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Q13075

- BIRC1_HUMAN

UniProt

Q13075 - BIRC1_HUMAN

Protein

Baculoviral IAP repeat-containing protein 1

Gene

NAIP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (30 May 2006)
      Previous versions | rss
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    Functioni

    Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
    Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi315 – 3151Zinc
    Metal bindingi318 – 3181Zinc
    Metal bindingi335 – 3351Zinc
    Metal bindingi342 – 3421Zinc
    Binding sitei476 – 4761ATP

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. nucleoside-triphosphatase activity Source: InterPro
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. inflammatory response Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW
    3. negative regulation of apoptotic process Source: UniProtKB
    4. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    5. negative regulation of neuron apoptotic process Source: UniProtKB
    6. nervous system development Source: ProtInc

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Keywords - Biological processi

    Apoptosis, Immunity, Inflammatory response, Innate immunity

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ13075.

    Protein family/group databases

    MEROPSiI32.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Baculoviral IAP repeat-containing protein 1
    Alternative name(s):
    Neuronal apoptosis inhibitory protein
    Gene namesi
    Name:NAIP
    Synonyms:BIRC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:7634. NAIP.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi476 – 4761K → T: Prevents the proper cleavage of pro-CASP9, but does not inhibit the cleavage of pro-CASP3 by CASP9. 1 Publication

    Organism-specific databases

    Orphaneti83330. Proximal spinal muscular atrophy type 1.
    83418. Proximal spinal muscular atrophy type 2.
    83419. Proximal spinal muscular atrophy type 3.
    PharmGKBiPA162396805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14031403Baculoviral IAP repeat-containing protein 1PRO_0000122341Add
    BLAST

    Proteomic databases

    PaxDbiQ13075.
    PRIDEiQ13075.

    PTM databases

    PhosphoSiteiQ13075.

    Expressioni

    Tissue specificityi

    Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.

    Gene expression databases

    ArrayExpressiQ13075.
    BgeeiQ13075.
    CleanExiHS_NAIP.
    GenevestigatoriQ13075.

    Organism-specific databases

    HPAiHPA042438.

    Interactioni

    Subunit structurei

    Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Interacts with C.violaceum needle protein CprI.3 Publications

    Protein-protein interaction databases

    BioGridi110752. 8 interactions.
    DIPiDIP-59150N.
    IntActiQ13075. 2 interactions.
    STRINGi9606.ENSP00000194097.

    Structurei

    Secondary structure

    1
    1403
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi159 – 1646
    Helixi165 – 1684
    Helixi171 – 1733
    Helixi178 – 1836
    Beta strandi186 – 1883
    Beta strandi195 – 1973
    Turni198 – 2003
    Beta strandi203 – 2064
    Helixi213 – 2208
    Helixi225 – 2317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VM5X-ray1.80A141-244[»]
    ProteinModelPortaliQ13075.
    SMRiQ13075. Positions 60-129, 140-244, 278-345, 451-929, 1072-1113, 1155-1370.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13075.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati60 – 12768BIR 1Add
    BLAST
    Repeati159 – 22769BIR 2Add
    BLAST
    Repeati278 – 34568BIR 3Add
    BLAST
    Domaini464 – 758295NACHTPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1.1 Publication

    Sequence similaritiesi

    Contains 3 BIR repeats.PROSITE-ProRule annotation
    Contains 1 NACHT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG291696.
    HOGENOMiHOG000236326.
    HOVERGENiHBG050689.
    InParanoidiQ13075.
    KOiK12807.
    OMAiDISRHIP.
    PhylomeDBiQ13075.
    TreeFamiTF105356.

    Family and domain databases

    Gene3Di1.10.1170.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR001370. BIR.
    IPR007111. NACHT_NTPase.
    IPR028789. Naip.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10044:SF94. PTHR10044:SF94. 1 hit.
    PfamiPF00653. BIR. 3 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00238. BIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS01282. BIR_REPEAT_1. 3 hits.
    PS50143. BIR_REPEAT_2. 3 hits.
    PS50837. NACHT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13075-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATQQKASDE RISQFDHNLL PELSALLGLD AVQLAKELEE EEQKERAKMQ     50
    KGYNSQMRSE AKRLKTFVTY EPYSSWIPQE MAAAGFYFTG VKSGIQCFCC 100
    SLILFGAGLT RLPIEDHKRF HPDCGFLLNK DVGNIAKYDI RVKNLKSRLR 150
    GGKMRYQEEE ARLASFRNWP FYVQGISPCV LSEAGFVFTG KQDTVQCFSC 200
    GGCLGNWEEG DDPWKEHAKW FPKCEFLRSK KSSEEITQYI QSYKGFVDIT 250
    GEHFVNSWVQ RELPMASAYC NDSIFAYEEL RLDSFKDWPR ESAVGVAALA 300
    KAGLFYTGIK DIVQCFSCGG CLEKWQEGDD PLDDHTRCFP NCPFLQNMKS 350
    SAEVTPDLQS RGELCELLET TSESNLEDSI AVGPIVPEMA QGEAQWFQEA 400
    KNLNEQLRAA YTSASFRHMS LLDISSDLAT DHLLGCDLSI ASKHISKPVQ 450
    EPLVLPEVFG NLNSVMCVEG EAGSGKTVLL KKIAFLWASG CCPLLNRFQL 500
    VFYLSLSSTR PDEGLASIIC DQLLEKEGSV TEMCVRNIIQ QLKNQVLFLL 550
    DDYKEICSIP QVIGKLIQKN HLSRTCLLIA VRTNRARDIR RYLETILEIK 600
    AFPFYNTVCI LRKLFSHNMT RLRKFMVYFG KNQSLQKIQK TPLFVAAICA 650
    HWFQYPFDPS FDDVAVFKSY MERLSLRNKA TAEILKATVS SCGELALKGF 700
    FSCCFEFNDD DLAEAGVDED EDLTMCLMSK FTAQRLRPFY RFLSPAFQEF 750
    LAGMRLIELL DSDRQEHQDL GLYHLKQINS PMMTVSAYNN FLNYVSSLPS 800
    TKAGPKIVSH LLHLVDNKES LENISENDDY LKHQPEISLQ MQLLRGLWQI 850
    CPQAYFSMVS EHLLVLALKT AYQSNTVAAC SPFVLQFLQG RTLTLGALNL 900
    QYFFDHPESL SLLRSIHFPI RGNKTSPRAH FSVLETCFDK SQVPTIDQDY 950
    ASAFEPMNEW ERNLAEKEDN VKSYMDMQRR ASPDLSTGYW KLSPKQYKIP 1000
    CLEVDVNDID VVGQDMLEIL MTVFSASQRI ELHLNHSRGF IESIRPALEL 1050
    SKASVTKCSI SKLELSAAEQ ELLLTLPSLE SLEVSGTIQS QDQIFPNLDK 1100
    FLCLKELSVD LEGNINVFSV IPEEFPNFHH MEKLLIQISA EYDPSKLVKL 1150
    IQNSPNLHVF HLKCNFFSDF GSLMTMLVSC KKLTEIKFSD SFFQAVPFVA 1200
    SLPNFISLKI LNLEGQQFPD EETSEKFAYI LGSLSNLEEL ILPTGDGIYR 1250
    VAKLIIQQCQ QLHCLRVLSF FKTLNDDSVV EIAKVAISGG FQKLENLKLS 1300
    INHKITEEGY RNFFQALDNM PNLQELDISR HFTECIKAQA TTVKSLSQCV 1350
    LRLPRLIRLN MLSWLLDADD IALLNVMKER HPQSKYLTIL QKWILPFSPI 1400
    IQK 1403
    Length:1,403
    Mass (Da):159,582
    Last modified:May 30, 2006 - v3
    Checksum:iC1CE163D55900C6D
    GO
    Isoform 2 (identifier: Q13075-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: MATQQKASDE...GYNSQMRSEA → MPLHIGDFVW...IRLELWINLR
         62-223: Missing.

    Show »
    Length:1,241
    Mass (Da):141,329
    Checksum:i51648FB32357B99A
    GO

    Sequence cautioni

    The sequence AAC62261.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti386 – 3872VP → ST in AAA64504. (PubMed:7552146)Curated
    Sequence conflicti553 – 5531Y → H in AAA64504. (PubMed:7552146)Curated
    Sequence conflicti567 – 5682IQ → FK in BAD92360. 1 PublicationCurated
    Sequence conflicti919 – 9191P → S in BAD92360. 1 PublicationCurated
    Sequence conflicti1066 – 10661S → T in BAD92360. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti535 – 5351V → M.5 Publications
    VAR_026477

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161MATQQ…MRSEA → MPLHIGDFVWDSKVHSLQSS LNIFSLLPTKGRTEHLFFSH ILSFHWPAFSSIRLELWINL R in isoform 2. 1 PublicationVSP_047196Add
    BLAST
    Alternative sequencei62 – 223162Missing in isoform 2. 1 PublicationVSP_047197Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19251 mRNA. Translation: AAC52045.1.
    U80017 Genomic DNA. Translation: AAC52047.1.
    AC005031 Genomic DNA. Translation: AAC62261.1. Sequence problems.
    AC044797 Genomic DNA. No translation available.
    BC136273 mRNA. Translation: AAI36274.1.
    AB048534 mRNA. Translation: BAB87181.1.
    AH003063 mRNA. Translation: AAA64504.1.
    AB209123 mRNA. Translation: BAD92360.1.
    CCDSiCCDS4009.1. [Q13075-1]
    CCDS43327.1. [Q13075-2]
    RefSeqiNP_004527.2. NM_004536.2. [Q13075-1]
    NP_075043.1. NM_022892.1. [Q13075-2]
    UniGeneiHs.654500.
    Hs.710305.

    Genome annotation databases

    EnsembliENST00000194097; ENSP00000443944; ENSG00000249437. [Q13075-1]
    ENST00000503719; ENSP00000424913; ENSG00000249437. [Q13075-2]
    ENST00000517649; ENSP00000428657; ENSG00000249437. [Q13075-1]
    ENST00000523981; ENSP00000428363; ENSG00000249437. [Q13075-2]
    GeneIDi4671.
    KEGGihsa:4671.
    UCSCiuc003jyj.1. human. [Q13075-1]

    Polymorphism databases

    DMDMi109940027.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19251 mRNA. Translation: AAC52045.1 .
    U80017 Genomic DNA. Translation: AAC52047.1 .
    AC005031 Genomic DNA. Translation: AAC62261.1 . Sequence problems.
    AC044797 Genomic DNA. No translation available.
    BC136273 mRNA. Translation: AAI36274.1 .
    AB048534 mRNA. Translation: BAB87181.1 .
    AH003063 mRNA. Translation: AAA64504.1 .
    AB209123 mRNA. Translation: BAD92360.1 .
    CCDSi CCDS4009.1. [Q13075-1 ]
    CCDS43327.1. [Q13075-2 ]
    RefSeqi NP_004527.2. NM_004536.2. [Q13075-1 ]
    NP_075043.1. NM_022892.1. [Q13075-2 ]
    UniGenei Hs.654500.
    Hs.710305.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VM5 X-ray 1.80 A 141-244 [» ]
    ProteinModelPortali Q13075.
    SMRi Q13075. Positions 60-129, 140-244, 278-345, 451-929, 1072-1113, 1155-1370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110752. 8 interactions.
    DIPi DIP-59150N.
    IntActi Q13075. 2 interactions.
    STRINGi 9606.ENSP00000194097.

    Protein family/group databases

    MEROPSi I32.001.

    PTM databases

    PhosphoSitei Q13075.

    Polymorphism databases

    DMDMi 109940027.

    Proteomic databases

    PaxDbi Q13075.
    PRIDEi Q13075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000194097 ; ENSP00000443944 ; ENSG00000249437 . [Q13075-1 ]
    ENST00000503719 ; ENSP00000424913 ; ENSG00000249437 . [Q13075-2 ]
    ENST00000517649 ; ENSP00000428657 ; ENSG00000249437 . [Q13075-1 ]
    ENST00000523981 ; ENSP00000428363 ; ENSG00000249437 . [Q13075-2 ]
    GeneIDi 4671.
    KEGGi hsa:4671.
    UCSCi uc003jyj.1. human. [Q13075-1 ]

    Organism-specific databases

    CTDi 4671.
    GeneCardsi GC05M070267.
    H-InvDB HIX0164257.
    HGNCi HGNC:7634. NAIP.
    HPAi HPA042438.
    MIMi 600355. gene.
    neXtProti NX_Q13075.
    Orphaneti 83330. Proximal spinal muscular atrophy type 1.
    83418. Proximal spinal muscular atrophy type 2.
    83419. Proximal spinal muscular atrophy type 3.
    PharmGKBi PA162396805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291696.
    HOGENOMi HOG000236326.
    HOVERGENi HBG050689.
    InParanoidi Q13075.
    KOi K12807.
    OMAi DISRHIP.
    PhylomeDBi Q13075.
    TreeFami TF105356.

    Enzyme and pathway databases

    SignaLinki Q13075.

    Miscellaneous databases

    ChiTaRSi NAIP. human.
    EvolutionaryTracei Q13075.
    GeneWikii NAIP_(gene).
    GenomeRNAii 4671.
    NextBioi 18000.
    PROi Q13075.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13075.
    Bgeei Q13075.
    CleanExi HS_NAIP.
    Genevestigatori Q13075.

    Family and domain databases

    Gene3Di 1.10.1170.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR001370. BIR.
    IPR007111. NACHT_NTPase.
    IPR028789. Naip.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10044:SF94. PTHR10044:SF94. 1 hit.
    Pfami PF00653. BIR. 3 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00238. BIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS01282. BIR_REPEAT_1. 3 hits.
    PS50143. BIR_REPEAT_2. 3 hits.
    PS50837. NACHT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-535, POSSIBLE ROLE IN THE PROTECTION FROM SPINAL MUSCULAR ATROPHY.
      Tissue: Fetal brain.
    2. "Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP."
      Chen Q., Baird S.D., Mahadevan M., Besner-Johnston A., Farahani R., Xuan J.-Y., Kang X., Lefebvre C., Ikeda J.-E., Korneluk R.G., MacKenzie A.E.
      Genomics 48:121-127(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION, VARIANT MET-535.
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-535.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-535.
      Tissue: Testis.
    5. "Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes."
      Xu M., Okada T., Sakai H., Miyamoto N., Yanagisawa Y., MacKenzie A.E., Hadano S., Ikeda J.-E.
      Biochim. Biophys. Acta 1574:35-50(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1160 (ISOFORM 2), VARIANT MET-535.
    6. "A provisional transcript map of the spinal muscular atrophy (SMA) critical region."
      van der Steege G., Draaijers T.G., Grootscholten P.M., Osinga J., Anzevino R., Velona I., Den Dunnen J.T., Scheffer H., Brahe C., van Ommen G.J.B., Buys C.H.C.M.
      Eur. J. Hum. Genet. 3:87-95(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 386-623 (ISOFORM 1/2).
      Tissue: Pre-B cell.
    7. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 567-1403 (ISOFORM 1/2).
      Tissue: Brain.
    8. "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes."
      Liston P., Roy N., Tamai K., Lefebvre C., Baird S., Cherton-Horvat G., Farahani R., McLean M., Ikeda J., Mackenzie A., Korneluk R.G.
      Nature 379:349-353(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Tissue: Liver.
    9. "The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7."
      Maier J.K., Lahoua Z., Gendron N.H., Fetni R., Johnston A., Davoodi J., Rasper D., Roy S., Slack R.S., Nicholson D.W., MacKenzie A.E.
      J. Neurosci. 22:2035-2043(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "IAPs: more than just inhibitors of apoptosis proteins."
      Dubrez-Daloz L., Dupoux A., Cartier J.
      Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    11. "Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP."
      Karimpour S., Davoodi J., Ghahremani M.H.
      Biochem. Biophys. Res. Commun. 407:158-162(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH APAF1, DOMAIN BIR3 AND NACHT, MUTAGENESIS OF LYS-476.
    12. "The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus."
      Zhao Y., Yang J., Shi J., Gong Y.N., Lu Q., Xu H., Liu L., Shao F.
      Nature 477:596-600(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INFLAMMASOME, INTERACTION WITH C.VIOLACEUM CPRI.
    13. "The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila."
      Katagiri N., Shobuike T., Chang B., Kukita A., Miyamoto H.
      Microbes Infect. 14:1123-1132(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INFLAMMASOME.
    14. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 141-244 IN COMPLEX WITH ZINC IONS.

    Entry informationi

    Entry nameiBIRC1_HUMAN
    AccessioniPrimary (citable) accession number: Q13075
    Secondary accession number(s): B9EG72
    , E9PHD1, O75857, Q13730, Q59GI6, Q8TDZ4, Q99796
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3