ID GAGE6_HUMAN Reviewed; 117 AA. AC Q13070; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 08-NOV-2023, entry version 125. DE RecName: Full=G antigen 6; DE Short=GAGE-6; DE AltName: Full=Cancer/testis antigen 4.6; DE Short=CT4.6; GN Name=GAGE6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Melanoma; RX PubMed=7544395; DOI=10.1084/jem.182.3.689; RA van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.; RT "A new family of genes coding for an antigen recognized by autologous RT cytolytic T lymphocytes on a human melanoma."; RL J. Exp. Med. 182:689-698(1995). RN [2] RP CHARACTERIZATION OF ANTIGENIC PEPTIDES. RX PubMed=10397259; RA De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., RA Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., RA van der Bruggen P.; RT "Characterization of the GAGE genes that are expressed in various human RT cancers and in normal testis."; RL Cancer Res. 59:3157-3165(1999). RN [3] RP GAGE FAMILY. RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x; RA Gjerstorff M.F., Ditzel H.J.; RT "An overview of the GAGE cancer/testis antigen family with the inclusion of RT newly identified members."; RL Tissue Antigens 71:187-192(2008). CC -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but not in CC normal tissues, except testis. CC -!- MISCELLANEOUS: This gene belongs to a family of genes organized in CC clustered repeats. They have a high degree of predicted sequence CC identity, but differ by scattered single nucleotide substitution. Their CC sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY CC which is recognized by cytotoxic T-cells. CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}. CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA CC sequences, but the high identity of the GAGE members made impossible to CC separate products of paralogous genes from polymorph products. CC PubMed:18179644 presented a new GAGE gene nomenclature based on the CC identified genes and their products. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U19147; AAA82749.1; -; mRNA. DR RefSeq; NP_001467.1; NM_001476.1. DR AlphaFoldDB; Q13070; -. DR BioGRID; 108851; 1. DR iPTMnet; Q13070; -. DR PhosphoSitePlus; Q13070; -. DR BioMuta; HGNC:4103; -. DR jPOST; Q13070; -. DR MassIVE; Q13070; -. DR MaxQB; Q13070; -. DR PeptideAtlas; Q13070; -. DR Pumba; Q13070; -. DR DNASU; 2578; -. DR GeneID; 2578; -. DR KEGG; hsa:2578; -. DR AGR; HGNC:4103; -. DR CTD; 2578; -. DR DisGeNET; 2578; -. DR GeneCards; GAGE6; -. DR HGNC; HGNC:4103; GAGE6. DR MIM; 300599; gene. DR neXtProt; NX_Q13070; -. DR PharmGKB; PA28518; -. DR InParanoid; Q13070; -. DR PathwayCommons; Q13070; -. DR SignaLink; Q13070; -. DR BioGRID-ORCS; 2578; 1 hit in 26 CRISPR screens. DR GenomeRNAi; 2578; -. DR Pharos; Q13070; Tdark. DR PRO; PR:Q13070; -. DR Proteomes; UP000005640; Unplaced. DR RNAct; Q13070; Protein. DR InterPro; IPR031320; GAGE. DR InterPro; IPR008625; GAGE_fam. DR PANTHER; PTHR14047:SF30; G ANTIGEN 1-RELATED; 1. DR PANTHER; PTHR14047; P ANTIGEN FAMILY MEMBER 5-RELATED; 1. DR Pfam; PF05831; GAGE; 1. DR SMART; SM01379; GAGE; 1. PE 1: Evidence at protein level; KW Reference proteome. FT CHAIN 1..117 FT /note="G antigen 6" FT /id="PRO_0000148344" FT REGION 1..117 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 99..117 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 117 AA; 12892 MW; 234A865E3FCCCD06 CRC64; MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEVDPP NPEEVKTPEE GEKQSQC //