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Protein

39S ribosomal protein L28, mitochondrial

Gene

MRPL28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
  6. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L28, mitochondrial
Short name:
L28mt
Short name:
MRP-L28
Alternative name(s):
Melanoma antigen p15
Melanoma-associated antigen recognized by T-lymphocytes
Gene namesi
Name:MRPL28
Synonyms:MAAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14484. MRPL28.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial ribosome Source: UniProtKB
  4. mitochondrion Source: HPA
  5. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5555MitochondrionBy similarityAdd
BLAST
Chaini56 – 25620139S ribosomal protein L28, mitochondrialPRO_0000030506Add
BLAST

Proteomic databases

MaxQBiQ13084.
PaxDbiQ13084.
PRIDEiQ13084.

PTM databases

PhosphoSiteiQ13084.

Expressioni

Tissue specificityi

Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.

Gene expression databases

BgeeiQ13084.
CleanExiHS_MRPL28.
ExpressionAtlasiQ13084. baseline and differential.
GenevestigatoriQ13084.

Organism-specific databases

HPAiCAB033542.
HPA030594.
HPA055589.

Interactioni

Subunit structurei

Interacts with OXA1L.By similarity

Protein-protein interaction databases

BioGridi115824. 59 interactions.
DIPiDIP-61135N.
IntActiQ13084. 4 interactions.
MINTiMINT-1383002.
STRINGi9606.ENSP00000199706.

Structurei

3D structure databases

ProteinModelPortaliQ13084.
SMRiQ13084. Positions 82-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L28P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG259466.
GeneTreeiENSGT00390000017359.
HOVERGENiHBG083707.
InParanoidiQ13084.
KOiK02902.
OMAiRPHGAKF.
OrthoDBiEOG70KGQ8.
PhylomeDBiQ13084.
TreeFamiTF313040.

Family and domain databases

InterProiIPR026569. Ribo_L28/L24.
[Graphical view]
PANTHERiPTHR13528. PTHR13528. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF
60 70 80 90 100
KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQI YANNDKLSKR
110 120 130 140 150
LKKVWKPQLF EREFYSEILD KKFTVTVTMR TLDLIDEAYG LDFYILKTPK
160 170 180 190 200
EDLCSKFGMD LKRGMLLRLA RQDPQLHPED PERRAAIYDK YKEFAIPEEE
210 220 230 240 250
AEWVGLTLEE AIEKQRLLEE KDPVPLFKIY VAELIQQLQQ QALSEPAVVQ

KRASGQ
Length:256
Mass (Da):30,157
Last modified:January 24, 2006 - v4
Checksum:i6578FD1E98FC5A6E
GO

Sequence cautioni

The sequence AAC50181.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAK61226.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471K → KASG in AAK61226 (PubMed:11157797).Curated
Sequence conflicti148 – 1503TPK → ASG (PubMed:15616553).Curated
Sequence conflicti252 – 2521R → T in AAC50181 (PubMed:7751637).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271H → Y.2 Publications
Corresponds to variant rs3194151 [ dbSNP | Ensembl ].
VAR_054219
Natural varianti160 – 1601D → E.1 Publication
Corresponds to variant rs11557302 [ dbSNP | Ensembl ].
VAR_052024
Natural varianti230 – 2301Y → C.
Corresponds to variant rs13226 [ dbSNP | Ensembl ].
VAR_061806

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315180 mRNA. Translation: BAG37621.1.
AE006463 Genomic DNA. Translation: AAK61226.1. Sequence problems.
Z97634 Genomic DNA. Translation: CAI95594.1.
CH471112 Genomic DNA. Translation: EAW85827.1.
CH471112 Genomic DNA. Translation: EAW85829.1.
CH471112 Genomic DNA. Translation: EAW85832.1.
CH471112 Genomic DNA. Translation: EAW85834.1.
BC000507 mRNA. Translation: AAH00507.2.
BC000990 mRNA. Translation: AAH00990.2.
U19796 mRNA. Translation: AAC50181.1. Different initiation.
BT009857 mRNA. Translation: AAP88859.1.
CCDSiCCDS32349.1.
RefSeqiNP_006419.2. NM_006428.4.
XP_005255098.1. XM_005255041.1.
UniGeneiHs.513230.

Genome annotation databases

EnsembliENST00000199706; ENSP00000199706; ENSG00000086504.
ENST00000389675; ENSP00000374326; ENSG00000086504.
GeneIDi10573.
KEGGihsa:10573.
UCSCiuc002cgs.2. human.

Polymorphism databases

DMDMi85695426.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315180 mRNA. Translation: BAG37621.1.
AE006463 Genomic DNA. Translation: AAK61226.1. Sequence problems.
Z97634 Genomic DNA. Translation: CAI95594.1.
CH471112 Genomic DNA. Translation: EAW85827.1.
CH471112 Genomic DNA. Translation: EAW85829.1.
CH471112 Genomic DNA. Translation: EAW85832.1.
CH471112 Genomic DNA. Translation: EAW85834.1.
BC000507 mRNA. Translation: AAH00507.2.
BC000990 mRNA. Translation: AAH00990.2.
U19796 mRNA. Translation: AAC50181.1. Different initiation.
BT009857 mRNA. Translation: AAP88859.1.
CCDSiCCDS32349.1.
RefSeqiNP_006419.2. NM_006428.4.
XP_005255098.1. XM_005255041.1.
UniGeneiHs.513230.

3D structure databases

ProteinModelPortaliQ13084.
SMRiQ13084. Positions 82-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115824. 59 interactions.
DIPiDIP-61135N.
IntActiQ13084. 4 interactions.
MINTiMINT-1383002.
STRINGi9606.ENSP00000199706.

PTM databases

PhosphoSiteiQ13084.

Polymorphism databases

DMDMi85695426.

Proteomic databases

MaxQBiQ13084.
PaxDbiQ13084.
PRIDEiQ13084.

Protocols and materials databases

DNASUi10573.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199706; ENSP00000199706; ENSG00000086504.
ENST00000389675; ENSP00000374326; ENSG00000086504.
GeneIDi10573.
KEGGihsa:10573.
UCSCiuc002cgs.2. human.

Organism-specific databases

CTDi10573.
GeneCardsiGC16M000357.
HGNCiHGNC:14484. MRPL28.
HPAiCAB033542.
HPA030594.
HPA055589.
MIMi604853. gene.
neXtProtiNX_Q13084.
PharmGKBiPA30515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG259466.
GeneTreeiENSGT00390000017359.
HOVERGENiHBG083707.
InParanoidiQ13084.
KOiK02902.
OMAiRPHGAKF.
OrthoDBiEOG70KGQ8.
PhylomeDBiQ13084.
TreeFamiTF313040.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSiMRPL28. human.
GeneWikiiMRPL28.
GenomeRNAii10573.
NextBioi40127.
PROiQ13084.
SOURCEiSearch...

Gene expression databases

BgeeiQ13084.
CleanExiHS_MRPL28.
ExpressionAtlasiQ13084. baseline and differential.
GenevestigatoriQ13084.

Family and domain databases

InterProiIPR026569. Ribo_L28/L24.
[Graphical view]
PANTHERiPTHR13528. PTHR13528. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-27.
    Tissue: Skeletal muscle.
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-27.
    Tissue: Lung and Placenta.
  6. "Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes."
    Robbins P.F., El-Gamil M., Li Y.F., Topalian S.L., Rivoltini L., Sakaguchi K., Appella E., Kawakami Y., Rosenberg S.A.
    J. Immunol. 154:5944-5950(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-256, SYNTHESIS OF 137-146, VARIANT GLU-160.
    Tissue: Melanoma.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-256.
  8. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM28_HUMAN
AccessioniPrimary (citable) accession number: Q13084
Secondary accession number(s): B2RCM4
, D3DU46, Q4TT39, Q96S26, Q9BQD8, Q9BR04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 24, 2006
Last modified: March 4, 2015
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.