Reviewed, UniProtKB/Swiss-Prot Q13072 (BAGE1_HUMAN)

Names and origin

Protein names

Recommended name:
    B melanoma antigen 1
      Short name=B melanoma antigen
Alternative name(s):
    Antigen MZ2-BA
    Cancer/testis antigen 2.1
      Short name=CT2.1

Gene names

Name:	BAGE
Synonyms:	BAGE1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	43 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Subcellular location	SecretedPotential.
Tissue specificity	Not expressed in normal tissues, except in testis. Expressed with significant proportion in melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas.
Miscellaneous	The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.
Sequence similarities	Belongs to the BAGE family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Notes: At least 6 different mRNAs, BAGE1a, BAGE1b, BAGE1c, BAGE1d, BAGE1e and BAGE1f, are produced by alternative splicing. They differ in the 3' region, but give rise to the same protein sequence.

Isoform 1 (identifier: Q13072-1)

Also known as: BAGE1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 43	26	B melanoma antigen 1		PRO_0000020774

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (BAGE1a) [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 36F3BBCE4012F1BB	FASTA	43	4,810
	10 20 30 40 MAARAVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALC FIF

References

[1]	"BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes." Boel P., Wildmann C., Sensi M.L., Brasseur R., Renauld J.-C., Coulie P., Boon T., van der Bruggen P. Immunity 2:167-175(1995) [PubMed: 7895173] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BAGE1A). Tissue: Melanoma.
[2]	"New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile." Ruault M., van der Bruggen P., Brun M.-E., Boyle S., Roizes G., De Sario A. Eur. J. Hum. Genet. 10:833-840(2002) [PubMed: 12461691] [Abstract] Cited for: ALTERNATIVE SPLICING.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U19180 mRNA. Translation: AAC50123.1. AF499647 Genomic DNA. Translation: AAP30743.1. AF527550 mRNA. Translation: AAO32670.1. AF527551 mRNA. Translation: AAO32671.1. AF527552 mRNA. Translation: AAO32672.1. AF527553 mRNA. Translation: AAO32673.1. AF527554 mRNA. Translation: AAO32674.1.
RefSeq	NP_001178.1.
UniGene	Hs.545789 Hs.624542 Hs.624543
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000187172. Homo sapiens. [Contig view]
GeneID	574.
KEGG	hsa:574.
Organism-specific databases
HGNC	HGNC:942. BAGE.
MIM	605167. gene.
PharmGKB	PA25242.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q13072.
Gene expression databases
CleanEx	HS_BAGE.
Family and domain databases
InterPro	IPR012530. BAGE. [Graphical view]
Pfam	PF08180. BAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	2341.
SOURCE	Search...

Entry information

Entry name

BAGE1_HUMAN

Accession

Primary (citable) accession number: Q13072

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	November 4, 2008
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)