Reviewed,
UniProtKB/Swiss-Prot Q13084 (RM28_HUMAN)
Last modified
November 25, 2008.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 39S ribosomal protein L28, mitochondrial Short name=L28mt Alternative name(s): MRP-L28 Melanoma antigen p15 Melanoma-associated antigen recognized by T lymphocytes | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 256 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | |
| Tissue specificity | Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue. |
| Miscellaneous | Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24. |
| Sequence similarities | Belongs to the ribosomal protein L28P family. |
| Sequence caution | The sequence AAK61226.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Molecular function | Ribonucleoprotein Ribosomal protein |
Gene Ontology (GO) | |
| Biological process | regulation of transcription Inferred from electronic annotation. Source: InterPro translationNon-traceable author statement. Source: UniProtKB |
| Cellular component | mitochondrial ribosome Non-traceable author statement. Source: UniProtKB nucleusInferred from electronic annotation. Source: InterPro |
| Molecular function | structural constituent of ribosome Non-traceable author statement. Source: UniProtKB transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | |||||||
| Chain | ? – 256 | 39S ribosomal protein L28, mitochondrial | PRO_0000030506 | ||||||
Experimental info | |||||||||
| Sequence conflict | 27 | 1 | H → Y in AAH00990. Ref.3 | ||||||
| Sequence conflict | 147 | 1 | K → KASG in AAK61226. Ref.1 | ||||||
| Sequence conflict | 148 – 150 | 3 | TPK → ASG Ref.2 | ||||||
| Sequence conflict | 160 | 1 | D → E in AAC50181. Ref.4 | ||||||
| Sequence conflict | 252 | 1 | R → T in AAC50181. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A.Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Placenta. |
| [4] | "Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes." Robbins P.F., El-Gamil M., Li Y.F., Topalian S.L., Rivoltini L., Sakaguchi K., Appella E., Kawakami Y., Rosenberg S.A. J. Immunol. 154:5944-5950(1995) [PubMed: 7751637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-256, SYNTHESIS OF 137-146. Tissue: Melanoma. |
| [5] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-256. |
| [6] | "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed: 11551941] [Abstract] Cited for: IDENTIFICATION. |
Cross-references
Sequence databases | |
|---|---|
| AE006463 Genomic DNA. Translation: AAK61226.1. Sequence problems. Z97634 Genomic DNA. Translation: CAI95594.1. BC000507 mRNA. Translation: AAH00507.2. BC000990 mRNA. Translation: AAH00990.2. U19796 mRNA. Translation: AAC50181.1. Different initiation. BT009857 mRNA. Translation: AAP88859.1. | |
| RefSeq | NP_006419.2. |
| UniGene | Hs.513230 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q13084. |
PTM databases | |
| PhosphoSite | Q13084. |
Genome annotation databases | |
| Ensembl | ENSG00000086504. Homo sapiens. [Contig view] |
| GeneID | 10573. |
| KEGG | hsa:10573. |
Organism-specific databases | |
| HGNC | HGNC:14484. MRPL28. |
| MIM | 604853. gene. |
| PharmGKB | PA30515. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | Q13084. |
Gene expression databases | |
| ArrayExpress | Q13084. |
| CleanEx | HS_MRPL28. |
| GermOnline | ENSG00000086504. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 40127. |
| SOURCE | Search... |
Entry information
| Entry name | RM28_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13084 Secondary accession number(s): Q4TT39 Q9BR04 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Ribosomal proteins Ribosomal proteins families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


