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Protein

B melanoma antigen 1

Gene

BAGE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Enzyme and pathway databases

BioCyciZFISH:G66-31315-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
B melanoma antigen 1
Short name:
B melanoma antigen
Alternative name(s):
Antigen MZ2-BA
Cancer/testis antigen 2.1
Short name:
CT2.1
Gene namesi
Name:BAGE
Synonyms:BAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:942. BAGE.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi574.
PharmGKBiPA25242.

Polymorphism and mutation databases

DMDMi5915765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002077418 – 43B melanoma antigen 1Add BLAST26

Proteomic databases

PaxDbiQ13072.
PRIDEiQ13072.

Expressioni

Tissue specificityi

Not expressed in normal tissues, except in testis. Expressed with significant proportion in melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas.

Gene expression databases

CleanExiHS_BAGE.

Interactioni

Protein-protein interaction databases

IntActiQ13072. 1 interactor.
STRINGi9606.ENSP00000472450.

Structurei

3D structure databases

ProteinModelPortaliQ13072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAGE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG050656.
PhylomeDBiQ13072.

Family and domain databases

InterProiIPR012530. BAGE.
[Graphical view]
PfamiPF08180. BAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: At least 6 different mRNAs, BAGE1a, BAGE1b, BAGE1c, BAGE1d, BAGE1e and BAGE1f, are produced by alternative splicing. They differ in the 3' region, but give rise to the same protein sequence.1 Publication
Isoform 1 (identifier: Q13072-1) [UniParc]FASTAAdd to basket
Also known as: BAGE1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40 
MAARAVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALC FIF
Length:43
Mass (Da):4,810
Last modified:November 1, 1996 - v1
Checksum:i36F3BBCE4012F1BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19180 mRNA. Translation: AAC50123.1.
AF499647 Genomic DNA. Translation: AAP30743.1.
AF527550 mRNA. Translation: AAO32670.1.
AF527551 mRNA. Translation: AAO32671.1.
AF527552 mRNA. Translation: AAO32672.1.
AF527553 mRNA. Translation: AAO32673.1.
AF527554 mRNA. Translation: AAO32674.1.
BC107038 mRNA. Translation: AAI07039.1.
RefSeqiNP_001178.1. NM_001187.1. [Q13072-1]
UniGeneiHs.545789.
Hs.571595.
Hs.624543.

Genome annotation databases

GeneIDi574.
KEGGihsa:574.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19180 mRNA. Translation: AAC50123.1.
AF499647 Genomic DNA. Translation: AAP30743.1.
AF527550 mRNA. Translation: AAO32670.1.
AF527551 mRNA. Translation: AAO32671.1.
AF527552 mRNA. Translation: AAO32672.1.
AF527553 mRNA. Translation: AAO32673.1.
AF527554 mRNA. Translation: AAO32674.1.
BC107038 mRNA. Translation: AAI07039.1.
RefSeqiNP_001178.1. NM_001187.1. [Q13072-1]
UniGeneiHs.545789.
Hs.571595.
Hs.624543.

3D structure databases

ProteinModelPortaliQ13072.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ13072. 1 interactor.
STRINGi9606.ENSP00000472450.

Polymorphism and mutation databases

DMDMi5915765.

Proteomic databases

PaxDbiQ13072.
PRIDEiQ13072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574.
KEGGihsa:574.

Organism-specific databases

CTDi574.
DisGeNETi574.
GeneCardsiBAGE.
HGNCiHGNC:942. BAGE.
MIMi605167. gene.
neXtProtiNX_Q13072.
PharmGKBiPA25242.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG050656.
PhylomeDBiQ13072.

Enzyme and pathway databases

BioCyciZFISH:G66-31315-MONOMER.

Miscellaneous databases

GenomeRNAii574.
PROiQ13072.
SOURCEiSearch...

Gene expression databases

CleanExiHS_BAGE.

Family and domain databases

InterProiIPR012530. BAGE.
[Graphical view]
PfamiPF08180. BAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q13072
Secondary accession number(s): A4IF47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.