...

Entry information

Entry name

RM28_HUMAN

Accession

Primary (citable) accession number: Q13084
Secondary accession number(s): Q4TT39 , Q96S26, Q9BQD8, Q9BR04

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 24, 2006
Last modified:	November 25, 2008
This is version 65 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)