Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13084

- RM28_HUMAN

UniProt

Q13084 - RM28_HUMAN

Protein

39S ribosomal protein L28, mitochondrial

Gene

MRPL28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 4 (24 Jan 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L28, mitochondrial
    Short name:
    L28mt
    Short name:
    MRP-L28
    Alternative name(s):
    Melanoma antigen p15
    Melanoma-associated antigen recognized by T-lymphocytes
    Gene namesi
    Name:MRPL28
    Synonyms:MAAT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14484. MRPL28.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrial ribosome Source: UniProtKB
    3. mitochondrion Source: HPA
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30515.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5555MitochondrionBy similarityAdd
    BLAST
    Chaini56 – 25620139S ribosomal protein L28, mitochondrialPRO_0000030506Add
    BLAST

    Proteomic databases

    MaxQBiQ13084.
    PaxDbiQ13084.
    PRIDEiQ13084.

    PTM databases

    PhosphoSiteiQ13084.

    Expressioni

    Tissue specificityi

    Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.

    Gene expression databases

    ArrayExpressiQ13084.
    BgeeiQ13084.
    CleanExiHS_MRPL28.
    GenevestigatoriQ13084.

    Organism-specific databases

    HPAiHPA030594.
    HPA055589.

    Interactioni

    Subunit structurei

    Interacts with OXA1L.By similarity

    Protein-protein interaction databases

    BioGridi115824. 14 interactions.
    IntActiQ13084. 3 interactions.
    MINTiMINT-1383002.
    STRINGi9606.ENSP00000199706.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13084.
    SMRiQ13084. Positions 82-138.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L28P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG259466.
    HOVERGENiHBG083707.
    KOiK02902.
    OMAiRPHGAKF.
    OrthoDBiEOG70KGQ8.
    PhylomeDBiQ13084.
    TreeFamiTF313040.

    Family and domain databases

    InterProiIPR026569. Ribo_L28/L24.
    [Graphical view]
    PANTHERiPTHR13528. PTHR13528. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13084-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF    50
    KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQI YANNDKLSKR 100
    LKKVWKPQLF EREFYSEILD KKFTVTVTMR TLDLIDEAYG LDFYILKTPK 150
    EDLCSKFGMD LKRGMLLRLA RQDPQLHPED PERRAAIYDK YKEFAIPEEE 200
    AEWVGLTLEE AIEKQRLLEE KDPVPLFKIY VAELIQQLQQ QALSEPAVVQ 250
    KRASGQ 256
    Length:256
    Mass (Da):30,157
    Last modified:January 24, 2006 - v4
    Checksum:i6578FD1E98FC5A6E
    GO

    Sequence cautioni

    The sequence AAC50181.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAK61226.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti147 – 1471K → KASG in AAK61226. (PubMed:11157797)Curated
    Sequence conflicti148 – 1503TPK → ASG(PubMed:15616553)Curated
    Sequence conflicti252 – 2521R → T in AAC50181. (PubMed:7751637)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271H → Y.2 Publications
    Corresponds to variant rs3194151 [ dbSNP | Ensembl ].
    VAR_054219
    Natural varianti160 – 1601D → E.1 Publication
    Corresponds to variant rs11557302 [ dbSNP | Ensembl ].
    VAR_052024
    Natural varianti230 – 2301Y → C.
    Corresponds to variant rs13226 [ dbSNP | Ensembl ].
    VAR_061806

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315180 mRNA. Translation: BAG37621.1.
    AE006463 Genomic DNA. Translation: AAK61226.1. Sequence problems.
    Z97634 Genomic DNA. Translation: CAI95594.1.
    CH471112 Genomic DNA. Translation: EAW85827.1.
    CH471112 Genomic DNA. Translation: EAW85829.1.
    CH471112 Genomic DNA. Translation: EAW85832.1.
    CH471112 Genomic DNA. Translation: EAW85834.1.
    BC000507 mRNA. Translation: AAH00507.2.
    BC000990 mRNA. Translation: AAH00990.2.
    U19796 mRNA. Translation: AAC50181.1. Different initiation.
    BT009857 mRNA. Translation: AAP88859.1.
    CCDSiCCDS32349.1.
    RefSeqiNP_006419.2. NM_006428.4.
    XP_005255098.1. XM_005255041.1.
    UniGeneiHs.513230.

    Genome annotation databases

    EnsembliENST00000199706; ENSP00000199706; ENSG00000086504.
    ENST00000389675; ENSP00000374326; ENSG00000086504.
    GeneIDi10573.
    KEGGihsa:10573.
    UCSCiuc002cgs.2. human.

    Polymorphism databases

    DMDMi85695426.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315180 mRNA. Translation: BAG37621.1 .
    AE006463 Genomic DNA. Translation: AAK61226.1 . Sequence problems.
    Z97634 Genomic DNA. Translation: CAI95594.1 .
    CH471112 Genomic DNA. Translation: EAW85827.1 .
    CH471112 Genomic DNA. Translation: EAW85829.1 .
    CH471112 Genomic DNA. Translation: EAW85832.1 .
    CH471112 Genomic DNA. Translation: EAW85834.1 .
    BC000507 mRNA. Translation: AAH00507.2 .
    BC000990 mRNA. Translation: AAH00990.2 .
    U19796 mRNA. Translation: AAC50181.1 . Different initiation.
    BT009857 mRNA. Translation: AAP88859.1 .
    CCDSi CCDS32349.1.
    RefSeqi NP_006419.2. NM_006428.4.
    XP_005255098.1. XM_005255041.1.
    UniGenei Hs.513230.

    3D structure databases

    ProteinModelPortali Q13084.
    SMRi Q13084. Positions 82-138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115824. 14 interactions.
    IntActi Q13084. 3 interactions.
    MINTi MINT-1383002.
    STRINGi 9606.ENSP00000199706.

    PTM databases

    PhosphoSitei Q13084.

    Polymorphism databases

    DMDMi 85695426.

    Proteomic databases

    MaxQBi Q13084.
    PaxDbi Q13084.
    PRIDEi Q13084.

    Protocols and materials databases

    DNASUi 10573.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000199706 ; ENSP00000199706 ; ENSG00000086504 .
    ENST00000389675 ; ENSP00000374326 ; ENSG00000086504 .
    GeneIDi 10573.
    KEGGi hsa:10573.
    UCSCi uc002cgs.2. human.

    Organism-specific databases

    CTDi 10573.
    GeneCardsi GC16M000357.
    HGNCi HGNC:14484. MRPL28.
    HPAi HPA030594.
    HPA055589.
    MIMi 604853. gene.
    neXtProti NX_Q13084.
    PharmGKBi PA30515.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259466.
    HOVERGENi HBG083707.
    KOi K02902.
    OMAi RPHGAKF.
    OrthoDBi EOG70KGQ8.
    PhylomeDBi Q13084.
    TreeFami TF313040.

    Miscellaneous databases

    GeneWikii MRPL28.
    GenomeRNAii 10573.
    NextBioi 40127.
    PROi Q13084.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13084.
    Bgeei Q13084.
    CleanExi HS_MRPL28.
    Genevestigatori Q13084.

    Family and domain databases

    InterProi IPR026569. Ribo_L28/L24.
    [Graphical view ]
    PANTHERi PTHR13528. PTHR13528. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-27.
      Tissue: Skeletal muscle.
    2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-27.
      Tissue: Lung and Placenta.
    6. "Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes."
      Robbins P.F., El-Gamil M., Li Y.F., Topalian S.L., Rivoltini L., Sakaguchi K., Appella E., Kawakami Y., Rosenberg S.A.
      J. Immunol. 154:5944-5950(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-256, SYNTHESIS OF 137-146, VARIANT GLU-160.
      Tissue: Melanoma.
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-256.
    8. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM28_HUMAN
    AccessioniPrimary (citable) accession number: Q13084
    Secondary accession number(s): B2RCM4
    , D3DU46, Q4TT39, Q96S26, Q9BQD8, Q9BR04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 116 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3