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Q13084

- RM28_HUMAN

UniProt

Q13084 - RM28_HUMAN

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Protein

39S ribosomal protein L28, mitochondrial

Gene
MRPL28, MAAT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L28, mitochondrial
Short name:
L28mt
Short name:
MRP-L28
Alternative name(s):
Melanoma antigen p15
Melanoma-associated antigen recognized by T-lymphocytes
Gene namesi
Name:MRPL28
Synonyms:MAAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14484. MRPL28.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrial ribosome Source: UniProtKB
  3. mitochondrion Source: HPA
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5555Mitochondrion By similarityAdd
BLAST
Chaini56 – 25620139S ribosomal protein L28, mitochondrialPRO_0000030506Add
BLAST

Proteomic databases

MaxQBiQ13084.
PaxDbiQ13084.
PRIDEiQ13084.

PTM databases

PhosphoSiteiQ13084.

Expressioni

Tissue specificityi

Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.

Gene expression databases

ArrayExpressiQ13084.
BgeeiQ13084.
CleanExiHS_MRPL28.
GenevestigatoriQ13084.

Organism-specific databases

HPAiHPA030594.
HPA055589.

Interactioni

Subunit structurei

Interacts with OXA1L By similarity.

Protein-protein interaction databases

BioGridi115824. 14 interactions.
IntActiQ13084. 3 interactions.
MINTiMINT-1383002.
STRINGi9606.ENSP00000199706.

Structurei

3D structure databases

ProteinModelPortaliQ13084.
SMRiQ13084. Positions 82-138.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG259466.
HOVERGENiHBG083707.
KOiK02902.
OMAiRPHGAKF.
OrthoDBiEOG70KGQ8.
PhylomeDBiQ13084.
TreeFamiTF313040.

Family and domain databases

InterProiIPR026569. Ribo_L28/L24.
[Graphical view]
PANTHERiPTHR13528. PTHR13528. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13084-1 [UniParc]FASTAAdd to Basket

« Hide

MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF    50
KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQI YANNDKLSKR 100
LKKVWKPQLF EREFYSEILD KKFTVTVTMR TLDLIDEAYG LDFYILKTPK 150
EDLCSKFGMD LKRGMLLRLA RQDPQLHPED PERRAAIYDK YKEFAIPEEE 200
AEWVGLTLEE AIEKQRLLEE KDPVPLFKIY VAELIQQLQQ QALSEPAVVQ 250
KRASGQ 256
Length:256
Mass (Da):30,157
Last modified:January 24, 2006 - v4
Checksum:i6578FD1E98FC5A6E
GO

Sequence cautioni

The sequence AAC50181.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAK61226.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271H → Y.2 Publications
Corresponds to variant rs3194151 [ dbSNP | Ensembl ].
VAR_054219
Natural varianti160 – 1601D → E.1 Publication
Corresponds to variant rs11557302 [ dbSNP | Ensembl ].
VAR_052024
Natural varianti230 – 2301Y → C.
Corresponds to variant rs13226 [ dbSNP | Ensembl ].
VAR_061806

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471K → KASG in AAK61226. 1 Publication
Sequence conflicti148 – 1503TPK → ASG1 Publication
Sequence conflicti252 – 2521R → T in AAC50181. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK315180 mRNA. Translation: BAG37621.1.
AE006463 Genomic DNA. Translation: AAK61226.1. Sequence problems.
Z97634 Genomic DNA. Translation: CAI95594.1.
CH471112 Genomic DNA. Translation: EAW85827.1.
CH471112 Genomic DNA. Translation: EAW85829.1.
CH471112 Genomic DNA. Translation: EAW85832.1.
CH471112 Genomic DNA. Translation: EAW85834.1.
BC000507 mRNA. Translation: AAH00507.2.
BC000990 mRNA. Translation: AAH00990.2.
U19796 mRNA. Translation: AAC50181.1. Different initiation.
BT009857 mRNA. Translation: AAP88859.1.
CCDSiCCDS32349.1.
RefSeqiNP_006419.2. NM_006428.4.
XP_005255098.1. XM_005255041.1.
UniGeneiHs.513230.

Genome annotation databases

EnsembliENST00000199706; ENSP00000199706; ENSG00000086504.
ENST00000389675; ENSP00000374326; ENSG00000086504.
GeneIDi10573.
KEGGihsa:10573.
UCSCiuc002cgs.2. human.

Polymorphism databases

DMDMi85695426.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK315180 mRNA. Translation: BAG37621.1 .
AE006463 Genomic DNA. Translation: AAK61226.1 . Sequence problems.
Z97634 Genomic DNA. Translation: CAI95594.1 .
CH471112 Genomic DNA. Translation: EAW85827.1 .
CH471112 Genomic DNA. Translation: EAW85829.1 .
CH471112 Genomic DNA. Translation: EAW85832.1 .
CH471112 Genomic DNA. Translation: EAW85834.1 .
BC000507 mRNA. Translation: AAH00507.2 .
BC000990 mRNA. Translation: AAH00990.2 .
U19796 mRNA. Translation: AAC50181.1 . Different initiation.
BT009857 mRNA. Translation: AAP88859.1 .
CCDSi CCDS32349.1.
RefSeqi NP_006419.2. NM_006428.4.
XP_005255098.1. XM_005255041.1.
UniGenei Hs.513230.

3D structure databases

ProteinModelPortali Q13084.
SMRi Q13084. Positions 82-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115824. 14 interactions.
IntActi Q13084. 3 interactions.
MINTi MINT-1383002.
STRINGi 9606.ENSP00000199706.

PTM databases

PhosphoSitei Q13084.

Polymorphism databases

DMDMi 85695426.

Proteomic databases

MaxQBi Q13084.
PaxDbi Q13084.
PRIDEi Q13084.

Protocols and materials databases

DNASUi 10573.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000199706 ; ENSP00000199706 ; ENSG00000086504 .
ENST00000389675 ; ENSP00000374326 ; ENSG00000086504 .
GeneIDi 10573.
KEGGi hsa:10573.
UCSCi uc002cgs.2. human.

Organism-specific databases

CTDi 10573.
GeneCardsi GC16M000357.
HGNCi HGNC:14484. MRPL28.
HPAi HPA030594.
HPA055589.
MIMi 604853. gene.
neXtProti NX_Q13084.
PharmGKBi PA30515.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259466.
HOVERGENi HBG083707.
KOi K02902.
OMAi RPHGAKF.
OrthoDBi EOG70KGQ8.
PhylomeDBi Q13084.
TreeFami TF313040.

Miscellaneous databases

GeneWikii MRPL28.
GenomeRNAii 10573.
NextBioi 40127.
PROi Q13084.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13084.
Bgeei Q13084.
CleanExi HS_MRPL28.
Genevestigatori Q13084.

Family and domain databases

InterProi IPR026569. Ribo_L28/L24.
[Graphical view ]
PANTHERi PTHR13528. PTHR13528. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-27.
    Tissue: Skeletal muscle.
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-27.
    Tissue: Lung and Placenta.
  6. "Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes."
    Robbins P.F., El-Gamil M., Li Y.F., Topalian S.L., Rivoltini L., Sakaguchi K., Appella E., Kawakami Y., Rosenberg S.A.
    J. Immunol. 154:5944-5950(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-256, SYNTHESIS OF 137-146, VARIANT GLU-160.
    Tissue: Melanoma.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-256.
  8. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM28_HUMAN
AccessioniPrimary (citable) accession number: Q13084
Secondary accession number(s): B2RCM4
, D3DU46, Q4TT39, Q96S26, Q9BQD8, Q9BR04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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