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Q13070

- GAGE6_HUMAN

UniProt

Q13070 - GAGE6_HUMAN

Protein

G antigen 6

Gene

GAGE6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 6
    Short name:
    GAGE-6
    Alternative name(s):
    Cancer/testis antigen 4.6
    Short name:
    CT4.6
    Gene namesi
    Name:GAGE6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4103. GAGE6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28518.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 117117G antigen 6PRO_0000148344Add
    BLAST

    Proteomic databases

    PRIDEiQ13070.

    PTM databases

    PhosphoSiteiQ13070.

    Expressioni

    Tissue specificityi

    Expressed in a variety of tumor tissues but not in normal tissues, except testis.

    Gene expression databases

    CleanExiHS_GAGE6.
    GenevestigatoriQ13070.

    Organism-specific databases

    HPAiHPA043232.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    HOVERGENiHBG056227.
    InParanoidiQ13070.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13070-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR    50
    QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEVDPP 100
    NPEEVKTPEE GEKQSQC 117
    Length:117
    Mass (Da):12,892
    Last modified:November 1, 1996 - v1
    Checksum:i234A865E3FCCCD06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19147 mRNA. Translation: AAA82749.1.
    RefSeqiNP_001467.1. NM_001476.1.
    UniGeneiHs.632808.

    Genome annotation databases

    GeneIDi2578.
    KEGGihsa:2578.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19147 mRNA. Translation: AAA82749.1 .
    RefSeqi NP_001467.1. NM_001476.1.
    UniGenei Hs.632808.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q13070.

    Proteomic databases

    PRIDEi Q13070.

    Protocols and materials databases

    DNASUi 2578.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2578.
    KEGGi hsa:2578.

    Organism-specific databases

    CTDi 2578.
    GeneCardsi GC0XU990069.
    HGNCi HGNC:4103. GAGE6.
    HPAi HPA043232.
    MIMi 300599. gene.
    neXtProti NX_Q13070.
    PharmGKBi PA28518.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG056227.
    InParanoidi Q13070.

    Miscellaneous databases

    GenomeRNAii 2578.
    NextBioi 10193.
    PROi Q13070.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_GAGE6.
    Genevestigatori Q13070.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
      van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
      J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Melanoma.
    2. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
      De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
      Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
    3. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGAGE6_HUMAN
    AccessioniPrimary (citable) accession number: Q13070
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3