ID   GAGE5_HUMAN             Reviewed;         117 AA.
AC   Q13069; Q6FG72;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 137.
DE   RecName: Full=G antigen 5;
DE            Short=GAGE-5;
DE   AltName: Full=Cancer/testis antigen 4.5;
DE            Short=CT4.5;
GN   Name=GAGE5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Melanoma;
RX   PubMed=7544395; DOI=10.1084/jem.182.3.689;
RA   van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.;
RT   "A new family of genes coding for an antigen recognized by autologous
RT   cytolytic T lymphocytes on a human melanoma.";
RL   J. Exp. Med. 182:689-698(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA   Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA   LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   CHARACTERIZATION OF ANTIGENIC PEPTIDES.
RX   PubMed=10397259;
RA   De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S.,
RA   Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T.,
RA   van der Bruggen P.;
RT   "Characterization of the GAGE genes that are expressed in various human
RT   cancers and in normal testis.";
RL   Cancer Res. 59:3157-3165(1999).
RN   [5]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- INTERACTION:
CC       Q13069; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-745702, EBI-10172181;
CC       Q13069; Q96IK5: GMCL1; NbExp=6; IntAct=EBI-745702, EBI-2548508;
CC       Q13069; Q8NEA9: GMCL2; NbExp=4; IntAct=EBI-745702, EBI-745707;
CC       Q13069; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-745702, EBI-750109;
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but not in
CC       normal tissues, except testis.
CC   -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC       clustered repeats. They have a high degree of predicted sequence
CC       identity, but differ by scattered single nucleotide substitution. Their
CC       sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY
CC       which is recognized by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
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DR   EMBL; U19146; AAA82748.1; -; mRNA.
DR   EMBL; CR542236; CAG47032.1; -; mRNA.
DR   EMBL; BC024914; AAH24914.1; -; mRNA.
DR   RefSeq; NP_001465.1; NM_001474.1.
DR   RefSeq; NP_001466.1; NM_001475.1.
DR   AlphaFoldDB; Q13069; -.
DR   BioGRID; 108850; 51.
DR   IntAct; Q13069; 4.
DR   MINT; Q13069; -.
DR   iPTMnet; Q13069; -.
DR   PhosphoSitePlus; Q13069; -.
DR   BioMuta; HGNC:4102; -.
DR   jPOST; Q13069; -.
DR   MassIVE; Q13069; -.
DR   MaxQB; Q13069; -.
DR   PeptideAtlas; Q13069; -.
DR   Pumba; Q13069; -.
DR   TopDownProteomics; Q13069; -.
DR   DNASU; 2576; -.
DR   GeneID; 2576; -.
DR   GeneID; 2577; -.
DR   KEGG; hsa:2576; -.
DR   KEGG; hsa:2577; -.
DR   AGR; HGNC:4101; -.
DR   AGR; HGNC:4102; -.
DR   CTD; 2576; -.
DR   CTD; 2577; -.
DR   DisGeNET; 2576; -.
DR   DisGeNET; 2577; -.
DR   GeneCards; GAGE5; -.
DR   HGNC; HGNC:4102; GAGE5.
DR   MIM; 300598; gene.
DR   neXtProt; NX_Q13069; -.
DR   PharmGKB; PA28517; -.
DR   eggNOG; ENOG502SZ68; Eukaryota.
DR   InParanoid; Q13069; -.
DR   OrthoDB; 4660048at2759; -.
DR   PathwayCommons; Q13069; -.
DR   SignaLink; Q13069; -.
DR   BioGRID-ORCS; 2576; 1 hit in 12 CRISPR screens.
DR   BioGRID-ORCS; 2577; 1 hit in 21 CRISPR screens.
DR   Pharos; Q13069; Tdark.
DR   PRO; PR:Q13069; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q13069; Protein.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047:SF30; G ANTIGEN 1-RELATED; 1.
DR   PANTHER; PTHR14047; P ANTIGEN FAMILY MEMBER 5-RELATED; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 5"
FT                   /id="PRO_0000148343"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        23
FT                   /note="V -> M (in Ref. 2; CAG47032)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   117 AA;  12924 MW;  234A865E2ECDDD06 CRC64;
     MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC
//