Q13070 (GAGE6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G antigen 6
Short name=GAGE-6

Alternative name(s):
Cancer/testis antigen 4.6
Short name=CT4.6

Gene names

Name:

GAGE6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in a variety of tumor tissues but not in normal tissues, except testis.
Miscellaneous	This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T cells.
Sequence similarities	Belongs to the GAGE family.
Caution	The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.3 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	G antigen 6		PRO_0000148344

Sequences

	Sequence		Length	Mass (Da)
	Q13070 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 234A865E3FCCCD06	FASTA	117	12,892
	10 20 30 40 50 60 MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE 70 80 90 100 110 DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEVDPP NPEEVKTPEE GEKQSQC

References

[1]	"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma." van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T. J. Exp. Med. 182:689-698(1995) [PubMed: 7544395] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanoma.
[2]	"Characterization of the GAGE genes that are expressed in various human cancers and in normal testis." De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P. Cancer Res. 59:3157-3165(1999) [PubMed: 10397259] [Abstract] Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
[3]	"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members." Gjerstorff M.F., Ditzel H.J. Tissue Antigens 71:187-192(2008) [PubMed: 18179644] [Abstract] Cited for: GAGE FAMILY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19147 mRNA. Translation: AAA82749.1.
IPI	IPI00011545.
RefSeq	NP_001467.1. NM_001476.1.
UniGene	Hs.632808.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q13070.
PTM databases
PhosphoSite	Q13070.
Polymorphism databases
DMDM	3023876.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000404804; ENSP00000384542; ENSG00000215269. ENST00000415752; ENSP00000391465; ENSG00000241465. ENST00000422672; ENSP00000405110; ENSG00000241465. ENST00000440137; ENSP00000404123; ENSG00000236362. ENST00000445148; ENSP00000416249; ENSG00000215269. ENST00000447358; ENSP00000399049; ENSG00000236362. ENST00000451387; ENSP00000406557; ENSG00000205777.
GeneID	2578.
KEGG	hsa:2578.
Organism-specific databases
CTD	2578.
GeneCards	GC0XP049365.
HGNC	HGNC:4103. GAGE6.
MIM	300599. gene.
neXtProt	NX_Q13070.
PharmGKB	PA28518.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG056227.
InParanoid	Q13070.
Gene expression databases
ArrayExpress	Q13070.
Bgee	Q13070.
CleanEx	HS_GAGE6.
Genevestigator	Q13070.
GermOnline	ENSG00000068990. Homo sapiens. ENSG00000198716. Homo sapiens. ENSG00000205777. Homo sapiens.
Family and domain databases
InterPro	IPR008625. GAGE. [Graphical view]
Pfam	PF05831. GAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	10193.
SOURCE	Search...

Entry information

Entry name

GAGE6_HUMAN

Accession

Primary (citable) accession number: Q13070

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.